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2000 Journal Article Safety, tolerability and humoral immune responses after intramuscular administration of a malaria DNA vaccine to healthy adult volunteersLe, T. P., Coonan, K. M., Hedstrom, R. C., Charoenvit, Y., Sedegah, M., Epstein, J. E., Kumar, S., Wang, R., Doolan, D. L., Maguire, J. D., Parker, S. E., Hobart, P., Norman, J. and Hoffman, S. L. (2000). Safety, tolerability and humoral immune responses after intramuscular administration of a malaria DNA vaccine to healthy adult volunteers. Vaccine, 18 (18), 1893-1901. doi: 10.1016/s0264-410x(99)00407-7 |
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2000 Journal Article Can malaria DNA vaccines on their own be as immunogenic and protective as prime-boost approaches to immunization?Hoffman, S. L. and Doolan, D. L. (2000). Can malaria DNA vaccines on their own be as immunogenic and protective as prime-boost approaches to immunization?. Developments in biologicals, 104, 121-132. |
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1999 Journal Article IL-12 and NK cells are required for antigen-specific adaptive immunity against malaria initiated by CD8+ T cells in the Plasmodium yoelii modelDoolan, Denise L. and Hoffman, Stephen L. (1999). IL-12 and NK cells are required for antigen-specific adaptive immunity against malaria initiated by CD8+ T cells in the Plasmodium yoelii model. Journal of Immunology, 163 (2), 884-892. |
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1999 Journal Article CD4+ T-cell- and gamma interferon-dependent protection against murine malaria by immunization with linear synthetic peptides from a Plasmodium yoelii 17-kilodalton hepatocyte erythrocyte proteinCharoenvit, Yupin, Majam, Victoria Fallarme, Corradin, Giampietro, Sacci Jr., John B., Wang, Ruobing, Doolan, Denise L., Jones, Trevor R., Abot, Esteban, Patarroyo, Manuel E., Guzman, Fanny and Hoffman, Stephen L. (1999). CD4+ T-cell- and gamma interferon-dependent protection against murine malaria by immunization with linear synthetic peptides from a Plasmodium yoelii 17-kilodalton hepatocyte erythrocyte protein. Infection and Immunity, 67 (11), 5604-5614. doi: 10.1128/iai.67.11.5604-5614.1999 |
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1999 Journal Article Immune effector mechanisms in malariaGood, Michael F. and Doolan, Denise L. (1999). Immune effector mechanisms in malaria. Current Opinion in Immunology, 11 (4), 412-419. doi: 10.1016/S0952-7915(99)80069-7 |
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1998 Journal Article Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccineWang, R, Doolan, D L, Le, T P, Hedstrom, R C, Coonan, K M, Charoenvit, Y, Jones, T R, Hobart, P, Margalith, M, Ng, J, Weiss, W R, Sedegah, M, de Taisne, C, Norman, J A and Hoffman, S L (1998). Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine. Science (New York, N.Y.), 282 (5388), 476-80. doi: 10.1126/science.282.5388.476 |
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1998 Journal Article Simultaneous induction of multiple antigen-specific cytotoxic T lymphocytes in nonhuman primates by immunization with a mixture of four Plasmodium falciparum DNA plasmidsWang, Ruobing, Doolan, Denise L., Charoenvit, Yupin, Hedstrom, Richard C., Gardner, Malcolm J., Hobart, Peter, Tine, John, Sedegah, Martha, Fallarme, Victoria, Sacci Jr., John B., Kaur, Manjit, Klinman, Dennis M., Hoffman, Stephen L. and Weiss, Walter R. (1998). Simultaneous induction of multiple antigen-specific cytotoxic T lymphocytes in nonhuman primates by immunization with a mixture of four Plasmodium falciparum DNA plasmids. Infection and Immunity, 66 (9), 4193-4202. doi: 10.1128/.66.9.4193-4202.1998 |
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1998 Journal Article In vitro expression and in vivo immunogenicity of Plasmodium falciparum pre-erythrocytic stage DNA vaccinesHedstrom, R. C., Doolan, D. L., Wang, R., Kumar, A., Sacci Jr., J. B., Gardner, M. J., Aguiar, J. C., Charoenvit, Y., Sedegah, M., Tine, J. A., Margalith, M., Hobart, P. and Hoffman, S. L. (1998). In vitro expression and in vivo immunogenicity of Plasmodium falciparum pre-erythrocytic stage DNA vaccines. International journal of molecular medicine, 2 (1), 29-38. doi: 10.3892/ijmm.2.1.29 |
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1997 Journal Article DNA vaccination as an approach to malaria control: Current status and strategiesDoolan, D. L., Hedstrom, R. C., Gardner, M. J., Sedegah, M., Wang, H., Gramzinski, R. A., Maroatith, M., Hobart, P. and Hoffman, S. L. (1997). DNA vaccination as an approach to malaria control: Current status and strategies. Current Topics in Microbiology and Immunology, 226, 37-56. |
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1997 Journal Article The development of a multivalent DNA vaccine for malariaHedstrom, Richard C., Doolan, Denise L., Wang, Ruobing, Gardner, Malcolm J., Kumar, Anita, Sedegah, Martha, Gramzinski, Robert A., Sacci Jr., John B., Charoenvit, Yupin, Weiss, Walter R., Margalith, Michal, Norman, Jon A., Hobart, Peter and Hoffman, Stephen L. (1997). The development of a multivalent DNA vaccine for malaria. Springer Seminars in Immunopathology, 19 (2), 147-159. doi: 10.1007/BF00870265 |
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1997 Journal Article DNA vaccines for malaria: The past, the present, and the futureDoolan, Denise L., Hedstrom, Richard C., Wang, Ruobing, Sedegah, Martha, Scheller, Libia F., Hobart, Peter, Norman, Jon A. and Hoffman, Stephen L. (1997). DNA vaccines for malaria: The past, the present, and the future. Indian Journal of Medical Research, 106 (AUG.), 109-119. |
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1997 Journal Article Multi-gene vaccination against malaria: A multistage, multi-immune response approachDoolan, D. L. and Hoffman, S. L. (1997). Multi-gene vaccination against malaria: A multistage, multi-immune response approach. Parasitology Today, 13 (5), 171-178. doi: 10.1016/s0169-4758(97)01040-5 |
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1997 Journal Article Pre-erythrocytic-stage immune effector mechanisms in plasmodium spp. infectionsDoolan, Denise L. and Hoffman, Stephen L. (1997). Pre-erythrocytic-stage immune effector mechanisms in plasmodium spp. infections. Philosophical Transactions of the Royal Society B: Biological Sciences, 352 (1359), 1361-1367. doi: 10.1098/rstb.1997.0121 |
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1997 Journal Article Degenerate cytotoxic T cell epitopes from P. falciparum restricted by multiple HLA-A and HLA-B supertype allelesDoolan, Denise L., Hoffman, Stephen L., Southwood, Scott, Wentworth, Peggy A., Sidney, John, Chesnut, Robert W., Keogh, Elissa, Appella, Ettore, Nutman, Thomas B., Lal, Altaf, Gordon, Daniel M., Oloo, Aggrey and Sette, Alessandro (1997). Degenerate cytotoxic T cell epitopes from P. falciparum restricted by multiple HLA-A and HLA-B supertype alleles. Immunity, 7 (1), 97-112. doi: 10.1016/S1074-7613(00)80513-0 |
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1997 Journal Article Toward clinical trials of DNA vaccines against malariaHoffman, Stephen L., Doolan, Denise L., Sedegah, Martha, Wang, Ruobing, Scheller, Libia F., Kumar, Anita, Weiss, Walter R., Le, Thong P., Klinman, Dennis M., Hobart, Peter, Norman, Jon A. and Hedstrom, Richard C. (1997). Toward clinical trials of DNA vaccines against malaria. Immunology and Cell Biology, 75 (4), 376-381. doi: 10.1038/icb.1997.59 |
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1996 Journal Article Class I HLA-restricted cytotoxic T lymphocyte responses against malaria-elucidation on the basis of HLA peptide binding motifsDoolan, Denise L., Wizel, Benjamin and Hoffman, Stephen L. (1996). Class I HLA-restricted cytotoxic T lymphocyte responses against malaria-elucidation on the basis of HLA peptide binding motifs. Immunologic Research, 15 (4), 280-305. doi: 10.1007/BF02935313 |
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1996 Journal Article DNA vaccination against malariaDoolan, Denise L., Sedegah, Martha, Hedstrom, Richard C., Aguiar, Joao C. and Hoffman, Stephen L. (1996). DNA vaccination against malaria. Advanced Drug Delivery Reviews, 21 (1), 49-61. doi: 10.1016/0169-409X(96)00018-X |
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1996 Journal Article Identification and characterization of the protective hepatocyte erythrocyte protein 17 kDa gene of Plasmodium yoelii, homolog of Plasmodium falciparum exported protein 1Doolan, D. L., Hedstrom, R. C., Rogers, W. O., Charoenvit, Y., Rogers, M., de la Vega, P. and Hoffman, S. L. (1996). Identification and characterization of the protective hepatocyte erythrocyte protein 17 kDa gene of Plasmodium yoelii, homolog of Plasmodium falciparum exported protein 1. The Journal of Biological Chemistry, 271 (30), 17861-17868. doi: 10.1074/jbc.271.30.17861 |
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1996 Journal Article Circumventing genetic restriction of protection against malaria with multigene DNA immunization: CD8+ cell-, interferon gamma-, and nitric oxide-dependent immunityDoolan, D. L., Sedegah, M., Hedstrom, R. C., Hobart, P., Charoenvit, Y. and Hoffman, S. L. (1996). Circumventing genetic restriction of protection against malaria with multigene DNA immunization: CD8+ cell-, interferon gamma-, and nitric oxide-dependent immunity. The Journal of Experimental Medicine, 183 (4), 1739-1746. doi: 10.1084/jem.183.4.1739 |
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1996 Journal Article DNA vaccines against malaria: Immunogenicity and protection in a rodent modelGardner, Malcolm J., Doolan, Denise L., Hedstrom, Richard C., Wang, Ruobing, Sedegah, Martha, Gramzinski, Robert A., Aguiar, Joao C., Wang, Helen, Margalith, Michal, Hobart, Peter and Hoffman, Stephen L. (1996). DNA vaccines against malaria: Immunogenicity and protection in a rodent model. Journal of Pharmaceutical Sciences, 85 (12), 1294-1300. doi: 10.1021/js960147h |
