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2023 Conference Publication Expanded genome-wide association study meta-analysis of hip and spine BMD identifies ∼45 novel loci and uncovers widespread pleiotropyLu, Haojie, Frysz, Monika, Lu, Tianyuan, Ohlsson, Claes, Rivadeneira, Fernando, Tobias, Jonathan, Richards, Brent, Kiel, Douglas P., Kemp, John P. and Medina-Gomez, Carolina (2023). Expanded genome-wide association study meta-analysis of hip and spine BMD identifies ∼45 novel loci and uncovers widespread pleiotropy. Annual Meeting of the American-Society-for-Bone-and-Mineral-Research (ASBMR), Austin, TX United States, 9-12 September 2022. Cary, NC United States: Oxford University Press. |
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2022 Journal Article Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer riskD’Urso, Shannon, Arumugam, Pooja, Weider, Therese, Hwang, Liang-Dar, Bond, Tom A., Kemp, John P., Warrington, Nicole M., Evans, David M., O’Mara, Tracy A. and Moen, Gunn-Helen (2022). Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer risk. BMC Medicine, 20 (1) 419, 1-17. doi: 10.1186/s12916-022-02585-w |
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2022 Conference Publication A Genome Wide Association Study Of DXA-derived Minimum Joint Space Width Of The Hip Provides Further Insights Into Its Genetic Architecture: Findings From UK BiobankFaber, B., Frysz, M., Ebsim, R., Lundberg, M., Southam, L., Hartley, A., Saunders, F.R., Lindner, C., Gregory, J.S., Aspden, R.M., Harvey, N.C., Zeggini, E., Smith, G. Davey, Cootes, T., Kemp, J.P. and Tobias, J.H. (2022). A Genome Wide Association Study Of DXA-derived Minimum Joint Space Width Of The Hip Provides Further Insights Into Its Genetic Architecture: Findings From UK Biobank. 2022 OARSI World Congress on Osteoarthritis, Online, 7-10 April 2022. London, United Kingdom: Elsevier. doi: 10.1016/j.joca.2022.02.051 |
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2022 Journal Article Regenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal diseaseBergen, Dylan J. M., Tong, Qiao, Shukla, Ankit, Newham, Elis, Zethof, Jan, Lundberg, Mischa, Ryan, Rebecca, Youlten, Scott E., Frysz, Monika, Croucher, Peter I., Flik, Gert, Richardson, Rebecca J., Kemp, John P., Hammond, Chrissy L. and Metz, Juriaan R. (2022). Regenerating zebrafish scales express a subset of evolutionary conserved genes involved in human skeletal disease. BMC Biology, 20 (1) 21, 21. doi: 10.1186/s12915-021-01209-8 |
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2022 Journal Article Limb development genes underlie variation in human fingerprint patternsLi, Jinxi, Glover, James D., Zhang, Haiguo, Peng, Meifang, Tan, Jingze, Mallick, Chandana Basu, Hou, Dan, Yang, Yajun, Wu, Sijie, Liu, Yu, Peng, Qianqian, Zheng, Shijie C., Crosse, Edie I., Medvinsky, Alexander, Anderson, Richard A., Brown, Helen, Yuan, Ziyu, Zhou, Shen, Xu, Yanqing, Kemp, John P., Ho, Yvonne Y.W., Loesch, Danuta Z., Wang, Lizhong, Li, Yingxiang, Tang, Senwei, Wu, Xiaoli, Walters, Robin G., Lin, Kuang, Meng, Ruogu ... Wang, Sijia (2022). Limb development genes underlie variation in human fingerprint patterns. Cell, 185 (1), 95-112.e18. doi: 10.1016/j.cell.2021.12.008 |
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2022 Journal Article Investigating a potential causal relationship between maternal blood pressure during pregnancy and future offspring cardiometabolic healthWang, Geng, Bhatta, Laxmi, Moen, Gunn-Helen, Hwang, Liang-Dar, Kemp, John P., Bond, Tom A., Åsvold, Bjørn Olav, Brumpton, Ben, Evans, David M. and Warrington, Nicole M. (2022). Investigating a potential causal relationship between maternal blood pressure during pregnancy and future offspring cardiometabolic health. Hypertension, 79 (1), 170-177. doi: 10.1161/hypertensionaha.121.17701 |
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2021 Conference Publication Investigating a potential causal relationship between maternal blood pressure during pregnancy and future offspring cardiometabolic healthWang, Geng, Bhatta, Laxmi, Moen, Gunn-Helen, Hwang, Liang-Dar, Kemp, John P., Bond, Tom A., Asvold, Bjorn Olav, Brumpton, Ben, Evans, David M. and Warrington, Nicole M. (2021). Investigating a potential causal relationship between maternal blood pressure during pregnancy and future offspring cardiometabolic health. Behavior Genetics Association 51st Annual Meeting, Online (Zoom), 29 June 2021. New York, United States: Springer. |
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2021 Journal Article Dnmt3a-mutated clonal hematopoiesis promotes osteoporosisKim, Peter Geon, Niroula, Abhishek, Shkolnik, Veronica, McConkey, Marie, Lin, Amy E., Słabicki, Mikołaj, Kemp, John P., Bick, Alexander, Gibson, Christopher J., Griffin, Gabriel, Sekar, Aswin, Brooks, Daniel J., Wong, Waihay J., Cohen, Drew N., Uddin, Md Mesbah, Shin, Wesley J., Pirruccello, James, Tsai, Jonathan M., Agrawal, Mridul, Kiel, Douglas P., Bouxsein, Mary L., Richards, J. Brent, Evans, David M., Wein, Marc N., Charles, Julia F., Jaiswal, Siddhartha, Natarajan, Pradeep and Ebert, Benjamin L. (2021). Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis. Journal of Experimental Medicine, 218 (12) e20211872. doi: 10.1084/jem.20211872 |
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2021 Conference Publication Investigating a potential causal relationship between maternal blood pressure during pregnancy and future offspring cardiometabolic healthWang, Geng, Bhatta, Laxmi, Moen, Gunn-Helen, Hwang, Liang-Dar, Kemp, John P., Bond, Tom A., Åsvold, Bjørn Olav, Brumpton, Ben, Evans, David M. and Warrington, Nicole M. (2021). Investigating a potential causal relationship between maternal blood pressure during pregnancy and future offspring cardiometabolic health. American Society of Human Genetics 2021 Annual Meeting, Virtual, 18 - 22 October 2021. |
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2021 Journal Article Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal diseaseYoulten, Scott E., Kemp, John P., Logan, John G., Ghirardello, Elena J., Sergio, Claudio M., Dack, Michael R. G., Guilfoyle, Siobhan E., Leitch, Victoria D., Butterfield, Natalie C., Komla-Ebri, Davide, Chai, Ryan C., Corr, Alexander P., Smith, James T., Mohanty, Sindhu T., Morris, John A., McDonald, Michelle M., Quinn, Julian M. W., McGlade, Amelia R., Bartonicek, Nenad, Jansson, Matt, Hatzikotoulas, Konstantinos, Irving, Melita D., Beleza-Meireles, Ana, Rivadeneira, Fernando, Duncan, Emma, Richards, J. Brent, Adams, David J., Lelliott, Christopher J., Brink, Robert ... Croucher, Peter I. (2021). Osteocyte transcriptome mapping identifies a molecular landscape controlling skeletal homeostasis and susceptibility to skeletal disease. Nature Communications, 12 (1) 2444, 1-21. doi: 10.1038/s41467-021-22517-1 |
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2021 Journal Article Erratum: Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption (Cell (2021) 184(5) (1330–1347.e13), (S0092867421001525), (10.1016/j.cell.2021.02.002))McDonald, Michelle M., Khoo, Weng Hua, Ng, Pei Ying, Xiao, Ya, Zamerli, Jad, Thatcher, Peter, Kyaw, Wunna, Pathmanandavel, Karrnan, Grootveld, Abigail K., Moran, Imogen, Butt, Danyal, Nguyen, Akira, Corr, Alexander, Warren, Sean, Biro, Maté, Butterfield, Natalie C., Guilfoyle, Siobhan E., Komla-Ebri, Davide, Dack, Michael R.G., Dewhurst, Hannah F., Logan, John G., Li, Yongxiao, Mohanty, Sindhu T., Byrne, Niall, Terry, Rachael L., Simic, Marija K., Chai, Ryan, Quinn, Julian M.W., Youlten, Scott E. ... Phan, Tri Giang (2021). Erratum: Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption (Cell (2021) 184(5) (1330–1347.e13), (S0092867421001525), (10.1016/j.cell.2021.02.002)). Cell, 184 (7), 1940-1940. doi: 10.1016/j.cell.2021.03.010 |
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2021 Journal Article Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorptionMcDonald, Michelle M., Khoo, Weng Hua, Ng, Pei Ying, Xiao, Ya, Zamerli, Jad, Thatcher, Peter, Kyaw, Wunna, Pathmanandavel, Karrnan, Grootveld, Abigail K., Moran, Imogen, Butt, Danyal, Nguyen, Akira, Corr, Alexander, Warren, Sean, Biro, Maté, Butterfield, Natalie C., Guilfoyle, Siobhan E., Komla-Ebri, Davide, Dack, Michael R. G., Dewhurst, Hannah F., Logan, John G., Li, Yongxiao, Mohanty, Sindhu T., Byrne, Niall, Terry, Rachael L., Simic, Marija K., Chai, Ryan, Quinn, Julian M. W., Youlten, Scott E. ... Phan, Tri Giang (2021). Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption. Cell, 184 (5), 1330-1347. doi: 10.1016/j.cell.2021.02.002 |
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2021 Journal Article Genome-wide association study of circulating interleukin 6 levels identifies novel lociAhluwalia, Tarunveer S., Prins, Bram P., Abdollahi, Mohammadreza, Armstrong, Nicola J., Aslibekyan, Stella, Bain, Lisa, Jefferis, Barbara, Baumert, Jens, Beekman, Marian, Ben-Shlomo, Yoav, Bis, Joshua C., Mitchell, Braxton D., de Geus, Eco, Delgado, Graciela E., Marek, Diana, Eriksson, Joel, Kajantie, Eero, Kanoni, Stavroula, Kemp, John P., Lu, Chen, Marioni, Riccardo E., McLachlan, Stela, Milaneschi, Yuri, Nolte, Ilja M., Petrelis, Alexandros M., Porcu, Eleonora, Sabater-Lleal, Maria, Naderi, Elnaz, Seppälä, Ilkka ... CHARGE Inflammation Working Group (2021). Genome-wide association study of circulating interleukin 6 levels identifies novel loci. Human Molecular Genetics, 30 (5), 393-409. doi: 10.1093/hmg/ddab023 |
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2021 Journal Article Opportunities and challenges in functional genomics research in osteoporosis: report From a workshop held by the Causes Working Group of the Osteoporosis and Bone Research Academy of the Royal Osteoporosis Society on October 5th 2020Tobias, Jonathan H., Duncan, Emma L., Kague, Erika, Hammond, Chrissy L., Gregson, Celia L., Bassett, Duncan, Williams, Graham R., Min, Josine L., Gaunt, Tom R., Karasik, David, Ohlsson, Claes, Rivadeneira, Fernando, Edwards, James R., Hannan, Fadil M., Kemp, John P., Gilbert, Sophie J., Alonso, Nerea, Hassan, Neelam, Compston, Juliet E. and Ralston, Stuart H. (2021). Opportunities and challenges in functional genomics research in osteoporosis: report From a workshop held by the Causes Working Group of the Osteoporosis and Bone Research Academy of the Royal Osteoporosis Society on October 5th 2020. Frontiers in Endocrinology, 11 630875, 630875. doi: 10.3389/fendo.2020.630875 |
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2020 Journal Article Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian womenSteinthorsdottir, Valgerdur, McGinnis, Ralph, Williams, Nicholas O., Stefansdottir, Lilja, Thorleifsson, Gudmar, Shooter, Scott, Fadista, João, Sigurdsson, Jon K., Auro, Kirsi M., Berezina, Galina, Borges, Maria-Carolina, Bumpstead, Suzannah, Bybjerg-Grauholm, Jonas, Colgiu, Irina, Dolby, Vivien A., Dudbridge, Frank, Engel, Stephanie M., Franklin, Christopher S., Frigge, Michael L., Frisbaek, Yr, Geirsson, Reynir T., Geller, Frank, Gretarsdottir, Solveig, Gudbjartsson, Daniel F., Harmon, Quaker, Hougaard, David Michael, Hegay, Tatyana, Helgadottir, Anna, Hjartardottir, Sigrun ... Morgan, Linda (2020). Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women. Nature Communications, 11 (1) 5976, 5976. doi: 10.1038/s41467-020-19733-6 |
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2020 Journal Article Genome-wide association study identifies 48 common genetic variants associated with handednessCuellar-Partida, Gabriel, Tung, Joyce Y., Eriksson, Nicholas, Albrecht, Eva, Aliev, Fazil, Andreassen, Ole A., Barroso, Inês, Beckmann, Jacques S., Boks, Marco P., Boomsma, Dorret I., Boyd, Heather A., Breteler, Monique M. B., Campbell, Harry, Chasman, Daniel I., Cherkas, Lynn F., Davies, Gail, de Geus, Eco J. C., Deary, Ian J., Deloukas, Panos, Dick, Danielle M., Duffy, David L., Eriksson, Johan G., Esko, Tõnu, Feenstra, Bjarke, Geller, Frank, Gieger, Christian, Giegling, Ina, Gordon, Scott D., Han, Jiali ... Medland, Sarah E. (2020). Genome-wide association study identifies 48 common genetic variants associated with handedness. Nature Human Behaviour, 5 (1), 59-70. doi: 10.1038/s41562-020-00956-y |
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2020 Journal Article The musculoskeletal knowledge portal: making omics data useful to the broader scientific communityKiel, Douglas P., Kemp, John P., Rivadeneira, Fernando, Westendorf, Jennifer J., Karasik, David, Duncan, Emma, Imai, Yuuki, Müller, Ralph, Flannick, Jason, Bonewald, Lynda and Burtt, Noel (2020). The musculoskeletal knowledge portal: making omics data useful to the broader scientific community. Journal of Bone and Mineral Research, 35 (9) jbmr.4147, 1626-1633. doi: 10.1002/jbmr.4147 |
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2020 Journal Article Development of a polygenic risk score to improve screening for fracture risk: a genetic risk prediction studyForgetta, Vincenzo, Keller-Baruch, Julyan, Forest, Marie, Durand, Audrey, Bhatnagar, Sahir, Kemp, John P., Nethander, Maria, Evans, Daniel, Morris, John A., Kiel, Douglas P., Rivadeneira, Fernando, Johansson, Helena, Harvey, Nicholas C., Mellström, Dan, Karlsson, Magnus, Cooper, Cyrus, Evans, David M., Clarke, Robert, Kanis, John A., Orwoll, Eric, McCloskey, Eugene V., Ohlsson, Claes, Pineau, Joelle, Leslie, William D., Greenwood, Celia M. T. and Richards, J. Brent (2020). Development of a polygenic risk score to improve screening for fracture risk: a genetic risk prediction study. PLOS Medicine, 17 (7) e1003152, e1003152. doi: 10.1371/journal.pmed.1003152 |
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2020 Journal Article RSPO3 impacts body fat distribution and regulates adipose cell biology in vitroLoh, Nellie Y., Minchin, James E. N., Pinnick, Katherine E., Verma, Manu, Todorčević, Marijana, Denton, Nathan, Moustafa, Julia El-Sayed, Kemp, John P., Gregson, Celia L., Evans, David M., Neville, Matt J., Small, Kerrin S., McCarthy, Mark I., Mahajan, Anubha, Rawls, John F., Karpe, Fredrik and Christodoulides, Constantinos (2020). RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro. Nature Communications, 11 (1) 2797, 1-15. doi: 10.1038/s41467-020-16592-z |
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2020 Journal Article The effect of plasma lipids and lipid-lowering interventions on bone mineral density: a Mendelian randomization studyZheng, Jie, Brion, Marie-Jo, Kemp, John P., Warrington, Nicole M., Borges, Maria-Carolina, Hemani, Gibran, Richardson, Tom G., Rasheed, Humaira, Qiao, Zhen, Haycock, Philip, Ala-Korpela, Mika, Davey Smith, George, Tobias, Jon H. and Evans, David M. (2020). The effect of plasma lipids and lipid-lowering interventions on bone mineral density: a Mendelian randomization study. Journal of Bone and Mineral Research, 35 (7) jbmr.3989, 1224-1235. doi: 10.1002/jbmr.3989 |
