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2020

Journal Article

GPR183 regulates interferons, autophagy, and bacterial growth during Mycobacterium tuberculosis infection and is associated with TB disease severity

Bartlett, Stacey, Gemiarto, Adrian Tandhyka, Ngo, Minh Dao, Sajiir, Haressh, Hailu, Semira, Sinha, Roma, Foo, Cheng Xiang, Kleynhans, Léanie, Tshivhula, Happy, Webber, Tariq, Bielefeldt-Ohmann, Helle, West, Nicholas P., Hiemstra, Andriette M., MacDonald, Candice E., Christensen, Liv von Voss, Schlesinger, Larry S., Walzl, Gerhard, Rosenkilde, Mette Marie, Mandrup-Poulsen, Thomas and Ronacher, Katharina (2020). GPR183 regulates interferons, autophagy, and bacterial growth during Mycobacterium tuberculosis infection and is associated with TB disease severity. Frontiers in Immunology, 11 601534, 601534. doi: 10.3389/fimmu.2020.601534

GPR183 regulates interferons, autophagy, and bacterial growth during Mycobacterium tuberculosis infection and is associated with TB disease severity

2020

Journal Article

Screening diabetes mellitus patients for pulmonary tuberculosis: a multisite study in Indonesia, Peru, Romania and South Africa

Alisjahbana, Bachti, McAllister, Susan M, Ugarte-Gil, Cesar, Panduru, Nicolae Mircea, Ronacher, Katharina, Koesoemadinata, Raspati C, Zubiate, Carlos, Riza, Anca Lelia, Malherbe, Stephanus T, Kleynhans, Leanie, Lopez, Sonia, Dockrell, Hazel M, Ruslami, Rovina, Ioana, Mihai, Walzl, Gerhard, Pearson, Fiona, Critchley, Julia A, Moore, David A J, van Crevel, Reinout and Hill, Philip C (2020). Screening diabetes mellitus patients for pulmonary tuberculosis: a multisite study in Indonesia, Peru, Romania and South Africa. Transactions of the Royal Society of Tropical Medicine and Hygiene, 115 (6), 1-10. doi: 10.1093/trstmh/traa100

Screening diabetes mellitus patients for pulmonary tuberculosis: a multisite study in Indonesia, Peru, Romania and South Africa

2020

Journal Article

High glucose levels increase influenza-associated damage to the pulmonary epithelial-endothelial barrier

Hulme, Katina Dee, Yan, Limin, Marshall, Rebecca J., Bloxham, Conor J., Upton, Kyle R., Hasnain, Sumaira Z., Bielefeldt-Ohmann, Helle, Loh, Zhixuan, Ronacher, Katharina, Chew, Keng Yih , Gallo, Linda A. and Short, Kirsty Renfree (2020). High glucose levels increase influenza-associated damage to the pulmonary epithelial-endothelial barrier. eLife, 9 e56907, 1-20. doi: 10.7554/elife.56907

High glucose levels increase influenza-associated damage to the pulmonary epithelial-endothelial barrier

2020

Other Outputs

GPR183 regulates interferons and bacterial growth during Mycobacterium tuberculosis infection: interaction with type 2 diabetes and TB disease severity

Bartlett, Stacey, Gemiarto, Adrian Tandhyka, Ngo, Minh Dao, Sajiir, Haressh, Hailu, Semira, Sinha, Roma, Foo, Cheng Xiang, Kleynhans, Léanie, Tshivhula, Happy, Webber, Tariq, Bielefeldt-Ohmann, Helle, West, Nicholas P., Hiemstra, Andriette M., MacDonald, Candice E., von Voss Christensen, Liv, Schlesinger, Larry S., Walzl, Gerhard, Rosenkilde, Mette Marie, Mandrup-Poulsen, Thomas and Ronacher, Katharina (2020). GPR183 regulates interferons and bacterial growth during Mycobacterium tuberculosis infection: interaction with type 2 diabetes and TB disease severity. doi: 10.1101/2020.07.15.203398

GPR183 regulates interferons and bacterial growth during Mycobacterium tuberculosis infection: interaction with type 2 diabetes and TB disease severity

2020

Journal Article

Impact of intermediate hyperglycaemia as well as diabetes on immune dysfunction in tuberculosis

Eckold, Clare, Kumar, Vinod, Weiner Rd, January, Alisjahbana, Bachti, Riza, Anca-Lelia, Ronacher, Katharina, Coronel, Jorge, Kerry-Barnard, Sarah, Malherbe, Stephanus T., Kleynhans, Leanie, Stanley, Kim, Ruslami, Rovina, Ioana, Mihai, Ugarte-Gil, Cesar, Walzl, Gerhard, van Crevel, Reinout, Wijmenga, Cisca, Critchley, Julia A., Dockrell, Hazel M., Cliff, Jacqueline M. and for the TANDEM consortium (2020). Impact of intermediate hyperglycaemia as well as diabetes on immune dysfunction in tuberculosis. Clinical Infectious Diseases, 72 (1), 69-78. doi: 10.1093/cid/ciaa751

Impact of intermediate hyperglycaemia as well as diabetes on immune dysfunction in tuberculosis

2020

Journal Article

Glycemic variability in diabetes increases the severity of influenza

Marshall, Rebecca J., Armart, Pornthida, Hulme, Katina D., Chew, Keng Yih, Brown, Alexandra C., Hansbro, Philip M., Bloxham, Conor J., Flint, Melanie, Ronacher, Katharina, Bielefeldt-Ohmann, Helle, Gallo, Linda A. and Short, Kirsty R. (2020). Glycemic variability in diabetes increases the severity of influenza. mBio, 11 (2) e02841-19. doi: 10.1128/mbio.02841-19

Glycemic variability in diabetes increases the severity of influenza

2020

Journal Article

Quantitative 18F-FDG PET-CT scan characteristics correlate with tuberculosis treatment response

Malherbe, Stephanus T., Chen, Ray Y., Dupont, Patrick, Kant, Ilse, Kriel, Magdalena, Loxton, André G., Smith, Bronwyn, Beltran, Caroline G. G., van Zyl, Susan, McAnda, Shirely, Abrahams, Charmaine, Maasdorp, Elizna, Doruyter, Alex, Via, Laura E., Barry, Clifton E., Alland, David, Griffith-Richards, Stephanie , Ellman, Annare, Peppard, Thomas, Belisle, John, Tromp, Gerard, Ronacher, Katharina, Warwick, James M., Winter, Jill and Walzl, Gerhard (2020). Quantitative 18F-FDG PET-CT scan characteristics correlate with tuberculosis treatment response. EJNMMI Research, 10 (1) 8, 8. doi: 10.1186/s13550-020-0591-9

Quantitative 18F-FDG PET-CT scan characteristics correlate with tuberculosis treatment response

2020

Conference Publication

A cholesterol receptor regulates interferons and bacterial growth during M. tuberculosis infection

Gemiarto, Adrian T., Sinha, Roma, Sajiir, Haressh, Hailu, Semira, Bartlett, Stacey, Ngo, Minh Dao, Foo, Cheng Xiang, Kleynhans, Leanie, Tshivhula, Happy, Bielefeldt-Ohmann, Helle, Schlesinger, Larry S., Walzl, Gerhard, Rosenkilde, Mette M., Mandrup-Poulsen, T and Ronacher, Katharina (2020). A cholesterol receptor regulates interferons and bacterial growth during M. tuberculosis infection. Keystone Symposia: Tuberculosis Immunity and Immune Evasion, Santa Fe, New Mexico, United States, 16-21 January 2020.

A cholesterol receptor regulates interferons and bacterial growth during M. tuberculosis infection

2019

Journal Article

Time-dependent changes in urinary metabolome before and after intensive phase tuberculosis therapy: A pharmacometabolomics study

Combrink, Monique, du Preez, Ilse, Ronacher, Katharina, Walzl, Gerhard and Loots, Du Toit (2019). Time-dependent changes in urinary metabolome before and after intensive phase tuberculosis therapy: A pharmacometabolomics study. OMICS: A Journal of Integrative Biology, 23 (11) omi.2019.0140, 560-572. doi: 10.1089/omi.2019.0140

Time-dependent changes in urinary metabolome before and after intensive phase tuberculosis therapy: A pharmacometabolomics study

2019

Journal Article

Distinct serum biosignatures are associated with different tuberculosis treatment outcomes

Ronacher, Katharina, Chegou, Novel N., Kleynhans, Léanie, Djoba Siawaya, Joel F., du Plessis, Nelita, Loxton, André G., Maasdorp, Elizna, Tromp, Gerard, Kidd, Martin, Stanley, Kim, Kriel, Magdalena, Menezes, Angela, Gutschmidt, Andrea, van der Spuy, Gian D., Warren, Robin M., Dietze, Reynaldo, Okwera, Alphonse, Thiel, Bonnie, Belisle, John T., Cliff, Jacqueline M., Boom, W. Henry, Johnson, John L., van Helden, Paul D., Dockrell, Hazel M. and Walzl, Gerhard (2019). Distinct serum biosignatures are associated with different tuberculosis treatment outcomes. Tuberculosis, 118 101859, 101859. doi: 10.1016/j.tube.2019.101859

Distinct serum biosignatures are associated with different tuberculosis treatment outcomes

2019

Journal Article

Diabetes mellitus among pulmonary tuberculosis patients from four TB-endemic countries: the TANDEM study

Ugarte-Gil, Cesar, Alisjahbana, Bachti, Ronacher, Katharina, Riza, Anca Lelia, Koesoemadinata, Raspati C., Malherbe, Stephanus T., Cioboata, Ramona, Llontop, Juan Carlos, Kleynhans, Leanie, Lopez, Sonia, Santoso, Prayudi, Marius, Ciontea, Villaizan, Katerine, Ruslami, Rovina, Walzl, Gerhard, Panduru, Nicolae Mircea, Dockrell, Hazel M., Hill, Philip C., Mc Allister, Susan, Pearson, Fiona, Moore, David A. J, Critchley, Julia A., van Crevel, Reinout and TANDEM Consortium (2019). Diabetes mellitus among pulmonary tuberculosis patients from four TB-endemic countries: the TANDEM study. Clinical Infectious Diseases, 70 (5), 780-788. doi: 10.1093/cid/ciz284

Diabetes mellitus among pulmonary tuberculosis patients from four TB-endemic countries: the TANDEM study

2019

Journal Article

Point of care HbA1c level for diabetes mellitus management and its accuracy among tuberculosis patients: a study in four countries

Huangfu, P., Laurence, Y. V., Alisjahbana, B., Ugarte-Gil, C., Riza, A-L., Walzl, G., Ruslami, R., Moore, D. A. J., Ioana, M.., McAllister, S., Ronacher, K., Koesoemadinata, R. C., Grint, D., Kerry, S., Coronel, J., Malherbe, S. T., Griffiths, U., Dockrell, H. M., Hill, P. C., van Crevel, R., Pearson, F. and Critchley, J. A. (2019). Point of care HbA1c level for diabetes mellitus management and its accuracy among tuberculosis patients: a study in four countries. International Journal of Tuberculosis and Lung Disease, 23 (3), 283-292. doi: 10.5588/ijtld.18.0359

Point of care HbA1c level for diabetes mellitus management and its accuracy among tuberculosis patients: a study in four countries

2018

Journal Article

Erratum to: A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes (Nature, (2018), 560, 7720, (644-648), 10.1038/s41586-018-0439-x)

Roy Chowdhury, Roshni, Vallania, Francesco, Yang, Qianting, Lopez Angel, Cesar Joel, Darboe, Fatoumatta, Penn-Nicholson, Adam, Rozot, Virginie, Nemes, Elisa, Malherbe, Stephanus T., Ronacher, Katharina, Walzl, Gerhard, Hanekom, Willem, Davis, Mark M., Winter, Jill, Chen, Xinchun, Scriba, Thomas J., Khatri, Purvesh and Chien, Yueh-hsiu (2018). Erratum to: A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes (Nature, (2018), 560, 7720, (644-648), 10.1038/s41586-018-0439-x). Nature, 564 (7734), E5-E5. doi: 10.1038/s41586-018-0635-8

Erratum to: A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes (Nature, (2018), 560, 7720, (644-648), 10.1038/s41586-018-0439-x)

2018

Journal Article

Diabetes screen during tuberculosis contact investigations highlights opportunity for new diabetes diagnosis and reveals metabolic differences between ethnic groups

Restrepo, Blanca I., Kleynhans, Léanie, Salinas, Alejandra B., Abdelbary, Bassent, Tshivhula, Happy, Aguillón-Durán, Genesis P., Kunsevi-Kilola, Carine, Salinas, Gloria, Stanley, Kim, Malherbe, Stephanus T., Maasdorp, Elizna, Garcia-Viveros, Moncerrato, Louw, Ilze, Garcia-Oropesa, Esperanza M., Lopez-Alvarenga, Juan Carlos, Prins, John B., Walzl, Gerhard, Schlesinger, Larry S. and Ronacher, Katharina (2018). Diabetes screen during tuberculosis contact investigations highlights opportunity for new diabetes diagnosis and reveals metabolic differences between ethnic groups. Tuberculosis, 113, 10-18. doi: 10.1016/j.tube.2018.08.007

Diabetes screen during tuberculosis contact investigations highlights opportunity for new diabetes diagnosis and reveals metabolic differences between ethnic groups

2018

Journal Article

119. Prospective Validation of a 3-Gene Signature for Tuberculosis Diagnosis, Predicting Progression and Evaluating Treatment Response

Warsinske, Hayley, Rao, Aditya, Moreira, Flora Martinez Figueira, Dos Santos, Paulo Cesar Pereira, Liu, Andrew, Scott, Madeleine, Malherbe, Stephanus, Ronacher, Katharina, Walzl, Gerhard, Winter, Jill, Sweeney, Timothy E, Croda, Julio, Andrews, Jason R and Khatri, Purvesh (2018). 119. Prospective Validation of a 3-Gene Signature for Tuberculosis Diagnosis, Predicting Progression and Evaluating Treatment Response. Open Forum Infectious Diseases, 5 (suppl_1). doi: 10.1093/ofid/ofy209.010

119. Prospective Validation of a 3-Gene Signature for Tuberculosis Diagnosis, Predicting Progression and Evaluating Treatment Response

2018

Journal Article

Assessment of validity of a blood-based 3-gene signature score for progression and diagnosis of tuberculosis, disease severity, and treatment response

Warsinske, Hayley C., Rao, Aditya M., Moreira, Flora M. F., Cesar, Paulo, Liu, Andrew B., Scott, Madeleine, Malherbe, Stephaus T., Ronacher, Katharina, Walzl, Gerhard, Winter, Jill , Sweeney, Timothy E. , Croda, Julio , Andrews, Jason R. and Khatri, Purvesh (2018). Assessment of validity of a blood-based 3-gene signature score for progression and diagnosis of tuberculosis, disease severity, and treatment response. JAMA Network Open, 1 (6), e183779. doi: 10.1001/jamanetworkopen.2018.3779

Assessment of validity of a blood-based 3-gene signature score for progression and diagnosis of tuberculosis, disease severity, and treatment response

2018

Journal Article

IL-22: an underestimated player in natural resistance to tuberculosis?

Ronacher, Katharina, Sinha, Roma and Cestari, Michelle (2018). IL-22: an underestimated player in natural resistance to tuberculosis?. Frontiers in Immunology, 9 (SEP) 2209. doi: 10.3389/fimmu.2018.02209

IL-22: an underestimated player in natural resistance to tuberculosis?

2018

Journal Article

Accuracy of diabetes screening methods used for people with tuberculosis, Indonesia, Peru, Romania, South Africa

Grint, Daniel, Alisjhabana, Bachti, Ugarte-Gil, Cesar, Riza, Anca-Leila, Walzl, Gerhard, Pearson, Fiona, Ruslami, Rovina, Moore, David A. J., Ioana, Mihai, McAllister, Susan, Ronacher, Katharina, Koeseomadinata, Raspati C., Kerry-Barnard, Sarah R., Coronel, Jorge, Malherbe, Stephanus T., Dockrell, Hazel M., Hill, Philip C., Van Crevel, Reinout and Critchley, Julia A. (2018). Accuracy of diabetes screening methods used for people with tuberculosis, Indonesia, Peru, Romania, South Africa. Bulletin of the World Health Organization, 96 (11), 738-749. doi: 10.2471/blt.17.206227

Accuracy of diabetes screening methods used for people with tuberculosis, Indonesia, Peru, Romania, South Africa

2018

Journal Article

A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes

Roy Chowdhury, Roshni, Vallania, Francesco, Yang, Qiantian, Lopez Angel, Cesar Joel, Darboe, Fatoumatta, Penn-Nicholson, Adam, Rozot, Virginie, Nemes, Elisa, Malherbe, Stephanus T., Ronacher, Katharina, Walzl, Gerhard, Hanekom, Willem, Davis, Mark M., Winter, Jill, Chen, Xinchun, Scriba, Thomas J., Khatri, Purvesh and Chien, Yueh-hsiu (2018). A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes. Nature, 560 (7720), 644-648. doi: 10.1038/s41586-018-0439-x

A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes

2018

Journal Article

Disease characteristics and treatment of patients with diabetes mellitus attending government health services in Indonesia, Peru, Romania and South Africa

Soetedjo, Nanny N. M., McAllister, Susan M., Ugarte-Gil, Cesar, Firanescu, Adela G., Ronacher, Katharina, Alisjahbana, Bachti, Costache, Anca L., Zubiate, Carlos, Malherbe, Stephanus T., Koesoemadinata, Raspati C., Laurence, Yoko V., Pearson, Fiona, Kerry-Barnard, Sarah, Ruslami, Rovina, Moore, David A. J., Ioana, Mihai, Kleynhans, Leanie, Pernama, Hikmat, Hill, Philip C., Mota, Maria, Walzl, Gerhard, Dockrell, Hazel M., Critchley, Julia A. and van Crevel, Reinout (2018). Disease characteristics and treatment of patients with diabetes mellitus attending government health services in Indonesia, Peru, Romania and South Africa. Tropical Medicine and International Health, 23 (10), 1118-1128. doi: 10.1111/tmi.13137

Disease characteristics and treatment of patients with diabetes mellitus attending government health services in Indonesia, Peru, Romania and South Africa