Overview
Background
MBBS(Hons), FRACP — Specialist Respiratory and Lung Transplant Physician
Dr John Mackintosh graduated from The University of Queensland in 2011 with honours. He trained in respiratory medicine in Queensland, before completing an interstitial lung disease clinical fellowship at the Royal Brompton Hospital in London — one of the world's leading interstitial lung disease (ILD) referral centres.
He returned to Brisbane in 2019 as a Respiratory & Lung Transplant Physician with the Queensland Lung Transplant Service at The Prince Charles Hospital, and as an academic at The University of Queensland, where he was promoted to Associate Professor in recognition of his clinical and research contribution to ILD. He leads The Prince Charles Hospital's ILD service and his research work centres on ILD, with particular expertise in idiopathic pulmonary fibrosis, familial pulmonary fibrosis and the genetic underpinnings of fibrotic lung disease.
Alongside his clinical practice, he co-chairs the Queensland Statewide ILD Multidisciplinary Meeting and is founder and chair of the Australasian ILD Genetics Multidisciplinary Meeting. Internationally, he was a Co-Lead for the International Society of Heart and Lung Transplantation's first consensus statement on short telomere syndrome and lung transplantation, and is first author of the current Thoracic Society of Australia and New Zealand position statement on the treatment of IPF and progressive pulmonary fibrosis.
Availability
- Dr John Mackintosh is:
- Not available for supervision
Research impacts
Dr Mackintosh's research centres on interstitial lung disease, with a particular focus on the genetics of pulmonary fibrosis, telomere biology disorders and outcomes after lung transplantation.
Works
Search Professor John Mackintosh’s works on UQ eSpace
2026
Journal Article
Inhaled treprostinil for idiopathic pulmonary fibrosis
Nathan, Steven D., Smith, Peter, Deng, Chunqin, De Salvo, Maria, Wuyts, Wim, Pavie-Gallegos, Juana, Song, Jin Woo, Kramer, Mordechai R., King, Christopher S., Mackintosh, John A., Chambers, Daniel, Miranda, Georgina Viviana, Breytenbach, Natalie, Peterson, Leigh, Bell, Heidi, Flaherty, Kevin R., Behr, Juergen and Cottin, Vincent (2026). Inhaled treprostinil for idiopathic pulmonary fibrosis. New England Journal of Medicine, 395 (2), 127-137. doi: 10.1056/NEJMoa2512911
2026
Journal Article
Deep-learning algorithm diagnostic support for usual interstitial pneumonia pattern recognition in fibrotic interstitial lung disease
Fermoyle, Caitlin C., Mackintosh, John A., Navaratnam, Vidya, Ellis, Samantha J., Cooper, Wendy A., Goh, Nicole S. L., Moodley, Yuben, Reynolds, Paul N., Zappala, Christopher J., Hopkins, Peter, Glaspole, Ian N., Corte, Tamera J., Walsh, Simon L. F., Accornero, Daniele, Agrawal, Aditya, Akilli, Isil Kibar, Alamoudi, Omer, Alberti, Maria Laura, Aliannejad, Rasoul, Aljahdali, Hamdan, Amanda, Gina, Anconina, Reut, Antuni, Julio Daniel, Aquaro, Giuseppe, Arenas-Jimenez, Juan, Asuquo, Bassey, Au-Yong, Iain, Avdeev, Sergey, Balbi, Maurizio ... Zompatori, Maurizio (2026). Deep-learning algorithm diagnostic support for usual interstitial pneumonia pattern recognition in fibrotic interstitial lung disease. Respirology, 31 (7), 711-720. doi: 10.1002/resp.70246
2026
Journal Article
Ambulatory oxygen for treatment of exertional hypoxaemia in pulmonary fibrosis (PFOX): a multicentre, randomised, sham-controlled trial
Holland, Anne E, Hoffman, Mariana, Corte, Tamera J, Chambers, Daniel C, Hepworth, Graham, Ekström, Magnus P, Glaspole, Ian, Goh, Nicole S, Khor, Yet H, Palmer, Andrew J, Barton, Carly, Cox, Ingrid, Dowman, Leona, Einarsson, Jonas, Fuhrmeister, Lisa, Mackintosh, John A, Neglén, Pernilla, Prasad, Jyotika D, Bucciarelli, Jessica, Scherp, Simon, Sköld, Magnus, Smallwood, Natasha, Symons, Karen, Thompson, Michelle and McDonald, Christine F (2026). Ambulatory oxygen for treatment of exertional hypoxaemia in pulmonary fibrosis (PFOX): a multicentre, randomised, sham-controlled trial. The Lancet Respiratory Medicine, 14 (4), 317-326. doi: 10.1016/S2213-2600(26)00005-6
2026
Conference Publication
Immunohistochemical expression within lung disease including carcinoma, with reference to cell lineage, the tumour microenvironment and elastin related proteins
Duhig, Edwina, van Zwieten, Anthony, Broomfield, Amy, Walsh, Michael, Lal, Sameeta, Godbolt, David, Davidson, Morgan, Mackintosh, John, Hopkins, Peter, Chambers, Daniel, Bowman, Rayleen, Fong, Kwun and Yang, Ian (2026). Immunohistochemical expression within lung disease including carcinoma, with reference to cell lineage, the tumour microenvironment and elastin related proteins. Pathology Update 2026, Sydney, NSW Australia, 6-8 March. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.pathol.2026.01.049
2025
Journal Article
A randomised clinical trial of a digital self-management package for people with interstitial lung disease: the REBUILD-SM protocol
Barton, Carly, Hoffman, Mariana, Cox, Narelle S., Glenn, Laura M., Lee, Joanna Y. T., Cox, Ingrid, Goh, Nicole S. L., Troy, Lauren K., Mackintosh, John, Chambers, Daniel C., Glaspole, Ian N., Gebski, Val, Keech, Anthony, Palmer, Andrew, Laranjo, Liliana, Knibbs, Luke D., Moodley, Yuben, Brooke, Mark, Holland, Anne E. and Corte, Tamera J. (2025). A randomised clinical trial of a digital self-management package for people with interstitial lung disease: the REBUILD-SM protocol. Respiratory Research, 27 (1) 14. doi: 10.1186/s12931-025-03442-z
2025
Journal Article
ABCA3 Surfactant‐Related Gene Variant Associated Interstitial Lung Disease in Adults: A Case Series and Review of the Literature
Nolan, James, Rodgers, Jonathan and Mackintosh, John A. (2025). ABCA3 Surfactant‐Related Gene Variant Associated Interstitial Lung Disease in Adults: A Case Series and Review of the Literature. Respirology Case Reports, 13 (8) e70304, 1-8. doi: 10.1002/rcr2.70304
2025
Journal Article
Telomeropathy: pretransplant and posttransplant considerations for clinicians
Mackintosh, John A. (2025). Telomeropathy: pretransplant and posttransplant considerations for clinicians. Current Opinion in Pulmonary Medicine, 31 (4), 366-373. doi: 10.1097/MCP.0000000000001169
2025
Journal Article
A Comprehensive Review of Interstitial Lung Abnormalities
Moodley, Yuben and Mackintosh, John A. (2025). A Comprehensive Review of Interstitial Lung Abnormalities. Respirology, 30 (5), 385-397. doi: 10.1111/resp.70026
2025
Journal Article
A novel TERT variant associated with a telomere biology disorder and challenges in variant classification
Pazhakh, Vahid, Fox, Lucy C., Elzen, Nicole Den, Emerson, Matthew R., Cohen, Scott B., Bryan, Tracy M., Norris, Kevin, Baird, Duncan M., Cochrane, Tara, Mackintosh, John, Scott, Ashleigh and Blombery, Piers (2025). A novel TERT variant associated with a telomere biology disorder and challenges in variant classification. eJHaem, 6 (1) e1066, 1-5. doi: 10.1002/jha2.1066
2025
Journal Article
Prognostication in patients with idiopathic pulmonary fibrosis using quantitative airway analysis from HRCT: a retrospective study
Nan, Yang, Felder, Federico N., Humphries, Stephen, Mackintosh, John A., Grainge, Christopher, Jo, Helen E., Goh, Nicole, Reynolds, Paul N., Hopkins, Peter M.A., Navaratnam, Vidya, Moodley, Yuben, Walters, Haydn, Ellis, Samantha, Keir, Gregory, Zappala, Chris, Corte, Tamera, Glaspole, Ian, Wells, Athol U., Yang, Guang and Walsh, Simon L.F. (2025). Prognostication in patients with idiopathic pulmonary fibrosis using quantitative airway analysis from HRCT: a retrospective study. European Respiratory Journal, 66 (4) 2500981, 1-14. doi: 10.1183/13993003.00981-2025
2024
Journal Article
Implications of the 2022 lung function update and GLI global reference equations among patients with interstitial lung disease
Li, Andrew, Teoh, Alan, Troy, Lauren, Glaspole, Ian, Wilsher, Margaret L., de Boer, Sally, Wrobel, Jeremy, Moodley, Yuben P., Thien, Francis, Gallagher, Henry, Galbraith, Michelle, Chambers, Daniel C., Mackintosh, John, Goh, Nicole, Khor, Yet Hong, Edwards, Adrienne, Royals, Karen, Grainge, Christopher, Kwan, Benjamin, Keir, Gregory J., Ong, Chong, Reynolds, Paul N., Veitch, Elizabeth, Chai, Gin Tsen, Ng, Ziqin, Tan, Geak Poh, Jackson, Dan, Corte, Tamera and Jo, Helen (2024). Implications of the 2022 lung function update and GLI global reference equations among patients with interstitial lung disease. Thorax, 79 (11), 1-9. doi: 10.1136/thorax-2024-221813
2024
Journal Article
A vexing case of a 73-year-old man with fevers, orbital cellulitis, and asymptomatic interstitial lung disease
Agwan, Sushil, Zhang, Lai-Ying, Baker, Thomas, Lane, Michael, Godbolt, David and Mackintosh, John A. (2024). A vexing case of a 73-year-old man with fevers, orbital cellulitis, and asymptomatic interstitial lung disease. Respirology Case Reports, 12 (9) e70020, e70020. doi: 10.1002/rcr2.70020
2024
Journal Article
Exertional desaturation during the 6-minute walk test versus daily life in people with fibrotic interstitial lung disease
Hoffman, Mariana, Burge, Angela T., Wong, Nick, McDonald, Christine F., Chambers, Daniel C., Glaspole, Ian, Mackintosh, John A., Ekstrom, Magnus, Sköld, Magnus, Goh, Nicole SL., Corte, Tamera J. and Holland, Anne E. (2024). Exertional desaturation during the 6-minute walk test versus daily life in people with fibrotic interstitial lung disease. CHEST, 165 (3), 632-635. doi: 10.1016/j.chest.2023.08.024
2024
Journal Article
Telomere length and immunosuppression in non-idiopathic pulmonary fibrosis interstitial lung disease
Mackintosh, John A. and Chambers, Daniel C. (2024). Telomere length and immunosuppression in non-idiopathic pulmonary fibrosis interstitial lung disease. European Respiratory Journal, 63 (1) 2301806, 2301806. doi: 10.1183/13993003.01806-2023
2023
Journal Article
Telomere biology disorder presenting acutely with pulmonary fibrosis and hepatopulmonary syndrome in a young adult male
Kung, Samantha Chin‐Yun, Dixon, Olivia, Kentwell, Sarah, Vasireddy, Raja S., Rodgers, Jonathan, Ding, Yuming, Rahman, Tony, Tallis, Caroline, Yang, Ian A. and Mackintosh, John A. (2023). Telomere biology disorder presenting acutely with pulmonary fibrosis and hepatopulmonary syndrome in a young adult male. Respirology Case Reports, 11 (8) e01182, 1-4. doi: 10.1002/rcr2.1182
2022
Journal Article
Deep Learning-based Outcome Prediction in Progressive Fibrotic Lung Disease Using High-Resolution Computed Tomography
Walsh, Simon L. F., Mackintosh, John A., Calandriello, Lucio, Silva, Mario, Sverzellati, Nicola, Larici, Anna Rita, Humphries, Stephen M., Lynch, David A., Jo, Helen E., Glaspole, Ian, Grainge, Christopher, Goh, Nicole, Hopkins, Peter M. A., Moodley, Yuben, Reynolds, Paul N., Zappala, Christopher, Keir, Gregory, Cooper, Wendy A., Mahar, Annabelle M., Ellis, Samantha, Wells, Athol U. and Corte, Tamera J. (2022). Deep Learning-based Outcome Prediction in Progressive Fibrotic Lung Disease Using High-Resolution Computed Tomography. American Journal of Respiratory and Critical Care Medicine, 206 (7), 883-891. doi: 10.1164/rccm.202112-2684OC
2022
Journal Article
Towards truly ‘idiopathic’ pulmonary fibrosis
Mackintosh, John A. and Chambers, Daniel C. (2022). Towards truly ‘idiopathic’ pulmonary fibrosis. Respirology, 27 (9), 682-683. doi: 10.1111/resp.14320
2022
Journal Article
Genomic lung allograft surveillance: is it primer time?
Mackintosh, John A. and Chambers, Daniel C. (2022). Genomic lung allograft surveillance: is it primer time?. The Journal of Heart and Lung Transplantation, 41 (4), 467-469. doi: 10.1016/j.healun.2022.01.016
2021
Journal Article
TELO-SCOPE study: A randomised, double-blind, placebo-controlled, phase 2 trial of danazol for short telomere related pulmonary fibrosis
MacKintosh, John A., Pietsch, Maria, Lutzky, Viviana, Enever, Debra, Bancroft, Sandra, Apte, Simon H., Tan, Maxine, Yerkovich, Stephanie T., Dickinson, Joanne L., Pickett, Hilda A., Selvadurai, Hiran, Grainge, Christopher, Goh, Nicole S., Hopkins, Peter, Glaspole, Ian, Reynolds, Paul N., Wrobel, Jeremy, Jaffe, Adam, Corte, Tamera J. and Chambers, Daniel C. (2021). TELO-SCOPE study: A randomised, double-blind, placebo-controlled, phase 2 trial of danazol for short telomere related pulmonary fibrosis. BMJ Open Respiratory Research, 8 (1) e001127, 1-8. doi: 10.1136/bmjresp-2021-001127
2021
Conference Publication
An evaluation of Vitamin D deficiency and supplementation in patients with idiopathic pulmonary fibrosis
Mackintosh, J., Mortimer, N., Kumar, R., Hay, K., Mann, J., Ryder, S., Jo, H., Glaspole, I., Grainge, C., Goh, N., Hopkins, P., Moodley, Y., Reynolds, P., Zappala, C., Allan, H., Keir, G., Hayen, A., Cooper, W., Mahar, A., Ellis, S., Macansh, S., Wells, A., Corte, T. and George, P. (2021). An evaluation of Vitamin D deficiency and supplementation in patients with idiopathic pulmonary fibrosis. TSANZSRS 2021 The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting for Leaders in Lung Health & Respiratory Science, Online, 1–2 May 2021. Richmond, VIC Australia: John Wiley & Sons.
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