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2026

Journal Article

Computational modelling of cell identity

Shim, Woo Jun, Chow, Chris Siu Yeung, Bao, Shaine Chenxin, Zhao, Qiongyi and Palpant, Nathan J. (2026). Computational modelling of cell identity. Biochemical Journal, 483 (6), 1049-1071. doi: 10.1042/bcj20250132

Computational modelling of cell identity

2026

Journal Article

Identifying therapeutic targets in low‐grade serous ovarian carcinomas with no specific molecular profile

Pishas, Kathleen I, Cowley, Karla J, Marinovic, Evanny, Köbel, Martin, Llaurado‐Fernandez, Marta, Kim, Hannah, Bao, Shaine Chenxin, Mizikovsky, Dalia, Palpant, Nathan J, Shrestha, Raunak, Vary, Robert, Luu, Jennii, Meunier, Liliane, Semple, Timothy, Blancafort, Pilar, Golden, Emily, Cohen, Paul A, Carey, Mark S, Campbell, Ian G, Simpson, Kaylene J and Cheasley, Dane (2026). Identifying therapeutic targets in low‐grade serous ovarian carcinomas with no specific molecular profile. The Journal of Pathology path.70075. doi: 10.1002/path.70075

Identifying therapeutic targets in low‐grade serous ovarian carcinomas with no specific molecular profile

2026

Journal Article

Preparing healthcare providers to use polygenic risk scores: a qualitative study of learning needs and educational preferences

Clark, Amy, Wallingford, Courtney K., Berkman, Jennifer, McInerney-Leo, Aideen, Nisselle, Amy, Terrill, Bronwyn, Palpant, Nathan, Young, Mary-Anne, James, Paul A. and Yanes, Tatiane (2026). Preparing healthcare providers to use polygenic risk scores: a qualitative study of learning needs and educational preferences. BMJ Open, 16 (5) e111898, e111898-5. doi: 10.1136/bmjopen-2025-111898

Preparing healthcare providers to use polygenic risk scores: a qualitative study of learning needs and educational preferences

2026

Journal Article

A scalable, multi-resolution consensus clustering approach for prioritizing robust signals from high-throughput screens

Bao, Shaine Chenxin, Pishas, Kathleen I, Cowley, Karla J, Zhao, Qiongyi, Goodall, Emily C A, Henderson, Ian R, Liu, Xin, Marinovic, Evanny, Carey, Mark S, Campbell, Ian G, Simpson, Kaylene J, Cheasley, Dane, Mizikovsky, Dalia and Palpant, Nathan J (2026). A scalable, multi-resolution consensus clustering approach for prioritizing robust signals from high-throughput screens. Briefings in Bioinformatics, 27 (3) bbag242. doi: 10.1093/bib/bbag242

A scalable, multi-resolution consensus clustering approach for prioritizing robust signals from high-throughput screens

2026

Journal Article

Glycaemic variability underlies myocyte dysfunction and myocardial injury risk in diabetes

Cao, Yuanzhao, Redd, Meredith A., Outhwaite, Jennifer E., Mizikovsky, Dalia, Shim, Woo Jun, Fang, Chen, Vedelago, Courtney, Tan, Clarissa, Wu, Zhixuan, Daygon, Dara, Stark, Terra, Palfreyman, Robin, Chiu, Han Sheng, Thomas, Ulrich, Dragicevic, Elena, Sng, Julian D. J., Saez, Natalie J., Barrett, Helen L., Dorey, Emily S., King, Glenn F., Wuethrich, Alain, Trau, Matt, Shah, Sonia, Short, Kirsty R. and Palpant, Nathan J. (2026). Glycaemic variability underlies myocyte dysfunction and myocardial injury risk in diabetes. Nature Communications. doi: 10.1038/s41467-026-71809-x

Glycaemic variability underlies myocyte dysfunction and myocardial injury risk in diabetes

2026

Journal Article

Bacterial reporter–paired scRNA sequencing reveals cross talk between zinc starvation and zinc toxicity in macrophage antibacterial defense

von Pein, Jessica B., Andersen, Stacey B., Xu, Jon, Phan, Minh-Duy, Dalton, Emma K., Koczerka, Michael, Stocks, Claudia J., Curson, James E. B., Vandeleur, Zoe, Condon, Nicholas D., Hancock, Steven J., Nefzger, Christian M., Palpant, Nathan J., Ramnath, Divya, Kapetanovic, Ronan, Schembri, Mark A. and Sweet, Matthew J. (2026). Bacterial reporter–paired scRNA sequencing reveals cross talk between zinc starvation and zinc toxicity in macrophage antibacterial defense. Proceedings of the National Academy of Sciences, 123 (11) e2530503123, 1-12. doi: 10.1073/pnas.2530503123

Bacterial reporter–paired scRNA sequencing reveals cross talk between zinc starvation and zinc toxicity in macrophage antibacterial defense

2026

Journal Article

The changing landscape of gene expression analysis

Zhao, Qiongyi, Shen, Sophie, Shim, Woo Jun and Palpant, Nathan J. (2026). The changing landscape of gene expression analysis. Briefings in Bioinformatics, 27 (2) bbag185, 2. doi: 10.1093/bib/bbag185

The changing landscape of gene expression analysis

2026

Journal Article

Human Hearts Intrinsically Increase Cardiomyocyte Mitosis Following Myocardial Infarction

Hume, Robert, Warwick, Jessica, Shim, Woo Jun, Malecki, Cassandra, Li, Mengbo, Harney, Dylan, Slaughter, Eugene, Wang, XiaoSuo, Nguyen, Lisa, Cole, Louise, Edelman, James, Rashid, Fairooj, Houlahan, Callum, Gao, Antony, Ferguson, Angela, Chong, James, Larance, Mark, O'Sullivan, John, Palpant, Nathan, Bannon, Paul and Lal, Sean (2026). Human Hearts Intrinsically Increase Cardiomyocyte Mitosis Following Myocardial Infarction. Journal of Molecular and Cellular Cardiology Plus, 15 100505, 100505. doi: 10.1016/j.jmccpl.2025.100505

Human Hearts Intrinsically Increase Cardiomyocyte Mitosis Following Myocardial Infarction

2026

Journal Article

Hi1a delivered in various modes reduces myocardial infarct size in mice

Wu, Jianxin, Gao, Ling, Villanueva, Jeanette, Doyle, Aoife, Dutta, Sanjay, Joshi, Yashutosh, MacLean, Campbell, Kesteven, Scott, King, Glenn, Palpant, Nathan, Feneley, Michael, Iismaa, Siiri, Graham, Robert and Macdonald, Peter (2026). Hi1a delivered in various modes reduces myocardial infarct size in mice. Journal of Molecular and Cellular Cardiology Plus, 15 100753, 100753. doi: 10.1016/j.jmccpl.2025.100753

Hi1a delivered in various modes reduces myocardial infarct size in mice

2026

Journal Article

Nanopatterned cell sheet assembly of biomimetic cardiac laminae for modeling structure-function relationships

Jiao, Alex, Macadangdang, Jesse, Kim, Jinsung, Moerk, Charles Travis, Palpant, Nathan J., Mengsteab, Paulos Y., Park, Hyeon-Cheol, Murry, Charles E. and Kim, Deok-Ho (2026). Nanopatterned cell sheet assembly of biomimetic cardiac laminae for modeling structure-function relationships. Biomaterials Research, 30 0339, 1-12. doi: 10.34133/bmr.0339

Nanopatterned cell sheet assembly of biomimetic cardiac laminae for modeling structure-function relationships

2025

Journal Article

Conserved facultative heterochromatin across cell types identify regulatory sequences underpinning cell identity and disease

Sinniah, Enakshi, Mizikovsky, Dalia, Shim, Woo Jun, Chow, Chris Siu Yeung, Souilmi, Yassine, Cheng, Fei-Fei, Zeng, Zhili, Laurie, Jordan, Foster, Matthew, Shah, Sonia, Bodén, Mikael, Zeng, Jian, Llamas, Bastien and Palpant, Nathan J. (2025). Conserved facultative heterochromatin across cell types identify regulatory sequences underpinning cell identity and disease. Nucleic Acids Research, 53 (20) gkaf971, 1-23. doi: 10.1093/nar/gkaf971

Conserved facultative heterochromatin across cell types identify regulatory sequences underpinning cell identity and disease

2025

Journal Article

Epigenomics and transcriptomics profiles of developing zebrafish heart cells

Chahal, Gulrez, Eichenlaub, Michael P., Tondl, Markus, Pawlak, Michał, Mohenska, Monika, Grimm, Lin, Bottrell, Lauren, Drvodelic, Mark, Alaei, Sara, Hallab, Jeannette, Waylen, Lisa N., Polo, Jose M., Blanpain, Cédric, Palpant, Nathan, Rossello, Fernando J., Änkö, Minna-Liisa, Currie, Peter D., Hogan, Benjamin M., Winata, Cecilia, Salimova, Ekaterina, Nim, Hieu T. and Ramialison, Mirana (2025). Epigenomics and transcriptomics profiles of developing zebrafish heart cells. Scientific Data, 12 (1) 1620, 1-10. doi: 10.1038/s41597-025-05895-9

Epigenomics and transcriptomics profiles of developing zebrafish heart cells

2025

Journal Article

A pluripotent stem cell atlas of multilineage differentiation

Shen, Sophie, Werner, Tessa, Chiu, Han Sheng, Chen, Xiaoli, Nguyen, Quan and Palpant, Nathan J. (2025). A pluripotent stem cell atlas of multilineage differentiation. Scientific Data, 12 (1) 1238, 1238. doi: 10.1038/s41597-025-05549-w

A pluripotent stem cell atlas of multilineage differentiation

2025

Journal Article

Atlas of multilineage stem cell differentiation reveals TMEM88 as a developmental regulator of blood pressure

Shen, Sophie, Werner, Tessa, Lukowski, Samuel W., Andersen, Stacey, Sun, Yuliangzi, Shim, Woo Jun, Mizikovsky, Dalia, Kobayashi, Sakurako, Outhwaite, Jennifer, Chiu, Han Sheng, Chen, Xiaoli, Chapman, Gavin, Martin, Ella M. M. A., Xia, Di, Pham, Duy, Su, Zezhuo, Kim, Daniel, Yang, Pengyi, Tan, Men Chee, Sinniah, Enakshi, Zhao, Qiongyi, Negi, Sumedha, Redd, Meredith A., Powell, Joseph E., Dunwoodie, Sally L., Tam, Patrick P. L., Bodén, Mikael, Ho, Joshua W. K., Nguyen, Quan and Palpant, Nathan J. (2025). Atlas of multilineage stem cell differentiation reveals TMEM88 as a developmental regulator of blood pressure. Nature Communications, 16 (1) 1356, 1-19. doi: 10.1038/s41467-025-56533-2

Atlas of multilineage stem cell differentiation reveals TMEM88 as a developmental regulator of blood pressure

2025

Journal Article

Glycaemic variability underlies myocyte dysfunction and myocardial injury risk in diabetes

Cao, Yuanzhao, Redd, Meredith, Outhwaite, Jennifer, Mizikovsky, Dalia, Shim, Woo Jun, Fang, Chen, Wu, Zhixuan, Daygon, Dara, Stark, Terra, Palfreyman, Robin, Chiu, Han Sheng, Tan, Clarissa, Thomas, Ulrich, Dragicevic, Elena, Sng, Julian, Barrett, Helen, Dorey, Emily, Shah, Sonia, Short, Kirsty and Palpant, Nathan J. (2025). Glycaemic variability underlies myocyte dysfunction and myocardial injury risk in diabetes. doi: 10.1101/2025.01.29.635173

Glycaemic variability underlies myocyte dysfunction and myocardial injury risk in diabetes

2025

Journal Article

Human hearts intrinsically increase cardiomyocyte mitosis after myocardial infarction

Hume, Robert D., Warwick, Jessica, Shim, Woo Jun, Malecki, Cassandra, Li, Mengbo, Seth, Lakshay, Harney, Dylan, Dagher, Julien, Lum, Trina, Tierney, Geraldine, Cooper, Wendy, Slaughter, Eugene, Wang, Xiaosuo, Nguyen, Lisa, Cole, Louise, Edelman, James, Rashid, Fairooj, Houlahan, Callum, Gao, Antony, Ferguson, Angela L., Chong, James J.H., Larance, Mark, O’Sullivan, John, Palpant, Nathan J., Bannon, Paul and Lal, Sean (2025). Human hearts intrinsically increase cardiomyocyte mitosis after myocardial infarction. Circulation Research, 138 (2) e327486, 367-382. doi: 10.1161/circresaha.125.327486

Human hearts intrinsically increase cardiomyocyte mitosis after myocardial infarction

2025

Journal Article

TRIAGE: an R package for regulatory gene analysis

Zhao, Qiongyi, Shim, Woo Jun, Sun, Yuliangzi, Sinniah, Enakshi, Shen, Sophie, Boden, Mikael and Palpant, Nathan J. (2025). TRIAGE: an R package for regulatory gene analysis. Briefings in Bioinformatics, 26 (1) bbaf004, 1-13. doi: 10.1093/bib/bbaf004

TRIAGE: an R package for regulatory gene analysis

2024

Journal Article

Post-acute sequelae of SARS-CoV-2 cardiovascular symptoms are associated with trace-level cytokines that affect cardiomyocyte function

Sinclair, Jane E., Vedelago, Courtney, Ryan, Feargal J., Carney, Meagan, Redd, Meredith A., Lynn, Miriam A., Grubor-Bauk, Branka, Cao, Yuanzhao, Henders, Anjali K., Chew, Keng Yih, Gilroy, Deborah, Greaves, Kim, Labzin, Larisa, Ziser, Laura, Ronacher, Katharina, Wallace, Leanne M., Zhang, Yiwen, Macauslane, Kyle, Ellis, Daniel J., Rao, Sudha, Burr, Lucy, Bain, Amanda, Karawita, Anjana, Schulz, Benjamin L., Li, Junrong, Lynn, David J., Palpant, Nathan, Wuethrich, Alain, Trau, Matt and Short, Kirsty R. (2024). Post-acute sequelae of SARS-CoV-2 cardiovascular symptoms are associated with trace-level cytokines that affect cardiomyocyte function. Nature Microbiology, 9 (12), 1-13. doi: 10.1038/s41564-024-01838-z

Post-acute sequelae of SARS-CoV-2 cardiovascular symptoms are associated with trace-level cytokines that affect cardiomyocyte function

2024

Journal Article

A community-oriented, data-driven resource to improve protocol design for cardiac modelling from human pluripotent stem cells

Chow, Chris Siu Yeung, Negi, Sumedha, Bao, Shaine, Fang, Chen, Hudson, James, Shim, Woo Jun, Yuanzhao Cao and Palpant, Nathan (2024). A community-oriented, data-driven resource to improve protocol design for cardiac modelling from human pluripotent stem cells. doi: 10.1101/2024.09.04.611313

A community-oriented, data-driven resource to improve protocol design for cardiac modelling from human pluripotent stem cells

2024

Journal Article

Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarction

Redd, Meredith A, Yoshikawa, Yusuke, Khan, Nemat, Waqar, Maleeha, Saez, Natalie J, Outhwaite, Jennifer E, Russell, Jake S, Hanna, Amy D, Chiu, Han S, Er, Sing Yan, Butcher, Neville J, Mardon, Karine, Fraser, John F, Smythe, Mark L, Rash, Lachlan D, Thomas, Walter G, King, Glenn F, Reichelt, Melissa E and Palpant, Nathan J (2024). Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarction. European Heart Journal, 45 (17), 1571-1574. doi: 10.1093/eurheartj/ehad793

Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarction