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2024 Journal Article Site-specific elastic and viscoelastic biomechanical properties of healthy and osteoarthritic human knee joint articular cartilageLinus, Awuniji, Tanska, Petri, Nippolainen, Ervin, Tiitu, Virpi, Töyras, Juha, Korhonen, Rami K., Afara, Isaac O. and Mononen, Mika E. (2024). Site-specific elastic and viscoelastic biomechanical properties of healthy and osteoarthritic human knee joint articular cartilage. Journal of Biomechanics, 169 112135. doi: 10.1016/j.jbiomech.2024.112135 |
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2024 Journal Article Reaction time in psychomotor vigilance task is related to hypoxic load in males with sleep apneaPahari, Purbanka, Korkalainen, Henri, Karhu, Tuomas, Arnardottir, Erna Sif, Töyräs, Juha, Leppänen, Timo and Nikkonen, Sami (2024). Reaction time in psychomotor vigilance task is related to hypoxic load in males with sleep apnea. Journal of Sleep Research, 33 (2) e13988, e13988. doi: 10.1111/jsr.13988 |
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2024 Journal Article Increased flow limitation during sleep is associated with increased psychomotor vigilance task lapses in individuals with suspected obstructive sleep apneaStaykov, Eric, Mann, Dwayne L., Duce, Brett, Kainulainen, Samu, Leppänen, Timo, Töyräs, Juha, Azarbarzin, Ali, Georgeson, Thomas, Sands, Scott A. and Terrill, Philip I. (2024). Increased flow limitation during sleep is associated with increased psychomotor vigilance task lapses in individuals with suspected obstructive sleep apnea. CHEST, 165 (4), 990-1003. doi: 10.1016/j.chest.2023.11.031 |
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2024 Journal Article Prolonged lung-to-finger circulation time indicates an increased risk of intermittent hypoxemia in sleep apnea patientsPahari, Purbanka, Korkalainen, Henri, Arnardóttir, Erna Sif, Islind, Anna Sigridur, August, Elias, Oksenberg, Arie, Töyräs, Juha, Leppänen, Timo and Nikkonen, Sami (2024). Prolonged lung-to-finger circulation time indicates an increased risk of intermittent hypoxemia in sleep apnea patients. ERJ Open Research, 10 (4) 01051-2023, 1-12. doi: 10.1183/23120541.01051-2023 |
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2024 Journal Article Beat-to-beat cardiac repolarization lability increases during hypoxemia and arousals in obstructive sleep apnea patientsEbrahimian, Serajeddin, Sillanmäki, Saara, Hietakoste, Salla, Kulkas, Antti, Töyräs, Juha, Bailon, Raquel, Hernando, David, Lombardi, Carolina, Grote, Ludger, Bonsignore, Maria R, Saaresranta, Tarja, Pépin, Jean-Louis, Leppänen, Timo and Kainulainen, Samu (2024). Beat-to-beat cardiac repolarization lability increases during hypoxemia and arousals in obstructive sleep apnea patients. American Journal of Physiology-Heart and Circulatory Physiology, 326 (5), H1094-H1104. doi: 10.1152/ajpheart.00760.2023 |
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2024 Journal Article Cationic tantalum oxide nanoparticle contrast agent for micro computed tomography reveals articular cartilage proteoglycan distribution and collagen architecture alterationsJäntti, Jiri, Joenathan, Anisha, Fugazzola, Maria, Tuppurainen, Juuso, Honkanen, Juuso T. J., Töyräs, Juha, van Weeren, René, Snyder, Brian D., Grinstaff, Mark W., Matikka, Hanna and Mäkelä, Janne T.A. (2024). Cationic tantalum oxide nanoparticle contrast agent for micro computed tomography reveals articular cartilage proteoglycan distribution and collagen architecture alterations. Osteoarthritis and Cartilage, 32 (3), 299-309. doi: 10.1016/j.joca.2023.11.020 |
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2024 Journal Article Variation in the photoplethysmogram response to arousal from sleep depending on the cause of arousal and the presence of desaturationLuukinen, Mieli, Pitkänen, Henna, Leppänen, Timo, Töyräs, Juha, Islind, Anna Sigridur, Kainulainen, Samu and Korkalainen, Henri (2024). Variation in the photoplethysmogram response to arousal from sleep depending on the cause of arousal and the presence of desaturation. IEEE Journal of Translational Engineering in Health and Medicine, 12, 328-339. doi: 10.1109/jtehm.2024.3349916 |
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2024 Journal Article Triple contrast computed tomography reveals site‐specific biomechanical differences in the human knee joint—A proof of concept studyOrava, Heta, Paakkari, Petri, Jäntti, Jiri, Honkanen, Miitu K. M., Honkanen, Juuso T. J., Virén, Tuomas, Joenathan, Anisha, Tanska, Petri, Korhonen, Rami K., Grinstaff, Mark W., Töyräs, Juha and Mäkelä, Janne T. A. (2024). Triple contrast computed tomography reveals site‐specific biomechanical differences in the human knee joint—A proof of concept study. Journal of Orthopaedic Research, 42 (2), 415-424. doi: 10.1002/jor.25683 |
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2024 Conference Publication Comparing novel electrophysiological biomarkers and circulating cardiac biomarkers in predicting cardiovascular mortality and all-cause mortality in the Akershus Sleep Apnea (ASAP) epidemiological cohortHrubos-Strøm, H., Øverby, T.C., Sigurdardottir, F., Feng, X., Nikkonen, S., Korkalainen, H., Leppanen, T., Töyräs, J. and Arnardottir, E.S. (2024). Comparing novel electrophysiological biomarkers and circulating cardiac biomarkers in predicting cardiovascular mortality and all-cause mortality in the Akershus Sleep Apnea (ASAP) epidemiological cohort. 17th World Sleep Congress, Rio de Janeiro, Brazil, 20-25 October 2023. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.sleep.2023.11.910 |
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2024 Journal Article Acute cardiorespiratory coupling impairment in worsening sleep apnea-related intermittent hypoxemiaHietakoste, Salla, Armañac-Julián, Pablo, Karhu, Tuomas, Bailón, Raquel, Sillanmäki, Saara, Töyräs, Juha, Leppänen, Timo, Myllymaa, Sami and Kainulainen, Samu (2024). Acute cardiorespiratory coupling impairment in worsening sleep apnea-related intermittent hypoxemia. IEEE Transactions on Biomedical Engineering, 71 (1), 326-333. doi: 10.1109/tbme.2023.3300079 |
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2023 Journal Article Respiratory event index underestimates severity of sleep apnea compared to apnea-hypopnea indexPitkänen, Minna, Nath, Rajdeep Kumar, Korkalainen, Henri, Nikkonen, Sami, Mahamid, Alaa, Oksenberg, Arie, Duce, Brett, Töyräs, Juha, Kainulainen, Samu and Leppänen, Timo (2023). Respiratory event index underestimates severity of sleep apnea compared to apnea-hypopnea index. Sleep Advances, 5 (1) zpad054, 1-9. doi: 10.1093/sleepadvances/zpad054 |
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2023 Journal Article Broadband scattering properties of articular cartilage zones and their relationship with the heterogenous structure of articular cartilage extracellular matrixKafian-Attari, Iman, Nippolainen, Ervin, Bergmann, Florian, George, Akuroma, Paakkari, Petri, Mirhashemi, Arash, Foschum, Florian, Kienle, Alwin, Töyräs, Juha and Afara, Isaac O. (2023). Broadband scattering properties of articular cartilage zones and their relationship with the heterogenous structure of articular cartilage extracellular matrix. Journal of biomedical optics, 28 (12) 125003, 1-16. doi: 10.1117/1.JBO.28.12.125003 |
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2023 Journal Article 3D T<sub>1</sub> relaxation time measurements in an equine model of subtle post‐traumatic osteoarthritis using MB‐SWIFTPala, Swetha, Hänninen, Nina E., Mohammadi, Ali, Ebrahimi, Mohammadhossein, te Moller, Nikae C. R., Brommer, Harold, René van Weeren, P., Mäkelä, Janne T. A., Korhonen, Rami K., Afara, Isaac O., Töyräs, Juha, Mikkonen, Santtu, Nissi, Mikko J. and Nykänen, Olli (2023). 3D T1 relaxation time measurements in an equine model of subtle post‐traumatic osteoarthritis using MB‐SWIFT. Journal of Orthopaedic Research, 41 (12), 2657-2666. doi: 10.1002/jor.25629 |
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2023 Conference Publication Should Hospitals Do Contract Research? Costs, Net Monetary Benefit, and Return on Public Sector Investments in Research at Kuopio University HospitalVäätäinen, S., Soini, E. and Töyräs, J. (2023). Should Hospitals Do Contract Research? Costs, Net Monetary Benefit, and Return on Public Sector Investments in Research at Kuopio University Hospital. ISPOR Europe 2023, Copenhagen, Denmark, 11-15 November 2023. New York, NY United States: Elsevier. doi: 10.1016/j.jval.2023.09.562 |
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2023 Journal Article Review and perspective on sleep-disordered breathing research and translation to clinicsKorkalainen, Henri, Kainulainen, Samu, Islind, Anna Sigridur, Óskarsdóttir, María, Strassberger, Christian, Nikkonen, Sami, Töyräs, Juha, Kulkas, Antti, Grote, Ludger, Hedner, Jan, Sund, Reijo, Hrubos-Strom, Harald, Saavedra, Jose M., Ólafsdóttir, Kristín Anna, Ágústsson, Jón S., Terrill, Philip I., McNicholas, Walter T., Arnardóttir, Erna Sif, Leppänen, Timo and On behalf of SLEEP REVOLUTION (2023). Review and perspective on sleep-disordered breathing research and translation to clinics. Sleep Medicine Reviews, 73 101874, 1-12. doi: 10.1016/j.smrv.2023.101874 |
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2023 Journal Article Refractive index of human articular cartilage varies with tissue structure and compositionKhan, Bilour, Nippolainen, Ervin, Shahini, Fatemeh, Torniainen, Jari, Mikkonen, Santtu, Nonappa, Popov, Alexey, Töyräs, Juha and Afara, Isaac (2023). Refractive index of human articular cartilage varies with tissue structure and composition. Journal of the Optical Society of America A, 40 (12), 2205-2214. doi: 10.1364/josaa.498722 |
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2023 Journal Article Self-applied somnography: technical feasibility of electroencephalography and electro-oculography signal characteristics in sleep staging of suspected sleep-disordered adultsRusanen, Matias, Korkalainen, Henri, Gretarsdottir, Heidur, Siilak, Tiina, Olafsdottir, Kristin Anna, Töyräs, Juha, Myllymaa, Sami, Arnardottir, Erna Sif, Leppänen, Timo and Kainulainen, Samu (2023). Self-applied somnography: technical feasibility of electroencephalography and electro-oculography signal characteristics in sleep staging of suspected sleep-disordered adults. Journal of Sleep Research, 33 (2) e13977, e13977. doi: 10.1111/jsr.13977 |
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2023 Conference Publication Nasal pressure derived airflow limitation and ventilation measurements are resilient to reduced signal qualityStaykov, Eric, Mann, Dwayne L, Kainulainen, Samu, Duce, Brett, Leppanen, Timo, Toyras, Juha, Sands, Scott A. and Terrill, Philip I. (2023). Nasal pressure derived airflow limitation and ventilation measurements are resilient to reduced signal quality. 45th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), Sydney, Australia, 24-27 July 2023. Piscataway, NJ, United States: Institute of Electrical and Electronics Engineers. doi: 10.1109/embc40787.2023.10340215 |
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2023 Journal Article Impact of experimental setup parameters on measurement of articular cartilage optical properties in the visible and short near-infrared spectral bandsKafian-Attari, Iman, Nippolainen, Ervin, Bergmann, Florian, Mirhashemi, Arash, Pakkari, Petri, Foschum, Florian, Kienle, Alwin, Töyräs, Juha and Afara, Isaac (2023). Impact of experimental setup parameters on measurement of articular cartilage optical properties in the visible and short near-infrared spectral bands. Biomedical Optics Express, 14 (7), 3397-3412. doi: 10.1364/boe.488801 |
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2023 Journal Article Oxygen resaturation rate is significantly associated with objectively assessed excessive daytime sleepiness in suspected obstructive sleep apnoea patientsHowarth, Timothy P., Karhu, Tuomas, Kainulainen, Samu, Chen, Xin, Mahamid, Alaa, Töyräs, Juha and Leppänen, Timo (2023). Oxygen resaturation rate is significantly associated with objectively assessed excessive daytime sleepiness in suspected obstructive sleep apnoea patients. Sleep Medicine, 107, 171-178. doi: 10.1016/j.sleep.2023.04.027 |
