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2025 Journal Article PEG-free lipid nanoparticles for mRNA delivery: superhydrophilic sulfoxide polymer coatingsChoy, On Ting, Fletcher, Nicholas L., Fu, Changkui, Vu, Mai N., Ediriweera, Gayathri R., Humphries, James, Hu, Mingdi, Kent, Stephen J., Cai, Rong, Chen, Chunying and Whittaker, Andrew K. (2025). PEG-free lipid nanoparticles for mRNA delivery: superhydrophilic sulfoxide polymer coatings. Biomacromolecules. doi: 10.1021/acs.biomac.5c01899 |
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2025 Journal Article Development of novel MnO2-based nanoparticles for PET/MRI-guided Alpha TherapyGulzar, Arif, Wang, Yanan, Balaji, Arunpandian, Fletcher, Nicholas and Thurecht, Kristofer (2025). Development of novel MnO2-based nanoparticles for PET/MRI-guided Alpha Therapy. Nuclear Medicine and Biology, 150-151 109532, 109532. doi: 10.1016/j.nucmedbio.2025.109532 |
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2025 Journal Article Trifunctional Albumin-Binding Constructs for Optimisation of In Vivo Delivery of Cancer Radio-TheranosticsHe, Xie (Kate), Thurecht, Kristofer, Fletcher, Nicholas, Bell, Craig and Kempe, Kristian (2025). Trifunctional Albumin-Binding Constructs for Optimisation of In Vivo Delivery of Cancer Radio-Theranostics. Nuclear Medicine and Biology, 150-151 109457, 109457. doi: 10.1016/j.nucmedbio.2025.109457 |
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2025 Journal Article Development of Thiosemicarbazonato Technetium-99m Complexes for SPECT ImagingMaclean, Rachel, Fletcher, Nicholas, Alsadig, Ahmed, Chu, Weijing, Sihver, Wiebke, Baraban, Larysa, Thurecht, Kristofer, Kubeil, Manja, Tuck, Kellie and Paterson, Brett (2025). Development of Thiosemicarbazonato Technetium-99m Complexes for SPECT Imaging. Nuclear Medicine and Biology, 150-151 109249, 109249. doi: 10.1016/j.nucmedbio.2025.109249 |
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2025 Journal Article D2 – Enabling a theranostic approach with 89Zr/177Lu in a single trifunctional ligand scaffoldWood, James, Ghosh, Saikat, Houston, Zachary, Fletcher, Nicholas, Humphries, James, Mardon, Karine, Akhter, Dewan, Tieu, William, Ivashkevich, Alesia, Wheatcroft, Michael, Thurecht, Kristofer and Codd, Rachel (2025). D2 – Enabling a theranostic approach with 89Zr/177Lu in a single trifunctional ligand scaffold. Nuclear Medicine and Biology, 150-151 109244, 109244. doi: 10.1016/j.nucmedbio.2025.109244 |
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2025 Journal Article Targeting the Oxytocin Receptor for Breast Cancer Imaging and RadiotherapyMuttenthaler, Markus, Perisic, Monika, Liu, Huiping, Kalaba, Predrag, Madge, Harrison, Dighe, Satish, Fletcher, Nicholas, Migotto, Mary-anne, Mardon, Karine, Thurecht, Kristofer, Keimpema, Erik and Gruber, Christian (2025). Targeting the Oxytocin Receptor for Breast Cancer Imaging and Radiotherapy. Nuclear Medicine and Biology, 150-151 109302, 109302. doi: 10.1016/j.nucmedbio.2025.109302 |
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2025 Journal Article Pre-targeting of PEG-based nanomedicines: precise delivery of potent payloadsFletcher, Nicholas, Thurecht, Kristofer, Chu, Weijing, Huda, Pie, Humphries, James and Wood, James (2025). Pre-targeting of PEG-based nanomedicines: precise delivery of potent payloads. Nuclear Medicine and Biology, 150-151 109150, 109150. doi: 10.1016/j.nucmedbio.2025.109150 |
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2025 Journal Article Preclinical Evaluation of [<sup>212</sup>Pb]Pb-ADVC001: A Prostate-Specific Membrane Antigen–Targeted α-Therapy for Prostate CancerLiu, Feifei, Monterosso, Melissa E., Boucher, Didier, Shakti, Stelle, Li, Kwong Ching, Kim, Chanwoo, Prior, Amber, Sydes, Abby, Soderholm, Amelia T., Fletcher, Nicholas, Akhter, Dewan, Thurecht, Kristofer, Tieu, William, Kuan, Kevin, Horsfall, Aimee, Kumar, Saawan, Koehbach, Johannes, Hammond, Edward, Karmann, Anna, Rose, Stephen, Li, Gary, Puttick, Simon and Kryza, Thomas (2025). Preclinical Evaluation of [212Pb]Pb-ADVC001: A Prostate-Specific Membrane Antigen–Targeted α-Therapy for Prostate Cancer. Journal of Nuclear Medicine, 66 (11), jnumed.125.269707-1713. doi: 10.2967/jnumed.125.269707 |
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2025 Journal Article Development of a novel engineered antibody format for PSMA-targeted radionuclide therapyFletcher, Nicholas L., Houston, Zachary H., Chandler, Peter G., Yan, Eddie, Holgate, Rob, Wheatcroft, Michael and Thurecht, Kristofer J. (2025). Development of a novel engineered antibody format for PSMA-targeted radionuclide therapy. Molecular Pharmaceutics, 22 (7), 3666-3678. doi: 10.1021/acs.molpharmaceut.4c01193 |
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2025 Journal Article Immune-modulating nanomedicines for enhanced drug delivery to non-small-cell lung cancerLiu, Feifei, Howard, Christopher B., Huda, Pie, Fletcher, Nicholas L., Bell, Craig A., Blakey, Idriss, Agrez, Michael and Thurecht, Kristofer J. (2025). Immune-modulating nanomedicines for enhanced drug delivery to non-small-cell lung cancer. Biomaterials, 317 123089, 1-14. doi: 10.1016/j.biomaterials.2025.123089 |
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2025 Journal Article Receptor CDCP1 is a potential target for personalized imaging and treatment of poor outcome HER2+, triple negative and metastatic ER+/HER2- breast cancersGough, Madeline, Kwah, Kayden KX., Khan, Tashbib, Ghosh, Saikat, Sun, Biao, Lee, Catherine YJ., Sokolowski, Kamil A., Tse, Brian WC., Wickramasuriya, Lashith, Ferguson, Kaltin, Rogers, Rebecca, Goh, Justin B., Fletcher, Nicholas L., Houston, Zachary H., Thurecht, Kristofer J., Bray, Laura J., Liu, Cheng, Pyke, Christopher, Lim, Elgene, Snell, Cameron E., He, Yaowu, Hooper, John D. and Kryza, Thomas (2025). Receptor CDCP1 is a potential target for personalized imaging and treatment of poor outcome HER2+, triple negative and metastatic ER+/HER2- breast cancers. Clinical Cancer Research, 31 (8), 1504-1519. doi: 10.1158/1078-0432.ccr-24-2865 |
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2025 Journal Article Harnessing nanoparticles and bioorthogonal chemistries for improving precision of nuclear medicineEdiriweera, Gayathri R., Li, Mengdie, Fletcher, Nicholas L., Houston, Zachary H., Ahamed, Muneer, Blakey, Idriss and Thurecht, Kristofer J. (2025). Harnessing nanoparticles and bioorthogonal chemistries for improving precision of nuclear medicine. Biomaterials Science, 13 (9), 2297-2319. doi: 10.1039/d4bm01387e |
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2025 Journal Article Lipid nanoparticles and transcranial focused ultrasound enhance the delivery of SOD1 antisense oligonucleotides to the murine brain for ALS therapyEdiriweera, Gayathri R., Sivaram, Amal J., Cowin, Gary, Brown, Mikayla L., McAlary, Luke, Lum, Jeremy S., Fletcher, Nicholas L., Robinson, Liam, Simpson, Joshua D., Chen, Liyu, Wasielewska, Joanna M., Byrne, Ella, Finnie, John W., Manavis, Jim, White, Anthony R., Yerbury, Justin J., Thurecht, Kristofer J. and Vine, Kara L. (2025). Lipid nanoparticles and transcranial focused ultrasound enhance the delivery of SOD1 antisense oligonucleotides to the murine brain for ALS therapy. Journal of Controlled Release, 378, 221-235. doi: 10.1016/j.jconrel.2024.11.074 |
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2025 Journal Article Nanobody-mediated cellular uptake maximizes the potency of polylysine dendrimers while preserving solid tumor penetrationYuen, Daniel, Feeney, Orlagh M., Noi, Leo, Shengule, Sudhir, McLeod, Victoria M., Reitano, Pauline, Tsegay, Sammi, Hufton, Richard, Houston, Zachary H., Fletcher, Nicholas L., Humphries, James, Thurecht, Kristofer J., Cullinane, Carleen, Owen, David J., Porter, Christopher J.H. and Johnston, Angus P.R. (2025). Nanobody-mediated cellular uptake maximizes the potency of polylysine dendrimers while preserving solid tumor penetration. ACS Nano, 19 (6), 6044-6057. doi: 10.1021/acsnano.4c10851 |
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2025 Journal Article Multiplexing label-free polymeric nanocarriers via antipolymer antibodiesHumphries, James, Hobson-Peters, Jody, Ghosh, Saikat, Howard, Christopher B., Huda, Pie, Bell, Craig A., Fletcher, Nicholas L., Kempe, Kristian and Thurecht, Kristofer J. (2025). Multiplexing label-free polymeric nanocarriers via antipolymer antibodies. ACS Sensors, 10 (2), 1280-1288. doi: 10.1021/acssensors.4c03184 |
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2024 Journal Article A novel immunomodulating peptide with potential to complement oligodeoxynucleotide-mediated adjuvanticity in vaccination strategiesAgrez, Michael, Chandler, Christopher, Thurecht, Kristofer J., Fletcher, Nicholas L., Liu, Feifei, Subramaniam, Gayathri, Howard, Christopher B., Parker, Stephen, Turner, Darryl, Rzepecka, Justyna, Knox, Gavin, Nika, Anastasia, Hall, Andrew M., Gooding, Hayley and Gallagher, Laura (2024). A novel immunomodulating peptide with potential to complement oligodeoxynucleotide-mediated adjuvanticity in vaccination strategies. Scientific Reports, 14 (1) 26737, 1-17. doi: 10.1038/s41598-024-78150-7 |
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2024 Journal Article Material trends and clinical costings in systematically identified CDER‐approved nanomedicinesJarrett, Thomas Ryan, Pregelj, Lisette, Bell, Craig Andrew, Fletcher, Nicholas Lyle and Thurecht, Kristofer James (2024). Material trends and clinical costings in systematically identified CDER‐approved nanomedicines. Advanced Therapeutics, 7 (10) 2400124. doi: 10.1002/adtp.202400124 |
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2024 Journal Article A first-in-class dual-chelator theranostic agent designed for use with imaging-therapy radiometal pairs of different elementsWood, James Liam, Ghosh, Saikat, Houston, Zachary, Fletcher, Nicholas, Humphries, James, Mardon, Karine, Akhter, Dewan T., Tieu, William, Ivashkevich, Alesia, Wheatcroft, Michael P., Thurecht, Kristofer J. and Codd, Rachel (2024). A first-in-class dual-chelator theranostic agent designed for use with imaging-therapy radiometal pairs of different elements. Chemical Science, 15 (30), 11748-11760. doi: 10.1039/d4sc02851a |
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2024 Journal Article Mitigating the effects of persistent antipolymer immune reactions in nanomedicine: Evaluating materials-based approaches using molecular imagingHumphries, James, Fletcher, Nicholas L., Sonderegger, Stefan E., Bell, Craig A., Kempe, Kristian and Thurecht, Kristofer J. (2024). Mitigating the effects of persistent antipolymer immune reactions in nanomedicine: Evaluating materials-based approaches using molecular imaging. ACS Nano, 18 (30), 19890-19904. doi: 10.1021/acsnano.4c07317 |
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2024 Journal Article Multifunctional fluoropolymer‐engineered magnetic nanoparticles to facilitate blood‐brain barrier penetration and effective gene silencing in medulloblastomaForgham, Helen, Zhu, Jiayuan, Huang, Xumin, Zhang, Cheng, Biggs, Heather, Liu, Liwei, Wang, Yi Cheng, Fletcher, Nicholas, Humphries, James, Cowin, Gary, Mardon, Karine, Kavallaris, Maria, Thurecht, Kristofer, Davis, Thomas P. and Qiao, Ruirui (2024). Multifunctional fluoropolymer‐engineered magnetic nanoparticles to facilitate blood‐brain barrier penetration and effective gene silencing in medulloblastoma. Advanced Science, 11 (25) 2401340, 1-20. doi: 10.1002/advs.202401340 |
