Overview
Background
Dr. Rabina Giri completed her PhD at Mater Research Institute – The University of Queensland, Australia, in 2024, where she established a bioactive discovery pipeline to understand the interactions between the gut immune system and microbial communities using cell-based assays and pre-clinical models. Currently, Dr. Giri is a postdoctoral researcher in the Inflammatory Bowel Disease (IBD) group within Jakob Begun's Laboratory investigating how the gut microbiome modulates immune responses in IBD and identifying and assessing efficacy of microbial derived small molecules as therapeutics in IBD.
Dr. Giri's research has led to the identification and characterization of a novel gene associated with ulcerative colitis through exome sequencing and the development of a spontaneous colitis animal model. Her work has also laid the groundwork for a provisional patent on a small molecule treatment for IBD and has supported the formation of Micromune Therapeutics, a start-up company focused on commercializing this innovative approach.
Availability
- Dr Rabina Giri is:
- Available for supervision
Qualifications
- Doctor of Philosophy of Microbiology, The University of Queensland
Works
Search Professor Rabina Giri’s works on UQ eSpace
2021
Journal Article
Gut microbiota shape the inflammatory response in mice with an epithelial defect
Wang, Ran, Moniruzzaman, Md, Wong, Kuan Yau, Wiid, Percival, Harding, Alexa, Giri, Rabina, Tong, Wendy Hui, Creagh, Jackie, Begun, Jakob, McGuckin, Michael A. and Hasnain, Sumaira Z. (2021). Gut microbiota shape the inflammatory response in mice with an epithelial defect. Gut microbes, 13 (1), 1-18. doi: 10.1080/19490976.2021.1887720
2020
Conference Publication
Curdlan-induced villous permeability, luminal pathobiont translocation to the ileal crypts, ileitis and arthritis are mitigated by clostridia in colonised germ-free SKG mice
Bergot, Anne-Sophie, Giri, Rabina, Cameron, Amy, Duggan, Emily, Loayza, Jeimy Jimenez, Morrison, Mark, Rehaume, Linda, Begun, Jakob and Thomas, Ranjeny (2020). Curdlan-induced villous permeability, luminal pathobiont translocation to the ileal crypts, ileitis and arthritis are mitigated by clostridia in colonised germ-free SKG mice. Annual Meeting of the American-College-of-Rheumatology (ACR), Virtual, 5-9 November 2020. Hoboken, NJ USA: John Wiley & Sons.
2020
Journal Article
The microbiome and rheumatoid arthritis
Bergot, Anne-Sophie, Giri, Rabina and Thomas, Ranjeny (2020). The microbiome and rheumatoid arthritis. Best Practice and Research: Clinical Rheumatology, 33 (6) 101497, 101497. doi: 10.1016/j.berh.2020.101497
2020
Conference Publication
Investigating the role of bioactives produced by gut bacteria to modulate immune response in inflammatory bowel disease
Giri, R., Shamsunnahar, K., Salim, A., Capon, R., Morrison, M., Cuiv, P. O. and Begun, J. (2020). Investigating the role of bioactives produced by gut bacteria to modulate immune response in inflammatory bowel disease. 15th Congress of ECCO, Vienna, Austria, 12-15 February 2020. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/ecco-jcc/jjz203.035
2020
Conference Publication
Thioguanine inhibits colorectal tumorigenesis via β-catenin signalling in intestinal epithelial cells independently of immunosuppression or autophagy
Sheng, Yong H., Giri, Rabina, Davies, Julie, Schreiber, Veronika, Alabbas, Saleh Y., He, Yaowu, Wu, Andy, Hooper, John, Oancea, Iulia, Kijanka, Gregor, Hasnain, Sumaira Z., McGuckin, Michael, Florin, Timothy H. and Begun, Jakob (2020). Thioguanine inhibits colorectal tumorigenesis via β-catenin signalling in intestinal epithelial cells independently of immunosuppression or autophagy. DDW 2020, Online, 2-5 May 2020. Philadelphia, PA United States: Elsevier . doi: 10.1016/s0016-5085(20)30856-8
2019
Journal Article
MUC13 promotes the development of colitis-associated colorectal tumors via β-catenin activity
Sheng, Yong Hua, Wong, Kuan Yau, Seim, Inge, Wang, Ran, He, Yaowu, Wu, Andy, Patrick, Maya, Lourie, Rohan, Schreiber, Veronika, Giri, Rabina, Ng, Choa Ping, Popat, Amirali, Hooper, John, Kijanka, Gregor, Florin, Timothy H., Begun, Jakob, Radford, Kristen J., Hasnain, Sumaira and McGuckin, Michael A. (2019). MUC13 promotes the development of colitis-associated colorectal tumors via β-catenin activity. Oncogene, 38 (48), 7294-7310. doi: 10.1038/s41388-019-0951-y
2019
Conference Publication
Investigating the role of bioactives produced by gut bacteria to modulate immune response in inflammatory bowel disease
Giri, R., Cuiv, P. O. and Begun, J. (2019). Investigating the role of bioactives produced by gut bacteria to modulate immune response in inflammatory bowel disease. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) “The Universe Within”, Adelaide, Australia, 8-10 September 2019. Hoboken, NJ, United States: Wiley-Blackwell. doi: 10.1111/jgh.14800
2018
Conference Publication
Enteric microbiota shape the inflammatory response in mice with a Muc2 misfolding mutation
Wang, R., Giri, R., Moniruzzaman, M., Tong, H., Wong, K. Y., Begun, J., McGuckin, M. A. and Hasnain, S. Z. (2018). Enteric microbiota shape the inflammatory response in mice with a Muc2 misfolding mutation. Gastroenterological Society of Australia (GESA) Australian Gastroenterology Week (AGW) “Gut Matters”, Brisbane, QLD, Australia, 8-10 September 2018. Richmond, VIC, Australia: John Wiley & Sons.
2018
Journal Article
Enterococcus faecalis AHG0090 is a genetically tractable bacterium and produces a secreted peptidic bioactive that suppresses nuclear factor Kappa B activation in human gut epithelial cells
Ó Cuív, Páraic, Giri, Rabina, Hoedt, Emily C., McGuckin, Michael A., Begun, Jakob and Morrison, Mark (2018). Enterococcus faecalis AHG0090 is a genetically tractable bacterium and produces a secreted peptidic bioactive that suppresses nuclear factor Kappa B activation in human gut epithelial cells. Frontiers in Immunology, 9 (April) 790, 790. doi: 10.3389/fimmu.2018.00790
2017
Journal Article
The gut bacterium and pathobiont Bacteroides vulgatus activates NF-κB in a human gut epithelial cell line in a strain and growth phase dependent manner
Cuív, Páraic Ó., de Wouters, Tomas, Giri, Rabina, Mondot, Stanislas, Smith, Wendy J., Blottière, Hervé M., Begun, Jakob and Morrison, Mark (2017). The gut bacterium and pathobiont Bacteroides vulgatus activates NF-κB in a human gut epithelial cell line in a strain and growth phase dependent manner. Anaerobe, 47, 209-217. doi: 10.1016/j.anaerobe.2017.06.002
2017
Conference Publication
Role of anti-inflammatory gut bioactives in the modulation of immune response in Crohn's disease
Giri, R., Cuiv, P. O. and Begun, J. (2017). Role of anti-inflammatory gut bioactives in the modulation of immune response in Crohn's disease. Gastroenterological Society of Australia Australian Gastroenterology Week Precision Medicine in Gastroenterology, Gold Coast, QLD Australia, 20–22 August 2017. Richmond, VIC Australia: Wiley.
2017
Conference Publication
Targeting interleukin-23(p19) secretion from intestinal epithelial cells to improve intestinal barrier integrity in inflammatory bowel disease
Wang, R., Lourie, R., Tong, H., Giri, R., Schreiber, V., Begun, J., Florin, T., McGuckin, M. A. and Hasnain, S. Z. (2017). Targeting interleukin-23(p19) secretion from intestinal epithelial cells to improve intestinal barrier integrity in inflammatory bowel disease. Gastroenterological Society of Australia Australian Gastroenterology Week Precision Medicine in Gastroenterology, Gold Coast, QLD Australia, 20–22 August 2017. Richmond, VIC Australia: Wiley.
Funding
Current funding
Supervision
Availability
- Dr Rabina Giri is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Investigating immunomodulatory function of gut microbiome and FXR pathway in IBD
Principal Advisor
Other advisors: Associate Professor Jakob Begun
-
Doctor Philosophy
Designer Nanoparticles for Oral and Targeted Delivery of Protein Therapeutics
Associate Advisor
Other advisors: Associate Professor Jakob Begun, Dr Md Moniruzzaman, Professor Amirali Popat
-
Doctor Philosophy
Reducing post-operative Crohn's disease recurrence
Associate Advisor
Other advisors: Professor David Clark, Associate Professor Jakob Begun
Media
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