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2022 Journal Article Don’t turn off the tap! The importance of discovery science to the Australian cardiovascular sector and improving clinical outcomes into the futureBursill, Christina A., Smith, Nicola J., Palpant, Nathan, Tan, Isabella, Sunde, Margaret, Harvey, Richard P., Lewis, Benjamin, Figtree, Gemma A., Vandenberg, Jamie I. and on behalf of the Australian Cardiovascular Alliance (2022). Don’t turn off the tap! The importance of discovery science to the Australian cardiovascular sector and improving clinical outcomes into the future. Heart, Lung and Circulation, 31 (10), 1321-1332. doi: 10.1016/j.hlc.2022.06.669 |
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2022 Journal Article Temporal perturbation of histone deacetylase activity reveals a requirement for HDAC1–3 in mesendoderm cell differentiationSinniah, Enakshi, Wu, Zhixuan, Shen, Sophie, Naval-Sanchez, Marina, Chen, Xiaoli, Lim, Junxian, Helfer, Abbigail, Iyer, Abishek, Tng, Jiahui, Lucke, Andrew J., Reid, Robert C., Redd, Meredith A., Nefzger, Christian M., Fairlie, David P. and Palpant, Nathan J. (2022). Temporal perturbation of histone deacetylase activity reveals a requirement for HDAC1–3 in mesendoderm cell differentiation. Cell Reports, 39 (7) 110818, 1-21. doi: 10.1016/j.celrep.2022.110818 |
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2021 Journal Article Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscleLo, Harriet P., Lim, Ye-Wheen, Xiong, Zherui, Martel, Nick, Ferguson, Charles, Ariotti, Nicholas, Giacomotto, Jean, Rae, James, Floetenmeyer, Matthias, Moradi, Shayli Varasteh, Gao, Ya, Tillu, Vikas A., Xia, Di, Wang, Huang, Rahnama, Samira, Nixon, Susan J., Bastiani, Michele, Day, Ryan D., Smith, Kelly A., Palpant, Nathan J., Johnston, Wayne A., Alexandrov, Kirill, Collins, Brett M., Hall, Thomas E. and Parton, Robert G. (2021). Cavin4 interacts with Bin1 to promote T-tubule formation and stability in developing skeletal muscle. Journal of Cell Biology, 220 (12) e201905065. doi: 10.1083/jcb.201905065 |
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2021 Journal Article scGPS: determining cell states and global fate potential of subpopulationsThompson, Michael, Matsumoto, Maika, Ma, Tianqi, Senabouth, Anne, Palpant, Nathan J., Powell, Joseph E. and Nguyen, Quan (2021). scGPS: determining cell states and global fate potential of subpopulations. Frontiers in Genetics, 12 666771, 666771. doi: 10.3389/fgene.2021.666771 |
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2021 Journal Article Elp2 mutations perturb the epitranscriptome and lead to a complex neurodevelopmental phenotypeKojic, Marija, Gawda, Tomasz, Gaik, Monika, Begg, Alexander, Salerno-Kochan, Anna, Kurniawan, Nyoman D., Jones, Alun, Drożdżyk, Katarzyna, Kościelniak, Anna, Chramiec-Głąbik, Andrzej, Hediyeh-Zadeh, Soroor, Kasherman, Maria, Shim, Woo Jun, Sinniah, Enakshi, Genovesi, Laura A., Abrahamsen, Rannvá K., Fenger, Christina D., Madsen, Camilla G., Cohen, Julie S., Fatemi, Ali, Stark, Zornitza, Lunke, Sebastian, Lee, Joy, Hansen, Jonas K., Boxill, Martin F., Keren, Boris, Marey, Isabelle, Saenz, Margarita S., Brown, Kathleen ... Wainwright, Brandon J. (2021). Elp2 mutations perturb the epitranscriptome and lead to a complex neurodevelopmental phenotype. Nature Communications, 12 (1) 2678, 2678. doi: 10.1038/s41467-021-22888-5 |
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2021 Journal Article Single cell eQTL analysis identifies cell type-specific genetic control of gene expression in fibroblasts and reprogrammed induced pluripotent stem cellsNeavin, Drew, Nguyen, Quan, Daniszewski, Maciej S., Liang, Helena H., Chiu, Han Sheng, Wee, Yong Kiat, Senabouth, Anne, Lukowski, Samuel W., Crombie, Duncan E., Lidgerwood, Grace E., Hernández, Damián, Vickers, James C., Cook, Anthony L., Palpant, Nathan J., Pébay, Alice, Hewitt, Alex W. and Powell, Joseph E. (2021). Single cell eQTL analysis identifies cell type-specific genetic control of gene expression in fibroblasts and reprogrammed induced pluripotent stem cells. Genome Biology, 22 (1) 76, 1-19. doi: 10.1186/s13059-021-02293-3 |
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2020 Journal Article Combined mesenchymal stromal cell therapy and ECMO in ARDS: a controlled experimental study in sheepMillar, Jonathan E., Bartnikowski, Nicole, Passmore, Margaret R., Obonyo, Nchafatso G, Malfertheiner, Maximillian V., von Bahr, Viktor, Redd, Meredith A., See Hoe, Louise, Ki, Katrina K., Pedersen, Sanne, Boyle, Andrew J., Baillie, J Kenneth, Shekar, Kiran, Palpant, Nathan, Suen, Jacky Y., Matthay, Michael A., McAuley, Daniel F., Fraser, John F. and Combining Extracorporeal Life Support and Cell Therapy in Critical Illness (CELTIC) investigators (2020). Combined mesenchymal stromal cell therapy and ECMO in ARDS: a controlled experimental study in sheep. American Journal of Respiratory and Critical Care Medicine, 202 (3) rccm.201911-2143OC, 383-392. doi: 10.1164/rccm.201911-2143oc |
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2019 Journal Article Genotype-free demultiplexing of pooled single-cell RNA-seqXu, Jun, Falconer, Caitlin, Nguyen, Quan, Crawford, Joanna, McKinnon, Brett D., Mortlock, Sally, Senabouth, Anne, Andersen, Stacey, Chiu, Han Sheng, Jiang, Longda, Palpant, Nathan J., Yang, Jian, Mueller, Michael D., Hewitt, Alex W., Pébay, Alice, Montgomery, Grant W., Powell, Joseph E. and Coin, Lachlan J. M. (2019). Genotype-free demultiplexing of pooled single-cell RNA-seq. Genome Biology, 20 (1) 290, 290. doi: 10.1186/s13059-019-1852-7 |
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2018 Journal Article Evidence for minimal cardiogenic potential of stem cell sntigen 1-positive cells in the adult mouse heartNeidig, Lauren E., Weinberger, Florian, Palpant, Nathan J., Mignone, John, Martinson, Amy M., Sorensen, Daniel W., Bender, Ingrid, Nemoto, Natsumi, Reinecke, Hans, Pabon, Lil, Molkentin, Jeffery D., Murry, Charles E. and van Berlo, Jop H. (2018). Evidence for minimal cardiogenic potential of stem cell sntigen 1-positive cells in the adult mouse heart. Circulation, 138 (25), 2960-2962. doi: 10.1161/CIRCULATIONAHA.118.035273 |
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2018 Journal Article Genetic lineage tracing of Sca-1 cells reveals endothelial but not myogenic contribution to the murine heartVagnozzi, Ronald J., Sargent, Michelle A., Lin, Suh-Chin J., Palpant, Nathan J., Murry, Charles E. and Molkentin, Jeffery D. (2018). Genetic lineage tracing of Sca-1 cells reveals endothelial but not myogenic contribution to the murine heart. Circulation, 138 (25), CIRCULATIONAHA.118.035210-2939. doi: 10.1161/CIRCULATIONAHA.118.035210 |
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2018 Journal Article Single-cell RNA-seq of human induced pluripotent stem cells reveals cellular heterogeneity and cell state transitions between subpopulationsNguyen, Quan H., Lukowski, Samuel W., Chiu, Han Sheng, Senabouth, Anne, Bruxner, Timothy J.C., Christ, Angelika N., Palpant, Nathan J. and Powell, Joseph E. (2018). Single-cell RNA-seq of human induced pluripotent stem cells reveals cellular heterogeneity and cell state transitions between subpopulations. Genome Research, 28 (7), 1053-1066. doi: 10.1101/gr.223925.117 |
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2018 Journal Article ALPK2 promotes cardiogenesis in zebrafish and human pluripotent stem cellsHofsteen, Peter, Robitaille, Aaron Mark, Strash, Nicholas, Palpant, Nathan, Moon, Randall T., Pabon, Lil and Murry, Charles E. (2018). ALPK2 promotes cardiogenesis in zebrafish and human pluripotent stem cells. iScience, 2, 88-100. doi: 10.1016/j.isci.2018.03.010 |
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2018 Journal Article Inducible CRISPR genome editing platform in naive human embryonic stem cells reveals JARID2 function in self-renewalFerreccio, Amy, Mathieu, Julie, Detraux, Damien, Logeshwaran, Somasundaram, Cavanaugh, Christopher, Sopher, Bryce, Fischer, Karin, Bello, Thomas, Hussein, Assis M., Levy, Shiri, Cook, Savannah, Sidhu, Sonia B, Artoni, Filippo, Palpant, Nathan J., Reinecke, Hans, Wang, Yuliang, Paddison, Patrick, Murry, Charles, Jayadev, Suman, Ware, Carol and Ruohola-Baker, Hannele (2018). Inducible CRISPR genome editing platform in naive human embryonic stem cells reveals JARID2 function in self-renewal. Cell Cycle, 17 (5), 1-15. doi: 10.1080/15384101.2018.1442621 |
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2017 Journal Article Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across speciesMuttenthaler, Markus, Andersson, Asa, Vetter, Irina, Menon, Rohit, Busnelli, Marta, Ragnarsson, Lotten, Bergmayr, Christian, Arrowsmith, Sarah, Deuis, Jennifer R., Chiu, Han Sheng, Palpant, Nathan J., O'Brien, Margaret, Smith, Terry J., Wray, Susan, Neumann, Inga D., Gruber, Christian W., Lewis, Richard J. and Alewood, Paul F. (2017). Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species. Science Signaling, 10 (508) eaan3398, 1-13. doi: 10.1126/scisignal.aan3398 |
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2017 Journal Article A transcribed enhancer dictates mesendoderm specification in pluripotencyAlexanian, Michael, Maric, Daniel, Jenkinson, Stephen P., Mina, Marco, Friedman, Clayton E., Ting, Ching-Chia, Micheletti, Rudi, Plaisance, Isabelle, Nemir, Mohamed, Maison, Damien, Kernen, Jasmin, Pezzuto, Iole, Villeneuve, Dominic, Burdet, Frederic, Ibberson, Mark, Leib, Stephen L., Palpant, Nathan J., Hernandez, Nouria, Ounzain, Samir and Pedrazzini, Thierry (2017). A transcribed enhancer dictates mesendoderm specification in pluripotency. Nature Communications, 8 (1) 1806, 1-19. doi: 10.1038/s41467-017-01804-w |
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2017 Journal Article Chromatin and transcriptional analysis of mesoderm progenitor cells identifies HOPX as a regulator of primitive hematopoiesisPalpant, Nathan J., Wang, Yuliang, Hadland, Brandon, Zaunbrecher, Rebecca J., Redd, Meredith, Jones, Daniel, Pabon, Lil, Jain, Rajan, Epstein, Jonathan, Ruzzo, Walter L., Zheng, Ying, Bernstein, Irwin, Margolin, Adam and Murry, Charles E. (2017). Chromatin and transcriptional analysis of mesoderm progenitor cells identifies HOPX as a regulator of primitive hematopoiesis. Cell Reports, 20 (7), 1597-1608. doi: 10.1016/j.celrep.2017.07.067 |
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2017 Journal Article Nkx2.5 marks angioblasts that contribute to hemogenic endothelium of the endocardium and dorsal aortaZamir, Lyad, Singh, Reena, Nathan, Elisha, Patrick, Ralph, Yifa, Oren, Yahalom-Ronen, Yfat, Arrafi, Alaa A., Schultheiss, Thomas M., Suo, Shengbao, Han, Jing-Dong Jackie, Peng, Guangdun, Jing, Naihe, Wang, Yuliang, Palpant, Nathan, Tam, Patrick P. L., Harveyz, Richard P. and Tzahor, Eldad (2017). Nkx2.5 marks angioblasts that contribute to hemogenic endothelium of the endocardium and dorsal aorta. ELife, 6 e20994. doi: 10.7554/eLife.20994 |
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2017 Journal Article Generating high-purity cardiac and endothelial derivatives from patterned mesoderm using human pluripotent stem cellsPalpant, Nathan J., Pabon, Lil, Friedman, Clayton E., Roberts, Meredith, Hadland, Brandon, Zaunbrecher, Rebecca J., Bernstein, Irwin, Zheng, Ying and Murry, Charles E. (2017). Generating high-purity cardiac and endothelial derivatives from patterned mesoderm using human pluripotent stem cells. Nature Protocols, 12 (1), 15-31. doi: 10.1038/nprot.2016.153 |
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2016 Journal Article Erratum to: Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development [Genome Biology, 16, (2016) (126)], DOI: 10.1186/s13059-015-0690-5Szabo, Linda, Morey, Robert, Palpant, Nathan J., Wang, Peter L., Afari, Nastaran, Jiang, Chuan, Parast, Mana M., Murry, Charles E., Laurent, Louise C. and Salzman, Julia (2016). Erratum to: Statistically based splicing detection reveals neural enrichment and tissue-specific induction of circular RNA during human fetal development [Genome Biology, 16, (2016) (126)], DOI: 10.1186/s13059-015-0690-5. Genome Biology, 17 (1) 263. doi: 10.1186/s13059-016-1123-9 |
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2016 Journal Article The developmental origins and lineage contributions of endocardial endotheliumNakano, Atsushi, Nakano, Haruko, Smith, Kelly A. and Palpant, Nathan J. (2016). The developmental origins and lineage contributions of endocardial endothelium. Biochimica et Biophysica Acta. Molecular Cell Research, 1863 (7), 1937-1947. doi: 10.1016/j.bbamcr.2016.01.022 |
