Overview
Background
Over 5 years of experience in translational biomedical research, specialising in monoclonal antibody-based therapies, immuno-oncology, target discovery and theranostics in cancer. My main research focus is on targeted cancer therapies, understanding how target receptor endocytosis affects antibody drug conjugate (ADC) and radioligand therapy delivery, immune-mediated ADCC, and how combination therapies with immune checkpoint inhibitors can potentially improve therapeutic outcomes for patients.
Availability
- Dr Benedict Lum is:
- Not available for supervision
Fields of research
Qualifications
- Bachelor (Honours) of Biomedical Sciences, The University of Queensland
- Doctor of Philosophy of Biomedical Science, The University of Queensland
Works
Search Professor Benedict Lum’s works on UQ eSpace
2024
Journal Article
Antibody dependent cellular cytotoxicity-inducing anti-EGFR antibodies as effective therapeutic option for cutaneous melanoma resistant to BRAF inhibitors
Muraro, Elena, Montico, Barbara, Lum, Benedict, Colizzi, Francesca, Giurato, Giorgio, Salvati, Annamaria, Guerrieri, Roberto, Rizzo, Aurora, Comaro, Elisa, Canzonieri, Vincenzo, Anichini, Andrea, Del Vecchio, Michele, Mortarini, Roberta, Milione, Massimo, Weisz, Alessandro, Pizzichetta, Maria Antonietta, Simpson, Fiona, Dolcetti, Riccardo, Fratta, Elisabetta and Sigalotti, Luca (2024). Antibody dependent cellular cytotoxicity-inducing anti-EGFR antibodies as effective therapeutic option for cutaneous melanoma resistant to BRAF inhibitors. Frontiers in Immunology, 15 1336566. doi: 10.3389/fimmu.2024.1336566
2023
Other Outputs
Improving monoclonal antibody therapies with temporary and reversible endocytosis inhibition
Lum, Benedict (2023). Improving monoclonal antibody therapies with temporary and reversible endocytosis inhibition. PhD Thesis, Frazer Institute, The University of Queensland. doi: 10.14264/12d5eba
2023
Journal Article
Endocytosis in cancer and cancer therapy
Banushi, Blerida, Joseph, Shannon R., Lum, Benedict, Lee, Jason J. and Simpson, Fiona (2023). Endocytosis in cancer and cancer therapy. Nature Reviews Cancer, 23 (7), 1-24. doi: 10.1038/s41568-023-00574-6
2021
Journal Article
Adenoid cystic carcinoma: a review of clinical features, treatment targets and advances in improving the immune response to monoclonal antibody therapy
Nightingale, James, Lum, Benedict, Ladwa, Rahul, Simpson, Fiona and Panizza, Benedict (2021). Adenoid cystic carcinoma: a review of clinical features, treatment targets and advances in improving the immune response to monoclonal antibody therapy. Biochimica et Biophysica Acta, 1875 (2) 188523, 1-9. doi: 10.1016/j.bbcan.2021.188523
2021
Journal Article
Adenoid cystic carcinoma: a review of clinical features, treatment targets and advancement in improving the immune response to monoclonal antibody therapy
Nightingale, James, Lum, Benedict, Ladwa, Rahul, Simpson, Fiona and Panizza, Benedict (2021). Adenoid cystic carcinoma: a review of clinical features, treatment targets and advancement in improving the immune response to monoclonal antibody therapy. Biochimica et Biophysica Acta. Reviews on Cancer, 1875 (2) 188523, 1-9. doi: 10.1016/j.bbcan.2021.188523
2020
Journal Article
Antibody/ligand-target receptor internalization assay protocol using fresh human or murine tumor ex vivo samples
Joseph, Shannon R., Lum, Benedict, Banushi, Blerida, Barry, Rachael, Panizza, Benedict, Walpole, Euan and Simpson, Fiona (2020). Antibody/ligand-target receptor internalization assay protocol using fresh human or murine tumor ex vivo samples. STAR Protocols, 1 (2) 100087, 100087. doi: 10.1016/j.xpro.2020.100087
2020
Journal Article
Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies
Chew, Hui Yi, De Lima, Priscila O., Gonzalez Cruz, Jazmina L., Banushi, Blerida, Echejoh, Godwins, Hu, Lingbo, Joseph, Shannon R., Lum, Benedict, Rae, James, O'Donnell, Jake S., Merida de Long, Lilia, Okano, Satomi, King, Brigid, Barry, Rachael, Moi, Davide, Mazzieri, Roberta, Thomas, Ranjeny, Souza-Fonseca-Guimaraes, Fernando, Foote, Matthew, McCluskey, Adam, Robinson, Phillip J., Frazer, Ian H., Saunders, Nicholas A., Parton, Robert G., Dolcetti, Riccardo, Cuff, Katharine, Martin, Jennifer H., Panizza, Benedict, Walpole, Euan ... Simpson, Fiona (2020). Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies. Cell, 180 (5), 895-914.e27. doi: 10.1016/j.cell.2020.02.019
Media
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