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2016 Journal Article Long-range regulators of the lncRNA HOTAIR enhance its prognostic potential in breast cancerMilevskiy, Michael J. G., Al-Ejeh, Fares, Saunus, Jodi M., Northwood, Korinne S., Bailey, Peter J., Betts, Joshua A., McCart Reed, Amy E., Nephew, Kenneth P., Stone, Andrew, Gee, Julia M. W., Dowhan, Dennis H., Dray, Eloise, Shewan, Annette M., French, Juliet D., Edwards, Stacey L., Clark, Susan J., Lakhani, Sunil R. and Brown, Melissa A. (2016). Long-range regulators of the lncRNA HOTAIR enhance its prognostic potential in breast cancer. Human Molecular Genetics, 25 (15), 3269-3283. doi: 10.1093/hmg/ddw177 |
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2016 Journal Article Landscape of somatic mutations in 560 breast cancer whole-genome sequencesNik-Zainal, Serena, Davies, Helen, Staaf, Johan, Ramakrishna, Manasa, Glodzik, Dominik, Zou, Xueqing, Martincorena, Inigo, Alexandrov, Ludmil B., Martin, Sancha, Wedge, David C., Van Loo, Peter, Ju, Young Seok, Smid, Marcel, Brinkman, Arie B., Morganella, Sandro, Aure, Miriam R., Lingjaerde, Ole Christian, Langerod, Anita, Ringner, Markus, Ahn, Sung-Min, Boyault, Sandrine, Brock, Jane E., Broeks, Annegien, Butler, Adam, Desmedt, Christine, Dirix, Luc, Dronov, Serge, Fatima, Aquila, Foekens, John A. ... Stratton, Michael R. (2016). Landscape of somatic mutations in 560 breast cancer whole-genome sequences. Nature, 534 (7605), 47-+. doi: 10.1038/nature17676 |
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2016 Journal Article Point mutations in Exon 1B of APC Reveal Gastric Adenocarcinoma and Proximal Polyposis of the Stomach as a Familial Adenomatous Polyposis VariantLi, Jun, Woods, Susan L., Healey, Sue, Beesley, Jonathan, Chen, Xiaoqing, Lee, Jason S., Sivakumaran, Haran, Wayte, Nicci, Nones, Katia, Waterfall, Joshua J., Pearson, John, Patch, Anne-Marie, Senz, Janine, Ferreira, Manuel A., Kaurah, Pardeep, Mackenzie, Robertson, Heravi-Moussavi, Alireza, Hansford, Samantha, Lannagan, Tamsin R. M., Spurdle, Amanda B., Simpson, Peter T., da Silva, Leonard, Lakhani, Sunil R., Clouston, Andrew D., Bettington, Mark, Grimpen, Florian, Busuttil, Rita A., Di Costanzo, Natasha, Boussioutas, Alex ... Chenevix-Trench, Georgia (2016). Point mutations in Exon 1B of APC Reveal Gastric Adenocarcinoma and Proximal Polyposis of the Stomach as a Familial Adenomatous Polyposis Variant. American Journal of Human Genetics, 98 (5), 830-842. doi: 10.1016/j.ajhg.2016.03.001 |
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2016 Journal Article The calcium pump plasma membrane Ca(2+)-ATPase 2 (PMCA2) regulates breast cancer cell proliferation and sensitivity to doxorubicinPeters, Amelia A., Milevskiy, Michael J. G., Lee, WeiC., Curry, Merril C., Smart, Chanel E., Saunus, Jodi M., Reid, Lynne, da Silva, Leonard, Marcial, Daneth L., Dray, Eloise, Brown, Melissa A., Lakhani, Sunil R., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2016). The calcium pump plasma membrane Ca(2+)-ATPase 2 (PMCA2) regulates breast cancer cell proliferation and sensitivity to doxorubicin. Scientific Reports, 6 (1) 25505, 25505. doi: 10.1038/srep25505 |
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2016 Journal Article The topography of mutational processes in breast cancer genomesMorganella, Sandro, Alexandrov, Ludmil B., Glodzik, Dominik, Zou, Xueqing, Davies, Helen, Staaf, Johan, Sieuwerts, Anieta M., Brinkman, Arie B., Martin, Sancha, Ramakrishna, Manasa, Butler, Adam, Kim, Hyung-Yong, Borg, Ake, Sotiriou, Christos, Futreal, P. Andrew, Campbell, Peter J., Span, Paul N., Van Laere, Steven, Lakhani, Sunil R., Eyfjord, Jorunn E., Thompson, Alastair M., Stunnenberg, Hendrik G., van de Vijver, Marc J., Martens, John W. M., Borresen-Dale, Anne-Lise, Richardson, Andrea L., Kong, Gu, Thomas, Gilles, Sale, Julian ... Nik-Zainal, Serena (2016). The topography of mutational processes in breast cancer genomes. Nature Communications, 7 (11383) 11383, 1-11. doi: 10.1038/ncomms11383 |
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2016 Journal Article Novel highly specific anti-periostin antibodies uncover the functional importance of the fascilin 1-1 domain and highlight preferential expression of periostin in aggressive breast cancerField, Sarah, Uyttenhove, Catherine, Stroobant, Vincent, Cheou, Paméla, Coutelier, Jean-Paul, Simpson, Peter T., Cummings, Margaret C., Saunus, Jodi M., Reid, Lynne E., Kutasovic, Jamie R., McNicol, Anne Marie, Kim, Ba Reun, Kim, Jae Ho, Lakhani, Sunil R., Neville, A. Munro, Van Snick, Jacques and Jat, Parmjit S. (2016). Novel highly specific anti-periostin antibodies uncover the functional importance of the fascilin 1-1 domain and highlight preferential expression of periostin in aggressive breast cancer. International Journal of Cancer, 138 (8), 1959-1970. doi: 10.1002/ijc.29946 |
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2016 Journal Article High content screening application for cell-type specific behaviour in heterogeneous primary breast epithelial subpopulationsJohnston, Rebecca L., Wockner, Leesa, McCart Reed, Amy E., Wiegmans, Adrian, Chenevix-Trench, Georgia, Khanna, Kum Kum, Lakhani, Sunil R. and Smart, Chanel E. (2016). High content screening application for cell-type specific behaviour in heterogeneous primary breast epithelial subpopulations. Breast Cancer Research, 18 (18) 18, 1-18. doi: 10.1186/s13058-016-0681-9 |
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2016 Journal Article An epithelial to mesenchymal transition programme does not usually drive the phenotype of invasive lobular carcinomasMcCart Reed, Amy E., Kutasovic, Jamie R., Vargas, Ana Cristina, Jayanthan, Janani, Al-Murrani, Amel, Reid, Lynne E., Chambers, Rachael, Da Silva, Leonard, Melville, Lewis, Evans, Elizabeth, Porter, Alan, Papadimos, David, Thompson, Erik W., Lakhani, Sunil R. and Simpson, Peter T. (2016). An epithelial to mesenchymal transition programme does not usually drive the phenotype of invasive lobular carcinomas. Journal of Pathology, 238 (4), 489-494. doi: 10.1002/path.4668 |
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2016 Journal Article The cancer genetics and pathology of male breast cancerDeb, Siddhartha, Lakhani, Sunil R., Ottini, Laura and Fox, Stephen B. (2016). The cancer genetics and pathology of male breast cancer. Histopathology, 68 (1), 110-118. doi: 10.1111/his.12862 |
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2016 Journal Article RAD51B in familial breast cancerPelttari, Liisa M., Khan, Sofia, Vuorela, Mikko, Kiiski, Johanna I., Vilske, Sara, Nevanlinna, Viivi, Ranta, Salla, Schleutker, Johanna, Winqvist, Robert, Kallioniemi, Anne, Dörk, Thilo, Bogdanova, Natalia V., Figueroa, Jonine, Pharoah, Paul D. P., Schmidt, Marjanka K., Dunning, Alison M., García-Closas, Montserrat, Bolla, Manjeet K., Dennis, Joe, Michailidou, Kyriaki, Wang, Qin, Hopper, John L., Southey, Melissa C., Rosenberg, Efraim H., Fasching, Peter A., Beckmann, Matthias W., Peto, Julian, Dos-Santos-silva, Isabel, Sawyer, Elinor J. ... Zeps, N. (2016). RAD51B in familial breast cancer. PLoS One, 11 (5) e0153788, e0153788. doi: 10.1371/journal.pone.0153788 |
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2016 Journal Article Phyllodes tumours of the breast: A consensus reviewTan, Benjamin Y., Acs, Geza, Apple, Sophia K., Badve, Sunil, Bleiweiss, Ira J., Brogi, Edi, Calvo, Jose P., Dabbs, David J., Ellis, Ian O., Eusebi, Vincenzo, Farshid, Gelareh, Fox, Stephen B., Ichihara, Shu, Lakhani, Sunil R., Rakha, Emad A., Reis-Filho, Jorge S., Richardson, Andrea L., Sahin, Aysegul, Schmitt, Fernando C., Schnitt, Stuart J., Siziopikou, Kalliopi P., Soares, Fernando A., Tse, Gary M., Vincent-Salomon, Anne and Puay Hoon Tan (2016). Phyllodes tumours of the breast: A consensus review. Histopathology, 68 (1), 5-21. doi: 10.1111/his.12876 |
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2015 Journal Article TGFβ isoforms and receptors mRNA expression in breast tumours: Prognostic value and clinical implicationsChen, Chenfeng, Zhao, Kong-Nan, Masci, Paul P., Lakhani, Sunil R., Antonsson, Annika, Simpson, Peter T. and Vitetta, Luis (2015). TGFβ isoforms and receptors mRNA expression in breast tumours: Prognostic value and clinical implications. BMC Cancer, 15 (1010) 1010, 1010. doi: 10.1186/s12885-015-1993-3 |
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2015 Journal Article Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowthZhang, Lin, Zhang, Siyuan, Yao, Jun, Lowery, Frank J., Zhang, Qingling, Huang, Wen-Chien, Li, Ping, Li, Min, Wang, Xiao, Zhang, Chenyu, Wang, Hai, Ellis, Kenneth, Cheerathodi, Mujeeburahiman, McCarty, Joseph H., Palmieri, Diane, Saunus, Jodi, Lakhani, Sunil, Huang, Suyun, Sahin, Aysegul A., Aldape, Kenneth D., Steeg, Patricia S. and Yu, Dihua (2015). Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth. Nature, 527 (7576), 100-104. doi: 10.1038/nature15376 |
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2015 Journal Article Integrated genomic and transcriptomic analysis of human brain metastases identifies recurrently altered pathways of potential clinical significanceSaunus, Jodi M., Quinn, MIchael C. J., Patch, Ann-Marie, Pearson, John V., Bailey, Peter J., Nones, Katia, McCart Reed, Amy E., Miller, David, Peter J. Wilson, Al-Ejeh, Fares, Mariasegaram, Mythily, Lau, Queenie, Withers, Teresa, Jeffree, Rosalind L., Reid, Lynne E., Da Silva, Leonard, Matsika, Admire, Niland, Colleen M., Cummings, Margaret C., Bruxner, Timothy J. C., Christ, Angelika N., Harliwong, Ivon, Idrisoglu, Senel, Manning, Suzanne, Nourse, Craig, Nourbakhsh, Ehsan, Wani, Shivangi, Anderson, Matthew J., Fink, J. Lynn ... Lakhani, Sunil R. (2015). Integrated genomic and transcriptomic analysis of human brain metastases identifies recurrently altered pathways of potential clinical significance. Journal of Pathology, 237 (3), 363-378. doi: 10.1002/path.4583 |
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2015 Journal Article Using the MCF10A/MCF10CA1a Breast Cancer Progression Cell Line Model to Investigate the Effect of Active, Mutant Forms of EGFR in Breast Cancer Development and Treatment Using GefitinibBessette, Darrell C., Tilch, Erik, Seidens, Tatjana, Quinn, Michael C. J., Wiegmans, Adrian P., Shi, Wei, Cocciardi, Sibylle, McCart-Reed, Amy, Saunus, Jodi M., Simpson, Peter T., Grimmond, Sean M., Lakhani, Sunil R., Khanna, Kum Kum, Waddell, Nic, Al-Ejeh, Fares and Chevenvix-Trench, Georgia (2015). Using the MCF10A/MCF10CA1a Breast Cancer Progression Cell Line Model to Investigate the Effect of Active, Mutant Forms of EGFR in Breast Cancer Development and Treatment Using Gefitinib. PLoS One, 10 (5) e0125232, e0125232-e0125232. doi: 10.1371/journal.pone.0125232 |
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2015 Journal Article Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cellsJu, Young Seok, Tubio, Jose M.C, Mifsud, William, Fu, Beiyuan, Davies, Helen R, Ramakrishna, Manasa, Li, Yilong, Yates, Lucy, Gundem, Gunes, Tarpey, Patrick S, Behjati, Sam, Papaemmanuil, Elli, Martin, Sancha, Fullam, Anthony, Gerstung, Moritz, Nangalia, Jyoti, Green, Anthony R, Caldas, Carlos, Borg, Ake, Tutt, Andrew, Michael Lee, Ming Ta, Van'T Veer, Laura J, Tan, Benita K.T, Aparicio, Samuel, Span, Paul N, Martens, John W.M, Knappskog, Stian, Vincent-Salomon, Ann, Borresen-Dale, Anne-Lise ... Simpson, Peter (2015). Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells. Genome Research, 25 (6), 814-824. doi: 10.1101/gr.190470.115 |
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2015 Journal Article Papillary and neuroendocrine breast lesions: the WHO stanceTan, Puay Hoon, Schnitt, Stuart J., van de Vijver, Marc J., Ellis, Ian O. and Lakhani, Sunil R. (2015). Papillary and neuroendocrine breast lesions: the WHO stance. Histopathology, 66 (6), 761-770. doi: 10.1111/his.12463 |
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2015 Journal Article An evaluation of the prognostic model PREDICT using the POSH cohort of women aged ≤40 years at breast cancer diagnosisMaishman, T., Copson, E., Stanton, L., Gerty, S., Dicks, E., Durcan, L., Wishart, G. C., Pharoah, P., POSH Steering Group, Lakhani, Sunil and Eccles, D. (2015). An evaluation of the prognostic model PREDICT using the POSH cohort of women aged ≤40 years at breast cancer diagnosis. British Journal of Cancer, 112 (6), 983-991. doi: 10.1038/bjc.2015.57 |
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2015 Journal Article Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell linesMomeny, Majid, Saunus, Jodi M., Marturana, Flavia, McCart Reed, Amy E., Black, Debra, Sala, Gianluca, Iacobelli, Stefano, Holland, Jane D., Yu, Dihua, Da Silva, Leonard, Simpson, Peter T., Khanna, Kum Kum, Chenevix-Trench, Georgia and Lakhani, Sunil R. (2015). Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell lines. Oncotarget, 6 (6), 3932-3946. doi: 10.18632/oncotarget.2846 |
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2015 Journal Article Invasive lobular carcinoma of the breast: morphology, biomarkers and 'omicsMcCart Reed, Amy E., Kutasovic, Jamie R., Lakhani, Sunil R. and Simpson, Peter T. (2015). Invasive lobular carcinoma of the breast: morphology, biomarkers and 'omics. Breast Cancer Research, 17 (12) 12, 1-11. doi: 10.1186/s13058-015-0519-x |
