Skip to menu Skip to content Skip to footer
Dr

Esteban Cruz Gonzalez

Email: 

Overview

Availability

Dr Esteban Cruz Gonzalez is:
Available for supervision

Qualifications

  • Doctor of Philosophy, University of Sydney

Works

Search Professor Esteban Cruz Gonzalez’s works on UQ eSpace

19 works between 2017 and 2024

1 - 19 of 19 works

2024

Journal Article

Proteostasis as a fundamental principle of Tau immunotherapy

Cruz, Esteban, Nisbet, Rebecca M, Padmanabhan, Pranesh, van Waardenberg, Ashley J, Graham, Mark E, Nkajja, Godfrey, Tapaswi, Swara, Connor, Bradley J, Robinson, Phil and Götz, Jürgen (2024). Proteostasis as a fundamental principle of Tau immunotherapy. Brain, 148 (1), 168-184. doi: 10.1093/brain/awae254

Proteostasis as a fundamental principle of Tau immunotherapy

2024

Journal Article

Single-molecule imaging of Tau reveals how phosphorylation affects its movement and confinement in living cells

Padmanabhan, Pranesh, Kneynsberg, Andrew, Cruz, Esteban, Briner, Adam and Götz, Jürgen (2024). Single-molecule imaging of Tau reveals how phosphorylation affects its movement and confinement in living cells. Molecular Brain, 17 (1) 7, 7. doi: 10.1186/s13041-024-01078-6

Single-molecule imaging of Tau reveals how phosphorylation affects its movement and confinement in living cells

2023

Journal Article

Break and accelerator—The mechanics of Tau (and amyloid) toxicity

Cruz, Esteban, Nisbet, Rebecca M. and Götz, Jürgen (2023). Break and accelerator—The mechanics of Tau (and amyloid) toxicity. Cytoskeleton, 81 (1), 24-29. doi: 10.1002/cm.21781

Break and accelerator—The mechanics of Tau (and amyloid) toxicity

2022

Journal Article

Opportunities and challenges in delivering biologics for Alzheimer's disease by low-intensity ultrasound

Chen, Liyu, Cruz, Esteban, Oikari, Lotta E., Padmanabhan, Pranesh, Song, Jae and Götz, Jürgen (2022). Opportunities and challenges in delivering biologics for Alzheimer's disease by low-intensity ultrasound. Advanced Drug Delivery Reviews, 189 114517, 1-18. doi: 10.1016/j.addr.2022.114517

Opportunities and challenges in delivering biologics for Alzheimer's disease by low-intensity ultrasound

2022

Journal Article

Ultrasound-mediated delivery of novel tau-specific monoclonal antibody enhances brain uptake but not therapeutic efficacy

Bajracharya, Rinie, Cruz, Esteban, Götz, Jürgen and Nisbet, Rebecca M. (2022). Ultrasound-mediated delivery of novel tau-specific monoclonal antibody enhances brain uptake but not therapeutic efficacy. Journal of Controlled Release, 349, 634-648. doi: 10.1016/j.jconrel.2022.07.026

Ultrasound-mediated delivery of novel tau-specific monoclonal antibody enhances brain uptake but not therapeutic efficacy

2022

Journal Article

Single‐molecule imaging reveals Tau trapping at nanometer‐sized dynamic hot spots near the plasma membrane that persists after microtubule perturbation and cholesterol depletion

Padmanabhan, Pranesh, Kneynsberg, Andrew, Cruz, Esteban, Amor, Rumelo, Sibarita, Jean‐Baptiste and Götz, Jürgen (2022). Single‐molecule imaging reveals Tau trapping at nanometer‐sized dynamic hot spots near the plasma membrane that persists after microtubule perturbation and cholesterol depletion. The EMBO Journal, 41 (19) e111265, 1-16. doi: 10.15252/embj.2022111265

Single‐molecule imaging reveals Tau trapping at nanometer‐sized dynamic hot spots near the plasma membrane that persists after microtubule perturbation and cholesterol depletion

2022

Journal Article

Claudin-5 binder enhances focused ultrasound-mediated opening in an in vitro blood-brain barrier model

Chen, Liyu, Sutharsan, Ratneswary, Lee, Jonathan LF, Cruz, Esteban, Asnicar, Blaise, Palliyaguru, Tishila, Wasielewska, Joanna M, Gaudin, Arnaud, Song, Jae, Leinenga, Gerhard and Götz, Jürgen (2022). Claudin-5 binder enhances focused ultrasound-mediated opening in an in vitro blood-brain barrier model. Theranostics, 12 (5), 1952-1970. doi: 10.7150/thno.65539

Claudin-5 binder enhances focused ultrasound-mediated opening in an in vitro blood-brain barrier model

2021

Journal Article

Glycan profile analysis of engineered trastuzumab with rationally added glycosylation sequons presents significantly increased glycan complexity

Cruz, Esteban, Sifniotis, Vicki, Sumer-Bayraktar, Zeynep, Reslan, Mouhamad, Wilkinson-White, Lorna, Cordwell, Stuart and Kayser, Veysel (2021). Glycan profile analysis of engineered trastuzumab with rationally added glycosylation sequons presents significantly increased glycan complexity. Pharmaceutics, 13 (11) 1747, 1747. doi: 10.3390/pharmaceutics13111747

Glycan profile analysis of engineered trastuzumab with rationally added glycosylation sequons presents significantly increased glycan complexity

2021

Journal Article

Therapeutic ultrasound as a treatment modality for physiological and pathological ageing including Alzheimer’s disease

Götz, Jürgen, Richter-Stretton, Gina and Cruz, Esteban (2021). Therapeutic ultrasound as a treatment modality for physiological and pathological ageing including Alzheimer’s disease. Pharmaceutics, 13 (7) 1002, 1002. doi: 10.3390/pharmaceutics13071002

Therapeutic ultrasound as a treatment modality for physiological and pathological ageing including Alzheimer’s disease

2021

Book Chapter

Drug targets for biologics

Lai, Felcia, Hawkins, Bryson A., Cruz, Esteban, Hanrahan, Jane R., Groundwater, Paul W. and Hibbs, David E. (2021). Drug targets for biologics. Biologics, biosimilars, and biobetters: an introduction for pharmacists, physicians, and other health practitioners. (pp. 195-212) edited by Iqbal Ramzan. Hoboken, NJ United States: Wiley. doi: 10.1002/9781119564690.ch5

Drug targets for biologics

2020

Journal Article

Enhancing the stability of adalimumab by engineering additional glycosylation motifs

Reslan, Mouhamad, Sifniotis, Vicki, Cruz, Esteban, Sumer-Bayraktar, Zeynep, Cordwell, Stuart and Kayser, Veysel (2020). Enhancing the stability of adalimumab by engineering additional glycosylation motifs. International Journal of Biological Macromolecules, 158, 189-196. doi: 10.1016/j.ijbiomac.2020.04.147

Enhancing the stability of adalimumab by engineering additional glycosylation motifs

2019

Journal Article

Structural biology workflow for the expression and characterization of functional human sodium glucose transporter type 1 in Pichia pastoris

Suades, Albert, Alcaraz, Antonio, Cruz, Esteban, Álvarez-Marimon, Elena, Whitelegge, Julian P., Manyosa, Joan, Cladera, Josep and Perálvarez-Marín, Alex (2019). Structural biology workflow for the expression and characterization of functional human sodium glucose transporter type 1 in Pichia pastoris. Scientific Reports, 9 (1) 1203. doi: 10.1038/s41598-018-37445-2

Structural biology workflow for the expression and characterization of functional human sodium glucose transporter type 1 in Pichia pastoris

2019

Journal Article

Current advancements in addressing key challenges of therapeutic antibody design, manufacture, and formulation

Sifniotis, Vicki, Cruz, Esteban, Eroglu, Barbaros and Kayser, Veysel (2019). Current advancements in addressing key challenges of therapeutic antibody design, manufacture, and formulation. Antibodies, 8 (2) 36, 36. doi: 10.3390/antib8020036

Current advancements in addressing key challenges of therapeutic antibody design, manufacture, and formulation

2019

Journal Article

Synthesis and enhanced cellular uptake in vitro of anti-HER2 multifunctional gold nanoparticles

Cruz, Esteban and Kayser, Veysel (2019). Synthesis and enhanced cellular uptake in vitro of anti-HER2 multifunctional gold nanoparticles. Cancers, 11 (6) 870, 870. doi: 10.3390/cancers11060870

Synthesis and enhanced cellular uptake in vitro of anti-HER2 multifunctional gold nanoparticles

2019

Journal Article

Monoclonal antibody therapy of solid tumors: clinical limitations and novel strategies to enhance treatment efficacy

Cruz, Esteban and Kayser, Veysel (2019). Monoclonal antibody therapy of solid tumors: clinical limitations and novel strategies to enhance treatment efficacy. Biologics: Targets and Therapy, 13, 33-51. doi: 10.2147/BTT.S166310

Monoclonal antibody therapy of solid tumors: clinical limitations and novel strategies to enhance treatment efficacy

2018

Journal Article

Demonstration of in vitro host-guest complex formation and safety of para-sulfonatocalix[8]arene as a delivery vehicle for two antibiotic drugs

Moussa, Yvonne E., Ong, Yu Qing Elysia, Perry, John D., Cheng, Zhengqi, Kayser, Veysel, Cruz, Esteban, Kim, Ryung Rae, Sciortino, Natasha and Wheate, Nial J. (2018). Demonstration of in vitro host-guest complex formation and safety of para-sulfonatocalix[8]arene as a delivery vehicle for two antibiotic drugs. Journal of Pharmaceutical Sciences, 107 (12), 3105-3111. doi: 10.1016/j.xphs.2018.08.016

Demonstration of in vitro host-guest complex formation and safety of para-sulfonatocalix[8]arene as a delivery vehicle for two antibiotic drugs

2018

Journal Article

Site-specific glycosylation profile of influenza A (H1N1) hemagglutinin through tandem mass spectrometry

Cruz, Esteban, Cain, Joel, Crossett, Ben and Kayser, Veysel (2018). Site-specific glycosylation profile of influenza A (H1N1) hemagglutinin through tandem mass spectrometry. Human Vaccines and Immunotherapeutics, 14 (3), 508-517. doi: 10.1080/21645515.2017.1377871

Site-specific glycosylation profile of influenza A (H1N1) hemagglutinin through tandem mass spectrometry

2017

Journal Article

The state-of-play and future of antibody therapeutics

Elgundi, Zehra, Reslan, Mouhamad, Cruz, Esteban, Sifniotis, Vicki and Kayser, Veysel (2017). The state-of-play and future of antibody therapeutics. Advanced Drug Delivery Reviews, 122, 2-19. doi: 10.1016/j.addr.2016.11.004

The state-of-play and future of antibody therapeutics

2017

Journal Article

Laboratory scale production and purification of a therapeutic antibody

Elgundi, Zehra, Sifniotis, Vicki, Reslan, Mouhamad, Cruz, Esteban and Kayser, Veysel (2017). Laboratory scale production and purification of a therapeutic antibody. Journal of Visualized Experiments, 2017 (119) e55153. doi: 10.3791/55153

Laboratory scale production and purification of a therapeutic antibody

Funding

Current funding

  • 2023 - 2025
    Facilitating focused ultrasound-mediated tau clearance in Alzheimer's disease and other tauopathies by understanding the underlying autophagic mechanisms (AUTOFUS)
    Boosting Dementia Research Grants (PR4): European Union Joint Program on Neurodegenerative Disease Research (JPND) Call for Multinational Projects
    Open grant
  • 2023 - 2025
    Facilitating focused ultrasound-mediated tau clearance in Alzheimer's disease and other taupathies by understanding the underlying autophagic mechanisms - AUTOFUS (EU-JPND grant)
    Boosting Dementia Research Grants (PR4): European Union Joint Program on Neurodegenerative Disease Research (JPND) Call for Multinational Projects
    Open grant

Supervision

Availability

Dr Esteban Cruz Gonzalez is:
Available for supervision

Before you email them, read our advice on how to contact a supervisor.

Supervision history

Current supervision

  • Doctor Philosophy

    Dissecting the molecular mechanisms of autophagy induction in neurons following application of focused ultrasound.

    Associate Advisor

    Other advisors: Professor Jurgen Götz

  • Doctor Philosophy

    Feasibility study of using low-intensity focused ultrasound as a novel modality for the delivery of genetic material such as expression vectors and gene editing reagents to the mouse brain

    Associate Advisor

    Other advisors: Professor Jurgen Götz

  • Doctor Philosophy

    Pathomechanistic and therapeutic studies in Alzheimer disease with a focus on the role of the blood-brain barrier

    Associate Advisor

    Other advisors: Professor Jurgen Götz

Media

Enquiries

For media enquiries about Dr Esteban Cruz Gonzalez's areas of expertise, story ideas and help finding experts, contact our Media team:

communications@uq.edu.au