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2017 Journal Article Correction: Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner (Proceedings of the National Academy of Sciences of the United States of America (2017) 114 (E961-E969) DOI: 10.1073/pnas.1613305114)Conos, Stephanie A., Chen, Kaiwen W., De Nardo, Dominic, Hara, Hideki, Whitehead, Lachlan, Núñez, Gabriel, Masters, Seth L., Murphy, James M., Schroder, Kate, Vaux, David L., Lawlor, Kate E., Lindqvist, Lisa M. and Vince, James E. (2017). Correction: Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner (Proceedings of the National Academy of Sciences of the United States of America (2017) 114 (E961-E969) DOI: 10.1073/pnas.1613305114). Proceedings of the National Academy of Sciences of the United States of America, 114 (28), E5762-E5763. doi: 10.1073/pnas.1710668114 |
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2017 Journal Article In life there is death: How epithelial tissue barriers are preserved despite the challenge of apoptosisDuszyc, Kinga, Gomez, Guillermo A., Schroder, Kate, Sweet, Matthew J. and Yap, Alpha S. (2017). In life there is death: How epithelial tissue barriers are preserved despite the challenge of apoptosis. Tissue Barriers, 5 (4) e1345353, e1345353. doi: 10.1080/21688370.2017.1345353 |
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2017 Journal Article XIAP loss triggers RIPK3- and caspase-8-driven IL-1β activation and cell death as a consequence of TLR-MyD88-induced cIAP1-TRAF2 degradationLawlor, Kate E., Feltham, Rebecca, Yabal, Monica, Conos, Stephanie A., Chen, Kaiwen W., Ziehe, Stephanie, Grass, Carina, Zhan, Yifan, Nguyen, Tan A., Hall, Cathrine, Vince, Angelina J., Chatfield, Simon M., D'Silva, Damian B., Pang, Kenneth C., Schroder, Kate, Silke, John, Vaux, David L., Jost, Philipp J. and Vince, James E. (2017). XIAP loss triggers RIPK3- and caspase-8-driven IL-1β activation and cell death as a consequence of TLR-MyD88-induced cIAP1-TRAF2 degradation. Cell Reports, 20 (3), 668-682. doi: 10.1016/j.celrep.2017.06.073 |
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2017 Other Outputs Novel compounds and usesO'Neill, L. A., Coll, R. C., Cooper, M. A., Robertson, A. A. B., Schroder, K., MacLeod, A. M. and Miller, D. J. (2017). Novel compounds and uses. PCT/IB2017/053059. |
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2017 Journal Article NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in miceMridha, Auvro R., Wree, Alexander, Robertson, Avril A. B., Yeh, Matthew M., Johnson, Casey D., Van Rooyen, Derrick M., Haczeyni, Fahrettin, Teoh, Narci C. -H., Savard, Christopher, Ioannou, George N., Masters, Seth L., Schroder, Kate, Cooper, Matthew A., Feldstein, Ariel E. and Farrell, Geoffrey C. (2017). NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice. Journal of Hepatology, 66 (5), 1037-1046. doi: 10.1016/j.jhep.2017.01.022 |
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2017 Journal Article Active MLKL triggers the NLRP3 inflammasome in a cell intrinsic mannerConos, Stephanie A. , Chen, Kaiwen W. , De Nardo, Dominic , Hara, Hideki , Whitehead, Lachlan , Núñez, Gabriel , Masters, Seth L. , Murphy, James M. , Schroder, Kate , Vaux, David L. , Lawlor, Kate E. , Lindqvist, Lisa M. and Vince, James E. (2017). Active MLKL triggers the NLRP3 inflammasome in a cell intrinsic manner. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 114 (6), E961-E969. doi: 10.1073/pnas.1613305114 |
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2016 Journal Article Role of NLRP3 inflammasome in a model of acute burn-induced painDeuis, Jennifer R., Yin, Kathleen, Cooper, Matthew A., Schroder, Kate and Vetter, Irina (2016). Role of NLRP3 inflammasome in a model of acute burn-induced pain. Burns, 43 (2), 304-309. doi: 10.1016/j.burns.2016.09.001 |
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2016 Journal Article Salmonella-induced inflammasome activation in humansBierschenk, Damien, Boucher, Dave and Schroder, Kate (2016). Salmonella-induced inflammasome activation in humans. Molecular Immunology, 86, 38-43. doi: 10.1016/j.molimm.2016.11.009 |
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2016 Journal Article K+ efflux-independent NLRP3 inflammasome activation by small molecules targeting mitochondriaGroß, Christina J., Mishra, Ritu, Schneider, Katharina S., Médard, Guillaume, Wettmarshausen, Jennifer, Dittlein, Daniela C., Shi, Hexin, Gorka, Oliver, Koenig, Paul-Albert, Fromm, Stephan, Magnani, Giovanni, Ćiković, Tamara, Hartjes, Lara, Smollich, Joachim, Robertson, Avril A. B., Cooper, Matthew A., Schmidt-Supprian, Marc, Schuster, Michael, Schroder, Kate, Broz, Petr, Traidl-Hoffmann, Claudia, Beutler, Bruce, Kuster, Bernhard, Ruland, Jürgen, Schneider, Sabine, Perocchi, Fabiana and Groß, Olaf (2016). K+ efflux-independent NLRP3 inflammasome activation by small molecules targeting mitochondria. Immunity, 45 (4), 761-773. doi: 10.1016/j.immuni.2016.08.010 |
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2016 Other Outputs Sulfonylureas and related compounds and use of the sameO'Neill, Luke, Coll, Rebecca, Cooper, Matt, Robertson, Avril and Schroder, Kate (2016). Sulfonylureas and related compounds and use of the same. WO2016131098. |
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2016 Journal Article IL-1 contributes to the anti-cancer efficacy of ingenol mebutateLe, Thuy T., Skak, Kresten, Schroder, Kate, Schroder, Wayne A., Boyle, Glen M., Pierce, Carly J. and Suhrbier, Andreas (2016). IL-1 contributes to the anti-cancer efficacy of ingenol mebutate. PLoS One, 11 (4) e0153975, e0153975. doi: 10.1371/journal.pone.0153975 |
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2016 Journal Article Questions and Controversies in innate immune research: What is the physiological role of NLRP3?Coll, R. C., O'Neill, L. A. J. and Schroder, K. (2016). Questions and Controversies in innate immune research: What is the physiological role of NLRP3?. Cell Death Discovery, 2 (Art No.: 16019) 16019, 16019. doi: 10.1038/cddiscovery.2016.19 |
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2016 Journal Article The murine neutrophil NLRP3 inflammasome is activated by soluble but not particulate or crystalline agonistsChen, Kaiwen W., Bezbradica, Jelena S., Gross, Christina J., Wall, Adam A., Sweet, Matthew J., Stow, Jennifer L. and Schroder, Kate (2016). The murine neutrophil NLRP3 inflammasome is activated by soluble but not particulate or crystalline agonists. European Journal of Immunology, 46 (4), 1004-1010. doi: 10.1002/eji.201545943 |
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2016 Journal Article Familial auto inflammation with neutrophilic dermatosis reveals a novel regulatory mechanism of pyrin activationMasters, Seth L., Lagou, Vasiliki, Jéru, Isabelle, Baker, Paul J., Van Eyck, Lien, Parry, David A., Lawless, Dylan, De Nardo, Dominic, Garcia-Perez, Josselyn E., Dagley, Laura F., Holley, Caroline L., Dooley, James, Moghaddas, Fiona, Pasciuto, Emanuela, Jeandel, Pierre-Yves, Sciot, Raf, Lyras, Dena, Webb, Andrew I., Nicholson, Sandra E., De Somer, Lien, van Nieuwenhove, Erika, Ruuth-Praz, Julia, Copin, Bruno, Cochet, Emmanuelle, Medlej-Hashim, Myrna, Megarbane, Andre, Schroder, Kate, Savic, Sinisa, Goris, An ... Liston, Adrian (2016). Familial auto inflammation with neutrophilic dermatosis reveals a novel regulatory mechanism of pyrin activation. Science Translational Medicine, 8 (332) 332ra45, 1-9. doi: 10.1126/scitranslmed.aaf1471 |
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2016 Journal Article Sterile signals generate weaker and delayed macrophage NLRP3 inflammasome responses relative to microbial signalsBezbradica, Jelena S., Coll, Rebecca C. and Schroder, Kate (2016). Sterile signals generate weaker and delayed macrophage NLRP3 inflammasome responses relative to microbial signals. Cellular and Molecular Immunology, 1-9. doi: 10.1038/cmi.2016.11 |
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2016 Journal Article Salmonella employs multiple mechanisms to subvert the TLR-inducible zinc-mediated antimicrobial response of human macrophagesKapetanovic, Ronan, Bokil, Nilesh J., Achard, Maud E. S., Ong, Cheryl-lynn Y, Peters, Kate M., Stocks, Claudia J., Phan, Minh-Duy, Monteleone, Mercedes, Schroder, Kate, Irvine, Katharine M., Saunders, Bernadette M., Walker, Mark J., Stacey, Katryn J., McEwan, Alastair G., Schembri, Mark A. and Sweet, Matthew J. (2016). Salmonella employs multiple mechanisms to subvert the TLR-inducible zinc-mediated antimicrobial response of human macrophages. The FASEB Journal, 30 (5), 1901-1912. doi: 10.1096/fj.201500061 |
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2016 Journal Article Strain- and host species-specific inflammasome activation, IL-1β release, and cell death in macrophages infected with uropathogenic Escherichia coli.Schaale, K., Peters, K. M., Murthy, A. M., Fritzsche, A. K., Phan, M.-D., Totsika, M., Robertson, A. A. B., Nichols, K. B., Cooper, M. A., Stacey, K. J., Ulett, G. C., Schroder, K., Schembri, M. A. and Sweet, M. J. (2016). Strain- and host species-specific inflammasome activation, IL-1β release, and cell death in macrophages infected with uropathogenic Escherichia coli.. Mucosal Immunology, 9 (1), 124-136. doi: 10.1038/mi.2015.44 |
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2016 Conference Publication Molecular arrangement and activation of procaspases-1 and-8 at inflammasomesVajjhala, P., Lu, A., Brown, D., Sagulenko, V, Schroder, K., Stow, J., Wu, H. and Stacey, K. (2016). Molecular arrangement and activation of procaspases-1 and-8 at inflammasomes. ICI 2016 International Congress of Immunology, Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley. |
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2016 Journal Article The E3 ubiquitin ligase RNF144B is LPS-inducible in human but not mouse macrophages, and promotes inducible IL-1β expressionAriffin, Juliana K., Kapetanovic, Ronan, Schaale, Kolja, Gatica-Andrades, Marcela, Blumenthal, Antje, Schroder, Kate and Sweet, Matthew J. (2016). The E3 ubiquitin ligase RNF144B is LPS-inducible in human but not mouse macrophages, and promotes inducible IL-1β expression. Journal of Leukocyte Biology, 100 (1), 155-161. doi: 10.1189/jlb.2AB0815-339R |
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2016 Journal Article NLRP12 is a neutrophil-specific, negative regulator of in vitro cell migration but does not modulate LPS- or infection-induced NF-κB or ERK signallingZamoshnikova, Alina, Grob, Christina J., Schuster, Steffen, Chen, Kaiwen W., Wilson, Anne, Tacchini-Cottier, Fabienne and Schroder, Kate (2016). NLRP12 is a neutrophil-specific, negative regulator of in vitro cell migration but does not modulate LPS- or infection-induced NF-κB or ERK signalling. Immunobiology, 221 (2), 341-346. doi: 10.1016/j.imbio.2015.10.001 |
