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Dr John Mackintosh
Dr

John Mackintosh

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Overview

Background

MBBS(Hons), FRACP — Specialist Respiratory and Lung Transplant Physician

Dr John Mackintosh graduated from The University of Queensland in 2011 with honours. He trained in respiratory medicine in Queensland, before completing an interstitial lung disease clinical fellowship at the Royal Brompton Hospital in London — one of the world's leading interstitial lung disease (ILD) referral centres.

He returned to Brisbane in 2019 as a Respiratory & Lung Transplant Physician with the Queensland Lung Transplant Service at The Prince Charles Hospital, and as an academic at The University of Queensland, where he was promoted to Associate Professor in recognition of his clinical and research contribution to ILD. He leads The Prince Charles Hospital's ILD service and his research work centres on ILD, with particular expertise in idiopathic pulmonary fibrosis, familial pulmonary fibrosis and the genetic underpinnings of fibrotic lung disease.

Alongside his clinical practice, he co-chairs the Queensland Statewide ILD Multidisciplinary Meeting and is founder and chair of the Australasian ILD Genetics Multidisciplinary Meeting. Internationally, he was a Co-Lead for the International Society of Heart and Lung Transplantation's first consensus statement on short telomere syndrome and lung transplantation, and is first author of the current Thoracic Society of Australia and New Zealand position statement on the treatment of IPF and progressive pulmonary fibrosis.

Availability

Dr John Mackintosh is:
Not available for supervision

Research impacts

Dr Mackintosh's research centres on interstitial lung disease, with a particular focus on the genetics of pulmonary fibrosis, telomere biology disorders and outcomes after lung transplantation.

Works

Search Professor John Mackintosh’s works on UQ eSpace

22 works between 2014 and 2026

1 - 20 of 22 works

2026

Journal Article

Inhaled treprostinil for idiopathic pulmonary fibrosis

Nathan, Steven D., Smith, Peter, Deng, Chunqin, De Salvo, Maria, Wuyts, Wim, Pavie-Gallegos, Juana, Song, Jin Woo, Kramer, Mordechai R., King, Christopher S., Mackintosh, John A., Chambers, Daniel, Miranda, Georgina Viviana, Breytenbach, Natalie, Peterson, Leigh, Bell, Heidi, Flaherty, Kevin R., Behr, Juergen and Cottin, Vincent (2026). Inhaled treprostinil for idiopathic pulmonary fibrosis. New England Journal of Medicine, 395 (2), 127-137. doi: 10.1056/NEJMoa2512911

Inhaled treprostinil for idiopathic pulmonary fibrosis

2026

Journal Article

Deep-learning algorithm diagnostic support for usual interstitial pneumonia pattern recognition in fibrotic interstitial lung disease

Fermoyle, Caitlin C., Mackintosh, John A., Navaratnam, Vidya, Ellis, Samantha J., Cooper, Wendy A., Goh, Nicole S. L., Moodley, Yuben, Reynolds, Paul N., Zappala, Christopher J., Hopkins, Peter, Glaspole, Ian N., Corte, Tamera J., Walsh, Simon L. F., Accornero, Daniele, Agrawal, Aditya, Akilli, Isil Kibar, Alamoudi, Omer, Alberti, Maria Laura, Aliannejad, Rasoul, Aljahdali, Hamdan, Amanda, Gina, Anconina, Reut, Antuni, Julio Daniel, Aquaro, Giuseppe, Arenas-Jimenez, Juan, Asuquo, Bassey, Au-Yong, Iain, Avdeev, Sergey, Balbi, Maurizio ... Zompatori, Maurizio (2026). Deep-learning algorithm diagnostic support for usual interstitial pneumonia pattern recognition in fibrotic interstitial lung disease. Respirology, 31 (7), 711-720. doi: 10.1002/resp.70246

Deep-learning algorithm diagnostic support for usual interstitial pneumonia pattern recognition in fibrotic interstitial lung disease

2026

Journal Article

Ambulatory oxygen for treatment of exertional hypoxaemia in pulmonary fibrosis (PFOX): a multicentre, randomised, sham-controlled trial

Holland, Anne E, Hoffman, Mariana, Corte, Tamera J, Chambers, Daniel C, Hepworth, Graham, Ekström, Magnus P, Glaspole, Ian, Goh, Nicole S, Khor, Yet H, Palmer, Andrew J, Barton, Carly, Cox, Ingrid, Dowman, Leona, Einarsson, Jonas, Fuhrmeister, Lisa, Mackintosh, John A, Neglén, Pernilla, Prasad, Jyotika D, Bucciarelli, Jessica, Scherp, Simon, Sköld, Magnus, Smallwood, Natasha, Symons, Karen, Thompson, Michelle and McDonald, Christine F (2026). Ambulatory oxygen for treatment of exertional hypoxaemia in pulmonary fibrosis (PFOX): a multicentre, randomised, sham-controlled trial. The Lancet Respiratory Medicine, 14 (4), 317-326. doi: 10.1016/S2213-2600(26)00005-6

Ambulatory oxygen for treatment of exertional hypoxaemia in pulmonary fibrosis (PFOX): a multicentre, randomised, sham-controlled trial

2026

Conference Publication

Immunohistochemical expression within lung disease including carcinoma, with reference to cell lineage, the tumour microenvironment and elastin related proteins

Duhig, Edwina, van Zwieten, Anthony, Broomfield, Amy, Walsh, Michael, Lal, Sameeta, Godbolt, David, Davidson, Morgan, Mackintosh, John, Hopkins, Peter, Chambers, Daniel, Bowman, Rayleen, Fong, Kwun and Yang, Ian (2026). Immunohistochemical expression within lung disease including carcinoma, with reference to cell lineage, the tumour microenvironment and elastin related proteins. Pathology Update 2026, Sydney, NSW Australia, 6-8 March. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.pathol.2026.01.049

Immunohistochemical expression within lung disease including carcinoma, with reference to cell lineage, the tumour microenvironment and elastin related proteins

2025

Journal Article

A randomised clinical trial of a digital self-management package for people with interstitial lung disease: the REBUILD-SM protocol

Barton, Carly, Hoffman, Mariana, Cox, Narelle S., Glenn, Laura M., Lee, Joanna Y. T., Cox, Ingrid, Goh, Nicole S. L., Troy, Lauren K., Mackintosh, John, Chambers, Daniel C., Glaspole, Ian N., Gebski, Val, Keech, Anthony, Palmer, Andrew, Laranjo, Liliana, Knibbs, Luke D., Moodley, Yuben, Brooke, Mark, Holland, Anne E. and Corte, Tamera J. (2025). A randomised clinical trial of a digital self-management package for people with interstitial lung disease: the REBUILD-SM protocol. Respiratory Research, 27 (1) 14. doi: 10.1186/s12931-025-03442-z

A randomised clinical trial of a digital self-management package for people with interstitial lung disease: the REBUILD-SM protocol

2025

Journal Article

ABCA3 Surfactant‐Related Gene Variant Associated Interstitial Lung Disease in Adults: A Case Series and Review of the Literature

Nolan, James, Rodgers, Jonathan and Mackintosh, John A. (2025). ABCA3 Surfactant‐Related Gene Variant Associated Interstitial Lung Disease in Adults: A Case Series and Review of the Literature. Respirology Case Reports, 13 (8) e70304, 1-8. doi: 10.1002/rcr2.70304

ABCA3 Surfactant‐Related Gene Variant Associated Interstitial Lung Disease in Adults: A Case Series and Review of the Literature

2025

Journal Article

Telomeropathy: pretransplant and posttransplant considerations for clinicians

Mackintosh, John A. (2025). Telomeropathy: pretransplant and posttransplant considerations for clinicians. Current Opinion in Pulmonary Medicine, 31 (4), 366-373. doi: 10.1097/MCP.0000000000001169

Telomeropathy: pretransplant and posttransplant considerations for clinicians

2025

Journal Article

A Comprehensive Review of Interstitial Lung Abnormalities

Moodley, Yuben and Mackintosh, John A. (2025). A Comprehensive Review of Interstitial Lung Abnormalities. Respirology, 30 (5), 385-397. doi: 10.1111/resp.70026

A Comprehensive Review of Interstitial Lung Abnormalities

2025

Journal Article

A novel TERT variant associated with a telomere biology disorder and challenges in variant classification

Pazhakh, Vahid, Fox, Lucy C., Elzen, Nicole Den, Emerson, Matthew R., Cohen, Scott B., Bryan, Tracy M., Norris, Kevin, Baird, Duncan M., Cochrane, Tara, Mackintosh, John, Scott, Ashleigh and Blombery, Piers (2025). A novel TERT variant associated with a telomere biology disorder and challenges in variant classification. eJHaem, 6 (1) e1066, 1-5. doi: 10.1002/jha2.1066

A novel TERT variant associated with a telomere biology disorder and challenges in variant classification

2025

Journal Article

Prognostication in patients with idiopathic pulmonary fibrosis using quantitative airway analysis from HRCT: a retrospective study

Nan, Yang, Felder, Federico N., Humphries, Stephen, Mackintosh, John A., Grainge, Christopher, Jo, Helen E., Goh, Nicole, Reynolds, Paul N., Hopkins, Peter M.A., Navaratnam, Vidya, Moodley, Yuben, Walters, Haydn, Ellis, Samantha, Keir, Gregory, Zappala, Chris, Corte, Tamera, Glaspole, Ian, Wells, Athol U., Yang, Guang and Walsh, Simon L.F. (2025). Prognostication in patients with idiopathic pulmonary fibrosis using quantitative airway analysis from HRCT: a retrospective study. European Respiratory Journal, 66 (4) 2500981, 1-14. doi: 10.1183/13993003.00981-2025

Prognostication in patients with idiopathic pulmonary fibrosis using quantitative airway analysis from HRCT: a retrospective study

2024

Journal Article

Implications of the 2022 lung function update and GLI global reference equations among patients with interstitial lung disease

Li, Andrew, Teoh, Alan, Troy, Lauren, Glaspole, Ian, Wilsher, Margaret L., de Boer, Sally, Wrobel, Jeremy, Moodley, Yuben P., Thien, Francis, Gallagher, Henry, Galbraith, Michelle, Chambers, Daniel C., Mackintosh, John, Goh, Nicole, Khor, Yet Hong, Edwards, Adrienne, Royals, Karen, Grainge, Christopher, Kwan, Benjamin, Keir, Gregory J., Ong, Chong, Reynolds, Paul N., Veitch, Elizabeth, Chai, Gin Tsen, Ng, Ziqin, Tan, Geak Poh, Jackson, Dan, Corte, Tamera and Jo, Helen (2024). Implications of the 2022 lung function update and GLI global reference equations among patients with interstitial lung disease. Thorax, 79 (11), 1-9. doi: 10.1136/thorax-2024-221813

Implications of the 2022 lung function update and GLI global reference equations among patients with interstitial lung disease

2024

Journal Article

A vexing case of a 73-year-old man with fevers, orbital cellulitis, and asymptomatic interstitial lung disease

Agwan, Sushil, Zhang, Lai-Ying, Baker, Thomas, Lane, Michael, Godbolt, David and Mackintosh, John A. (2024). A vexing case of a 73-year-old man with fevers, orbital cellulitis, and asymptomatic interstitial lung disease. Respirology Case Reports, 12 (9) e70020, e70020. doi: 10.1002/rcr2.70020

A vexing case of a 73-year-old man with fevers, orbital cellulitis, and asymptomatic interstitial lung disease

2024

Journal Article

Exertional desaturation during the 6-minute walk test versus daily life in people with fibrotic interstitial lung disease

Hoffman, Mariana, Burge, Angela T., Wong, Nick, McDonald, Christine F., Chambers, Daniel C., Glaspole, Ian, Mackintosh, John A., Ekstrom, Magnus, Sköld, Magnus, Goh, Nicole SL., Corte, Tamera J. and Holland, Anne E. (2024). Exertional desaturation during the 6-minute walk test versus daily life in people with fibrotic interstitial lung disease. CHEST, 165 (3), 632-635. doi: 10.1016/j.chest.2023.08.024

Exertional desaturation during the 6-minute walk test versus daily life in people with fibrotic interstitial lung disease

2024

Journal Article

Telomere length and immunosuppression in non-idiopathic pulmonary fibrosis interstitial lung disease

Mackintosh, John A. and Chambers, Daniel C. (2024). Telomere length and immunosuppression in non-idiopathic pulmonary fibrosis interstitial lung disease. European Respiratory Journal, 63 (1) 2301806, 2301806. doi: 10.1183/13993003.01806-2023

Telomere length and immunosuppression in non-idiopathic pulmonary fibrosis interstitial lung disease

2023

Journal Article

Telomere biology disorder presenting acutely with pulmonary fibrosis and hepatopulmonary syndrome in a young adult male

Kung, Samantha Chin‐Yun, Dixon, Olivia, Kentwell, Sarah, Vasireddy, Raja S., Rodgers, Jonathan, Ding, Yuming, Rahman, Tony, Tallis, Caroline, Yang, Ian A. and Mackintosh, John A. (2023). Telomere biology disorder presenting acutely with pulmonary fibrosis and hepatopulmonary syndrome in a young adult male. Respirology Case Reports, 11 (8) e01182, 1-4. doi: 10.1002/rcr2.1182

Telomere biology disorder presenting acutely with pulmonary fibrosis and hepatopulmonary syndrome in a young adult male

2022

Journal Article

Deep Learning-based Outcome Prediction in Progressive Fibrotic Lung Disease Using High-Resolution Computed Tomography

Walsh, Simon L. F., Mackintosh, John A., Calandriello, Lucio, Silva, Mario, Sverzellati, Nicola, Larici, Anna Rita, Humphries, Stephen M., Lynch, David A., Jo, Helen E., Glaspole, Ian, Grainge, Christopher, Goh, Nicole, Hopkins, Peter M. A., Moodley, Yuben, Reynolds, Paul N., Zappala, Christopher, Keir, Gregory, Cooper, Wendy A., Mahar, Annabelle M., Ellis, Samantha, Wells, Athol U. and Corte, Tamera J. (2022). Deep Learning-based Outcome Prediction in Progressive Fibrotic Lung Disease Using High-Resolution Computed Tomography. American Journal of Respiratory and Critical Care Medicine, 206 (7), 883-891. doi: 10.1164/rccm.202112-2684OC

Deep Learning-based Outcome Prediction in Progressive Fibrotic Lung Disease Using High-Resolution Computed Tomography

2022

Journal Article

Towards truly ‘idiopathic’ pulmonary fibrosis

Mackintosh, John A. and Chambers, Daniel C. (2022). Towards truly ‘idiopathic’ pulmonary fibrosis. Respirology, 27 (9), 682-683. doi: 10.1111/resp.14320

Towards truly ‘idiopathic’ pulmonary fibrosis

2022

Journal Article

Genomic lung allograft surveillance: is it primer time?

Mackintosh, John A. and Chambers, Daniel C. (2022). Genomic lung allograft surveillance: is it primer time?. The Journal of Heart and Lung Transplantation, 41 (4), 467-469. doi: 10.1016/j.healun.2022.01.016

Genomic lung allograft surveillance: is it primer time?

2021

Journal Article

TELO-SCOPE study: A randomised, double-blind, placebo-controlled, phase 2 trial of danazol for short telomere related pulmonary fibrosis

MacKintosh, John A., Pietsch, Maria, Lutzky, Viviana, Enever, Debra, Bancroft, Sandra, Apte, Simon H., Tan, Maxine, Yerkovich, Stephanie T., Dickinson, Joanne L., Pickett, Hilda A., Selvadurai, Hiran, Grainge, Christopher, Goh, Nicole S., Hopkins, Peter, Glaspole, Ian, Reynolds, Paul N., Wrobel, Jeremy, Jaffe, Adam, Corte, Tamera J. and Chambers, Daniel C. (2021). TELO-SCOPE study: A randomised, double-blind, placebo-controlled, phase 2 trial of danazol for short telomere related pulmonary fibrosis. BMJ Open Respiratory Research, 8 (1) e001127, 1-8. doi: 10.1136/bmjresp-2021-001127

TELO-SCOPE study: A randomised, double-blind, placebo-controlled, phase 2 trial of danazol for short telomere related pulmonary fibrosis

2021

Conference Publication

An evaluation of Vitamin D deficiency and supplementation in patients with idiopathic pulmonary fibrosis

Mackintosh, J., Mortimer, N., Kumar, R., Hay, K., Mann, J., Ryder, S., Jo, H., Glaspole, I., Grainge, C., Goh, N., Hopkins, P., Moodley, Y., Reynolds, P., Zappala, C., Allan, H., Keir, G., Hayen, A., Cooper, W., Mahar, A., Ellis, S., Macansh, S., Wells, A., Corte, T. and George, P. (2021). An evaluation of Vitamin D deficiency and supplementation in patients with idiopathic pulmonary fibrosis. TSANZSRS 2021 The Australia & New Zealand Society of Respiratory Science and The Thoracic Society of Australia and New Zealand (ANZSRS/TSANZ) Annual Scientific Meeting for Leaders in Lung Health & Respiratory Science, Online, 1–2 May 2021. Richmond, VIC Australia: John Wiley & Sons.

An evaluation of Vitamin D deficiency and supplementation in patients with idiopathic pulmonary fibrosis

Funding

Current funding

  • 2023 - 2028
    Treatable Traits in Interstitial Lung Disease (TTRILD) Study: The New Frontier (MRFF Preventive and Public Health Research Initiative grant administered by The University of Western Australia)
    University of Western Australia
    Open grant

Past funding

  • 2020 - 2025
    The TELO-SCOPE study: Attenuating Telomere Attrition with Danazol. Is there Scope to Dramatically Improve Health Outcomes for Adults and Children with Pulmonary Fibrosis?
    NHMRC MRFF - Rare Cancers, Rare Diseases and Unmet Need
    Open grant

Media

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