Dr

Kevin Chen

Email: 

Background

Dr Chen’s research aims to understand the molecular details of how phosphatases, kinases and their associated proteins regulate cell signaling and homeostasis.

In 2011, Dr Chen completed his PhD on structural studies of macrophage proteins in Professor Jennifer Martin’s laboratory at The University of Queensland’s Institute for Molecular Bioscience.

In 2012, Dr Chen secured a postdoctoral research position at Academia Sinica (Taipei, Taiwan) to work on the molecular insights of phosphatases and kinases interaction using the combination of X-ray crystallography, small-angle X-ray scattering and chemical cross-linking coupled with mass spectrometry.

In 2015, he also received the Outstanding Young Postdoctoral Research Award from the Biophysics Society of Republic of China (Taiwan).

In June 2016, Dr Chen joined Associate Professor Brett Collins’ group at IMB, where he is working to understand how lipid kinases and lipid-binding proteins are involved in the regulation of cellular membrane transport.

Availability

Dr Kevin Chen is:
Available for supervision

Qualifications

  • Bachelor, Queensland University of Technology
  • Masters (Research) of Biotechnology, Queensland University of Technology
  • Doctor of Philosophy, The University of Queensland

Search Professor Kevin Chen’s works on UQ eSpace

26 works between 2009 and 2024
All (26) Journal Article (24) Conference Publication (2)

1 - 20 of 26 works

2024

Journal Article

Structural basis for coupling of the WASH subunit FAM21 with the endosomal SNX27–Retromer complex

Guo, Qian, Chen, Kai-en, Gimenez-Andres, Manuel, Jellett, Adam P., Gao, Ya, Simonetti, Boris, Liu, Meihan, Danson, Chris M., Heesom, Kate J., Cullen, Peter J. and Collins, Brett M. (2024). Structural basis for coupling of the WASH subunit FAM21 with the endosomal SNX27–Retromer complex. Proceedings of the National Academy of Sciences, 121 (33) e2405041121, e2405041121. doi: 10.1073/pnas.2405041121

Structural basis for coupling of the WASH subunit FAM21 with the endosomal SNX27–Retromer complex

2024

Journal Article

Assembly and fission of tubular carriers mediating protein sorting in endosomes

Gopaldass, Navin, Chen, Kai-En, Collins, Brett and Mayer, Andreas (2024). Assembly and fission of tubular carriers mediating protein sorting in endosomes. Nature Reviews Molecular Cell Biology, 25 (10), 1-19. doi: 10.1038/s41580-024-00746-8

Assembly and fission of tubular carriers mediating protein sorting in endosomes

2023

Conference Publication

Structural basis for coupling of the WASH subunit Fam21 with the SNX27–retromer endosomal trafficking complex

Guo, Qian, Chen, Kai-En, Simonetti, Boris, Gimenez-Andres, Manuel, Cullen, Peter J. and Collins, Brett M. (2023). Structural basis for coupling of the WASH subunit Fam21 with the SNX27–retromer endosomal trafficking complex. XXVI IUCr Congress, Melbourne, VIC Australia, 22-29 August 2023. Hoboken, NJ United States: Wiley-Blackwell. doi: 10.1107/s2053273323086837

Structural basis for coupling of the WASH subunit Fam21 with the SNX27–retromer endosomal trafficking complex

2023

Journal Article

Discovery and structural characterization of novel nanobodies targeting the Cavin1 complex essential for forming caveola membrane vesicles

Gao, Ya, Tillu, Vikas A., Wu, Yeping, Rae, James, Hall, Thomas E., Chen, Kai-En, Weeratunga, Saroja, Guo, Qian, Parton, Robert G. and Collins, Brett M. (2023). Discovery and structural characterization of novel nanobodies targeting the Cavin1 complex essential for forming caveola membrane vesicles. Acta Crystallographica. Section A: Foundations and Advances, 79 (a2), C939-C939. doi: 10.1107/s2053273323086825

Discovery and structural characterization of novel nanobodies targeting the Cavin1 complex essential for forming caveola membrane vesicles

2023

Conference Publication

Discovery and structural characterization of novel nanobodies targeting the Cavin1 complex essential for forming caveola membrane vesicles

Gao, Ya, Tillu, Vikas A., Wu, Yeping, Rae, James, Hall, Thomas E., Chen, Kai-en, Weeratunga, Saroja, Guo, Qian, Parton, Robert G. and Collins, Brett M. (2023). Discovery and structural characterization of novel nanobodies targeting the Cavin1 complex essential for forming caveola membrane vesicles. CHESTER: INT UNION CRYSTALLOGRAPHY.

Discovery and structural characterization of novel nanobodies targeting the Cavin1 complex essential for forming caveola membrane vesicles

2023

Journal Article

Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome

Healy, Michael D., McNally, Kerrie E., Butkovič, Rebeka, Chilton, Molly, Kato, Kohji, Sacharz, Joanna, McConville, Calum, Moody, Edmund R. R., Shaw, Shrestha, Planelles-Herrero, Vicente J., Yadav, Sathish K. N., Ross, Jennifer, Borucu, Ufuk, Palmer, Catherine S., Chen, Kai-En, Croll, Tristan I., Hall, Ryan J., Caruana, Nikeisha J., Ghai, Rajesh, Nguyen, Thi H. D., Heesom, Kate J., Saitoh, Shinji, Berger, Imre, Schaffitzel, Christiane, Williams, Tom A., Stroud, David A., Derivery, Emmanuel, Collins, Brett M. and Cullen, Peter J. (2023). Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome. Cell, 186 (10), 2219-2237.e29. doi: 10.1016/j.cell.2023.04.003

Structure of the endosomal Commander complex linked to Ritscher-Schinzel syndrome

2022

Journal Article

SNX27–Retromer directly binds ESCPE-1 to transfer cargo proteins during endosomal recycling

Simonetti, Boris, Guo, Qian, Giménez-Andrés, Manuel, Chen, Kai-En, Moody, Edmund R. R., Evans, Ashley J., Chandra, Mintu, Danson, Chris M., Williams, Tom A., Collins, Brett M. and Cullen, Peter J. (2022). SNX27–Retromer directly binds ESCPE-1 to transfer cargo proteins during endosomal recycling. PLoS Biology, 20 (4) e3001601, e3001601. doi: 10.1371/journal.pbio.3001601

SNX27–Retromer directly binds ESCPE-1 to transfer cargo proteins during endosomal recycling

2022

Journal Article

Towards a generic prototyping approach for therapeutically-relevant peptides and proteins in a cell-free translation system

Wu, Yue, Cui, Zhenling, Huang, Yen-Hua, de Veer, Simon J., Aralov, Andrey V., Guo, Zhong, Moradi, Shayli V., Hinton, Alexandra O., Deuis, Jennifer R., Guo, Shaodong, Chen, Kai-En, Collins, Brett M., Vetter, Irina, Herzig, Volker, Jones, Alun, Cooper, Matthew A., King, Glenn F., Craik, David J., Alexandrov, Kirill and Mureev, Sergey (2022). Towards a generic prototyping approach for therapeutically-relevant peptides and proteins in a cell-free translation system. Nature Communications, 13 (1) 260, 260. doi: 10.1038/s41467-021-27854-9

Towards a generic prototyping approach for therapeutically-relevant peptides and proteins in a cell-free translation system

2021

Journal Article

De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex

Chen, Kai-En, Guo, Qian, Hill, Timothy A., Cui, Yi, Kendall, Amy K., Yang, Zhe, Hall, Ryan J., Healy, Michael D., Sacharz, Joanna, Norwood, Suzanne J., Fonseka, Sachini, Xie, Boyang, Reid, Robert C., Leneva, Natalya, Parton, Robert G., Ghai, Rajesh, Stroud, David A., Fairlie, David P, Suga, Hiroaki, Jackson, Lauren P., Teasdale, Rohan D., Passioura, Toby and Collins, Brett M. (2021). De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex. Science Advances, 7 (49) eabg4007, eabg4007. doi: 10.1126/sciadv.abg4007

De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex

2021

Journal Article

Structural basis for the binding of the cancer targeting scorpion toxin, ClTx, to the vascular endothelia growth factor receptor neuropilin-1

Sharma, Gagan, Braga, Carolyne B., Chen, Kai-En, Jia, Xinying, Ramanujam, Venkatraman, Collins, Brett M., Rittner, Roberto and Mobli, Mehdi (2021). Structural basis for the binding of the cancer targeting scorpion toxin, ClTx, to the vascular endothelia growth factor receptor neuropilin-1. Current Research in Structural Biology, 3, 179-186. doi: 10.1016/j.crstbi.2021.07.003

Structural basis for the binding of the cancer targeting scorpion toxin, ClTx, to the vascular endothelia growth factor receptor neuropilin-1

2021

Journal Article

Community-wide experimental evaluation of the PROSS stability-design method

Peleg, Yoav, Vincentelli, Renaud, Collins, Brett M., Chen, Kai-En, Livingstone, Emma K., Weeratunga, Saroja, Leneva, Natalya, Guo, Qian, Remans, Kim, Perez, Kathryn, Bjerga, Gro E K, Larsen, Øivind, Vaněk, Ondřej, Skořepa, Ondřej, Jacquemin, Sophie, Poterszman, Arnaud, Kjær, Svend, Christodoulou, Evangelos, Albeck, Shira, Dym, Orly, Ainbinder, Elena, Unger, Tamar, Schuetz, Anja, Matthes, Susann, Bader, Michael, de Marco, Ario, Storici, Paola, Semrau, Marta S., Stolt-Bergner, Peggy ... Fleishman, Sarel J. (2021). Community-wide experimental evaluation of the PROSS stability-design method. Journal of Molecular Biology, 433 (13) 166964, 166964. doi: 10.1016/j.jmb.2021.166964

Community-wide experimental evaluation of the PROSS stability-design method

2020

Journal Article

Neuropilin-1 is a host factor for SARS-CoV-2 infection

Daly, James L., Simonetti, Boris, Klein, Katja, Chen, Kai-En, Williamson, Maia Kavanagh, Antón-Plágaro, Carlos, Shoemark, Deborah K., Simón-Gracia, Lorena, Bauer, Michael, Hollandi, Reka, Greber, Urs F., Horvath, Peter, Sessions, Richard B., Helenius, Ari, Hiscox, Julian A., Teesalu, Tambet, Matthews, David A., Davidson, Andrew D., Collins, Brett M., Cullen, Peter J. and Yamauchi, Yohei (2020). Neuropilin-1 is a host factor for SARS-CoV-2 infection. Science, 370 (6518), 861-865. doi: 10.1126/science.abd3072

Neuropilin-1 is a host factor for SARS-CoV-2 infection

2019

Journal Article

Drosophila snazarus regulates a lipid droplet population at plasma membrane-droplet contacts in adipocytes

Ugrankar, Rupali, Bowerman, Jade, Hariri, Hanaa, Chandra, Mintu, Chen, Kevin, Bossanyi, Marie-France, Datta, Sanchari, Rogers, Sean, Eckert, Kaitlyn M., Vale, Gonçalo, Victoria, Alexia, Fresquez, Joseph, McDonald, Jeffrey G., Jean, Steve, Collins, Brett M. and Henne, W. Mike (2019). Drosophila snazarus regulates a lipid droplet population at plasma membrane-droplet contacts in adipocytes. Developmental Cell, 50 (5), 557-572.e5. doi: 10.1016/j.devcel.2019.07.021

Drosophila snazarus regulates a lipid droplet population at plasma membrane-droplet contacts in adipocytes

2019

Journal Article

Towards a molecular understanding of endosomal trafficking by Retromer and Retriever

Chen, Kai‐En, Healy, Michael D. and Collins, Brett M. (2019). Towards a molecular understanding of endosomal trafficking by Retromer and Retriever. Traffic, 20 (7) tra.12649, 465-478. doi: 10.1111/tra.12649

Towards a molecular understanding of endosomal trafficking by Retromer and Retriever

2019

Journal Article

Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities

Chandra, Mintu, Chin, Yanni K.-Y., Mas, Caroline, Feathers, J. Ryan, Paul, Blessy, Datta, Sanchari, Chen, Kai-En, Jia, Xinying, Yang, Zhe, Norwood, Suzanne J., Mohanty, Biswaranjan, Bugarcic, Andrea, Teasdale, Rohan D., Henne, W. Mike, Mobli, Mehdi and Collins, Brett M. (2019). Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities. Nature Communications, 10 (1) 1528, 1528. doi: 10.1038/s41467-019-09355-y

Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities

2018

Journal Article

Molecular basis for membrane recruitment by the PX and C2 domains of Class II Phosphoinositide 3-Kinase-C2α

Chen, Kai-En, Tillu, Vikas A., Chandra, Mintu and Collins, Brett M. (2018). Molecular basis for membrane recruitment by the PX and C2 domains of Class II Phosphoinositide 3-Kinase-C2α. Structure, 26 (12), 1612-1625.e4. doi: 10.1016/j.str.2018.08.010

Molecular basis for membrane recruitment by the PX and C2 domains of Class II Phosphoinositide 3-Kinase-C2α

2018

Journal Article

Structural insights into the architecture and membrane interactions of the conserved COMMD proteins

Healy, Michael D., Hospenthal, Manuela K., Hall, Ryan J., Chandra, Mintu, Chilton, Molly, Tillu, Vikas, Chen, Kai-En, Celligoi, Dion J., McDonald, Fiona J., Cullen, Peter J., Lott, J. Shaun, Collins, Brett M. and Ghai, Rajesh (2018). Structural insights into the architecture and membrane interactions of the conserved COMMD proteins. eLife, 7 e35898. doi: 10.7554/elife.35898

Structural insights into the architecture and membrane interactions of the conserved COMMD proteins

2015

Journal Article

Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases

Chen, Kai-En, Li, Meng-Yen, Chou, Chia-Cheng, Ho, Meng-Ru, Chen, Guang-Chao, Meng, Tzu-Ching and Wang, Andrew H. -J. (2015). Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases. Structure, 23 (4), 653-664. doi: 10.1016/j.str.2015.01.017

Substrate specificity and plasticity of FERM-containing protein tyrosine phosphatases

2014

Journal Article

Reciprocal allosteric regulation of p38γ and PTPN3 involves a PDZ domain-modulated complex formation

Chen, Kai-En, Lin, Shu-Yu, Wu, Mei-Ju, Ho, Meng-Ru, Santhanam, Abirami, Chou, Chia-Cheng, Meng, Tzu-Ching and Wang, Andrew H. -J. (2014). Reciprocal allosteric regulation of p38γ and PTPN3 involves a PDZ domain-modulated complex formation. Science Signaling, 7 (347), ra98-ra98. doi: 10.1126/scisignal.2005722

Reciprocal allosteric regulation of p38γ and PTPN3 involves a PDZ domain-modulated complex formation

2014

Journal Article

Science signaling podcast: 14 October 2014

Meng, Tzu-Ching, Chen, Kai-En, Wang, Andrew H.-J. and Van Hook, Annalisa M. (2014). Science signaling podcast: 14 October 2014. Science Signaling, 7 (347), pc28-pc28. doi: 10.1126/scisignal.2005939

Science signaling podcast: 14 October 2014

Past funding

  • 2018 - 2019
    Stabilising the retromer protein complex with molecular chaperones for Alzheimer's and Parkinson's diseases
    Dementia Australia Research Foundation
    Open grant

Availability

Dr Kevin Chen is:
Available for supervision

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Supervision history

Current supervision

  • Doctor Philosophy

    Studying the role of the Retromer trafficking complex as a hub for regulating Rab GTPases at the endosome.

    Associate Advisor

    Other advisors: Professor Brett Collins

Completed supervision

Enquiries

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communications@uq.edu.au