Overview
Background
Dr Jan Lauko is a graduate of the Comenius University in Bratislava with a Masters Degree in Organic chemistry. In 2007 he started a PhD in the group of Prof Alan Rowan in Nijmegen, the Netherlands where he was focusing on the design of extended-conjugation supramolecular graphene constructs using click chemistry and macrocyclic sensor probes for mechanistic studies of epoxidation reactions. In 2012 he joined a Dutch start-up company NovioSense BV as CTO where he developed the coating and sensor elements as well as the integration of electronics and medical device design for the NovioSense sensor platform. At the end of 2016 he joined the newly formed group of Prof. Rowan at the Australian Institute for Bioengineering and Nanotechnology as a research fellow and group manager. Currently, he is focused on the study of synthetic biomimetic extracellular matrices, for use in cell growth and wound healing.
Availability
- Dr Jan Lauko is:
- Available for supervision
Qualifications
- Doctor of Philosophy, Radboud Universiteit Nijmegen
Research impacts
In his previous appointment, Jan was developing electrochemical sensors, where specific enzymes embedded in polysaccharide coatings were able to detect trace amounts of analyte such as glucose or lactate and translate these into electrochemical signal. These were then utilised as the core technology of a non-invasive glucose sensor, in direct collaboration with industrial and clinical partners. At this moment this technology is in the clinical stage of development. Within AIBN, Jan is studying synthetic biomimetic extracellular matrices, for use in cell growth and wound healing. To enable the study of the influence of external forces on cellular development, Jan has designed, procured and constructed the so-called confocal-rheometer. This state-of-the-art equipment enables to directly visualise the processes in and responses of a material when external shear is applied.
Works
Search Professor Jan Lauko’s works on UQ eSpace
2025
Journal Article
Tuning collagen nonlinear mechanics with interpenetrating networks drives adaptive cellular phenotypes in three dimensions
Enriquez Martinez, Marco A., Wang, Zhao, Alvarez, Yanina D., O’Neill, Jade E., Ju, Robert J., Turunen, Petri, White, Melanie D., Mata, Jitendra, Gilbert, Elliot P., Lauko, Jan, Rowan, Alan E. and Stehbens, Samantha J. (2025). Tuning collagen nonlinear mechanics with interpenetrating networks drives adaptive cellular phenotypes in three dimensions. Science Advances, 11 (25) eadt3352, eadt3352. doi: 10.1126/sciadv.adt3352
2024
Journal Article
Sensitive label free imaging of 3D cell models with minimal toxicity using confocal reflectance
Taylor, Michael A., Choi, Jung Un Ally, Muthuswamy, Shiva, Martinez, Marco A. Enriquez, Lauko, Jan, Kijas, Amanda W. and Rowan, Alan E. (2024). Sensitive label free imaging of 3D cell models with minimal toxicity using confocal reflectance. Biomaterials Science, 12 (22), 5722-5727. doi: 10.1039/d4bm00304g
2024
Journal Article
Controlling ligand density and viscoelasticity in synthetic biomimetic polyisocyanide hydrogels for studying cell behaviours: the key to truly biomimetic hydrogels
Westra van Holthe, Nicholas J., Wang, Zhao, Lauko, Jan, Gilbert, Elliot P., Gangasandra, Vishaak and Rowan, Alan E. (2024). Controlling ligand density and viscoelasticity in synthetic biomimetic polyisocyanide hydrogels for studying cell behaviours: the key to truly biomimetic hydrogels. Materials Advances, 5 (23), 9458-9470. doi: 10.1039/d4ma00793j
2024
Journal Article
The potential of sugarcane waste-derived cellulose fibres as haemostatic agents
Malone, Siobhan, Yegappan, Ramanathan, Kijas, Amanda, Gemmell, Anna, Rowan, Alan, Rajah, Divya, Kim, Minjun, Lauko, Jan and Amiralian, Nasim (2024). The potential of sugarcane waste-derived cellulose fibres as haemostatic agents. Polymers, 16 (12) 1654, 1654. doi: 10.3390/polym16121654
2024
Journal Article
Hyaluronic acid turnover controls the severity of cerebral cavernous malformations in bioengineered human micro-vessels
Yordanov, Teodor E., Keyser, Mikaela S., Enriquez Martinez, Marco A., Esposito, Tyron, Tefft, Juliann B., Morris, Elysse K., Labzin, Larisa I., Stehbens, Samantha J., Rowan, Alan E., Hogan, Benjamin M., Chen, Christopher S., Lauko, Jan and Lagendijk, Anne K. (2024). Hyaluronic acid turnover controls the severity of cerebral cavernous malformations in bioengineered human micro-vessels. APL Bioengineering, 8 (1) 016108, 016108. doi: 10.1063/5.0159330
2024
Other Outputs
Data: confocal reflectance imaging as a highly sensitive imaging modality for 3D cell culture
Taylor, Michael, Lauko, Jan, Choi, Jung, Rowan, Alan, Kijas, Amanda, Enriquez Martinez, Marco, Wang, Zhao and Muthuswamy, Shiva (2024). Data: confocal reflectance imaging as a highly sensitive imaging modality for 3D cell culture. The University of Queensland. (Dataset) doi: 10.48610/7f3ae88
2023
Journal Article
Alteration of the cellulose nanocrystal surface chemistry for guided formation of polymer brushes
Geurds, Lauren, Kępa, Katarzyna, Lauko, Jan, Rowan, Alan E. and Amiralian, Nasim (2023). Alteration of the cellulose nanocrystal surface chemistry for guided formation of polymer brushes. Polymer Chemistry, 14 (18), 2164-2173. doi: 10.1039/d3py00043e
2023
Journal Article
Snake venom-defined fibrin architecture dictates fibroblast survival and differentiation
Wang, Zhao, Lauko, Jan, Kijas, Amanda W., Gilbert, Elliot P., Turunen, Petri, Yegappan, Ramanathan, Zou, Dongxiu, Mata, Jitendra and Rowan, Alan E. (2023). Snake venom-defined fibrin architecture dictates fibroblast survival and differentiation. Nature Communications, 14 (1) 1029, 1-16. doi: 10.1038/s41467-023-36437-9
2022
Journal Article
Snake venom hydrogels as a rapid hemostatic agent for uncontrolled bleeding
Yegappan, Ramanathan, Lauko, Jan, Wang, Zhao, Lavin, Martin F., Kijas, Amanda W. and Rowan, Alan E. (2022). Snake venom hydrogels as a rapid hemostatic agent for uncontrolled bleeding. Advanced Healthcare Materials, 11 (15) 2200574, 2200574. doi: 10.1002/adhm.202200574
2022
Journal Article
The Mechanosensory Role of Osteocytes and Implications for Bone Health and Disease States
Choi, Jung Un Ally, Kijas, Amanda W., Lauko, Jan and Rowan, Alan E. (2022). The Mechanosensory Role of Osteocytes and Implications for Bone Health and Disease States. Frontiers in Cell and Developmental Biology, 9 770143, 770143. doi: 10.3389/fcell.2021.770143
2022
Conference Publication
Guided formation of nanoparticles and polymer brushes on nanocellulose
Amiralian, Nasim, Geurds, Lauren, Lauko, Jan and Rowan, Alan (2022). Guided formation of nanoparticles and polymer brushes on nanocellulose. International Conference on Materials Science and Engineering, Gold Coast, QLD, Australia, 5-8 December 2022.
2021
Journal Article
Heterodyne Brillouin microscopy for biomechanical imaging
Taylor, Michael A., Kijas, Amanda W., Wang, Zhao, Lauko, Jan and Rowan, Alan E. (2021). Heterodyne Brillouin microscopy for biomechanical imaging. Biomedical Optics Express, 12 (10) 6259, 6259-6268. doi: 10.1364/boe.435869
2021
Journal Article
Tailored nanocellulose-grafted polymer brush applications
Geurds, Lauren, Lauko, Jan, Rowan, Alan E. and Amiralian, Nasim (2021). Tailored nanocellulose-grafted polymer brush applications. Journal of Materials Chemistry A, 9 (32), 17173-17188. doi: 10.1039/d1ta03264j
2020
Journal Article
Modeling the impact of microgravity at the cellular level: implications for human disease
Bradbury, Peta, Wu, Hanjie, Choi, Jung Un, Rowan, Alan E., Zhang, Hongyu, Poole, Kate, Lauko, Jan and Chou, Joshua (2020). Modeling the impact of microgravity at the cellular level: implications for human disease. Frontiers in Cell and Developmental Biology, 8 96, 96. doi: 10.3389/fcell.2020.00096
2020
Journal Article
Structural insights into the mechanism of heat-set gel formation of polyisocyanopeptide polymers
Gavrilov, Mikhail, Gilbert, Elliot P., Rowan, Alan E., Lauko, Jan and Yakubov, Gleb E. (2020). Structural insights into the mechanism of heat-set gel formation of polyisocyanopeptide polymers. Macromolecular Rapid Communications, 41 (18) 2000304, 2000304. doi: 10.1002/marc.202000304
2018
Journal Article
Tunable properties based on regioselectivity of 1,2,3-triazole units in axially chiral 2,2′-linked 1,1′-binaphthyl-based copolymers for ions and acid responsiveness
Lauko, Ján, Kouwer, Paul H. J., Kasak, Peter and Rowan, Alan E. (2018). Tunable properties based on regioselectivity of 1,2,3-triazole units in axially chiral 2,2′-linked 1,1′-binaphthyl-based copolymers for ions and acid responsiveness. European Polymer Journal, 108, 191-198. doi: 10.1016/j.eurpolymj.2018.08.030
2018
Journal Article
Clinical evidence for use of a non-invasive biosensor for tear glucose as an alternative to painful finger-prick for diabetes management utilizing biopolymer coating
Kownacka, Alicja E., Vegelyte, Dovile, Joosse, Maurits, Anton, Nicoleta, Toebes, B. Jelle, Lauko, Jan, Buzzacchera, Irene, Lipinska, Katarzyna, Wilson, Daniela A., Geelhoed-Duijvestijn, Nel and Wilson, Christopher James (2018). Clinical evidence for use of a non-invasive biosensor for tear glucose as an alternative to painful finger-prick for diabetes management utilizing biopolymer coating. Biomacromolecules, 19 (11) acs.biomac.8b01429, 4504-4511. doi: 10.1021/acs.biomac.8b01429
2016
Journal Article
1H-1,2,3-triazole: from structure to function and catalysis
Lauko, Jan , Kouwer, Paul H. J. and Rowan, Alan E. (2016). 1H-1,2,3-triazole: from structure to function and catalysis. Journal of Heterocyclic Chemistry, 54 (3), 1677-1699. doi: 10.1002/jhet.2770
2016
Journal Article
Sensor devices inspired by the five senses: a review
Svechtarova, Mila I., Buzzacchera, Irene, Toebes, B. Jelle, Lauko, Jan, Anton, Nicoleta and Wilson, Christopher J. (2016). Sensor devices inspired by the five senses: a review. Electroanalysis, 28 (6), 1201-1241. doi: 10.1002/elan.201600047
2015
Conference Publication
Telemetry System for non-invasive measurement of glucose in tear fluid Telemetriesystem zur nicht-invasiven Glukosemessung in der Tränenflüssigkeit
Fischer, Roland, Hennig, Andreas, Lauko, Jan, Wilson, Christopher, Goertz, Michael and Mokwa, Wilfried (2015). Telemetry System for non-invasive measurement of glucose in tear fluid Telemetriesystem zur nicht-invasiven Glukosemessung in der Tränenflüssigkeit. VDE Verlag GmbH.
Funding
Past funding
Supervision
Availability
- Dr Jan Lauko is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Differential regulation of osteocyte behaviour and function by integrin mediated biophysical cues
Associate Advisor
Other advisors: Dr Amanda Kijas, Professor Alan Rowan
Completed supervision
-
2025
Doctor Philosophy
Study of cellular responses for mechanical unloading under microgravity in a 3D cell culture system
Associate Advisor
Other advisors: Dr Nicholas Westra Van Holthe, Professor Alan Rowan
-
2025
Doctor Philosophy
Modelling biological response to simulated microgravity
Associate Advisor
Other advisors: Dr Mel White, Professor Alan Rowan
-
2024
Doctor Philosophy
Controlling hybrid systems
Associate Advisor
Other advisors: Associate Professor Samantha Stehbens, Professor Alan Rowan
-
2023
Doctor Philosophy
Understanding the science and application of snake venom proteins in wound management
Associate Advisor
Other advisors: Dr Amanda Kijas, Professor Alan Rowan
-
2023
Doctor Philosophy
Snake venom-controlled fibrin networks for wound healing studies
Associate Advisor
Other advisors: Dr Amanda Kijas, Professor Alan Rowan
-
2022
Doctor Philosophy
Control of osteocyte behaviour by tailoring extracellular matrix
Associate Advisor
Other advisors: Dr Amanda Kijas, Professor Alan Rowan
Media
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