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2015 Journal Article Personalised pathway analysis reveals association between DNA repair pathway dysregulation and chromosomal instability in sporadic breast cancerLiu, Chao, Srihari, Sriganesh, Lal, Samir, Gautier, Benoit, Simpson, Peter T., Khanna, Kum Kum, Ragan, Mark A. and LeCao, Kim-Anh (2015). Personalised pathway analysis reveals association between DNA repair pathway dysregulation and chromosomal instability in sporadic breast cancer. Molecular Oncology, 10 (1), 179-193. doi: 10.1016/j.molonc.2015.09.007 |
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2015 Journal Article Using the MCF10A/MCF10CA1a Breast Cancer Progression Cell Line Model to Investigate the Effect of Active, Mutant Forms of EGFR in Breast Cancer Development and Treatment Using GefitinibBessette, Darrell C., Tilch, Erik, Seidens, Tatjana, Quinn, Michael C. J., Wiegmans, Adrian P., Shi, Wei, Cocciardi, Sibylle, McCart-Reed, Amy, Saunus, Jodi M., Simpson, Peter T., Grimmond, Sean M., Lakhani, Sunil R., Khanna, Kum Kum, Waddell, Nic, Al-Ejeh, Fares and Chevenvix-Trench, Georgia (2015). Using the MCF10A/MCF10CA1a Breast Cancer Progression Cell Line Model to Investigate the Effect of Active, Mutant Forms of EGFR in Breast Cancer Development and Treatment Using Gefitinib. PLoS One, 10 (5) e0125232, e0125232-e0125232. doi: 10.1371/journal.pone.0125232 |
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2015 Journal Article Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cellsJu, Young Seok, Tubio, Jose M.C, Mifsud, William, Fu, Beiyuan, Davies, Helen R, Ramakrishna, Manasa, Li, Yilong, Yates, Lucy, Gundem, Gunes, Tarpey, Patrick S, Behjati, Sam, Papaemmanuil, Elli, Martin, Sancha, Fullam, Anthony, Gerstung, Moritz, Nangalia, Jyoti, Green, Anthony R, Caldas, Carlos, Borg, Ake, Tutt, Andrew, Michael Lee, Ming Ta, Van'T Veer, Laura J, Tan, Benita K.T, Aparicio, Samuel, Span, Paul N, Martens, John W.M, Knappskog, Stian, Vincent-Salomon, Ann, Borresen-Dale, Anne-Lise ... Simpson, Peter (2015). Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells. Genome Research, 25 (6), 814-824. doi: 10.1101/gr.190470.115 |
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2015 Journal Article Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell linesMomeny, Majid, Saunus, Jodi M., Marturana, Flavia, McCart Reed, Amy E., Black, Debra, Sala, Gianluca, Iacobelli, Stefano, Holland, Jane D., Yu, Dihua, Da Silva, Leonard, Simpson, Peter T., Khanna, Kum Kum, Chenevix-Trench, Georgia and Lakhani, Sunil R. (2015). Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell lines. Oncotarget, 6 (6), 3932-3946. doi: 10.18632/oncotarget.2846 |
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2015 Journal Article Invasive lobular carcinoma of the breast: morphology, biomarkers and 'omicsMcCart Reed, Amy E., Kutasovic, Jamie R., Lakhani, Sunil R. and Simpson, Peter T. (2015). Invasive lobular carcinoma of the breast: morphology, biomarkers and 'omics. Breast Cancer Research, 17 (12) 12, 1-11. doi: 10.1186/s13058-015-0519-x |
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2015 Conference Publication Genomic and transcriptomic landscapes of human brain metastasesSaunus, J. M., Quinn, M. C. J., Patch, A. M., Pearson, J. V., Bailey, P. J., Cloonan, N., Nones, K., Miller, D., Mariasegaram, M., Lau, Q., Jeffree, L., Khanna, K. K., Chenevix-Trench, G., Grimmond, S. M., Simpson, P. T., Waddell, N. and Lakhani, S. R. (2015). Genomic and transcriptomic landscapes of human brain metastases. 15th International Biennial Congress of the Metastasis Research Society, Heidelberg, Germany, June 28th–July 1st, 2014. Dordrecht, Netherlands: Springer Netherlands. doi: 10.1007/s10585-015-9708-3 |
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2015 Conference Publication Exploring the HER3 tyrosine kinase as a therapeutic target for treatment of brain metastasesSaunus, Jodi M., Momeny, Majid, Da Silva, Leonard, Reid, Lynne, Holland, Jane D., Birchmeier, Walter, Jat, Parmjit, Brandner, Sebastian, Al-Ejeh, Fares, Khanna, Kum Kum, Chenevix-Trench, Georgia, Simpson, Peter T. and Lakhani, Sunil R. (2015). Exploring the HER3 tyrosine kinase as a therapeutic target for treatment of brain metastases. 15th International Biennial Congress of the Metastasis Research Society, Heidelberg, Germany, 28 June - 01 July 2014. Dordrecht, Netherlands: Springer. doi: 10.1007/s10585-015-9708-3 |
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2015 Journal Article ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotypeJunankar, Simon, Baker, Laura A., Roden, Daniel L., Nair, Radhika, Elsworth, Ben, Gallego-Ortega, David, Lacaze, Paul, Cazet, Aurelie, Nikolic, Iva, Teo, Wee Siang, Yang, Jessica, McFarland, Andrea, Harvey, Kate, Naylor, Matthew J., Lakhani, Sunil R., Simpson, Peter T., Raghavendra, Ashwini, Saunus, Jodi, Madore, Jason, Kaplan, Warren, Ormandy, Christopher, Millar, Ewan K. A., O'Toole, Sandra, Yun, Kyuson and Swarbrick, Alexander (2015). ID4 controls mammary stem cells and marks breast cancers with a stem cell-like phenotype. Nature Communications, 6 (1) 6548, 6548.1-6548.12. doi: 10.1038/ncomms7548 |
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2015 Conference Publication Breast cancer metastasis to gynaecological organs: impacting young women diagnosed with a luminal tumour subtypeKutasovic, Jamie, Reed, Amy McCart, Sim, Sarah, Cummings, Margaret, Lakhani, Sunil and Simpson, Peter (2015). Breast cancer metastasis to gynaecological organs: impacting young women diagnosed with a luminal tumour subtype. 15th International Biennial Congress of the Metastasis Research Society, Heidelberg, Germany, June 28th–July 1st, 2014. Dordrecht, Netherlands: Springer Netherlands. doi: 10.1007/s10585-015-9708-3 |
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2015 Conference Publication The role of epithelial to mesenchymal plasticity in driving the invasive capacity of 'lobular-like' tumour cell differentiation in breast cancerReed, McCart A. E., Kutasovic, J. R., Vargas, A. C., Da Silva, L., Jayanthan, J., Al-Murrani, A., Reid, L. E., Evans, E., Porter, A., Lakhani, S. R. and Simpson, P. T. (2015). The role of epithelial to mesenchymal plasticity in driving the invasive capacity of 'lobular-like' tumour cell differentiation in breast cancer. 15th International Biennial Congress of the Metastasis Research Society, Heidelberg, Germany, June 28th–July 1st, 2014. Dordrecht, Netherlands: Springer Netherlands. doi: 10.1007/s10585-015-9708-3 |
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2015 Conference Publication Erk5 as a therapeutic target in triple negative breast cancer (TNBC)Miranda, Mariska Sauzine, Al Ejeh, Fares, Shi, Wei, Simpson, Peter, Lakhani, Sunil and Khanna, Kum Kum (2015). Erk5 as a therapeutic target in triple negative breast cancer (TNBC). 37th Annual CTRC-AACR San Antonio Breast Cancer Symposium, San Antonio, TX, United States, 9-13 December 2014. Philadelphia, PA, United States: American Association for Cancer Research. doi: 10.1158/1538-7445.SABCS14-P6-03-11 |
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2015 Conference Publication Flipping pathology and its impact on learning in second year medical students at University of Queensland, School of Medicine, AustraliaKoteeswaran, Raja, Deborah Smith, Ekta Bhutada, Simpson, Peter T., Emma Bartle, Julie Elizabeth Ayre, Galea, Melanie, Joanne Lester, Bowker, Shari and Lakhani, Sunil (2015). Flipping pathology and its impact on learning in second year medical students at University of Queensland, School of Medicine, Australia. The 2015 AAMC Medical Education Meeting, Baltimore, Maryland, USA, 10-12 November 2015. |
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2014 Journal Article Complex-based analysis of dysregulated cellular processes in cancerSrihari, Sriganesh, Madhamshettiwar, Piyush B., Song, Sarah, Liu, Chao, Simpson, Peter T., Khanna, Kumkum and Ragan, Mark A. (2014). Complex-based analysis of dysregulated cellular processes in cancer. BMC Systems Biology, 8 (Supplement 4) S1. doi: 10.1186/1752-0509-8-S4-S1 |
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2014 Journal Article Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesisNones, Katia, Waddell, Nicola, Wayte, Nicci, Patch, Ann-Marie, Bailey, Peter, Newell, Felicity, Holmes, Oliver, Fink, J. Lynn, Quinn, Michael C. J., Tang, Yue Hang, Lampe, Guy, Quek, Kelly, Loffler, Kelly A., Manning, Suzanne, Idrisoglu, Senel, Miller, David, Xu, Qinying, Waddell, Nick, Wilson, Peter J., Bruxner, Timothy J. C., Christ, Angelika N., Harliwong, Ivon, Nourse, Craig, Nourbakhsh, Ehsan, Anderson, Matthew, Kazakoff, Stephen, Leonard, Conrad, Wood, Scott, Simpson, Peter T. ... Barbour, Andrew P. (2014). Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis. Nature Communications, 5 (1) 6224, 5224.1-5224.9. doi: 10.1038/ncomms6224 |
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2014 Journal Article Erratum: Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancerAl-Ejeh, F, Simpson, P T, Saunus, J M, Klein, K, Kalimutho, M, Shi, W, Miranda, M, Kutasovic, J, Raghavendra, A, Madore, J, Reid, L, Krause, L, Chenevix-Trench, G, Lakhani, S R and Khanna, K K (2014). Erratum: Meta-analysis of the global gene expression profile of triple-negative breast cancer identifies genes for the prognostication and treatment of aggressive breast cancer. Oncogenesis, 3 (10) e124, e124-e124. doi: 10.1038/oncsis.2014.41 |
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2014 Journal Article Runx2 is a novel regulator of mammary epithelial cell fate in development and breast cancerOwens, Thomas W., Rogers, Renee L., Best, Sarah A., Ledger, Anita, Mooney, Anne-Marie, Ferguson, Alison, Shore, Paul, Swarbrick, Alexander, Ormandy, Christopher J., Simpson, Peter T., Carroll, Jason S., Visvader, Jane E. and Naylor, Matthew J. (2014). Runx2 is a novel regulator of mammary epithelial cell fate in development and breast cancer. Cancer Research, 74 (18), 5277-5286. doi: 10.1158/0008-5472.CAN-14-0053 |
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2014 Journal Article Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomesTubio, Jose M. C., Li, Yilong, Ju, Young S., Martincorena, Inigo, Cooke, Susanna L., Tojo, Marta, Gundem, Gunes, Pipinikas, Christodoulos P., Zamora, Jorge, Raine, Keiran, Menzies, Andrew, Roman-Garcia, Pablo, Fullam, Anthony, Gerstung, Moritz, Shlien, Adam, Tarpey, Patrick S., Papaemmanuil, Elli, Knappskog, Stian, Van Loo, Peter, Ramakrishna, Manasa, Davies, Helen R., Marshall, John, Wedge, David C., Teague, Jon W., Butler, Adam P., Nik-Zainal, Serena, Alexandrov, Ludmil, Behjati, Sam, Yates, Lucy R. ... Simpson, Peter (2014). Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes. Science, 345 (6196) 1251343, 1251343.1-1251343.12. doi: 10.1126/science.1251343 |
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2014 Journal Article Intratumour heterogeneity in the progression to breast cancer metastasisKutasovic, Jamie R., Sim, Sarah Y. M., McCart Reed, Amy E., Cummings, Margaret C. and Simpson, Peter T. (2014). Intratumour heterogeneity in the progression to breast cancer metastasis. Cancer Forum, 38 (2), 138-142. |
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2014 Journal Article Molecular classification of breast cancerVuong, Darina, Simpson, Peter T., Green, Benjamin, Cummings, Margaret C. and Lakhani, Sunil R. (2014). Molecular classification of breast cancer. Virchows Archiv, 465 (1), 1-14. doi: 10.1007/s00428-014-1593-7 |
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2014 Journal Article A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapyLiu, Chao, Srihari, Sriganesh, Le Cao, Kim-Anh, Chenevix-Trench, Georgia, Simpson, Peter T., Ragan, Mark A. and Khanna, Kum Kum (2014). A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy. Nucleic Acids Research, 42 (10), 6106-6127. doi: 10.1093/nar/gku284 |
