Overview
Background
Dr. Rabina Giri completed her PhD at Mater Research Institute – The University of Queensland, Australia, in 2024, where she established a bioactive discovery pipeline to understand the interactions between the gut immune system and microbial communities using cell-based assays and pre-clinical models. Currently, Dr. Giri is a postdoctoral researcher in the Inflammatory Bowel Disease (IBD) group within Jakob Begun's Laboratory investigating how the gut microbiome modulates immune responses in IBD and identifying and assessing efficacy of microbial derived small molecules as therapeutics in IBD.
Dr. Giri's research has led to the identification and characterization of a novel gene associated with ulcerative colitis through exome sequencing and the development of a spontaneous colitis animal model. Her work has also laid the groundwork for a provisional patent on a small molecule treatment for IBD and has supported the formation of Micromune Therapeutics, a start-up company focused on commercializing this innovative approach.
Availability
- Dr Rabina Giri is:
- Available for supervision
Qualifications
- Doctor of Philosophy of Microbiology, The University of Queensland
Works
Search Professor Rabina Giri’s works on UQ eSpace
2024
Journal Article
A truncation mutant of adenomatous polyposis coli impairs apical cell extrusion through elevated epithelial tissue tension
Gan, Wan J., Giri, Rabina, Begun, Jakob, Abud, Helen E., Hardeman, Edna C., Gunning, Peter W., Yap, Alpha S. and Noordstra, Ivar (2024). A truncation mutant of adenomatous polyposis coli impairs apical cell extrusion through elevated epithelial tissue tension. Cytoskeleton. doi: 10.1002/cm.21893
2024
Conference Publication
Type 3 cytokine blockade in translocation of instestinal bacteria in spondyloarthropathy
Cai, B., Giri, R., Benham, H., Rehaume, L., Strutton, G., Bergot, A. S. and Thomas, R. (2024). Type 3 cytokine blockade in translocation of instestinal bacteria in spondyloarthropathy. EULAR 2024 European Congress of Rheumatology, Vienna, Austria, 12-15 June 2024. London, United Kingdom: BMJ Group. doi: 10.1136/annrheumdis-2024-eular.2408
2024
Other Outputs
Drugs from Bugs: Harnessing the host-microbe interactions that modulate the immune responses in Inflammatory Bowel Disease
Giri, Rabina (2024). Drugs from Bugs: Harnessing the host-microbe interactions that modulate the immune responses in Inflammatory Bowel Disease. PhD Thesis, Faculty of Medicine, The University of Queensland. doi: 10.14264/e022ffa
2023
Conference Publication
Goblet cell specific anti-apoptotic role of interleukin-24 in spondyloarthritis-associated ileitis
Cameron, Amy, Giri, Rabina, Begun, Jakob, Wells, Timothy, Thomas, Ranjeny and Bergot, Anne-Sophie (2023). Goblet cell specific anti-apoptotic role of interleukin-24 in spondyloarthritis-associated ileitis. ACR Convergence 2023, San Diego, CA, United States, 10 - 15 November 2023. Hoboken, NJ, United States: John Wiley & Sons.
2023
Conference Publication
Translocation of intestinal bacteria to axial and peripheral joints in a model of spondyloarthropathy
Cai, Benjamin, Giri, Rabina, Benham, Helen, Rehaume, Linda, Strutton, Geoffery, Bergot, Anne-Sophie and Thomas, Ranjeny (2023). Translocation of intestinal bacteria to axial and peripheral joints in a model of spondyloarthropathy. ACR Convergence 2023, San Diego, CA, United States, 10 - 15 November 2023. Hoboken, NJ, United States: John Wiley & Sons.
2023
Journal Article
MUC13 cell surface mucin limits Salmonella Typhimurium infection by protecting the mucosal epithelial barrier
McGuckin, Michael A., Davies, Julie M., Felgner, Pascal, Wong, Kuan Yau, Giri, Rabina, He, Yaowu, Moniruzzaman, Md., Kryza, Thomas, Sajiir, Haressh, Hooper, John D., Florin, Timothy H., Begun, Jakob, Oussalah, Abderrahim, Hasnain, Sumaira Z., Hensel, Michael and Sheng, Yong H. (2023). MUC13 cell surface mucin limits Salmonella Typhimurium infection by protecting the mucosal epithelial barrier. Cellular and Molecular Gastroenterology and Hepatology, 16 (6), 985-1009. doi: 10.1016/j.jcmgh.2023.08.011
2023
Conference Publication
Goblet cell specific anti-apoptotic role of interleukin-24 in spondyloarthritis-associated ileitis
Cameron, A., Giri, R., Begun, J., Wells, T., Bergot, A. S. and Thomas, R. (2023). Goblet cell specific anti-apoptotic role of interleukin-24 in spondyloarthritis-associated ileitis. EULAR 2023 European Congress of Rheumatology, Milan, Italy, 31 May-3 June 2023. London, United Kingdom: BMJ Group. doi: 10.1136/annrheumdis-2023-eular.1346
2023
Conference Publication
Baseline cytokine levels and microbiome signatures are associted with clinical response following ustekinumab induction in a multi-centre prospective cohort study of crohn's disease patients: results from the aurora study
An, Yoon-Kyo, Lindsay, Niamh, Allan, Natalie, Khoo, Emi, Fernandes, Richard, Amiss, Anna, Pham, Hai, Giri, Rabina, Ooi, Soong-Yuan, Thin, Lena, Lightowler, Daniel, Connor, Susan J., Williams, Astrid-Jane, De Cruz, Peter, Suen, Christopher Li Wai, Kariyawasam, Viraj C., Mitrev, Nikola, Ghaly, Simon, Andrews, Jane M., Christensen, Britt, Sparrow, Miles, White, Lauren S., Bryant, Robert V., Ding, Nik S., Leong, Rupert, Van Langenberg, Daniel R., Seltenreich, Hansjoerg, Subramaniam, Kavitha, Radford-Smith, Graham L. and Begun, Jakob (2023). Baseline cytokine levels and microbiome signatures are associted with clinical response following ustekinumab induction in a multi-centre prospective cohort study of crohn's disease patients: results from the aurora study. Digestive Disease Week (DDW), Chicago, IL, United States, 6-9 May 2023. Philadelphia, PA, United States: Elsevier. doi: 10.1016/S0016-5085(23)02531-3
2023
Journal Article
Gut inflammation and adaptive immunity amplify acetaminophen toxicity in bowel and liver
Alabbas, Saleh Y., Giri, Rabina, Oancea, Iulia, Davies, Julie, Schreibner, Veronika, Florin, Timothy H. and Begun, Jakob (2023). Gut inflammation and adaptive immunity amplify acetaminophen toxicity in bowel and liver. Journal of Gastroenterology and Hepatology, 38 (4), 609-618. doi: 10.1111/jgh.16102
2023
Conference Publication
The interplay of IL-23, probiotic and pathobiont bacteria in the pathogenesis of ileitis and spondyloarthritis in the SKG mouse model
Bergot, Anne-Sophie, Cai, Benjamin, Giri, Rabina, Cameron, Amy, Duggan, Emily, Lim, Kai, Rehaume, Linda, Morrison, Mark, Begun, Jakob and Thomas, Ranjeny (2023). The interplay of IL-23, probiotic and pathobiont bacteria in the pathogenesis of ileitis and spondyloarthritis in the SKG mouse model. 2023 Australian Rheumatology Association (ARA) 63rd Annual Scientific Meeting, Hobart, TAS, Australia, 6–9 May 2023. Hoboken, NJ, United States: Wiley.
2023
Journal Article
Reactive oxygen species as mediators of disease progression and therapeutic response in colorectal cancer
Lyons, Nicholas, Giri, Rabina, Begun, Jakob, Clark, David A, Proud, David, He, Yaowu, Hooper, John and Kryza, Thomas (2023). Reactive oxygen species as mediators of disease progression and therapeutic response in colorectal cancer. Antioxidants and Redox Signaling, 39 (1-3), 186-205. doi: 10.1089/ars.2022.0127
2022
Journal Article
MUC1 mediated macrophage activation promotes colitis-associated colorectal cancer via activating the IL-6/STAT3 axis
Sheng, Yong H., Davies, Julie M., Wang, Ran, Wong, Kuan Yau, Giri, Rabina, Yang, Yuanhao, Begun, Jakob, Florin, Timothy H., Hasnain, Sumaira Z. and McGuckin, Michael A. (2022). MUC1 mediated macrophage activation promotes colitis-associated colorectal cancer via activating the IL-6/STAT3 axis. Cellular and Molecular Gastroenterology and Hepatology, 14 (4), 789-811. doi: 10.1016/j.jcmgh.2022.06.010
2022
Journal Article
Secreted NF-κB suppressive microbial metabolites modulate gut inflammation
Giri, Rabina, Hoedt, Emily C., Khushi, Shamsunnahar, Salim, Angela A., Bergot, Anne-Sophie, Schreiber, Veronika, Thomas, Ranjeny, McGuckin, Michael A., Florin, Timothy H., Morrison, Mark, Capon, Robert J., Ó Cuív, Páraic and Begun, Jakob (2022). Secreted NF-κB suppressive microbial metabolites modulate gut inflammation. Cell Reports, 39 (2) 110646, 110646. doi: 10.1016/j.celrep.2022.110646
2022
Journal Article
Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages
Tran, Thao Thanh, Mathmann, Carmen D., Gatica-Andrades, Marcela, Rollo, Rachel F., Oelker, Melanie, Ljungberg, Johanna K., Nguyen, Tam T. K., Zamoshnikova, Alina, Kummari, Lalith K., Wyer, Orry J. K., Irvine, Katharine M., Melo-Bolívar, Javier, Gross, Annette, Brown, Darren, Mak, Jeffrey Y. W., Fairlie, David P., Hansford, Karl A., Cooper, Matthew A., Giri, Rabina, Schreiber, Veronika, Joseph, Shannon R., Simpson, Fiona, Barnett, Timothy C., Johansson, Jörgen, Dankers, Wendy, Harris, James, Wells, Timothy J., Kapetanovic, Ronan, Sweet, Matthew J. ... Blumenthal, Antje (2022). Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages. PLoS Pathogens, 18 (1) e1010166, e1010166. doi: 10.1371/journal.ppat.1010166
2022
Journal Article
Successful Manipulation of the Gut Microbiome to Treat Spontaneous and Induced Murine Models of Colitis
Movva, Ramya, Murtaza, Nida, Giri, Rabina, Png, Chin Wen, Davies, Julie, Alabbas, Saleh, Oancea, Iulia, O'Cuiv, Páraic, Morrison, Mark, Begun, Jakob and Florin, Timothy H. (2022). Successful Manipulation of the Gut Microbiome to Treat Spontaneous and Induced Murine Models of Colitis. Gastro Hep Advances, 1 (3), 359-374. doi: 10.1016/j.gastha.2021.12.008
2021
Journal Article
IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease
Henden, Andrea S., Koyama, Motoko, Robb, Renee J., Forero, Adriana, Kuns, Rachel D., Chang, Karshing, Ensbey, Kathleen S., Varelias, Antiopi, Kazakoff, Stephen H., Waddell, Nicole, Clouston, Andrew D., Giri, Rabina, Begun, Jakob, Blazar, Bruce R., Degli-Esposti, Mariapia A., Kotenko, Sergei V., Lane, Steven W., Bowerman, Kate L., Savan, Ram, Hugenholtz, Philip, Gartlan, Kate H. and Hill, Geoffrey R. (2021). IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease. Blood, 138 (8), 722-737. doi: 10.1182/blood.2020006375
2021
Journal Article
pH – responsive colloidal carriers assembled from β-lactoglobulin and epsilon poly-l-lysine for oral drug delivery
Pujara, Naisarg, Giri, Rabina, Yau Wong, Kuan, Qu, Zhi, Rewatkar, Prarthana, Moniruzzaman, Md., Begun, Jakob, Ross, Benjamin P., McGuckin, Michael and Popat, Amirali (2021). pH – responsive colloidal carriers assembled from β-lactoglobulin and epsilon poly-l-lysine for oral drug delivery. Journal of Colloid and Interface Science, 589, 45-55. doi: 10.1016/j.jcis.2020.12.054
2021
Conference Publication
Interferon Lambda Protects Gastrointestinal Stem Cells from Acute Gvhd
Henden, Andrea S., Robb, Renee, Forero, Adriana, Kuns, Rachel D., Ensbey, Kathleen S., Chang, Karshing, Varelias, Antiopi, Kazakoff, Stephen H., Waddell, Nic, Clouston, Andrew D., Giri, Rabina, Begun, Jakob, Blazar, Bruce R., Degli-Esposti, Mariapia A., Kotenko, Sergei V., Lane, Steven W., Bowerman, Kate L., Savan, Ram, Hugenholtz, Philip, Gartlan, Kate H. and Hill, Geoffrey (2021). Interferon Lambda Protects Gastrointestinal Stem Cells from Acute Gvhd. 2021 TCT Meetings of ASTCT and CIBMTR, Online, 8-12 February 2021. Amsterdam, Netherlands: Elsevier. doi: 10.1016/s2666-6367(21)00107-x
2021
Journal Article
A nucleotide analog prevents colitis associated cancer via Β-catenin independently of inflammation and autophagy
Sheng, Yong Hua, Giri, Rabina, Davies, Julie, Schreiber, Veronika, Alabbas, Saleh, Movva, Ramya, He, Yaowu, Wu, Andy, Hooper, John, McWhinney, Brett, Oancea, Iulia, Kijanka, Gregor, Hasnain, Sumaira, Lucke, Andrew J., Fairlie, David P., McGuckin, Michael A., Florin, Timothy H. and Begun, Jakob (2021). A nucleotide analog prevents colitis associated cancer via Β-catenin independently of inflammation and autophagy. Cellular and Molecular Gastroenterology and Hepatology, 11 (1), 33-53. doi: 10.1016/j.jcmgh.2020.05.012
2021
Journal Article
Gut microbiota shape the inflammatory response in mice with an epithelial defect
Wang, Ran, Moniruzzaman, Md, Wong, Kuan Yau, Wiid, Percival, Harding, Alexa, Giri, Rabina, Tong, Wendy Hui, Creagh, Jackie, Begun, Jakob, McGuckin, Michael A. and Hasnain, Sumaira Z. (2021). Gut microbiota shape the inflammatory response in mice with an epithelial defect. Gut microbes, 13 (1), 1-18. doi: 10.1080/19490976.2021.1887720
Funding
Current funding
Supervision
Availability
- Dr Rabina Giri is:
- Available for supervision
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Supervision history
Current supervision
-
Doctor Philosophy
Reducing post-operative Crohn's disease recurrence
Associate Advisor
Other advisors: Professor David Clark, Associate Professor Jakob Begun
-
Doctor Philosophy
Designer Nanoparticles for Oral and Targeted Delivery of Protein Therapeutics
Associate Advisor
Other advisors: Associate Professor Jakob Begun, Dr Md Moniruzzaman, Professor Amirali Popat
-
Doctor Philosophy
Investigating immunomodulatory function of gut microbiome and FXR pathway in IBD
Associate Advisor
Other advisors: Associate Professor Jakob Begun
Media
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