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2015

Journal Article

A novel flow cytometric method to assess inflammasome formation

Sester, David P., Thygesen, Sara J., Sagulenko, Vitaliya, Vajjhala, Parimala R., Cridland, Jasmyn A., Vitak, Nazarii, Chen, Kaiwen W., Osborne, Geoffrey W., Schroder, Kate and Katryn J. Stacey (2015). A novel flow cytometric method to assess inflammasome formation. The Journal of Immunology, 194 (1), 455-462. doi: 10.4049/jimmunol.1401110

A novel flow cytometric method to assess inflammasome formation

2015

Journal Article

Burn the house, save the day: pyroptosis in pathogen restriction

Boucher, Dave, Chen, Kaiwen W. and Schroder, Kate (2015). Burn the house, save the day: pyroptosis in pathogen restriction. Inflammasome, 2 (1), 1-6. doi: 10.1515/infl-2015-0001

Burn the house, save the day: pyroptosis in pathogen restriction

2014

Journal Article

Sphingomyelin phosphodiesterase Acid-like 3A (SMPDL3A) is a novel nucleotide phosphodiesterase regulated by cholesterol in human macrophages

Traini, Mathew, Quinn, Carmel M., Sandoval, Cecilia, Johansson, Erik, Schroder, Kate, Kockx, Maaike, Meikle, Peter J., Jessup, Wendy and Kritharides, Leonard (2014). Sphingomyelin phosphodiesterase Acid-like 3A (SMPDL3A) is a novel nucleotide phosphodiesterase regulated by cholesterol in human macrophages. Journal of Biological Chemistry, 289 (47), 32895-32913. doi: 10.1074/jbc.M114.612341

Sphingomyelin phosphodiesterase Acid-like 3A (SMPDL3A) is a novel nucleotide phosphodiesterase regulated by cholesterol in human macrophages

2014

Journal Article

TRAF6 is a nexus for TLR-STAT1 crosstalk

Bezbradica, Jelena S. and Schroder, Kate (2014). TRAF6 is a nexus for TLR-STAT1 crosstalk. Immunology and Cell Biology, 92 (9), 737-738. doi: 10.1038/icb.2014.71

TRAF6 is a nexus for TLR-STAT1 crosstalk

2014

Journal Article

Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling

Luo, Lin, Wall, Adam A., Yeo, Jeremy C., Condon, Nicholas D., Norwood, Suzanne J., Schoenwaelder, Simone, Chen, Kaiwen W., Jackson, Shaun, Jenkins, Brendan J., Hartland, Elizabeth L., Schroder, Kate, Collins, Brett M., Sweet, Matthew J. and Stow, Jennifer L. (2014). Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling. Nature Communications, 5 (1) 4407, 4407.1-4407.13. doi: 10.1038/ncomms5407

Rab8a interacts directly with PI3Kγ to modulate TLR4-driven PI3K and mTOR signalling

2014

Conference Publication

MCC950 is a potent and specific inhibitor of the NLRP3 inflammasome and a novel potential therapeutic for NLRP3 driven diseases

Coll, Rebecca C., Robertson, Avril A. B., Chae, Jae Jin, Higgins, Sarah C., Dungan, Lara S., Munoz-Planillo, Raul, Monks, Brian G., Croker, Daniel E., Sutton, Caroline E., Stutz, Andrea, Nunez, Gabriel, Latz, Eicke, Kastner, Daniel L., Mills, Kingston H. G., Masters, Seth L., Schroder, Kate, Cooper, Matt A. and O'Neill, Luke A. J. (2014). MCC950 is a potent and specific inhibitor of the NLRP3 inflammasome and a novel potential therapeutic for NLRP3 driven diseases. 2nd Annual Meeting of the International-Cytokine-and-Interferon-Society (ICIS), Melbourne Australia, Oct 26-29, 2014. London United Kingdom: Academic Press. doi: 10.1016/j.cyto.2014.07.037

MCC950 is a potent and specific inhibitor of the NLRP3 inflammasome and a novel potential therapeutic for NLRP3 driven diseases

2014

Conference Publication

A novel approach to investigate the assembly of the NOD-like receptor inflammasomes

Giles, Nichole, Sierecki, Emma, Polinkovsky, Mark, Schroder, Kate, Alexandrov, Kirill and Gambin, Yann (2014). A novel approach to investigate the assembly of the NOD-like receptor inflammasomes. Experimental Biology Meeting, San Diego Ca, 26-30 April 2014. Bethesda, MD United States: Federation of American Societies for Experimental Biology.

A novel approach to investigate the assembly of the NOD-like receptor inflammasomes

2014

Conference Publication

Exploring NLRP12-An emerging member of NOD-like receptor family

Zamoshnikova, Alina, Gross, Christina J., Vasquez, Flor, Schuster, Steffen, Tacchini-Cottier, Fabienne, Richards, Ayanthi and Schroder, Kate (2014). Exploring NLRP12-An emerging member of NOD-like receptor family. 2nd Annual Meeting of the International-Cytokine-and-Interferon-Society (ICIS), Melbourne Australia, 26-29 October 2014. London, United Kingdom: Academic Press. doi: 10.1016/j.cyto.2014.07.217

Exploring NLRP12-An emerging member of NOD-like receptor family

2014

Book Chapter

Inflammasomes and inflammation

Chen, Kaiwen W., Richards, Ayanthi A., Zamoshnikova, Alina and Schroder, Kate (2014). Inflammasomes and inflammation. Cancer and Inflammation Mechanisms: Chemical, Biological, and Clinical Aspects. (pp. 103-117) edited by Yusuke Hiraku, Shosuke Kawanishi and Hiroshi Ohshima. Hoboken, NJ, USA: John Wiley & Sons. doi: 10.1002/9781118826621.ch8

Inflammasomes and inflammation

2013

Journal Article

AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC

Sagulenko, V., Thygesen, S. J., Sester, D. P., Idris, A., Cridland, J. A., Vajjhala, P. R., Roberts, T., Schroder, K., Vince, J. E., Hill, J. M., Silke, J. and Stacey, K. J. (2013). AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC. Cell Death and Differentiation, 20 (9), 1149-1160. doi: 10.1038/cdd.2013.37

AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC

2013

Journal Article

Pattern recognition receptor function in neutrophils

Thomas, Christina J. and Schroder, Kate (2013). Pattern recognition receptor function in neutrophils. Trends in Immunology, 34 (7), 317-328. doi: 10.1016/j.it.2013.02.008

Pattern recognition receptor function in neutrophils

2013

Journal Article

An antioxidant role for catecholate siderophores in Salmonella

Achard, Maud E. S, Chen, Kaiwen W., Sweet, Matthew J., Watts, Rebecca E., Schroder, Kate, Schembri, Mark A. and McEwan, Alastair G. (2013). An antioxidant role for catecholate siderophores in Salmonella. Biochemical Journal, 454 (3), 543-549. doi: 10.1042/BJ20121771

An antioxidant role for catecholate siderophores in Salmonella

2013

Journal Article

Histone deacetylase 7 promotes Toll-like Receptor 4-dependent pro-inflammatory gene expression in macrophages

Shakespear, Melanie R., Hohenhaus, Daniel M., Kelly, Greg M., Kamal, Nabilah A., Gupta, Praveer, Labzin, Larisa I., Schroder, Kate, Garceau, Valerie, Barbero, Sheila, Iyer, Abishek, Hume, David A., Reid, Robert C., Irvine, Katharine M., Fairlie, David P. and Sweet, Matthew J. (2013). Histone deacetylase 7 promotes Toll-like Receptor 4-dependent pro-inflammatory gene expression in macrophages. Journal of Biological Chemistry, 288 (35), 25362-25374. doi: 10.1074/jbc.M113.496281

Histone deacetylase 7 promotes Toll-like Receptor 4-dependent pro-inflammatory gene expression in macrophages

2013

Journal Article

Antimicrobial functions of inflammasomes

Chen, Kaiwen W. and Schroder, Kate (2013). Antimicrobial functions of inflammasomes. Current Opinion in Microbiology, 16 (3), 311-318. doi: 10.1016/j.mib.2013.02.004

Antimicrobial functions of inflammasomes

2013

Journal Article

Innate immunity, the constant gardener of antimicrobial defense

Schroder, Kate and Deretic, Vojo (2013). Innate immunity, the constant gardener of antimicrobial defense. Current Opinion in Microbiology, 16 (3), 293-295. doi: 10.1016/j.mib.2013.06.007

Innate immunity, the constant gardener of antimicrobial defense

2013

Journal Article

The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized

Chen, Kai-En, Richards, Ayanthi A., Caradoc-Davies, Tom T., Vajjhala, Parimala R., Robin, Gautier, Lua, Linda H. L., Hill, Justine M., Schroder, Kate, Sweet, Matthew J., Kellie, Stuart, Kobe, Bostjan and Martin, Jennifer (2013). The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized. Acta Crystallographica Section D: Biological Crystallography, 69 (5), 774-784. doi: 10.1107/S0907444913001558

The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized

2012

Journal Article

Acute lipopolysaccharide priming boosts inflammasome activation independently of inflammasome sensor induction

Schroder, Kate, Sagulenko, Vitaliya, Zamoshnikova, Alina, Richards, Ayanthi A., Cridland, Jasmyn A., Irvine, Katharine M., Stacey, Katryn J. and Sweet, Matthew J. (2012). Acute lipopolysaccharide priming boosts inflammasome activation independently of inflammasome sensor induction. Immunobiology, 217 (12), 1325-1329. doi: 10.1016/j.imbio.2012.07.020

Acute lipopolysaccharide priming boosts inflammasome activation independently of inflammasome sensor induction

2012

Journal Article

Liver repercussions of defective gut surveillance

Irvine, Katharine M., Schroder, Elizabeth E. and Powell, Elizabeth E. (2012). Liver repercussions of defective gut surveillance. Hepatology, 56 (3), 1174-1177. doi: 10.1002/hep.25944

Liver repercussions of defective gut surveillance

2012

Journal Article

The mammalian PYHIN gene family: Phylogeny, evolution and expression

Cridland, Jasmyn A., Curley, Eva Z., Wykes, Michelle N ., Schroder, Kate, Sweet, Matthew J., Roberts, Tara L., Ragan, Mark A., Kassahn, Karin S. and Stacey, Katryn J. (2012). The mammalian PYHIN gene family: Phylogeny, evolution and expression. BMC Evolutionary Biology, 12 (1) 140, 140.1-140.33. doi: 10.1186/1471-2148-12-140

The mammalian PYHIN gene family: Phylogeny, evolution and expression

2012

Journal Article

Novel insights into the innate immune response to non-tuberculous Mycobacteria

Heinz, Leonhard X. and Schroder, Kate (2012). Novel insights into the innate immune response to non-tuberculous Mycobacteria. Immunology and Cell Biology, 90 (6), 568-570. doi: 10.1038/icb.2011.86

Novel insights into the innate immune response to non-tuberculous Mycobacteria