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2026 Journal Article Mitochondrial fission mediates an evolutionarily conserved antibacterial defense responseKapetanovic, Ronan, Afroz, Syeda Farhana, Curson, James E. B., Kirmes, Ina, Ramnath, Divya, Nothjunge, Stephan, Liu, Jinting, Atkinson, Jordan D., Ahier, Arnaud, Raven, Karoline D., Bosch, Marta, Keller, Bernhard, Lawrence, Grace M. E. P., Gupta, Kaustav Das, Shakespear, Melanie R., Ferguson, Charles, Stocks, Claudia J., Bokil, Nilesh J., Matthias, Gabriele, Nguyen, Tam T. K., Khalil, Zeinab G., Reid, Robert C., Hansford, Karl A., Hansbro, Philip M., Cooper, Matthew A., Schembri, Mark A., Blumenthal, Antje, Schroder, Kate, Fairlie, David P. ... Sweet, Matthew J. (2026). Mitochondrial fission mediates an evolutionarily conserved antibacterial defense response. Science Immunology, 11 (118) eaed2623. doi: 10.1126/sciimmunol.aed2623 |
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2026 Journal Article Development of a novel polyleucine-based immunopotentiator for subunit vaccines against Group A StreptococcusLu, Lantian, Cruz, Jazmina L. Gonzalez, Giri, Rabina, Zhang, Yuexiao, Bashiri, Sahra, Cadena, Leslie C. Domínguez, Li, Shuhang, Khalil, Zeinab G., Hussein, Waleed M., Wang, Jingwen, Kiong, Jolynn, Lu, Xuehan, Zhang, Jiahui, Lu, Miao, Huang, Wenbin, Kong, Wei Yang, Nahar, Ummey Jannatun, Koirala, Prashamsa, Guo, Zhong, Walden, Patricia, Blumenthal, Antje, Begun, Jakob, Alexandrov, Kirill, Toth, Istvan, Stephenson, Rachel J. and Skwarczynski, Mariusz (2026). Development of a novel polyleucine-based immunopotentiator for subunit vaccines against Group A Streptococcus. Small, 22 (22) e11459, 1-20. doi: 10.1002/smll.202511459 |
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2026 Journal Article Sweep Flow Nitric Oxide Effects on Coagulation, Inflammation, and Endothelial System Activation During Extracorporeal Membrane OxygenationMattke, Adrian C., Schlapbach, Luregn J., Takashima, Mari, Johnson, Kerry E., McPherson, Stephen, Venugopal, Prem S. and Blumenthal, Antje (2026). Sweep Flow Nitric Oxide Effects on Coagulation, Inflammation, and Endothelial System Activation During Extracorporeal Membrane Oxygenation. ASAIO Journal 10.1097/MAT.0000000000002709. doi: 10.1097/mat.0000000000002709 |
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2026 Journal Article CD8+ T cells sustain vaccination-induced immunity against dissemination of contained tuberculosis in immunosuppressed hostsMiranda-Hernandez, Socorro, Kumar, Manoharan, Henderson, Alec, Graham, Erin, Tan, Xiao, Taylor, Jim, Meehan, Michael T., Ceja, Zuriel, del Pozo-Ramos, Lidia, Pan, Yi, Tsui, Ellen, Donovan, Meg L., Rentería, Miguel E., Flores-Valdez, Mario Alberto, Blumenthal, Antje, Nguyen, Quan, Subbian, Selvakumar, Field, Matt A. and Kupz, Andreas (2026). CD8+ T cells sustain vaccination-induced immunity against dissemination of contained tuberculosis in immunosuppressed hosts. Nature Communications. doi: 10.1038/s41467-026-70911-4 |
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2026 Journal Article Sweep Gas Nitric Oxide During Extracorporeal Membrane Oxygenation in Neonates and Children (NECTAR Trial): A Single-Center, Pilot Randomized Controlled TrialMattke, Adrian C., Johnson, Kerry, Gibbons, Kristen, Le Marsney, Renate, Long, Debbie A., O’Brien, Christopher, Blumenthal, Antje, Venugopal, Prem S., Alphonso, Nelson and Schlapbach, Luregn J. (2026). Sweep Gas Nitric Oxide During Extracorporeal Membrane Oxygenation in Neonates and Children (NECTAR Trial): A Single-Center, Pilot Randomized Controlled Trial. Pediatric Critical Care Medicine, Publish Ahead of Print. doi: 10.1097/PCC.0000000000003926 |
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2025 Journal Article The microbiome and gut–lung axis in nontuberculous mycobacterial pulmonary diseaseThompson, Ria N., Blumenthal, Antje, Morrison, Mark and Thomson, Rachel M. (2025). The microbiome and gut–lung axis in nontuberculous mycobacterial pulmonary disease. PLOS Pathogens, 21 (10) e1013603, 1-25. doi: 10.1371/journal.ppat.1013603 |
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2025 Journal Article Histone deacetylase 7 mediates lipopolysaccharide-inducible mitochondrial fission in macrophagesAbrol, Rishika, Afroz, Syeda Farhana, Curson, James E. B., Raven, Karoline D., Das Gupta, Kaustav, Gunther, Kimberley S., Jones, Alun, Reid, Robert C., Xiong, Zherui, Gunter, Jennifer H., Engel, Jessica A., Engwerda, Christian R., Blumenthal, Antje, Fairlie, David P., Parton, Robert G., Zuryn, Steven, Kapetanovic, Ronan, Ramnath, Divya and Sweet, Matthew J. (2025). Histone deacetylase 7 mediates lipopolysaccharide-inducible mitochondrial fission in macrophages. Journal of Cell Science, 138 (19) jcs.264376, 1-14. doi: 10.1242/jcs.264376 |
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2025 Journal Article Utilizing Nanopore direct RNA sequencing of blood from patients with sepsis for discovery of co- and post-transcriptional disease biomarkersHe, Jingni, Ganesamoorthy, Devika, Chang, Jessie J.-Y., Zhang, Jianshu, Trevor, Sharon L., Gibbons, Kristen S., McPherson, Stephen J., Kling, Jessica C., Schlapbach, Luregn J., Blumenthal, Antje, Coin, Lachlan J. M., RAPIDS Study Group, Irwin, Adam and Bialasiewicz, Seweryn (RAPIDS Study Group member) (2025). Utilizing Nanopore direct RNA sequencing of blood from patients with sepsis for discovery of co- and post-transcriptional disease biomarkers. BMC Infectious Diseases, 25 (1) 692, 1-19. doi: 10.1186/s12879-025-11078-z |
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2025 Journal Article TLR4 endocytosis and endosomal TLR4 signaling are distinct and independent outcomes of TLR4 activationSchultz, Thomas E., Mathmann, Carmen D., Domínguez Cadena, Leslie C., Muusse, Timothy W., Kim, Hyoyoung, Wells, James W., Ulett, Glen C., Hamerman, Jessica A., Brooks, Andrew J., Kobe, Bostjan, Sweet, Matthew J., Stacey, Katryn J. and Blumenthal, Antje (2025). TLR4 endocytosis and endosomal TLR4 signaling are distinct and independent outcomes of TLR4 activation. EMBO Reports, 26 (10) 2250056, 2740-2766. doi: 10.1038/s44319-025-00444-2 |
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2025 Journal Article Signalling by co-operative higher-order assembly formation: linking evidence at molecular and cellular levelsKobe, Bostjan, Nanson, Jeffrey D., Hoad, Mikayla, Blumenthal, Antje, Gambin, Yann, Sierecki, Emma, Stacey, Katryn J., Ve, Thomas and Halfmann, Randal (2025). Signalling by co-operative higher-order assembly formation: linking evidence at molecular and cellular levels. Biochemical Journal, 482 (05), 275-294. doi: 10.1042/bcj20220094 |
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2025 Journal Article No added sugar: CCDC134 stabilizes ER chaperone Gp96 for TLR biogenesisBlumenthal, Antje and Domínguez Cadena, Leslie C. (2025). No added sugar: CCDC134 stabilizes ER chaperone Gp96 for TLR biogenesis. Journal of Experimental Medicine, 222 (3) e20242285, 1-3. doi: 10.1084/jem.20242285 |
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2024 Journal Article Fludrocortisone dose–response relationship in septic shock: a randomised phase II trialWalsham, James, Hammond, Naomi, Blumenthal, Antje, Cohen, Jeremy, Myburgh, John, Finfer, Simon, Evans, David, Peake, Sandra, Kruger, Peter, McCullough, James, Johnk, Loki, Ghelani, Dhaval, Billot, Laurent, Shan, Sana, Meyer, Jason, Rajbhandari, Dorrilyn, Koch, Carolyn, Bellomo, Rinaldo, Burrell, Louise M., Young, Morag, Roberts, Michael, Mackenzie, Lorraine, Medley, Gregory, Dalton, Joshua and Venkatesh, Balasubramanian (2024). Fludrocortisone dose–response relationship in septic shock: a randomised phase II trial. Intensive Care Medicine, 50 (12), 2050-2060. doi: 10.1007/s00134-024-07616-z |
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2024 Journal Article Myddosomes in Toll-like receptor signaling-one to bind and rule them allMathmann, Carmen D., Schultz, Thomas E., Cadena, Leslie C. Dominguez and Blumenthal, Antje (2024). Myddosomes in Toll-like receptor signaling-one to bind and rule them all. Immunology and Cell Biology, 102 (9), 752-756. doi: 10.1111/imcb.12816 |
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2024 Journal Article Host gene expression signatures to identify infection type and organ dysfunction in children evaluated for sepsis: a multicentre cohort studySchlapbach, Luregn J., Ganesamoorthy, Devika, Wilson, Clare, Raman, Sainath, George, Shane, Snelling, Peter J., Phillips, Natalie, Irwin, Adam, Sharp, Natalie, Le Marsney, Renate, Chavan, Arjun, Hempenstall, Allison, Bialasiewicz, Seweryn, MacDonald, Anna D., Grimwood, Keith, Cling, Jessica C., McPherson, Stephen J., Blumenthal, Antje, Kaforou, Myrsini, Levin, Michael, Herberg, Jethro A., Gibbons, Kristen S., Coin, Lachlan J. M., EUCLIDS consortium and RAPIDS Study Group (2024). Host gene expression signatures to identify infection type and organ dysfunction in children evaluated for sepsis: a multicentre cohort study. The Lancet Child and Adolescent Health, 8 (5), 325-338. doi: 10.1016/S2352-4642(24)00017-8 |
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2024 Journal Article Inhibiting Eph/ephrin signaling reduces vascular leak and endothelial cell dysfunction in mice with sepsisKhan, Nemat, Kumar, Vinod, Li, Pengcheng, RAPIDS Study Group, Raman, Sainath (RSG member), Sharp, Natalie (RSG member), Phillips, Natalie (RSG member), Irwin, Adam (RSG member), George, Shane (RSG member), Grimwood, Keith (RSG member), Snelling, Peter (RSG member), Chavan, Arjun (RSG member), Hempenstall, Allison (RSG member), Gibbons, Kristen (RSG member), Le Marsney, Renate (RSG member), Blumenthal, Antje (RSG member), Ganesamoorthy, Devika (RSG member), Coin, Lachlan (RSG member), Schlapbach, Luregn J., Boyd, Andrew W., Coulthard, Mark G. and Woodruff, Trent M. (2024). Inhibiting Eph/ephrin signaling reduces vascular leak and endothelial cell dysfunction in mice with sepsis. Science Translational Medicine, 16 (744) eadg5768, 1-15. doi: 10.1126/scitranslmed.adg5768 |
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2023 Journal Article Wollamide cyclic hexapeptides synergize with established and new tuberculosis antibiotics in targeting Mycobacterium tuberculosisRollo, Rachel F., Mori, Giorgia, Hill, Timothy A., Hillemann, Doris, Niemann, Stefan, Homolka, Susanne, Fairlie, David P. and Blumenthal, Antje (2023). Wollamide cyclic hexapeptides synergize with established and new tuberculosis antibiotics in targeting Mycobacterium tuberculosis. Microbiology Spectrum, 11 (4). doi: 10.1128/spectrum.00465-23 |
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2023 Journal Article Nitric oxide on extracorporeal membrane oxygenation in neonates and children (NECTAR Trial): Protocol for a randomized controlled trialMattke, Adrian, Johnson, Kerry, Gibbons, Kristen, Long, Debbie, Robertson, Jeremy, Venugopal, Prem, Blumenthal, Antje, Schibler, Andreas and Schlapbach, Luregn (2023). Nitric oxide on extracorporeal membrane oxygenation in neonates and children (NECTAR Trial): Protocol for a randomized controlled trial. JMIR Research Protocols, 12 e43760, 1-10. doi: 10.2196/43760 |
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2023 Journal Article Immunity against Moraxella catarrhalis requires guanylate‐binding proteins and caspase‐11‐ NLRP3 inflammasomesEnosi Tuipulotu, Daniel, Feng, Shouya, Pandey, Abhimanu, Zhao, Anyang, Ngo, Chinh, Mathur, Anukriti, Lee, Jiwon, Shen, Cheng, Fox, Daniel, Xue, Yansong, Kay, Callum, Kirkby, Max, Lo Pilato, Jordan, Kaakoush, Nadeem O, Webb, Daryl, Rug, Melanie, Robertson, Avril AB, Tessema, Melkamu B, Pang, Stanley, Degrandi, Daniel, Pfeffer, Klaus, Augustyniak, Daria, Blumenthal, Antje, Miosge, Lisa A, Brüstle, Anne, Yamamoto, Masahiro, Reading, Patrick C, Burgio, Gaetan and Man, Si Ming (2023). Immunity against Moraxella catarrhalis requires guanylate‐binding proteins and caspase‐11‐ NLRP3 inflammasomes. The EMBO Journal, 42 (6) e112558, e112558. doi: 10.15252/embj.2022112558 |
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2022 Journal Article Distinct contributions of the innate immune receptors TLR2 and RP105 to formation and architecture of structured lung granulomas in mice infected with Mycobacterium tuberculosisDonovan, Meg L., Bielefeldt‐Ohmann, Helle, Rollo, Rachel F., McPherson, Stephen, Schultz, Thomas E., Mori, Giorgia, Kling, Jessica C. and Blumenthal, Antje (2022). Distinct contributions of the innate immune receptors TLR2 and RP105 to formation and architecture of structured lung granulomas in mice infected with Mycobacterium tuberculosis. Immunology, 169 (1), 13-26. doi: 10.1111/imm.13606 |
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2022 Journal Article Myeloid Wls expression is dispensable for skin wound healing and blood vessel regenerationSim, Seen Ling, Blumenthal, Antje, Kaur, Simranpreet and Khosrotehrani, Kiarash (2022). Myeloid Wls expression is dispensable for skin wound healing and blood vessel regeneration. Frontiers in Endocrinology, 13 957833, 957833. doi: 10.3389/fendo.2022.957833 |
