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2011 Journal Article Understanding the structure/activity relationships of the iron regulatory peptide hepcidinClark, Richard J., Tan, Chia Chia, Preza, Gloria C., Nemeth, Elizabeta, Ganz, Tomas and Craik, David J. (2011). Understanding the structure/activity relationships of the iron regulatory peptide hepcidin. Chemistry and Biology, 18 (3), 336-343. doi: 10.1016/j.chembiol.2010.12.009 |
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2011 Journal Article Chemical re-engineering of chlorotoxin improves bioconjugation properties for tumor imaging and targeted therapyAkcan, M, Stroud, MR, Hansen, SJ, Clark, RJ, Daly, NL, Craik, DJ and Olson, JM (2011). Chemical re-engineering of chlorotoxin improves bioconjugation properties for tumor imaging and targeted therapy. Journal of Medicinal Chemistry, 54 (3), 782-787. doi: 10.1021/jm101018r |
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2011 Journal Article Stabilization of α-conotoxin AuIB: Influences of disulfide connectivity and backbone cyclizationLovelace, Erica S., Gunasekera, Sunithi, Alvarmo, Charlotta, Clark, Richard J., Nevin, Simon T., Grishin, Anton A., Adams, David J., Craik, David J. and Daly, Norelle L. (2011). Stabilization of α-conotoxin AuIB: Influences of disulfide connectivity and backbone cyclization. Antioxidants and Redox Signaling, 14 (1), 87-95. doi: 10.1089/ars.2009.3068 |
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2011 Journal Article Interlocking Disulfides in Circular Proteins: Toward Efficient Oxidative Folding of CyclotidesAboye, Teshome Leta, Clark, Richard J., Burman, Robert, Roig, Marta Bajona, Craik, David J. and Goransson, Ulf (2011). Interlocking Disulfides in Circular Proteins: Toward Efficient Oxidative Folding of Cyclotides. Antioxidants & Redox Signaling, 14 (1), 77-86. doi: 10.1089/ars.2010.3112 |
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2010 Journal Article Structural and functional analysis of human liver-expressed antimicrobial peptide 2Henriques, Sonia Troeira, Tan, Chia Chia, Craik, David J. and Clark, Richard J. (2010). Structural and functional analysis of human liver-expressed antimicrobial peptide 2. ChemBioChem, 11 (15), 2148-2157. doi: 10.1002/cbic.201000400 |
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2010 Journal Article Isolation, sequencing, and structure - Activity relationships of cyclotidesIreland, David C., Clark, Richard J., Daly, Norelle L. and Craik, David J. (2010). Isolation, sequencing, and structure - Activity relationships of cyclotides. Journal of Natural Products, 73 (9), 1610-1622. doi: 10.1021/np1000413 |
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2010 Journal Article The engineering of an orally active conotoxin for the treatment of neuropathic painClark, Richard J., Jensen, Jonas, Nevin, Simon T., Callaghan, Brid P., Adams, David J. and Craik, David J. (2010). The engineering of an orally active conotoxin for the treatment of neuropathic pain. Angewandte Chemie (International Edition), 49 (37), 6545-6548. doi: 10.1002/anie.201000620 |
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2010 Journal Article Lysine-scanning mutagenesis reveals an amendable face of the cyclotide kalata B1 for the optimization of nematocidal activityHuang, Yen-Hua (黃彥華), Colgrave, Michelle L., Clark, Richard J., Kotze, Andrew C. and Craik, David J. (2010). Lysine-scanning mutagenesis reveals an amendable face of the cyclotide kalata B1 for the optimization of nematocidal activity. Journal of Biological Chemistry, 285 (14), 10797-10805. doi: 10.1074/jbc.M109.089854 |
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2010 Journal Article Native chemical ligation applied to the synthesis and bioengineering of circular peptides and proteinsClark, Richard J. and Craik, David J. (2010). Native chemical ligation applied to the synthesis and bioengineering of circular peptides and proteins. Biopolymers, 94 (4), 414-422. doi: 10.1002/bip.21372 |
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2009 Journal Article Beta-arrestin 2 is required for complement C1q expression in macrophages and constrains factor-independent survivalLattin, J. E., Greenwood, K. P., Daly, N. L., Kelly, G, Zidar, D. A., Clark, R. J., Thomas, W. G., Kellie, Stuart, Craik, D. J., Hume, D. A. and Sweet, M. J. (2009). Beta-arrestin 2 is required for complement C1q expression in macrophages and constrains factor-independent survival. Molecular Immunology, 47 (2-3), 340-347. doi: 10.1016/j.molimm.2009.09.012 |
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2009 Journal Article A synthetic combinatorial strategy for developing alpha-conotoxin analogs as potent alpha7 nicotinic acetylcholine receptor antagonistsArmishaw, Christopher J., Singh, Narender, Medina-Franco, Jose L., Clark, Richard J., Scott, Krystle C. M., Houghten, Richard A. and Jensen, Anders A. (2009). A synthetic combinatorial strategy for developing alpha-conotoxin analogs as potent alpha7 nicotinic acetylcholine receptor antagonists. Journal of Biological Chemistry, 285 (3), 1809-1821. doi: 10.1074/jbc.M109.071183 |
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2009 Journal Article Scanning mutagenesis of alpha-conotoxin Vc1.1 reveals residues crucial for activity at the alpha-9 alpha-10 nicotinic acetylcholine receptorHalai, Reena, Clark, Richard J., Nevin, Simon T., Jensen, Jonas E., Adams, David J. and Craik, David J. (2009). Scanning mutagenesis of alpha-conotoxin Vc1.1 reveals residues crucial for activity at the alpha-9 alpha-10 nicotinic acetylcholine receptor. Journal of Biological Chemistry, 284 (30), 20275-20284. doi: 10.1074/jbc.M109.015339 |
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2009 Journal Article Dissecting the oxidative folding of circular cystine knot miniproteinsGunasekera, Sunithi, Daly, Norelle L., Clark, Richard J. and Craik, David J. (2009). Dissecting the oxidative folding of circular cystine knot miniproteins. Antioxidants and Redox Signalling, 11 (5), 971-980. doi: 10.1089/ars.2008.2295 |
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2009 Journal Article Rational design of alpha-conotoxin analogues targeting alpha 7 nicotinic acetylcholine receptors: Improved antagonistic activity by incorporation of proline derivativesArmishaw, Christopher, Jensen, Anders A., Balle, Thomas, Clark, Richard J., Harpsøe, Kasper, Skonberg, Christian, Liljefors, Tommy and Strømgaard, Kristian (2009). Rational design of alpha-conotoxin analogues targeting alpha 7 nicotinic acetylcholine receptors: Improved antagonistic activity by incorporation of proline derivatives. Journal of Biological Chemistry, 284 (14), 9498-9512. doi: 10.1074/jbc.M806136200 |
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2009 Journal Article Inhibition of neuronal nicotinic acetylcholine receptor subtypes by alpha-conotoxin GID and analoguesMillard, Emma L., Nevin, Simon T., Loughnan, Marion L., Nicke, Annette, Clark, Richard J., Alewood, Paul F., Lewis, Richard J., Adams, David J., Craik, David J. and Daly, Norelle L. (2009). Inhibition of neuronal nicotinic acetylcholine receptor subtypes by alpha-conotoxin GID and analogues. Journal of Biological Chemistry, 284 (8), 4944-4951. doi: 10.1074/jbc.M804950200 |
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2008 Journal Article Analgesic alpha-Conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABA-B receptor activationCallaghan, Brid, Haythornthwaite, Alison R., Berecki, Geza, Clark, Richard J., Craik, David J. and Adams, David J. (2008). Analgesic alpha-Conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABA-B receptor activation. The Journal of Neuroscience, 28 (43), 10943-10951. doi: 10.1523/JNEUROSCI.3594-08.2008 |
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2008 Journal Article Engineering stablized vascular endothelial growth factor-A antagonists: synthesis, structural characterization and bioactivity of grafted analogues of cyclotidesGunasekera, Sunithi, Foley, Fiona M., Clark, Richard J., Sando, Lillian, Fabri, Louis J., Craik, David J. and Daly, Norelle L. (2008). Engineering stablized vascular endothelial growth factor-A antagonists: synthesis, structural characterization and bioactivity of grafted analogues of cyclotides. Journal of Medicinal Chemistry, 51 (24), 7697-7704. doi: 10.1021/jm800704e |
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2008 Journal Article Binding mode of alpha-conotoxins to an acetylcholine binding protein determined by saturation transfer difference NMRWestermann, Jan, Clark, Richard J. and Craik, David J. (2008). Binding mode of alpha-conotoxins to an acetylcholine binding protein determined by saturation transfer difference NMR. Protein And Peptide Letters, 15 (9), 910-914. doi: 10.2174/092986608785849335 |
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2008 Journal Article The three-dimensional structure of the analgesic alpha-conotoxin, RgIAClark, Richard J., Daly, Norelle L., Halai, Reena, Nevin, Simon T., Adams, David J. and Craik, David J. (2008). The three-dimensional structure of the analgesic alpha-conotoxin, RgIA. FEBS Letters, 582 (5), 597-602. doi: 10.1016/j.febslet.2008.01.027 |
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2008 Journal Article The alpine violet, Viola biflora, is a rich source of cyclotides with potent cytotoxicityHerrman, Anders, Burman, Robert, Mylne, Joshua S., Karlsson, Gustav, Gullbo, Joachim, Craik, David J., Clark, Richard J. and Goransson, Ulf (2008). The alpine violet, Viola biflora, is a rich source of cyclotides with potent cytotoxicity. Phytochemistry, 69 (4), 939-952. doi: 10.1016/j.phytochem.2007.10.023 |
