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2021

Journal Article

Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity

Christo, Susan N., Evrard, Maximilien, Park, Simone L., Gandolfo, Luke C., Burn, Thomas N., Fonseca, Raissa, Newman, Dane M., Alexandre, Yannick O., Collins, Nicholas, Zamudio, Natasha M., Souza-Fonseca-Guimaraes, Fernando, Pellicci, Daniel G., Chisanga, David, Shi, Wei, Bartholin, Laurent, Belz, Gabrielle T., Huntington, Nicholas D., Lucas, Andrew, Lucas, Michaela, Mueller, Scott N., Heath, William R., Ginhoux, Florent, Speed, Terence P., Carbone, Francis R., Kallies, Axel and Mackay, Laura K. (2021). Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity. Nature Immunology, 22 (9), 1140-1151. doi: 10.1038/s41590-021-01004-1

Discrete tissue microenvironments instruct diversity in resident memory T cell function and plasticity

2021

Journal Article

Natural killer cells and type 1 innate lymphoid cells in hepatocellular carcinoma: current knowledge and future perspectives

Jacquelot, Nicolas, Seillet, Cyril, Souza-Fonseca-Guimaraes, Fernando, Sacher, Adrian G, Belz, Gabrielle T and Ohashi, Pamela S (2021). Natural killer cells and type 1 innate lymphoid cells in hepatocellular carcinoma: current knowledge and future perspectives. International Journal of Molecular Sciences, 22 (16) 9044, 1-32. doi: 10.3390/ijms22169044

Natural killer cells and type 1 innate lymphoid cells in hepatocellular carcinoma: current knowledge and future perspectives

2021

Journal Article

Transforming growth factor-β-regulated mTOR activity preserves cellular metabolism to maintain long-term T cell responses in chronic infection

Gabriel, Sarah S., Tsui, Carlson, Chisanga, David, Weber, Flora, Llano-León, Manuela, Gubser, Patrick M., Bartholin, Laurent, Souza-Fonseca-Guimaraes, Fernando, Huntington, Nicholas D., Shi, Wei, Utzschneider, Daniel T. and Kallies, Axel (2021). Transforming growth factor-β-regulated mTOR activity preserves cellular metabolism to maintain long-term T cell responses in chronic infection. Immunity, 54 (8), 1698-1714.e5. doi: 10.1016/j.immuni.2021.06.007

Transforming growth factor-β-regulated mTOR activity preserves cellular metabolism to maintain long-term T cell responses in chronic infection

2021

Journal Article

MAIT cells regulate NK cell-mediated tumor immunity

Petley, Emma V., Koay, Hui-Fern, Henderson, Melissa A., Sek, Kevin, Todd, Kirsten L., Keam, Simon P., Lai, Junyun, House, Imran G., Li, Jasmine, Zethoven, Magnus, Chen, Amanda X. Y., Oliver, Amanda J., Michie, Jessica, Freeman, Andrew J., Giuffrida, Lauren, Chan, Jack D., Pizzolla, Angela, Mak, Jeffrey Y. W., McCulloch, Timothy R., Souza-Fonseca-Guimaraes, Fernando, Kearney, Conor J., Millen, Rosemary, Ramsay, Robert G., Huntington, Nicholas D., McCluskey, James, Oliaro, Jane, Fairlie, David P., Neeson, Paul J., Godfrey, Dale I. ... Darcy, Phillip K. (2021). MAIT cells regulate NK cell-mediated tumor immunity. Nature Communications, 12 (1) 4746, 1-15. doi: 10.1038/s41467-021-25009-4

MAIT cells regulate NK cell-mediated tumor immunity

2021

Journal Article

Towards efficient immunotherapy for bacterial infection

McCulloch, Timothy R., Wells, Timothy J. and Souza-Fonseca-Guimaraes, Fernando (2021). Towards efficient immunotherapy for bacterial infection. Trends in Microbiology, 30 (2), 158-169. doi: 10.1016/j.tim.2021.05.005

Towards efficient immunotherapy for bacterial infection

2021

Journal Article

New horizons for natural killer cell research in cancer, infection and inflammation

Souza-Fonseca-Guimaraes, Fernando (2021). New horizons for natural killer cell research in cancer, infection and inflammation. Clinical & Translational Immunology, 10 (4) e1275, e1275. doi: 10.1002/cti2.1275

New horizons for natural killer cell research in cancer, infection and inflammation

2021

Journal Article

Type 2 innate lymphoid cells protect against colorectal cancer progression and predict improved patient survival

Huang, Qiutong, Jacquelot, Nicolas, Preaudet, Adele, Hediyeh-zadeh, Soroor, Souza-Fonseca-Guimaraes, Fernando, McKenzie, Andrew N. J., Hansbro, Philip M., Davis, Melissa J., Mielke, Lisa A., Putoczki, Tracy L. and Belz, Gabrielle T. (2021). Type 2 innate lymphoid cells protect against colorectal cancer progression and predict improved patient survival. Cancers, 13 (3) 559, 559-16. doi: 10.3390/cancers13030559

Type 2 innate lymphoid cells protect against colorectal cancer progression and predict improved patient survival

2021

Journal Article

Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma

Jacquelot, Nicolas, Seillet, Cyril, Wang, Minyu, Pizzolla, Angela, Liao, Yang, Hediyeh-zadeh, Soroor, Grisaru-Tal, Sharon, Louis, Cynthia, Huang, Qiutong, Schreuder, Jaring, Souza-Fonseca-Guimaraes, Fernando, de Graaf, Carolyn A., Thia, Kevin, Macdonald, Sean, Camilleri, Mary, Luong, Kylie, Zhang, Shengbo, Chopin, Michael, Molden-Hauer, Tristan, Nutt, Stephen L., Umansky, Viktor, Ciric, Bogoljub, Groom, Joanna R., Foster, Paul S., Hansbro, Philip M., McKenzie, Andrew N. J., Gray, Daniel H. D., Behren, Andreas, Cebon, Jonathan ... Belz, Gabrielle T. (2021). Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma. Nature Immunology, 22 (7), 851-864. doi: 10.1038/s41590-021-00943-z

Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma

2021

Journal Article

Natural killer cells in inflammatory autoimmune diseases

Yang, Yuyan, Day, Jessica, Souza-Fonseca Guimaraes, Fernando, Wicks, Ian P. and Louis, Cynthia (2021). Natural killer cells in inflammatory autoimmune diseases. Clinical & Translational Immunology, 10 (2) e1250, e1250. doi: 10.1002/cti2.1250

Natural killer cells in inflammatory autoimmune diseases

2020

Journal Article

Natural killer cell engineering – a new hope for cancer immunotherapy

Lin, Cheng-Yu, Gobius, Ilan and Souza-Fonseca-Guimaraes, Fernando (2020). Natural killer cell engineering – a new hope for cancer immunotherapy. Seminars in Hematology, 57 (4), 194-200. doi: 10.1053/j.seminhematol.2020.10.002

Natural killer cell engineering – a new hope for cancer immunotherapy

2020

Journal Article

The antitumor effect of heparin is not mediated by direct NK cell activation

Rossi, Gustavo R., Gonçalves, Jenifer P., McCulloch, Timothy, Delconte, Rebecca B., Hennessy, Robert J., Huntington, Nicholas D., Trindade, Edvaldo S. and Souza-Fonseca-Guimaraes, Fernando (2020). The antitumor effect of heparin is not mediated by direct NK cell activation. Journal of Clinical Medicine, 9 (8) 2666, 2666-11. doi: 10.3390/jcm9082666

The antitumor effect of heparin is not mediated by direct NK cell activation

2020

Journal Article

Harnessing natural killer immunity in metastatic SCLC

Best, Sarah A., Hess, Jonas B., Souza-Fonseca-Guimaraes, Fernando, Cursons, Joseph, Kersbergen, Ariena, Dong, Xueyi, Rautela, Jai, Hyslop, Stephanie R., Ritchie, Matthew E., Davis, Melissa J., Leong, Tracy L., Irving, Louis, Steinfort, Daniel, Huntington, Nicholas D. and Sutherland, Kate D. (2020). Harnessing natural killer immunity in metastatic SCLC. Journal of Thoracic Oncology, 15 (9), 1507-1521. doi: 10.1016/j.jtho.2020.05.008

Harnessing natural killer immunity in metastatic SCLC

2020

Journal Article

Erratum:NK cell-derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS (Journal of Experimental Medicine (2020) 217:5 DOI: 10.1084/jem.20191421)

Louis, Cynthia, Souza-Fonseca-Guimaraes, Fernando, Yang, Yuyan, D'Silva, Damian, Kratina, Tobias, Dagley, Laura, Hediyeh-Zadeh, Soroor, Rautela, Jai, Masters, Seth Lucian, Davis, Melissa J., Babon, Jeffrey J., Ciric, Bogoljub, Vivier, Eric, Alexander, Warren S., Huntington, Nicholas D. and Wicks, Ian P. (2020). Erratum:NK cell-derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS (Journal of Experimental Medicine (2020) 217:5 DOI: 10.1084/jem.20191421). Journal of Experimental Medicine, 217 (5) e2019142103192020c. doi: 10.1084/jem.2019142103192020c

Erratum:NK cell-derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS (Journal of Experimental Medicine (2020) 217:5 DOI: 10.1084/jem.20191421)

2020

Journal Article

Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies

Chew, Hui Yi, De Lima, Priscila O., Gonzalez Cruz, Jazmina L., Banushi, Blerida, Echejoh, Godwins, Hu, Lingbo, Joseph, Shannon R., Lum, Benedict, Rae, James, O'Donnell, Jake S., Merida de Long, Lilia, Okano, Satomi, King, Brigid, Barry, Rachael, Moi, Davide, Mazzieri, Roberta, Thomas, Ranjeny, Souza-Fonseca-Guimaraes, Fernando, Foote, Matthew, McCluskey, Adam, Robinson, Phillip J., Frazer, Ian H., Saunders, Nicholas A., Parton, Robert G., Dolcetti, Riccardo, Cuff, Katharine, Martin, Jennifer H., Panizza, Benedict, Walpole, Euan ... Simpson, Fiona (2020). Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies. Cell, 180 (5), 895-914.e27. doi: 10.1016/j.cell.2020.02.019

Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies

2020

Journal Article

NK cell–derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS

Louis, Cynthia, Souza-Fonseca-Guimaraes, Fernando, Yang, Yuyan, D’Silva, Damian, Kratina, Tobias, Dagley, Laura, Hediyeh-Zadeh, Soroor, Rautela, Jai, Masters, Seth Lucian, Davis, Melissa J., Babon, Jeffrey J., Ciric, Bogoljub, Vivier, Eric, Alexander, Warren S., Huntington, Nicholas D. and Wicks, Ian P. (2020). NK cell–derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS. Journal of Experimental Medicine, 217 (5) e20191421. doi: 10.1084/jem.20191421

NK cell–derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS

2020

Journal Article

NK cell priming from endogenous homeostatic signals is modulated by CIS

Delconte, Rebecca B., Guittard, Geoffrey, Goh, Wilford, Hediyeh-Zadeh, Soroor, Hennessy, Robert J., Rautela, Jai, Davis, Melissa J., Souza-Fonseca-Guimaraes, Fernando, Nunes, Jacques A. and Huntington, Nicholas D. (2020). NK cell priming from endogenous homeostatic signals is modulated by CIS. Frontiers in Immunology, 11 75, 75. doi: 10.3389/fimmu.2020.00075

NK cell priming from endogenous homeostatic signals is modulated by CIS

2020

Journal Article

Tumor microenvironment-associated extracellular matrix components regulate NK cell function

Rossi, Gustavo Rodrigues, Trindade, Edvaldo S. and Souza-Fonseca-Guimaraes, Fernando (2020). Tumor microenvironment-associated extracellular matrix components regulate NK cell function. Frontiers in Immunology, 11 73, 73. doi: 10.3389/fimmu.2020.00073

Tumor microenvironment-associated extracellular matrix components regulate NK cell function

2019

Journal Article

Generation of novel Id2 and E2-2, E2A and HEB antibodies reveals novel Id2 binding partners and species-specific expression of E-proteins in NK cells

Rautela, Jai, Dagley, Laura F., Kratina, Tobias, Anthony, Angaleena, Goh, Wilford, Surgenor, Elliot, Delconte, Rebecca B., Webb, Andrew I., Elwood, Ngaire, Groom, Joanna R., Souza-Fonseca-Guimaraes, Fernando, Corcoran, Lynn and Huntington, Nicholas D. (2019). Generation of novel Id2 and E2-2, E2A and HEB antibodies reveals novel Id2 binding partners and species-specific expression of E-proteins in NK cells. Molecular Immunology, 115, 56-63. doi: 10.1016/j.molimm.2018.08.017

Generation of novel Id2 and E2-2, E2A and HEB antibodies reveals novel Id2 binding partners and species-specific expression of E-proteins in NK cells

2019

Journal Article

Therapeutic blockade of activin-A improves NK cell function and antitumor immunity

Rautela, Jai, Dagley, Laura F., de Oliveira, Carolina C., Schuster, Iona S., Hediyeh-Zadeh, Soroor, Delconte, Rebecca B., Cursons, Joseph, Hennessy, Robert, Hutchinson, Dana S., Harrison, Craig, Kita, Badia, Vivier, Eric, Webb, Andrew I., Degli-Esposti, Mariapia A., Davis, Melissa J., Huntington, Nicholas D. and Souza-Fonseca-Guimaraes, Fernando (2019). Therapeutic blockade of activin-A improves NK cell function and antitumor immunity. Science Signaling, 12 (596) aat7527, eaat7527. doi: 10.1126/scisignal.aat7527

Therapeutic blockade of activin-A improves NK cell function and antitumor immunity

2019

Journal Article

A gene signature predicting natural killer cell infiltration and improved survival in melanoma patients

Cursons, Joseph, Souza-Fonseca-Guimaraes, Fernando, Foroutan, Momeneh, Anderson, Ashley, Hollande, Frédéric, Hediyeh-Zadeh, Soroor, Behren, Andreas, Huntington, Nicholas D. and Davis, Melissa J. (2019). A gene signature predicting natural killer cell infiltration and improved survival in melanoma patients. Cancer Immunology Research, 7 (7), 1162-1174. doi: 10.1158/2326-6066.cir-18-0500

A gene signature predicting natural killer cell infiltration and improved survival in melanoma patients