Overview
Availability
- Dr Liyu Chen is:
- Available for supervision
Qualifications
- Doctor of Philosophy, The University of Queensland
Works
Search Professor Liyu Chen’s works on UQ eSpace
2025
Journal Article
Lipid nanoparticles and transcranial focused ultrasound enhance the delivery of SOD1 antisense oligonucleotides to the murine brain for ALS therapy
Ediriweera, Gayathri R., Sivaram, Amal J., Cowin, Gary, Brown, Mikayla L., McAlary, Luke, Lum, Jeremy S., Fletcher, Nicholas L., Robinson, Liam, Simpson, Joshua D., Chen, Liyu, Wasielewska, Joanna M., Byrne, Ella, Finnie, John W., Manavis, Jim, White, Anthony R., Yerbury, Justin J., Thurecht, Kristofer J. and Vine, Kara L. (2025). Lipid nanoparticles and transcranial focused ultrasound enhance the delivery of SOD1 antisense oligonucleotides to the murine brain for ALS therapy. Journal of Controlled Release, 378, 221-235. doi: 10.1016/j.jconrel.2024.11.074
2024
Journal Article
Multimodal evaluation of blood-brain barrier opening in mice in response to low-intensity ultrasound and a claudin-5 binder
Chen, Liyu, Song, Jae, Richter-Stretton, Gina, Lee, Wendy, Padmanabhan, Pranesh and Götz, Jürgen (2024). Multimodal evaluation of blood-brain barrier opening in mice in response to low-intensity ultrasound and a claudin-5 binder. Nanotheranostics, 8 (4), 427-441. doi: 10.7150/ntno.95146
2022
Journal Article
Opportunities and challenges in delivering biologics for Alzheimer's disease by low-intensity ultrasound
Chen, Liyu, Cruz, Esteban, Oikari, Lotta E., Padmanabhan, Pranesh, Song, Jae and Götz, Jürgen (2022). Opportunities and challenges in delivering biologics for Alzheimer's disease by low-intensity ultrasound. Advanced Drug Delivery Reviews, 189 114517, 1-18. doi: 10.1016/j.addr.2022.114517
2022
Journal Article
Claudin-5 binder enhances focused ultrasound-mediated opening in an in vitro blood-brain barrier model
Chen, Liyu, Sutharsan, Ratneswary, Lee, Jonathan L. F., Cruz, Esteban, Asnicar, Blaise, Palliyaguru, Tishila, Wasielewska, Joanna M., Gaudin, Arnaud, Song, Jae, Leinenga, Gerhard and Götz, Jürgen (2022). Claudin-5 binder enhances focused ultrasound-mediated opening in an in vitro blood-brain barrier model. Theranostics, 12 (5), 1952-1970. doi: 10.7150/thno.65539
2022
Journal Article
A sporadic Alzheimer’s blood-brain barrier model for developing ultrasound-mediated delivery of Aducanumab and anti-Tau antibodies
Wasielewska, Joanna M., Chaves, Juliana C.S., Johnston, Rebecca L., Milton, Laura A., Hernández, Damián, Chen, Liyu, Song, Jae, Lee, Wendy, Leinenga, Gerhard, Nisbet, Rebecca M., Pébay, Alice, Götz, Jürgen, White, Anthony R. and Oikari, Lotta E. (2022). A sporadic Alzheimer’s blood-brain barrier model for developing ultrasound-mediated delivery of Aducanumab and anti-Tau antibodies. Theranostics, 12 (16), 6826-6847. doi: 10.7150/thno.72685
2021
Journal Article
Non-viral vector-mediated gene therapy for ALS: challenges and future perspectives
Ediriweera, Gayathri R., Chen, Liyu, Yerbury, Justin J., Thurecht, Kristofer J. and Vine, Kara L. (2021). Non-viral vector-mediated gene therapy for ALS: challenges and future perspectives. Molecular Pharmaceutics, 18 (6), 2142-2160. doi: 10.1021/acs.molpharmaceut.1c00297
2019
Journal Article
The blood-brain barrier: physiology and strategies for drug delivery
Pandit, Rucha, Chen, Liyu and Götz, Jürgen (2019). The blood-brain barrier: physiology and strategies for drug delivery. Advanced Drug Delivery Reviews, 165-166, 1-14. doi: 10.1016/j.addr.2019.11.009
2018
Journal Article
Influence of Charge on Hemocompatibility and Immunoreactivity of Polymeric Nanoparticles
Chen, Liyu, Glass, Joshua J., De Rose, Robert, Sperling, Claudia, Kent, Stephen J., Houston, Zachary H., Fletcher, Nicholas L., Rolfe, Barbara E. and Thurecht, Kristofer J. (2018). Influence of Charge on Hemocompatibility and Immunoreactivity of Polymeric Nanoparticles. ACS Applied Bio Materials, 1 (3) acsabm.8b00220, 756-767. doi: 10.1021/acsabm.8b00220
2017
Journal Article
Effects of Surface Charge of Hyperbranched Polymers on Cytotoxicity, Dynamic Cellular Uptake and Localization, Hemotoxicity, and Pharmacokinetics in Mice
Chen, Liyu, Simpson, Joshua D, Fuchs, Adrian V, Rolfe, Barbara E and Thurecht, Kristofer J (2017). Effects of Surface Charge of Hyperbranched Polymers on Cytotoxicity, Dynamic Cellular Uptake and Localization, Hemotoxicity, and Pharmacokinetics in Mice. Molecular pharmaceutics, 14 (12), 4485-4497. doi: 10.1021/acs.molpharmaceut.7b00611
2017
Journal Article
Using peptide aptamer targeted polymers as a model nanomedicine for investigating drug distribution in cancer nanotheranostics
Zhao, Yongmei, Houston, Zachary H., Simpson, Joshua D., Chen, Liyu, Fletcher, Nicholas L., Fuchs, Adrian V., Blakey, Idriss and Thurecht, Kristofer J. (2017). Using peptide aptamer targeted polymers as a model nanomedicine for investigating drug distribution in cancer nanotheranostics. Molecular Pharmaceutics, 14 (10), 3539-3549. doi: 10.1021/acs.molpharmaceut.7b00560
2017
Journal Article
Improving the delivery of SOD1 antisense oligonucleotides to motor neurons using calcium phosphate-lipid nanoparticle
Chen, Liyu, Watson, Clare, Morsch, Marco, Cole, Nicholas J., Chung, Roger S., Saunders, Darren N., Yerbury, Justin J. and Vine, Kara L. (2017). Improving the delivery of SOD1 antisense oligonucleotides to motor neurons using calcium phosphate-lipid nanoparticle. Frontiers in Neuroscience, 11 (AUG) 476, 476. doi: 10.3389/fnins.2017.00476
2017
Journal Article
Charge has a marked influence on hyperbranched polymer nanoparticle association in whole human blood
Glass, Joshua J., Chen, Liyu, Alcantara, Sheilajen, Crampin, Edmund J., Thurecht, Kristofer J., De Rose, Robert and Kent, Stephen J. (2017). Charge has a marked influence on hyperbranched polymer nanoparticle association in whole human blood. ACS Macro Letters, 6 (6), 586-592. doi: 10.1021/acsmacrolett.7b00229
2016
Other Outputs
Physiological response to polymeric materials in nanomedicine
Chen, Liyu (2016). Physiological response to polymeric materials in nanomedicine. PhD Thesis, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland. doi: 10.14264/uql.2016.994
2013
Journal Article
Vesicular phospholipid gels using low concentrations of phospholipids for the sustained release of thymopentin: Pharmacokinetics and pharmacodynamics
Zhong, Ying, Chen, Liyu, Zhang, Yu, Li, Wenhao, Sun, Xun, Gong, Tao and Zhang, Zhirong (2013). Vesicular phospholipid gels using low concentrations of phospholipids for the sustained release of thymopentin: Pharmacokinetics and pharmacodynamics. Pharmazie, 68 (10), 811-815. doi: 10.1691/ph.2013.3008
2012
Journal Article
Novel brain targeting prodrugs of naproxen based on dimethylamino group with various linkages
Zhang, Q., Liang, Z., Chen, L. Y., Sun, X., Gong, T. and Zhang, Z. R. (2012). Novel brain targeting prodrugs of naproxen based on dimethylamino group with various linkages. Arzneimittel-Forschung/Drug Research, 62 (6), 261-266. doi: 10.1055/s-0032-1306273
Supervision
Availability
- Dr Liyu Chen is:
- Available for supervision
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