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Dr John Mackintosh
Dr

John Mackintosh

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Overview

Background

MBBS(Hons), FRACP — Specialist Respiratory and Lung Transplant Physician

Dr John Mackintosh graduated from The University of Queensland in 2011 with honours. He trained in respiratory medicine in Queensland, before completing an interstitial lung disease clinical fellowship at the Royal Brompton Hospital in London — one of the world's leading interstitial lung disease (ILD) referral centres.

He returned to Brisbane in 2019 as a Respiratory & Lung Transplant Physician with the Queensland Lung Transplant Service at The Prince Charles Hospital, and as an academic at The University of Queensland, where he was promoted to Associate Professor in recognition of his clinical and research contribution to ILD. He leads The Prince Charles Hospital's ILD service and his research work centres on ILD, with particular expertise in idiopathic pulmonary fibrosis, familial pulmonary fibrosis and the genetic underpinnings of fibrotic lung disease.

Alongside his clinical practice, he co-chairs the Queensland Statewide ILD Multidisciplinary Meeting and is founder and chair of the Australasian ILD Genetics Multidisciplinary Meeting. Internationally, he was a Co-Lead for the International Society of Heart and Lung Transplantation's first consensus statement on short telomere syndrome and lung transplantation, and is first author of the current Thoracic Society of Australia and New Zealand position statement on the treatment of IPF and progressive pulmonary fibrosis.

Availability

Dr John Mackintosh is:
Not available for supervision

Research impacts

Dr Mackintosh's research centres on interstitial lung disease, with a particular focus on the genetics of pulmonary fibrosis, telomere biology disorders and outcomes after lung transplantation.

Works

Search Professor John Mackintosh’s works on UQ eSpace

84 works between 2012 and 2026

41 - 60 of 84 works

2024

Conference Publication

Telomere length in Australian adults with pulmonary fibrosis

Mackintosh, J., Zhang, L., Lutzky, , Tan, M., Apte, S., Groves, P., O'Sullivan, B., Watson, S., Dixon, O., Hopkins, P., Corte, T. and Chambers, D. (2024). Telomere length in Australian adults with pulmonary fibrosis. HOBOKEN: WILEY.

Telomere length in Australian adults with pulmonary fibrosis

2024

Journal Article

Exertional desaturation during the 6-minute walk test versus daily life in people with fibrotic interstitial lung disease

Hoffman, Mariana, Burge, Angela T., Wong, Nick, McDonald, Christine F., Chambers, Daniel C., Glaspole, Ian, Mackintosh, John A., Ekstrom, Magnus, Sköld, Magnus, Goh, Nicole SL., Corte, Tamera J. and Holland, Anne E. (2024). Exertional desaturation during the 6-minute walk test versus daily life in people with fibrotic interstitial lung disease. CHEST, 165 (3), 632-635. doi: 10.1016/j.chest.2023.08.024

Exertional desaturation during the 6-minute walk test versus daily life in people with fibrotic interstitial lung disease

2024

Conference Publication

The utility of genetic testing in adults with pulmonary fibrosis: a retrospective cohort study

Dixon, O., Lutzky, , Zhang, L., Watson, S., Rodgers, D., Chambers, D. and Mackintosh, J. (2024). The utility of genetic testing in adults with pulmonary fibrosis: A retrospective cohort study. HOBOKEN: WILEY.

The utility of genetic testing in adults with pulmonary fibrosis: a retrospective cohort study

2024

Journal Article

Treatment of idiopathic pulmonary fibrosis and progressive pulmonary fibrosis: A position statement from the Thoracic Society of Australia and New Zealand 2023 revision

Mackintosh, John A., Keir, Gregory, Troy, Lauren K., Holland, Anne E., Grainge, Christopher, Chambers, Daniel C., Sandford, Debra, Jo, Helen E., Glaspole, Ian, Wilsher, Margaret, Goh, Nicole S. L., Reynolds, Paul N., Chapman, Sally, Mutsaers, Steven E., de Boer, Sally, Webster, Susanne, Moodley, Yuben and Corte, Tamera J. (2024). Treatment of idiopathic pulmonary fibrosis and progressive pulmonary fibrosis: A position statement from the Thoracic Society of Australia and New Zealand 2023 revision. Respirology, 29 (2), 105-135. doi: 10.1111/resp.14656

Treatment of idiopathic pulmonary fibrosis and progressive pulmonary fibrosis: A position statement from the Thoracic Society of Australia and New Zealand 2023 revision

2024

Book Chapter

Post-Transplant Phase: Issues in the Early Postoperative Period

Mackintosh, John and Hopkins, Peter (2024). Post-Transplant Phase: Issues in the Early Postoperative Period. Textbook of Transplantation and Mechanical Support for End-Stage Heart and Lung Disease. (pp. 1217-1239) Hoboken, NJ United States: John Wiley & Sons. doi: 10.1002/9781119633884.ch89

Post-Transplant Phase: Issues in the Early Postoperative Period

2024

Journal Article

Telomere length and immunosuppression in non-idiopathic pulmonary fibrosis interstitial lung disease

Mackintosh, John A. and Chambers, Daniel C. (2024). Telomere length and immunosuppression in non-idiopathic pulmonary fibrosis interstitial lung disease. European Respiratory Journal, 63 (1) 2301806, 2301806. doi: 10.1183/13993003.01806-2023

Telomere length and immunosuppression in non-idiopathic pulmonary fibrosis interstitial lung disease

2023

Journal Article

Long‐term exposure to low concentrations of air pollution and decline in lung function in people with idiopathic pulmonary fibrosis: Evidence from Australia

Zheng, Qiang, Cox, Ingrid A., Leigh, Lucy, de Graaff, Barbara, Johnston, Fay H., Corte, Tamera J., Knibbs, Luke D., Otahal, Petr, Navaratnam, Vidya, Campbell, Julie A., Glaspole, Ian, Moodley, Yuben, Hopkins, Peter, Mackintosh, John A., Ahmad, Hasnat, Walters, E. Haydn and Palmer, Andrew J. (2023). Long‐term exposure to low concentrations of air pollution and decline in lung function in people with idiopathic pulmonary fibrosis: Evidence from Australia. Respirology, 28 (10), 916-924. doi: 10.1111/resp.14552

Long‐term exposure to low concentrations of air pollution and decline in lung function in people with idiopathic pulmonary fibrosis: Evidence from Australia

2023

Conference Publication

Deep learning-based quantification of traction bronchiectasis severity for predicting outcome in idiopathic pulmonary fibrosis

Felder, Federico, Nan, Yang, Yang, Guang, Mackintosh, John, Calandriello, Lucio, Silva, Mario, Glaspole, Ian, Goh, Nicole, Cooper, Wendy, Grainge, Christopher, Hopkins, Peter, Moodley, Yuben, Vidya, Navaratnam, Reynolds, Paul, Wells, Athol, Corte, Tamera and Walsh, Simon (2023). Deep learning-based quantification of traction bronchiectasis severity for predicting outcome in idiopathic pulmonary fibrosis. Annual congress of the European-Respiratory-Society (ERS), Milan Ia, Sep 09-13, 2023. SHEFFIELD: EUROPEAN RESPIRATORY SOC JOURNALS LTD. doi: 10.1183/13993003.congress-2023.OA4853

Deep learning-based quantification of traction bronchiectasis severity for predicting outcome in idiopathic pulmonary fibrosis

2023

Conference Publication

A deep learning algorithm for predicting disease progression in idiopathic pulmonary fibrosis

Fang, Yingying, Felder, Federico, Yang, Guang, Mackintosh, John, Calandriello, Lucio, Silva, Mario, Cooper, Wendy, Glaspole, Ian, Goh, Nicole, Grainge, Christopher, Hopkins, Peter, Moodley, Yuben, Vidya, Navaratnam, Reynolds, Paul, Wells, Athol, Corte, Tamera and Walsh, Simon (2023). A deep learning algorithm for predicting disease progression in idiopathic pulmonary fibrosis. Annual congress of the European-Respiratory-Society (ERS), Milan Ia, Sep 09-13, 2023. SHEFFIELD: EUROPEAN RESPIRATORY SOC JOURNALS LTD. doi: 10.1183/13993003.congress-2023.OA4852

A deep learning algorithm for predicting disease progression in idiopathic pulmonary fibrosis

2023

Journal Article

Telomere biology disorder presenting acutely with pulmonary fibrosis and hepatopulmonary syndrome in a young adult male

Kung, Samantha Chin‐Yun, Dixon, Olivia, Kentwell, Sarah, Vasireddy, Raja S., Rodgers, Jonathan, Ding, Yuming, Rahman, Tony, Tallis, Caroline, Yang, Ian A. and Mackintosh, John A. (2023). Telomere biology disorder presenting acutely with pulmonary fibrosis and hepatopulmonary syndrome in a young adult male. Respirology Case Reports, 11 (8) e01182, 1-4. doi: 10.1002/rcr2.1182

Telomere biology disorder presenting acutely with pulmonary fibrosis and hepatopulmonary syndrome in a young adult male

2023

Journal Article

Preclinical interstitial lung disease in relatives of familial pulmonary fibrosis patients

Lucas, S. E. M., Raspin, K., Mackintosh, J., Glaspole, I., Reynolds, P. N., Chia, C., Grainge, C., Kendall, P., Troy, L., Schwartz, D. A., Wood-Baker, R., Walsh, S. L. F., Moodley, Y., Robertson, J., Macansh, S., Walters, E. H., Chambers, D., Corte, T.J. and Dickinson, J. L. (2023). Preclinical interstitial lung disease in relatives of familial pulmonary fibrosis patients. Pulmonology, 29 (3), 257-260. doi: 10.1016/j.pulmoe.2022.09.002

Preclinical interstitial lung disease in relatives of familial pulmonary fibrosis patients

2023

Journal Article

Sex- and race-based differences in the treatment of interstitial lung diseases in North America And Australasia

Assayag, Deborah, Adegunsoye, Ayodeji, Sheehy, Robert, Morisset, Julie, Khalil, Nasreen, Johannson, Kerri A., Marcoux, Veronica, Kolb, Martin, Fisher, Jolene H., Manganas, Helene, Wrobel, Jeremy, Wilsher, Margaret, De Boer, Sally, Mackintosh, John, Chambers, Daniel C., Glaspole, Ian, Keir, Gregory J., Lee, Cathryn T., Jablonski, Renea, Vij, Rekha, Strek, Mary E., Corte, Tamera J. and Ryerson, Christopher J. (2023). Sex- and race-based differences in the treatment of interstitial lung diseases in North America And Australasia. Chest, 163 (5), 1156-1165. doi: 10.1016/j.chest.2022.12.039

Sex- and race-based differences in the treatment of interstitial lung diseases in North America And Australasia

2023

Conference Publication

Gender and treatment of interstitial lung disease: a registry study

Sheehy, R., Wrobel, J., Wilsher, M., de Boer, S., Mackintosh, J., Chambers, D., Glaspole, , Keir, G. and Corte, T. (2023). Gender and treatment of interstitial lung disease: A registry study. HOBOKEN: WILEY.

Gender and treatment of interstitial lung disease: a registry study

2023

Journal Article

Machine learning in radiology: the new frontier in interstitial lung diseases

Barnes, Hayley, Humphries, Stephen M., George, Peter M., Assayag, Deborah, Glaspole, Ian, Mackintosh, John A., Corte, Tamera J., Glassberg, Marilyn, Johannson, Kerri A., Calandriello, Lucio, Felder, Federico, Wells, Athol and Walsh, Simon (2023). Machine learning in radiology: the new frontier in interstitial lung diseases. The Lancet Digital Health, 5 (1), e41-e50. doi: 10.1016/S2589-7500(22)00230-8

Machine learning in radiology: the new frontier in interstitial lung diseases

2023

Journal Article

Multi-center evaluation of baseline neutrophil-to-lymphocyte (NLR) ratio as an independent predictor of mortality and clinical risk stratifier in idiopathic pulmonary fibrosis

Mikolasch, Theresia A., George, Peter M., Sahota, Jagdeep, Nancarrow, Thomas, Barratt, Shaney L., Woodhead, Felix A., Kouranos, Vasilis, Cope, Victoria S.A., Creamer, Andrew W., Fidan, Silan, Ganeshan, Balaji, Hoy, Luke, Mackintosh, John A., Shortman, Robert, Duckworth, Anna, Fallon, Janet, Garthwaite, Helen, Heightman, Melissa, Adamali, Huzaifa I., Lines, Sarah, Win, Thida, Wollerton, Rebecca, Renzoni, Elisabetta A., Steward, Matthew, Wells, Athol U., Gibbons, Michael, Groves, Ashley M., Gooptu, Bibek, Scotton, Chris J. and Porter, Joanna C. (2023). Multi-center evaluation of baseline neutrophil-to-lymphocyte (NLR) ratio as an independent predictor of mortality and clinical risk stratifier in idiopathic pulmonary fibrosis. eClinicalMedicine, 55 101758. doi: 10.1016/j.eclinm.2022.101758

Multi-center evaluation of baseline neutrophil-to-lymphocyte (NLR) ratio as an independent predictor of mortality and clinical risk stratifier in idiopathic pulmonary fibrosis

2022

Book Chapter

Interstitial abnormalities from solid and haematological cancers

Mackintosh, John A., Duhig, Edwina E., Reddy, Taryn, Stephens, Edward K.H., Fong, Kwun M. and Yang, Ian A. (2022). Interstitial abnormalities from solid and haematological cancers. Lung diseases and cancer. (pp. 225-240) edited by Miguel Ángel Martínez-García, Mina Gaga, Kwun M. Fong and Peter M.A. Calverley. Sheffield, United Kingdom: European Respiratory Society. doi: 10.1183/2312508x.10020221

Interstitial abnormalities from solid and haematological cancers

2022

Journal Article

Quantitative computed tomography predicts outcomes in idiopathic pulmonary fibrosis

Humphries, Stephen M., Mackintosh, John A., Jo, Helen E., Walsh, Simon L. F., Silva, Mario, Calandriello, Lucio, Chapman, Sally, Ellis, Samantha, Glaspole, Ian, Goh, Nicole, Grainge, Christopher, Hopkins, Peter M. A., Keir, Gregory J., Moodley, Yuben, Reynolds, Paul N., Walters, E. Haydn, Baraghoshi, David, Wells, Athol U., Lynch, David A. and Corte, Tamera J. (2022). Quantitative computed tomography predicts outcomes in idiopathic pulmonary fibrosis. Respirology, 27 (12), 1045-1053. doi: 10.1111/resp.14333

Quantitative computed tomography predicts outcomes in idiopathic pulmonary fibrosis

2022

Journal Article

Deep Learning-based Outcome Prediction in Progressive Fibrotic Lung Disease Using High-Resolution Computed Tomography

Walsh, Simon L. F., Mackintosh, John A., Calandriello, Lucio, Silva, Mario, Sverzellati, Nicola, Larici, Anna Rita, Humphries, Stephen M., Lynch, David A., Jo, Helen E., Glaspole, Ian, Grainge, Christopher, Goh, Nicole, Hopkins, Peter M. A., Moodley, Yuben, Reynolds, Paul N., Zappala, Christopher, Keir, Gregory, Cooper, Wendy A., Mahar, Annabelle M., Ellis, Samantha, Wells, Athol U. and Corte, Tamera J. (2022). Deep Learning-based Outcome Prediction in Progressive Fibrotic Lung Disease Using High-Resolution Computed Tomography. American Journal of Respiratory and Critical Care Medicine, 206 (7), 883-891. doi: 10.1164/rccm.202112-2684OC

Deep Learning-based Outcome Prediction in Progressive Fibrotic Lung Disease Using High-Resolution Computed Tomography

2022

Journal Article

Airway complications—lung transplantation’s Achilles’ heel

Carew, Alan M. and Mackintosh, John A. (2022). Airway complications—lung transplantation’s Achilles’ heel. Journal of Thoracic Disease, 14 (9), 3116-3118. doi: 10.21037/jtd-22-889

Airway complications—lung transplantation’s Achilles’ heel

2022

Journal Article

Towards truly ‘idiopathic’ pulmonary fibrosis

Mackintosh, John A. and Chambers, Daniel C. (2022). Towards truly ‘idiopathic’ pulmonary fibrosis. Respirology, 27 (9), 682-683. doi: 10.1111/resp.14320

Towards truly ‘idiopathic’ pulmonary fibrosis

Funding

Current funding

  • 2023 - 2028
    Treatable Traits in Interstitial Lung Disease (TTRILD) Study: The New Frontier (MRFF Preventive and Public Health Research Initiative grant administered by The University of Western Australia)
    University of Western Australia
    Open grant

Past funding

  • 2020 - 2025
    The TELO-SCOPE study: Attenuating Telomere Attrition with Danazol. Is there Scope to Dramatically Improve Health Outcomes for Adults and Children with Pulmonary Fibrosis?
    NHMRC MRFF - Rare Cancers, Rare Diseases and Unmet Need
    Open grant

Media

Enquiries

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