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2024

Journal Article

Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarction

Redd, Meredith A, Yoshikawa, Yusuke, Khan, Nemat, Waqar, Maleeha, Saez, Natalie J, Outhwaite, Jennifer E, Russell, Jake S, Hanna, Amy D, Chiu, Han S, Er, Sing Yan, Butcher, Neville J, Mardon, Karine, Fraser, John F, Smythe, Mark L, Rash, Lachlan D, Thomas, Walter G, King, Glenn F, Reichelt, Melissa E and Palpant, Nathan J (2024). Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarction. European Heart Journal, 45 (17), 1571-1574. doi: 10.1093/eurheartj/ehad793

Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarction

2024

Journal Article

Wnt dose escalation during the exit from pluripotency identifies tranilast as a regulator of cardiac mesoderm

Wu, Zhixuan, Shen, Sophie, Mizikovsky, Dalia, Cao, Yuanzhao, Naval-Sanchez, Marina, Tan, Siew Zhuan, Alvarez, Yanina D., Sun, Yuliangzi, Chen, Xiaoli, Zhao, Qiongyi, Kim, Daniel, Yang, Pengyi, Hill, Timothy A., Jones, Alun, Fairlie, David P., Pébay, Alice, Hewitt, Alex W., Tam, Patrick P.L., White, Melanie D., Nefzger, Christian M. and Palpant, Nathan J. (2024). Wnt dose escalation during the exit from pluripotency identifies tranilast as a regulator of cardiac mesoderm. Developmental Cell, 59 (6), 705-722.e8. doi: 10.1016/j.devcel.2024.01.019

Wnt dose escalation during the exit from pluripotency identifies tranilast as a regulator of cardiac mesoderm

2023

Journal Article

HOPX-associated molecular programs control cardiomyocyte cell states underpinning cardiac structure and function

Friedman, Clayton E., Cheetham, Seth W., Negi, Sumedha, Mills, Richard J., Ogawa, Masahito, Redd, Meredith A., Chiu, Han Sheng, Shen, Sophie, Sun, Yuliangzi, Mizikovsky, Dalia, Bouveret, Romaric, Chen, Xiaoli, Voges, Holly K., Paterson, Scott, De Angelis, Jessica E., Andersen, Stacey B., Cao, Yuanzhao, Wu, Yang, Jafrani, Yohaann M.A., Yoon, Sohye, Faulkner, Geoffrey J., Smith, Kelly A., Porrello, Enzo, Harvey, Richard P., Hogan, Benjamin M., Nguyen, Quan, Zeng, Jian, Kikuchi, Kazu, Hudson, James E. and Palpant, Nathan J. (2023). HOPX-associated molecular programs control cardiomyocyte cell states underpinning cardiac structure and function. Developmental Cell, 59 (1), 91-107.e1. doi: 10.1016/j.devcel.2023.11.012

HOPX-associated molecular programs control cardiomyocyte cell states underpinning cardiac structure and function

2023

Journal Article

Inferring cell diversity in single cell data using consortium-scale epigenetic data as a biological anchor for cell identity

Sun, Yuliangzi, Shim, Woo Jun, Shen, Sophie, Sinniah, Enakshi, Pham, Duy, Su, Zezhuo, Mizikovsky, Dalia, White, Melanie D., Ho, Joshua W. K., Nguyen, Quan, Bodén, Mikael and Palpant, Nathan J (2023). Inferring cell diversity in single cell data using consortium-scale epigenetic data as a biological anchor for cell identity. Nucleic Acids Research, 51 (11), e62-e62. doi: 10.1093/nar/gkad307

Inferring cell diversity in single cell data using consortium-scale epigenetic data as a biological anchor for cell identity

2022

Journal Article

Organization of gene programs revealed by unsupervised analysis of diverse gene–trait associations

Mizikovsky, Dalia, Naval Sanchez, Marina, Nefzger, Christian M, Cuellar Partida, Gabriel and Palpant, Nathan J (2022). Organization of gene programs revealed by unsupervised analysis of diverse gene–trait associations. Nucleic Acids Research, 50 (15) e87, 1-12. doi: 10.1093/nar/gkac413

Organization of gene programs revealed by unsupervised analysis of diverse gene–trait associations

2021

Journal Article

Integrating single-cell genomics pipelines to discover mechanisms of stem cell differentiation

Shen, Sophie, Sun, Yuliangzi, Matsumoto, Maika, Shim, Woo Jun, Sinniah, Enakshi, Wilson, Sean B., Werner, Tessa, Wu, Zhixuan, Bradford, Stephen T., Hudson, James, Little, Melissa H., Powell, Joseph, Nguyen, Quan and Palpant, Nathan J. (2021). Integrating single-cell genomics pipelines to discover mechanisms of stem cell differentiation. Trends in Molecular Medicine, 27 (12), 1135-1158. doi: 10.1016/j.molmed.2021.09.006

Integrating single-cell genomics pipelines to discover mechanisms of stem cell differentiation

2021

Journal Article

Therapeutic inhibition of acid sensing ion channel 1a recovers heart function after ischemia-reperfusion injury

Redd, Meredith A., Scheuer, Sarah E., Saez, Natalie J., Yoshikawa, Yusuke, Chiu, Han Sheng, Gao, Ling, Hicks, Mark, Villanueva, Jeanette E., Joshi, Yashutosh, Chow, Chun Yuen, Cuellar-Partida, Gabriel, Peart, Jason N., See Hoe, Louise E., Chen, Xiaoli, Sun, Yuliangzi, Suen, Jacky Y., Hatch, Robert J., Rollo, Ben, Xiao, Di, Alzubaidi, Mubarak A.H., Maljevic, Snezana, Quaife-Ryan, Gregory A., Hudson, James E., Porrello, Enzo R., White, Melanie Y., Cordwell, Stuart J., Fraser, John F., Petrou, Steven, Reichelt, Melissa E. ... Palpant, Nathan J. (2021). Therapeutic inhibition of acid sensing ion channel 1a recovers heart function after ischemia-reperfusion injury. Circulation, 144 (12), 947-960. doi: 10.1161/circulationaha.121.054360

Therapeutic inhibition of acid sensing ion channel 1a recovers heart function after ischemia-reperfusion injury

2020

Journal Article

Conserved epigenetic regulatory logic infers genes governing cell identity

Shim, Woo Jun, Sinniah, Enakshi, Xu, Jun, Vitrinel, Burcu, Alexanian, Michael, Andreoletti, Gaia, Shen, Sophie, Sun, Yuliangzi, Balderson, Brad, Boix, Carles, Peng, Guangdun, Jing, Naihe, Wang, Yuliang, Kellis, Manolis, Tam, Patrick P L, Smith, Aaron, Piper, Michael, Christiaen, Lionel, Nguyen, Quan, Bodén, Mikael and Palpant, Nathan J. (2020). Conserved epigenetic regulatory logic infers genes governing cell identity. Cell Systems, 11 (6), 625-639.e13. doi: 10.1016/j.cels.2020.11.001

Conserved epigenetic regulatory logic infers genes governing cell identity

2018

Journal Article

Single-cell transcriptomic analysis of cardiac differentiation from human PSCs reveals HOPX-dependent cardiomyocyte maturation

Friedman, Clayton E., Nguyen, Quan, Lukowski, Samuel W., Helfer, Abbigail, Chiu, Han Sheng, Miklas, Jason, Levy, Shiri, Suo, Shengbao, Han, Jing-Dong Jackie, Osteil, Pierre, Peng, Guangdun, Jing, Naihe, Baillie, Greg J., Senabouth, Anne, Christ, Angelika N., Bruxner, Timothy J., Murry, Charles E., Wong, Emily S., Ding, Jun, Wang, Yuliang, Hudson, James, Ruohola-Baker, Hannele, Bar-Joseph, Ziv, Tam, Patrick P.L., Powell, Joseph E. and Palpant, Nathan J. (2018). Single-cell transcriptomic analysis of cardiac differentiation from human PSCs reveals HOPX-dependent cardiomyocyte maturation. Cell Stem Cell, 23 (4), 586-598. doi: 10.1016/j.stem.2018.09.009

Single-cell transcriptomic analysis of cardiac differentiation from human PSCs reveals HOPX-dependent cardiomyocyte maturation

2024

Journal Article

448.5: Improved recovery of rat hearts after prolonged cold storage by acid sensing ion channel (ASIC) inhibitor Hi1a varies with preservation solution

Dutta, Sanjay, Villanueva, Jeanette E, Gao, Ling, Doyle, Aoife, Palpant, Nathan, King, Glenn and Macdonald, Peter S (2024). 448.5: Improved recovery of rat hearts after prolonged cold storage by acid sensing ion channel (ASIC) inhibitor Hi1a varies with preservation solution. Transplantation, 108 (9S). doi: 10.1097/01.tp.0001066648.27486.ce

448.5: Improved recovery of rat hearts after prolonged cold storage by acid sensing ion channel (ASIC) inhibitor Hi1a varies with preservation solution

2024

Conference Publication

Trastuzumab-Induced Cardiotoxicity Involves Antibody Dependent Cell Cytotoxicity (ADCC)

Griffiths, L., Ho, U., Burt, K., Watson, S., Patel, K., Bradford, J., Tan, C., Bhavsar, C., Palpant, N., Souza-Fonseca-Guimaraes, F., Wu, S., Reichelt, M. and Thomas, W. (2024). Trastuzumab-Induced Cardiotoxicity Involves Antibody Dependent Cell Cytotoxicity (ADCC). 72nd Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand, Perth, WA Australia, 1-4 August 2024. Chatswood, NSW Australia: Elsevier. doi: 10.1016/j.hlc.2024.06.397

Trastuzumab-Induced Cardiotoxicity Involves Antibody Dependent Cell Cytotoxicity (ADCC)

2024

Conference Publication

Preclinical models of Glycaemic variability recapitulate Clinical Cardiovascular outcomes in Diabetes

Cao, Y., Redd, M., Outhwaite, J., Shim, W., Fang, C., Negi, S., Shen, S., Mizikovsky, D., Chiu, H., Tan, C., Thomas, U., Dragicevic, E., Sng, J., Short, K. and Palpant, N. (2024). Preclinical models of Glycaemic variability recapitulate Clinical Cardiovascular outcomes in Diabetes. 72nd Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand, Perth, WA Australia, 1-4 August 2024. Chatswood, NSW Australia: Elsevier. doi: 10.1016/j.hlc.2024.06.332

Preclinical models of Glycaemic variability recapitulate Clinical Cardiovascular outcomes in Diabetes

2024

Conference Publication

Dissecting the Role of Hopx Variants in Cardiac Remodelling and Dysfunction

Hanna, A., Negi, S., Outhwaite, J., Cheng, T., Tan, C., Chen, J., Fatkin, D., Haas, J. and Palpant, N. (2024). Dissecting the Role of Hopx Variants in Cardiac Remodelling and Dysfunction. International Clinical Cardiovascular Genetics Conference 2024, Brisbane, QLD Australia, 8-10 May 2024. Chatswood, NSW Australia: Elsevier. doi: 10.1016/j.hlc.2024.04.189

Dissecting the Role of Hopx Variants in Cardiac Remodelling and Dysfunction

2024

Other Outputs

Cell cultures and methods of use thereof

Hewitt, Alex, Powell, Joseph, Neavin, Drew, Farbehi, Nona, Pebay, Alice, Daniszewski, Maciej and Palpant, Nathan (2024). Cell cultures and methods of use thereof. 2023901013.

Cell cultures and methods of use thereof

2024

Journal Article

High-content fluorescence bioassay investigates pore formation, ion channel modulation and cell membrane lysis induced by venoms

Kramer, Simon, Kotapati, Charan, Cao, Yuanzhao, Fry, Bryan G., Palpant, Nathan J., King, Glenn F. and Cardoso, Fernanda C. (2024). High-content fluorescence bioassay investigates pore formation, ion channel modulation and cell membrane lysis induced by venoms. Toxicon: X, 21 100184, 100184. doi: 10.1016/j.toxcx.2024.100184

High-content fluorescence bioassay investigates pore formation, ion channel modulation and cell membrane lysis induced by venoms

2024

Journal Article

Cellular heterogeneity of pluripotent stem cell-derived cardiomyocyte grafts is mechanistically linked to treatable arrhythmias

Selvakumar, Dinesh, Clayton, Zoe E., Prowse, Andrew, Dingwall, Steve, Kim, Sul Ki, Reyes, Leila, George, Jacob, Shah, Haisam, Chen, Siqi, Leung, Halina H. L., Hume, Robert D., Tjahjadi, Laurentius, Igoor, Sindhu, Skelton, Rhys J. P., Hing, Alfred, Paterson, Hugh, Foster, Sheryl L., Pearson, Lachlan, Wilkie, Emma, Marcus, Alan D., Jeyaprakash, Prajith, Wu, Zhixuan, Chiu, Han Shen, Ongtengco, Cherica Felize J., Mulay, Onkar, McArthur, Jeffrey R., Barry, Tony, Lu, Juntang, Tran, Vu ... Chong, James J. H. (2024). Cellular heterogeneity of pluripotent stem cell-derived cardiomyocyte grafts is mechanistically linked to treatable arrhythmias. Nature Cardiovascular Research, 3 (2), 145-165. doi: 10.1038/s44161-023-00419-3

Cellular heterogeneity of pluripotent stem cell-derived cardiomyocyte grafts is mechanistically linked to treatable arrhythmias

2024

Conference Publication

How the Australian Functional Genomics Network (AFGN) contributes to improved patient care

Scott, Hamish S., Matotek, Ebony, Mattiske, Tessa, Bryson-Richardson, Robert J., Smyth, Ian, Gecz, Jozef, Christodoulou, John, Palpant, Nathan, Smith, Kelly, Warr, Coral, Bennetts, Bruce, Thomas, Paul, Bowles, Josephine, Hilliard, Massimo, Hime, Gary, Hool, Livia, Quinn, Leonie, Wolvetang, Ernst, Jamieson, Robyn, Baynam, Gareth, Dudding-Byth, Tracy, Tan, Tiong Yang, Milnes, Di, Wallis, Mathew, Palmer, Elizabeth, Patel, Chirag, Jones, Kristi, Tam, Patrick, Stark, Zornitza ... Sinclair, Andrew (2024). How the Australian Functional Genomics Network (AFGN) contributes to improved patient care. Pathology Update 2024, Adelaide, SA, Australia, 1-3 March 2024. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.pathol.2023.12.084

How the Australian Functional Genomics Network (AFGN) contributes to improved patient care

2023

Conference Publication

Disease modeling utilizing human pluripotent stem cell-derived cardiomyocytes and physiological characterization

Cao, Yuanzhao, Redd, Meredith A., Shim, Woo Jun, Fang, Chen, Chiu, Han, Azofeifa, Daniela Rojas, Thomas, Ulrich, Lemme, Marta, Dragicevic, Elena, Stoelzle-Feix, Sonja and Palpant, Nathan J. (2023). Disease modeling utilizing human pluripotent stem cell-derived cardiomyocytes and physiological characterization. Safety Pharmacology Society Annual Meeting, Brussels, Belgium, 18-21 September 2023. Philadelphia, PA United States: Elsevier. doi: 10.1016/j.vascn.2023.107267

Disease modeling utilizing human pluripotent stem cell-derived cardiomyocytes and physiological characterization

2023

Journal Article

A village in a dish model system for population-scale hiPSC studies

Neavin, Drew R., Steinmann, Angela M., Farbehi, Nona, Chiu, Han Sheng, Daniszewski, Maciej S., Arora, Himanshi, Bermudez, Yasmin, Moutinho, Cátia, Chan, Chia-Ling, Bax, Monique, Tyebally, Mubarika, Gnanasambandapillai, Vikkitharan, Lam, Chuan E., Nguyen, Uyen, Hernández, Damián, Lidgerwood, Grace E., Graham, Robert M., Hewitt, Alex W., Pébay, Alice, Palpant, Nathan J. and Powell, Joseph E. (2023). A village in a dish model system for population-scale hiPSC studies. Nature Communications, 14 (1) 3240, 1-12. doi: 10.1038/s41467-023-38704-1

A village in a dish model system for population-scale hiPSC studies

2023

Journal Article

Vascular cells improve functionality of human cardiac organoids

Voges, Holly K., Foster, Simon R., Reynolds, Liam, Parker, Benjamin L., Devilée, Lynn, Quaife-Ryan, Gregory A., Fortuna, Patrick R.J., Mathieson, Ellen, Fitzsimmons, Rebecca, Lor, Mary, Batho, Christopher, Reid, Janice, Pocock, Mark, Friedman, Clayton E., Mizikovsky, Dalia, Francois, Mathias, Palpant, Nathan J., Needham, Elise J., Peralta, Marina, Monte-Nieto, Gonzalo del, Jones, Lynelle K., Smyth, Ian M., Mehdiabadi, Neda R., Bolk, Francesca, Janbandhu, Vaibhao, Yao, Ernestene, Harvey, Richard P., Chong, James J.H., Elliott, David A. ... Hudson, James E. (2023). Vascular cells improve functionality of human cardiac organoids. Cell Reports, 42 (5) 112322, 112322. doi: 10.1016/j.celrep.2023.112322

Vascular cells improve functionality of human cardiac organoids