Overview
Availability
- Dr Rachel Gormal is:
- Available for supervision
Qualifications
- Doctor of Philosophy, Griffith University
Research interests
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Super-resolution Microscopy Techniques and Analysis
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The applicaton of nanobodies in cell biology
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Structural Biology and in silico modelling
Works
Search Professor Rachel Gormal’s works on UQ eSpace
2020
Journal Article
Modular transient nanoclustering of activated β2-adrenergic receptors revealed by single-molecule tracking of conformation-specific nanobodies
Gormal, Rachel S., Padmanabhan, Pranesh, Kasula, Ravikiran, Bademosi, Adekunle T., Coakley, Sean, Giacomotto, Jean, Blum, Ailisa, Joensuu, Merja, Wallis, Tristan P., Lo, Harriet P., Budnar, Srikanth, Rae, James, Ferguson, Charles, Bastiani, Michele, Thomas, Walter G., Pardon, Els, Steyaert, Jan, Yap, Alpha S., Goodhill, Geoffrey J., Hilliard, Massimo A., Parton, Robert G. and Meunier, Frédéric A. (2020). Modular transient nanoclustering of activated β2-adrenergic receptors revealed by single-molecule tracking of conformation-specific nanobodies. Proceedings of the National Academy of Sciences of the United States of America, 117 (48), 30476-30487. doi: 10.1073/pnas.2007443117
2020
Other Outputs
Super resolving Fyn at the nanoscale
Gormal, Rachel (2020). Super resolving Fyn at the nanoscale. The University of Queensland. (Dataset) doi: 10.48610/29ab270
2020
Other Outputs
The role of Munc18-1 mutations in early infantile epiletic encephalopathy (EIEE)
Gormal, Rachel (2020). The role of Munc18-1 mutations in early infantile epiletic encephalopathy (EIEE). The University of Queensland. (Dataset) doi: 10.48610/26604da
2020
Other Outputs
Raw Super-resolution Microscopy acquisition files.
Gormal, Rachel (2020). Raw Super-resolution Microscopy acquisition files.. The University of Queensland. (Dataset) doi: 10.14264/03a862c
2019
Journal Article
p110δ PI 3-kinase inhibition perturbs APP and TNFα trafficking, reduces plaque burden, dampens neuroinflammation and prevents cognitive decline in an Alzheimer's disease mouse model
Martínez-Mármol, Ramón, Mohannak, Nika, Qian, Lei, Wang, Tong, Gormal, Rachel S, Ruitenberg, Marc J, Vanhaesebroeck, Bart, Coulson, Elizabeth J and Meunier, Frédéric A (2019). p110δ PI 3-kinase inhibition perturbs APP and TNFα trafficking, reduces plaque burden, dampens neuroinflammation and prevents cognitive decline in an Alzheimer's disease mouse model. Journal of Neuroscience, 39 (40), 7976-7991. doi: 10.1523/JNEUROSCI.0674-19.2019
2019
Other Outputs
Munc18-1/Vamp2 interaction, priming and exoctyosis
Gormal, Rachel (2019). Munc18-1/Vamp2 interaction, priming and exoctyosis. The University of Queensland. (Dataset) doi: 10.48610/0d9d904
2019
Journal Article
VAMP2 Binding to Munc18-1 Domain 3a Controls the Nanoscale Reorganization of the Plasma Membrane and Vesicle Interface During Vesicular Priming
Kasula, Ravikiran, Blum, Ailisa, Salla-Martret, Merce, Chai, Ye Jin, Jiang, Anmin, Wallis, Tristan P., Gormal, Rachel S., Brouillet, Julie Z., Padmanabhan, Pranesh, Weeratunga, Saroja K., Livingstone, Emma K., Mollazade, Mahdie, Joensuu, Merja, Martínez-Mármol, Ramón, Collins, Brett M. and Meunier, Frederic (2019). VAMP2 Binding to Munc18-1 Domain 3a Controls the Nanoscale Reorganization of the Plasma Membrane and Vesicle Interface During Vesicular Priming. SSRN Electronic Journal. doi: 10.2139/ssrn.3362260
2018
Journal Article
Trapping of Syntaxin1a in Presynaptic Nanoclusters by a Clinically Relevant General Anesthetic
Bademosi, Adekunle T. , Steeves, James, Karunanithi, Shanker, Zalucki, Oressia H, Gormal, Rachel S, Liu, Shu, Lauwers, Elsa, Verstreken, Patrik, Anggono, Victor, Meunier, Frederic A and van Swinderen, Bruno (2018). Trapping of Syntaxin1a in Presynaptic Nanoclusters by a Clinically Relevant General Anesthetic. Cell reports, 22 (2), 427-440. doi: 10.1016/j.celrep.2017.12.054
2017
Journal Article
ENA/VASP proteins regulate exocytosis by mediating myosin VI-dependent recruitment of secretory granules to the cortical actin network
Tomatis, Vanesa M., Josh, Peter, Papadopulos, Andreas, Gormal, Rachel S., Lanoue, Vanessa, Martin, Sally and Meunier, Frédéric A. (2017). ENA/VASP proteins regulate exocytosis by mediating myosin VI-dependent recruitment of secretory granules to the cortical actin network. Molecular and Cellular Neuroscience, 84, 100-111. doi: 10.1016/j.mcn.2017.07.005
2017
Journal Article
A role for tropomyosins in activity-dependent bulk endocytosis?
Gormal, R. S., Valmas, N., Fath, T. and Meunier, F. A. (2017). A role for tropomyosins in activity-dependent bulk endocytosis?. Molecular and Cellular Neuroscience, 84, 112-118. doi: 10.1016/j.mcn.2017.04.003
2016
Journal Article
Flux of signalling endosomes undergoing axonal retrograde transport is encoded by presynaptic activity and TrkB
Wang, Tong, Martin, Sally, Nguyen, Tam H., Harper, Callista B., Gormal, Rachel S., Martinez-Marmol, Ramon, Karunanithi, Shanker, Coulson, Elizabeth J., Glass, Nick R., Cooper-White, Justin J., Van Swinderen, Bruno and Meunier, Frederic A. (2016). Flux of signalling endosomes undergoing axonal retrograde transport is encoded by presynaptic activity and TrkB. Nature Communications, 7 (1) 12976, 12976. doi: 10.1038/ncomms12976
Featured
2016
Journal Article
The Munc18-1 domain 3a hinge-loop controls syntaxin-1A nanodomain assembly and engagement with the SNARE complex during secretory vesicle priming
Kasula, Ravikiran, Chai, Ye Jin, Bademosi, Adekunle T., Harper, Callista B., Gormal, Rachel S., Morrow, Isabel C., Hosy, Eric, Collins, Brett M., Choquet, Daniel, Papadopulos, Andreas and Meunier, Frederic A. (2016). The Munc18-1 domain 3a hinge-loop controls syntaxin-1A nanodomain assembly and engagement with the SNARE complex during secretory vesicle priming. The Journal of Cell Biology, 214 (7) 847, 847-858. doi: 10.1083/jcb.201508118
Featured
2016
Journal Article
Munc18-1 is a molecular chaperone for α-synuclein, controlling its self-replicating aggregation
Chai, Ye Jin, Sierecki, Emma, Tomatis, Vanesa M., Gormal, Rachel S., Giles, Nichole, Morrow, Isabel C., Xia, Di, Götz, Jürgen, Parton, Robert G., Collins, Brett M., Gambin, Yann and Meunier, Frédéric A. (2016). Munc18-1 is a molecular chaperone for α-synuclein, controlling its self-replicating aggregation. The Journal of Cell Biology, 214 (6) 705, 705-718. doi: 10.1083/jcb.201512016
2015
Journal Article
Activity-driven relaxation of the cortical actomyosin II network synchronizes Munc18-1-dependent neurosecretory vesicle docking
Papadopulos, Andreas, Gomez, Guillermo A., Martin, Sally, Jackson, Jade, Gormal, Rachel S., Keating, Damien J., Yap, Alpha S. and Meunier, Frederic A. (2015). Activity-driven relaxation of the cortical actomyosin II network synchronizes Munc18-1-dependent neurosecretory vesicle docking. Nature Communications, 6 (6297) 6297, 1-11. doi: 10.1038/ncomms7297
2015
Journal Article
An acto-myosin II constricting ring initiates the fission of activity-dependent bulk endosomes in neurosecretory cells
Gormal, Rachel S, Nguyen, Tam H, Martin, Sally, Papadopulos, Andreas and Meunier, Frederic A (2015). An acto-myosin II constricting ring initiates the fission of activity-dependent bulk endosomes in neurosecretory cells. Journal of Neuroscience, 35 (4), 1380-1389. doi: 10.1523/JNEUROSCI.3228-14.2015
2014
Journal Article
Increased polyubiquitination and proteasomal degradation of a Munc18-1 disease-linked mutant causes temperature-sensitive defect in exocytosis
Martin, Sally, Papadopulos, Andreas, Tomatis, Vanesa M., Sierecki, Emma, Malintan, Nancy T., Gormal, Rachel S., Giles, Nichole, Johnston, Wayne A., Alexandrov, Kirill, Gambin, Yann, Collins, Brett M. and Meunier, Frederic A. (2014). Increased polyubiquitination and proteasomal degradation of a Munc18-1 disease-linked mutant causes temperature-sensitive defect in exocytosis. Cell Reports, 9 (1), 206-218. doi: 10.1016/j.celrep.2014.08.059
2013
Journal Article
The Munc18-1 domain 3a loop is essential for neuroexocytosis but not for syntaxin-1A transport to the plasma membrane
Martin, Sally, Tomatis, Vanesa M., Papadopulos, Andreas, Christie, Michelle P., Malintan, Nancy T., Gormal, Rachel S., Sugita, Shuzo, Martin, Jennifer L., Collins, Brett M. and Meunier, Frederic A. (2013). The Munc18-1 domain 3a loop is essential for neuroexocytosis but not for syntaxin-1A transport to the plasma membrane. Journal of Cell Science, 126 (11), 2353-2360. doi: 10.1242/jcs.126813
2013
Journal Article
Myosin VI small insert isoform maintains exocytosis by tethering secretory granules to the cortical actin
Tomatis, Vanesa M., Papadopulos, Andreas, Malintan, Nancy T., Martin, Sally, Wallis, Tristan, Gormal, Rachel S., Kendrick-Jones, John, Buss, Folma and Meunier, Frederic A. (2013). Myosin VI small insert isoform maintains exocytosis by tethering secretory granules to the cortical actin. Journal of Cell Biology, 200 (3), 301-320. doi: 10.1083/jcb.201204092
2013
Journal Article
Secretagogue stimulation of neurosecretory cells elicits filopodial extensions uncovering new functional release sites
Papadopulos, Andreas, Martin, Sally, Tomatis, Vanesa M., Gormal, Rachel S. and Meunier, Frederic A. (2013). Secretagogue stimulation of neurosecretory cells elicits filopodial extensions uncovering new functional release sites. Journal of Neuroscience, 33 (49), 19143-19153. doi: 10.1523/JNEUROSCI.2634-13.2013
Supervision
Availability
- Dr Rachel Gormal is:
- Available for supervision
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Supervision history
Current supervision
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Doctor Philosophy
Dynamic nanoscale organisation of trans-synaptic nanocolumns
Associate Advisor
Other advisors: Dr Adekunle Bademosi, Professor Frederic Meunier
Media
Enquiries
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