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2022 Journal Article On the utility of chemical strategies to improve peptide gut stabilityKremsmayr, Thomas, Aljnabi, Aws, Blanco-Canosa, Juan B., Tran, Hue N. T., Emidio, Nayara Braga and Muttenthaler, Markus (2022). On the utility of chemical strategies to improve peptide gut stability. Journal of Medicinal Chemistry, 65 (8), 6191-6206. doi: 10.1021/acs.jmedchem.2c00094 |
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2022 Book Chapter Fmoc Solid Phase Peptide Synthesis of Oxytocin and AnaloguesKremsmayr, Thomas and Muttenthaler, Markus (2022). Fmoc Solid Phase Peptide Synthesis of Oxytocin and Analogues. Methods in Molecular Biology. (pp. 175-199) New York, NY: Humana Press Inc.. doi: 10.1007/978-1-0716-1759-5_11 |
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2021 Journal Article Mucosal biofilms are an endoscopic feature of irritable bowel syndrome and ulcerative colitisBaumgartner, Maximilian, Lang, Michaela, Holley, Hunter, Crepaz, Daniel, Hausmann, Bela, Pjevac, Petra, Moser, Doris, Haller, Felix, Hof, Fabian, Beer, Andrea, Orgler, Elisabeth, Frick, Adrian, Khare, Vineeta, Evstatiev, Rayko, Strohmaier, Susanne, Primas, Christian, Dolak, Werner, Köcher, Thomas, Klavins, Kristaps, Rath, Timo, Neurath, Markus F., Berry, David, Makristathis, Athanasios, Muttenthaler, Markus and Gasche, Christoph (2021). Mucosal biofilms are an endoscopic feature of irritable bowel syndrome and ulcerative colitis. Gastroenterology, 161 (4), 1245-1256.e20. doi: 10.1053/j.gastro.2021.06.024 |
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2021 Journal Article Chemical synthesis of TFF3 reveals novel mechanistic insights and a gut-stable metaboliteBraga Emidio, Nayara, Meli, Rajeshwari, Tran, Hue N. T., Baik, Hayeon, Morisset-Lopez, Séverine, Elliott, Alysha G., Blaskovich, Mark A. T., Spiller, Sabrina, Beck-Sickinger, Annette G., Schroeder, Christina I. and Muttenthaler, Markus (2021). Chemical synthesis of TFF3 reveals novel mechanistic insights and a gut-stable metabolite. Journal of Medicinal Chemistry, 64 (13) acs.jmedchem.1c00767, 9484-9495. doi: 10.1021/acs.jmedchem.1c00767 |
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2021 Journal Article Improving the gastrointestinal stability of linaclotideBraga Emidio, Nayara, Tran, Hue N. T., Andersson, Asa, Dawson, Philip E., Albericio, Fernando, Vetter, Irina and Muttenthaler, Markus (2021). Improving the gastrointestinal stability of linaclotide. Journal of Medicinal Chemistry, 64 (12) acs.jmedchem.1c00380, 8384-8390. doi: 10.1021/acs.jmedchem.1c00380 |
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2021 Journal Article Trends in peptide drug discoveryMuttenthaler, Markus, King, Glenn F., Adams, David J. and Alewood, Paul F. (2021). Trends in peptide drug discovery. Nature Reviews Drug Discovery, 20 (4), 309-325. doi: 10.1038/s41573-020-00135-8 |
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2021 Journal Article Nature-inspired dimerization as a strategy to modulate neuropeptide pharmacology exemplified with vasopressin and oxytocinDekan, Zoltan, Kremsmayr, Thomas, Keov, Peter, Godin, Mathilde, Teakle, Ngari, Dürrauer, Leopold, Xiang, Huang, Gharib, Dalia, Bergmayr, Christian, Hellinger, Roland, Gay, Marina, Vilaseca, Marta, Kurzbach, Dennis, Albericio, Fernando, Alewood, Paul F., Gruber, Christian W. and Muttenthaler, Markus (2021). Nature-inspired dimerization as a strategy to modulate neuropeptide pharmacology exemplified with vasopressin and oxytocin. Chemical Science, 12 (11), 4057-4062. doi: 10.1039/d0sc05501h |
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2021 Journal Article Conformational selection of vasopressin upon V1a receptor bindingChe, Kateryna, Muttenthaler, Markus and Kurzbach, Dennis (2021). Conformational selection of vasopressin upon V1a receptor binding. Computational and Structural Biotechnology Journal, 19, 5826-5833. doi: 10.1016/j.csbj.2021.10.024 |
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2020 Journal Article Two for the price of one: heterobivalent ligand design targeting two binding sites on voltage-gated sodium channels slows ligand dissociation and enhances otencyPeschel, Alicia, Cardoso, Fernanda C., Walker, Andrew A., Durek, Thomas, Stone, M Rhia L., Braga Emidio, Nayara, Dawson, Philip E., Muttenthaler, Markus and King, Glenn F. (2020). Two for the price of one: heterobivalent ligand design targeting two binding sites on voltage-gated sodium channels slows ligand dissociation and enhances otency. Journal of Medicinal Chemistry, 63 (21), 12773-12785. doi: 10.1021/acs.jmedchem.0c01107 |
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2020 Journal Article Heterodimeric insecticidal peptide provides new insights into the molecular and functional diversity of ant venomsTouchard, Axel, Mendel, Helen C., Boulogne, Isabelle, Herzig, Volker, Braga Emidio, Nayara, King, Glenn F., Triquigneaux, Mathilde, Jaquillard, Lucie, Beroud, Rémy, De Waard, Michel, Delalande, Olivier, Dejean, Alain, Muttenthaler, Markus and Duplais, Christophe (2020). Heterodimeric insecticidal peptide provides new insights into the molecular and functional diversity of ant venoms. ACS Pharmacology and Translational Science, 3 (6) acsptsci.0c00119, 1211-1224. doi: 10.1021/acsptsci.0c00119 |
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2020 Journal Article The oxytocin receptor signalling system and breast cancer: a critical reviewLiu, Huiping, Gruber, Christian W., Alewood, Paul F., Möller, Andreas and Muttenthaler, Markus (2020). The oxytocin receptor signalling system and breast cancer: a critical review. Oncogene, 39 (37), 5917-5932. doi: 10.1038/s41388-020-01415-8 |
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2020 Journal Article Structure, function, and therapeutic potential of the trefoil factor family in the gastrointestinal tractBraga Emidio, Nayara, Brierley, Stuart M., Schroeder, Christina I. and Muttenthaler, Markus (2020). Structure, function, and therapeutic potential of the trefoil factor family in the gastrointestinal tract. ACS Pharmacology and Translational Science, 3 (4) acsptsci.0c00023, 583-597. doi: 10.1021/acsptsci.0c00023 |
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2020 Journal Article Neuropeptide signalling systems -an underexplored target for venom drug discoveryMendel, Helen C., Kaas, Quentin and Muttenthaler, Markus (2020). Neuropeptide signalling systems -an underexplored target for venom drug discovery. Biochemical Pharmacology, 181 114129, 114129. doi: 10.1016/j.bcp.2020.114129 |
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2020 Journal Article Correction: Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of actionBraga Emidio, Nayara, Baik, Hayeon, Lee, David, Stürmer, René, Heuer, Jörn, Elliott, Alysha G, Blaskovich, Mark A T, Haupenthal, Katharina, Tegtmeyer, Nicole, Hoffmann, Werner, Schroeder, Christina I and Muttenthaler, Markus (2020). Correction: Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action. Chemical communications (Cambridge, England), 56 (51), 7049-7049. doi: 10.1039/d0cc90250k |
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2020 Journal Article The tumor suppressor TFF1 occurs in different forms and interacts with multiple partners in the human gastric mucus barrier: indications for diverse protective functionsHeuer, Jörn, Heuer, Franziska, Stürmer, René, Harder, Sönke, Schlüter, Hartmut, Braga Emidio, Nayara, Muttenthaler, Markus, Jechorek, Dörthe, Meyer, Frank and Hoffmann, Werner (2020). The tumor suppressor TFF1 occurs in different forms and interacts with multiple partners in the human gastric mucus barrier: indications for diverse protective functions. International Journal of Molecular Sciences, 21 (7) 2508, 2508. doi: 10.3390/ijms21072508 |
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2020 Book Chapter Anhydrous hydrogen fluoride cleavage in boc solid phase peptide synthesisJadhav, Kirtikumar B, Woolcock, Katrina J and Muttenthaler, Markus (2020). Anhydrous hydrogen fluoride cleavage in boc solid phase peptide synthesis. Peptide Synthesis. (pp. 41-57) edited by Waleed M. Hussein, Mariusz Skwarczynski and Istvan Toth. New York, NY, United States: Humana. doi: 10.1007/978-1-0716-0227-0_4 |
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2020 Journal Article Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of actionBraga Emidio, Nayara, Baik, Hayeon, Lee, David, Stürmer, René, Heuer, Jörn, Elliott, Alysha G., Blaskovich, Mark A. T., Haupenthal, Katharina, Tegtmeyer, Nicole, Hoffmann, Werner, Schroeder, Christina I. and Muttenthaler, Markus (2020). Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action. Chemical Communications, 56 (47), 6420-6423. doi: 10.1039/d0cc02321c |
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2019 Journal Article I8-arachnotocin–an arthropod-derived G protein-biased ligand of the human vasopressin V2 receptorDuerrauer, Leopold, Muratspahić, Edin, Gattringer, Jasmin, Keov, Peter, Mendel, Helen C., Pfleger, Kevin D. G., Muttenthaler, Markus and Gruber, Christian W. (2019). I8-arachnotocin–an arthropod-derived G protein-biased ligand of the human vasopressin V2 receptor. Scientific Reports, 9 (1) 19295, 19295. doi: 10.1038/s41598-019-55675-w |
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2019 Journal Article Conotoxins: chemistry and biologyJin, Ai-Hua, Muttenthaler, Markus, Dutertre, Sebastien, Himaya, S.W.A., Kaas, Quentin, Craik, David J., Lewis, Richard J. and Alewood, Paul F. (2019). Conotoxins: chemistry and biology. Chemical Reviews, 119 (21), 11510-11549. doi: 10.1021/acs.chemrev.9b00207 |
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2019 Journal Article Trefoil Factor Family: Unresolved Questions and Clinical PerspectivesBraga Emidio, Nayara, Hoffmann, Werner, Brierley, Stuart M. and Muttenthaler, Markus (2019). Trefoil Factor Family: Unresolved Questions and Clinical Perspectives. Trends in Biochemical Sciences, 44 (5), 387-390. doi: 10.1016/j.tibs.2019.01.004 |
