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2026

Journal Article

Bacterial reporter–paired scRNA sequencing reveals cross talk between zinc starvation and zinc toxicity in macrophage antibacterial defense

von Pein, Jessica B., Andersen, Stacey B., Xu, Jon, Phan, Minh-Duy, Dalton, Emma K., Koczerka, Michael, Stocks, Claudia J., Curson, James E. B., Vandeleur, Zoe, Condon, Nicholas D., Hancock, Steven J., Nefzger, Christian M., Palpant, Nathan J., Ramnath, Divya, Kapetanovic, Ronan, Schembri, Mark A. and Sweet, Matthew J. (2026). Bacterial reporter–paired scRNA sequencing reveals cross talk between zinc starvation and zinc toxicity in macrophage antibacterial defense. Proceedings of the National Academy of Sciences, 123 (11) e2530503123, e2530503123. doi: 10.1073/pnas.2530503123

Bacterial reporter–paired scRNA sequencing reveals cross talk between zinc starvation and zinc toxicity in macrophage antibacterial defense

2025

Journal Article

Conserved facultative heterochromatin across cell types identify regulatory sequences underpinning cell identity and disease

Sinniah, Enakshi, Mizikovsky, Dalia, Shim, Woo Jun, Chow, Chris Siu Yeung, Souilmi, Yassine, Cheng, Fei-Fei, Zeng, Zhili, Laurie, Jordan, Foster, Matthew, Shah, Sonia, Bodén, Mikael, Zeng, Jian, Llamas, Bastien and Palpant, Nathan J. (2025). Conserved facultative heterochromatin across cell types identify regulatory sequences underpinning cell identity and disease. Nucleic Acids Research, 53 (20) gkaf971, 1-23. doi: 10.1093/nar/gkaf971

Conserved facultative heterochromatin across cell types identify regulatory sequences underpinning cell identity and disease

2025

Journal Article

Epigenomics and transcriptomics profiles of developing zebrafish heart cells

Chahal, Gulrez, Eichenlaub, Michael P., Tondl, Markus, Pawlak, Michał, Mohenska, Monika, Grimm, Lin, Bottrell, Lauren, Drvodelic, Mark, Alaei, Sara, Hallab, Jeannette, Waylen, Lisa N., Polo, Jose M., Blanpain, Cédric, Palpant, Nathan, Rossello, Fernando J., Änkö, Minna-Liisa, Currie, Peter D., Hogan, Benjamin M., Winata, Cecilia, Salimova, Ekaterina, Nim, Hieu T. and Ramialison, Mirana (2025). Epigenomics and transcriptomics profiles of developing zebrafish heart cells. Scientific data, 12 (1) 1620, 1620. doi: 10.1038/s41597-025-05895-9

Epigenomics and transcriptomics profiles of developing zebrafish heart cells

2025

Conference Publication

Glycaemic variability underlies myocyte dysfunction and myocardial injury risk in diabetes

Cao, Y., Redd, M., Outhwaite, J., Mizikovsky, D., Shim, W., Fang, C., Wu, Z., Daygon, D., Stark, T., Palfreyman, R., Chiu, H., Tan, C., Thomas, U., Dragicevic, E., Sng, J., Barrett, H., Dorey, E., Shah, S., Short, K. and Palpant, N. (2025). Glycaemic variability underlies myocyte dysfunction and myocardial injury risk in diabetes. 73rd Annual Scientific Meeting ofthe Cardiac Society of Australia and New Zealand, Brisbane, QLD Australia, 14-17 August 2025. Chatswood, NSW Australia: Elsevier Australia. doi: 10.1016/j.hlc.2025.06.821

Glycaemic variability underlies myocyte dysfunction and myocardial injury risk in diabetes

2025

Conference Publication

Multidimensional-Spatial Profiling of Human Heart Failure Reveals New Cardiomyocyte Subtypes and Fibro-Inflammatory Niches

Rashid, F., Muthiah, K., Qin, A., Sun, V., Nim, H., Sivasubramaniam, V., Barua, S., Eckford, H., O’Neil, T., Patrick, E., Clayton, Z., Reyes, L., Palpant, N., Ramialison, M., Hayward, C., Kizana, E. and Chong, J. (2025). Multidimensional-Spatial Profiling of Human Heart Failure Reveals New Cardiomyocyte Subtypes and Fibro-Inflammatory Niches. 73rd Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand, Sydney, NSW Australia, 14-17 August 2025. Chatswood, NSW Australia: Elsevier. doi: 10.1016/j.hlc.2025.06.018

Multidimensional-Spatial Profiling of Human Heart Failure Reveals New Cardiomyocyte Subtypes and Fibro-Inflammatory Niches

2025

Conference Publication

Human Hearts Intrinsically Increase Cardiomyocyte Mitosis Following Myocardial Infarction

Hume, R., Warwick, J., Shim, W., Malecki, C., Li, M., Harney, D., Slaughter, E., Wang, X., Nguyen, L., Cole, L., Edelman, J., Rashid, F., Houlahan, C., Gao, A., Ferguson, A., Chong, J., Larance, M., O’Sullivan, J., Palpant, N., Bannon, P. and Lal, S. (2025). Human Hearts Intrinsically Increase Cardiomyocyte Mitosis Following Myocardial Infarction. 73rd Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand, Sydney, NSW Australia, 14-17 August 2025. Chatswood, NSW Australia: Elsevier. doi: 10.1016/j.hlc.2025.06.332

Human Hearts Intrinsically Increase Cardiomyocyte Mitosis Following Myocardial Infarction

2025

Journal Article

A pluripotent stem cell atlas of multilineage differentiation

Shen, Sophie, Werner, Tessa, Chiu, Han Sheng, Chen, Xiaoli, Nguyen, Quan and Palpant, Nathan J. (2025). A pluripotent stem cell atlas of multilineage differentiation. Scientific Data, 12 (1) 1238, 1238. doi: 10.1038/s41597-025-05549-w

A pluripotent stem cell atlas of multilineage differentiation

2025

Conference Publication

Spider-Heart: Spider-Venom Derived Peptide Hi1a Can Prolong Asystolic Warm Ischaemia Tolerance in Donation After Circulatory Death Donor Hearts

Joshi, Y., MacLean, C., Wang, K., Villanueva, J., Gao, L., Wu, J., Soto, C., Doyle, A., Palpant, N., King, G., Connellan, M., Granger, E., Iyer, A., Watson, A., Jansz, P. and MacDonald, P. (2025). Spider-Heart: Spider-Venom Derived Peptide Hi1a Can Prolong Asystolic Warm Ischaemia Tolerance in Donation After Circulatory Death Donor Hearts. International Society for Heart and Lung Transplantation ISHLT 45th Annual Meeting and Scientific Sessions, Boston, MA United States, 27-30 April 2025. Philadelphia, PA United States: Elsevier. doi: 10.1016/j.healun.2025.02.1409

Spider-Heart: Spider-Venom Derived Peptide Hi1a Can Prolong Asystolic Warm Ischaemia Tolerance in Donation After Circulatory Death Donor Hearts

2025

Journal Article

Atlas of multilineage stem cell differentiation reveals TMEM88 as a developmental regulator of blood pressure

Shen, Sophie, Werner, Tessa, Lukowski, Samuel W., Andersen, Stacey, Sun, Yuliangzi, Shim, Woo Jun, Mizikovsky, Dalia, Kobayashi, Sakurako, Outhwaite, Jennifer, Chiu, Han Sheng, Chen, Xiaoli, Chapman, Gavin, Martin, Ella M. M. A., Xia, Di, Pham, Duy, Su, Zezhuo, Kim, Daniel, Yang, Pengyi, Tan, Men Chee, Sinniah, Enakshi, Zhao, Qiongyi, Negi, Sumedha, Redd, Meredith A., Powell, Joseph E., Dunwoodie, Sally L., Tam, Patrick P. L., Bodén, Mikael, Ho, Joshua W. K., Nguyen, Quan and Palpant, Nathan J. (2025). Atlas of multilineage stem cell differentiation reveals TMEM88 as a developmental regulator of blood pressure. Nature Communications, 16 (1) 1356, 1-19. doi: 10.1038/s41467-025-56533-2

Atlas of multilineage stem cell differentiation reveals TMEM88 as a developmental regulator of blood pressure

2025

Journal Article

Glycaemic variability underlies myocyte dysfunction and myocardial injury risk in diabetes

Cao, Yuanzhao, Redd, Meredith, Outhwaite, Jennifer, Mizikovsky, Dalia, Shim, Woo Jun, Fang, Chen, Wu, Zhixuan, Daygon, Dara, Stark, Terra, Palfreyman, Robin, Chiu, Han Sheng, Tan, Clarissa, Thomas, Ulrich, Dragicevic, Elena, Sng, Julian, Barrett, Helen, Dorey, Emily, Shah, Sonia, Short, Kirsty and Palpant, Nathan J. (2025). Glycaemic variability underlies myocyte dysfunction and myocardial injury risk in diabetes. doi: 10.1101/2025.01.29.635173

Glycaemic variability underlies myocyte dysfunction and myocardial injury risk in diabetes

2025

Journal Article

Human hearts intrinsically increase cardiomyocyte mitosis after myocardial infarction

Hume, Robert D., Warwick, Jessica, Shim, Woo Jun, Malecki, Cassandra, Li, Mengbo, Seth, Lakshay, Harney, Dylan, Dagher, Julien, Lum, Trina, Tierney, Geraldine, Cooper, Wendy, Slaughter, Eugene, Wang, Xiaosuo, Nguyen, Lisa, Cole, Louise, Edelman, James, Rashid, Fairooj, Houlahan, Callum, Gao, Antony, Ferguson, Angela L., Chong, James J.H., Larance, Mark, O’Sullivan, John, Palpant, Nathan J., Bannon, Paul and Lal, Sean (2025). Human hearts intrinsically increase cardiomyocyte mitosis after myocardial infarction. Circulation Research, 138 (2) e327486, 367-382. doi: 10.1161/circresaha.125.327486

Human hearts intrinsically increase cardiomyocyte mitosis after myocardial infarction

2025

Journal Article

TRIAGE: an R package for regulatory gene analysis

Zhao, Qiongyi, Shim, Woo Jun, Sun, Yuliangzi, Sinniah, Enakshi, Shen, Sophie, Boden, Mikael and Palpant, Nathan J. (2025). TRIAGE: an R package for regulatory gene analysis. Briefings in Bioinformatics, 26 (1) bbaf004, 1-13. doi: 10.1093/bib/bbaf004

TRIAGE: an R package for regulatory gene analysis

2024

Journal Article

Post-acute sequelae of SARS-CoV-2 cardiovascular symptoms are associated with trace-level cytokines that affect cardiomyocyte function

Sinclair, Jane E., Vedelago, Courtney, Ryan, Feargal J., Carney, Meagan, Redd, Meredith A., Lynn, Miriam A., Grubor-Bauk, Branka, Cao, Yuanzhao, Henders, Anjali K., Chew, Keng Yih, Gilroy, Deborah, Greaves, Kim, Labzin, Larisa, Ziser, Laura, Ronacher, Katharina, Wallace, Leanne M., Zhang, Yiwen, Macauslane, Kyle, Ellis, Daniel J., Rao, Sudha, Burr, Lucy, Bain, Amanda, Karawita, Anjana, Schulz, Benjamin L., Li, Junrong, Lynn, David J., Palpant, Nathan, Wuethrich, Alain, Trau, Matt and Short, Kirsty R. (2024). Post-acute sequelae of SARS-CoV-2 cardiovascular symptoms are associated with trace-level cytokines that affect cardiomyocyte function. Nature Microbiology, 9 (12), 1-13. doi: 10.1038/s41564-024-01838-z

Post-acute sequelae of SARS-CoV-2 cardiovascular symptoms are associated with trace-level cytokines that affect cardiomyocyte function

2024

Journal Article

A community-oriented, data-driven resource to improve protocol design for cardiac modelling from human pluripotent stem cells

Chow, Chris Siu Yeung, Negi, Sumedha, Bao, Shaine, Fang, Chen, Hudson, James, Shim, Woo Jun, Yuanzhao Cao and Palpant, Nathan (2024). A community-oriented, data-driven resource to improve protocol design for cardiac modelling from human pluripotent stem cells. doi: 10.1101/2024.09.04.611313

A community-oriented, data-driven resource to improve protocol design for cardiac modelling from human pluripotent stem cells

2024

Conference Publication

Improved recovery of rat hearts after prolonged cold storage by acid sensing ion channel (ASIC) inhibitor Hi1a varies with preservation solution

Dutta, Sanjay, Villanueva, Jeanette E., Gao, Ling, Doyle, Aoife, Palpant, Nathan, King, Glenn and Macdonald, Peter S. (2024). Improved recovery of rat hearts after prolonged cold storage by acid sensing ion channel (ASIC) inhibitor Hi1a varies with preservation solution. 30th International Congress of the Transplantation Society, Istanbul, Turkey, 22-25 September 2024. Philadelphia, PA United States: Lippincott Williams & Wilkins. doi: 10.1097/01.tp.0001066648.27486.ce

Improved recovery of rat hearts after prolonged cold storage by acid sensing ion channel (ASIC) inhibitor Hi1a varies with preservation solution

2024

Conference Publication

Improving donor heart preservation with funnel web spider venom and the anti-diabetic drug empagliflozin

Villanueva, Jeanette, Dutta, Sanjay, Gao, Ling, Doyle, Aoife, Palpant, Nathan, King, Glenn and Macdonald, Peter (2024). Improving donor heart preservation with funnel web spider venom and the anti-diabetic drug empagliflozin. 30th International Congress of the Transplantation-Society (TTS), Istanbul Turkey, Sep 22-25, 2024. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS. doi: 10.1097/01.tp.0001064488.47051.12

Improving donor heart preservation with funnel web spider venom and the anti-diabetic drug empagliflozin

2024

Conference Publication

Improved recovery of rat hearts after prolonged cold storage by acid sensing ion channel (ASIC) inhibitor Hi1a varies with preservation solution

Dutta, Sanjay, Villanueva, Jeanette E., Gao, Ling, Doyle, Aoife, Palpant, Nathan, King, Glenn and Macdonald, Peter S. (2024). Improved recovery of rat hearts after prolonged cold storage by acid sensing ion channel (ASIC) inhibitor Hi1a varies with preservation solution. 30th International Congress of The Transplantation-Society (TTS), Istanbul, Turkey, 22-25 September 2024. Philadelphia, PA United States: Lippincott Williams & Wilkins.

Improved recovery of rat hearts after prolonged cold storage by acid sensing ion channel (ASIC) inhibitor Hi1a varies with preservation solution

2024

Conference Publication

Mending achy-breaky hearts: cyclic peptide TL01 is an enhancer of cardiac intracellular protein-protein interactions and promotes heart contractility

Rojas-Azofeifa, Daniela, Passioura, Toby, McMillen, Timothy, Cheesman, Elisabeth, Saez, Natalie, Chow, Jonathan, Eagles, David, Norman, Alexander, Perry, Matthew, Molenar, Peter, Regnier, Michael, King, Glenn and Palpant, Nathan (2024). Mending achy-breaky hearts: cyclic peptide TL01 is an enhancer of cardiac intracellular protein-protein interactions and promotes heart contractility. 37th European Peptide Symposium 14th International Peptide Symposium, Florence, Italy, 25-29 August 2024. Oxford, United Kingdom: John Wiley & Sons.

Mending achy-breaky hearts: cyclic peptide TL01 is an enhancer of cardiac intracellular protein-protein interactions and promotes heart contractility

2024

Conference Publication

Preclinical models of Glycaemic variability recapitulate Clinical Cardiovascular outcomes in Diabetes

Cao, Y., Redd, M., Outhwaite, J., Shim, W., Fang, C., Negi, S., Shen, S., Mizikovsky, D., Chiu, H., Tan, C., Thomas, U., Dragicevic, E., Sng, J., Short, K. and Palpant, N. (2024). Preclinical models of Glycaemic variability recapitulate Clinical Cardiovascular outcomes in Diabetes. 72nd Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand, Perth, WA Australia, 1-4 August 2024. Chatswood, NSW Australia: Elsevier. doi: 10.1016/j.hlc.2024.06.332

Preclinical models of Glycaemic variability recapitulate Clinical Cardiovascular outcomes in Diabetes

2024

Conference Publication

Trastuzumab-induced cardiotoxicity involves antibody dependent cell cytotoxicity (ADCC)

Griffiths, L., Ho, U., Burt, K., Watson, S., Patel, K., Bradford, J., Tan, C., Bhavsar, C., Palpant, N., Souza-Fonseca-Guimaraes, F., Wu, S., Reichelt, M. and Thomas, W. (2024). Trastuzumab-induced cardiotoxicity involves antibody dependent cell cytotoxicity (ADCC). 72nd Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand, Perth, WA Australia, 1-4 August 2024. Chatswood, NSW Australia: Elsevier. doi: 10.1016/j.hlc.2024.06.397

Trastuzumab-induced cardiotoxicity involves antibody dependent cell cytotoxicity (ADCC)