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2024

Conference Publication

Ventilatory burden predicts change in self‑reported sleepiness following continuous positive airway pressure treatment in obstructive sleep apnoea

Staykov, E., Mann, D., Duce, B., Kainulainen, S., Leppänen, T., Töyräs, J., Azarbarzin, A., Sands, S. and Terrill, P. (2024). Ventilatory burden predicts change in self‑reported sleepiness following continuous positive airway pressure treatment in obstructive sleep apnoea. 2024 Australasian Sleep Association, Gold Coast, QLD Australia, 16-19 October 2024. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/sleepadvances/zpae070.090

Ventilatory burden predicts change in self‑reported sleepiness following continuous positive airway pressure treatment in obstructive sleep apnoea

2024

Conference Publication

O004 Incorporating Arousals into Sleep vs. Wakefulness Classification Outperforms Traditional Binary Classification at 1-Second Epoch Resolution

Somaskandhan, P., Korkalainen, H., Leppänen, T., Töyräs, J., Melehan, K., Wilson, D., Ruehland, W., Mann, D. and Terrill, P. (2024). O004 Incorporating Arousals into Sleep vs. Wakefulness Classification Outperforms Traditional Binary Classification at 1-Second Epoch Resolution. Sleep DownUnder 2024, Gold Coast, QLD Australia, 16-19 October 2024. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/sleepadvances/zpae070.004

O004 Incorporating Arousals into Sleep vs. Wakefulness Classification Outperforms Traditional Binary Classification at 1-Second Epoch Resolution

2024

Journal Article

An automated and robust tool for musculoskeletal and finite element modeling of the knee joint

Esrafilian, Amir, Chandra, Shekhar S., Gatti, Anthony A., Nissi, Mikko, Mustonen, Anne-Mari, Saisanen, Laura, Reijonen, Jusa, Nieminen, Petteri, Julkunen, Petro, Toyras, Juha, Saxby, David J., Lloyd, David G. and Korhonen, Rami K. (2024). An automated and robust tool for musculoskeletal and finite element modeling of the knee joint. IEEE Transactions on Biomedical Engineering, 72 (1), 1-13. doi: 10.1109/tbme.2024.3438272

An automated and robust tool for musculoskeletal and finite element modeling of the knee joint

2024

Journal Article

“An excellent servant but a terrible master”: understanding the value of wearables for self-management in people with cystic fibrosis and their healthcare providers – a qualitative study

Mattison, Graeme, Canfell, Oliver J., Smith, Daniel, Forrester, Doug, Reid, David, Töyräs, Juha and Dobbins, Chelsea (2024). “An excellent servant but a terrible master”: understanding the value of wearables for self-management in people with cystic fibrosis and their healthcare providers – a qualitative study. International Journal of Medical Informatics, 189 105532, 105532. doi: 10.1016/j.ijmedinf.2024.105532

“An excellent servant but a terrible master”: understanding the value of wearables for self-management in people with cystic fibrosis and their healthcare providers – a qualitative study

2024

Journal Article

Relationship between depth-wise refractive index and biomechanical properties of human articular cartilage

Khan, Bilour, Nippolainen, Ervin, Shahini, Fatemeh, Nonappa,, Popov, Alexey, Töyräs, Juha and Afara, Isaac O. (2024). Relationship between depth-wise refractive index and biomechanical properties of human articular cartilage. Journal of biomedical optics, 29 (9) 095003, 095003. doi: 10.1117/1.JBO.29.9.095003

Relationship between depth-wise refractive index and biomechanical properties of human articular cartilage

2024

Journal Article

Estimation of photon path length and penetration depth in articular cartilage zonal architecture over the therapeutic window

Kafian-Attari, I., Nippolainen, E., Bergmann, F., George, A., Paakkari, P., Mirhashemi, A., Foschum, F., Kienle, A., Toyras, J. and Afara, I. O. (2024). Estimation of photon path length and penetration depth in articular cartilage zonal architecture over the therapeutic window. IEEE Transactions on Biomedical Engineering, 71 (8), 2300-2310. doi: 10.1109/TBME.2024.3368012

Estimation of photon path length and penetration depth in articular cartilage zonal architecture over the therapeutic window

2024

Journal Article

Infrared spectroscopy can differentiate between cartilage injury models: implication for assessment of cartilage integrity

Shahini, Fatemeh, Oskouei, Soroush, Nippolainen, Ervin, Mohammadi, Ali, Sarin, Jaakko K., Moller, Nikae C. R. te, Brommer, Harold, Shaikh, Rubina, Korhonen, Rami K., van Weeren, P. René, Töyräs, Juha and Afara, Isaac O. (2024). Infrared spectroscopy can differentiate between cartilage injury models: implication for assessment of cartilage integrity. Annals of Biomedical Engineering, 52 (9), 2521-2533. doi: 10.1007/s10439-024-03540-x

Infrared spectroscopy can differentiate between cartilage injury models: implication for assessment of cartilage integrity

2024

Journal Article

Laser-irradiating infrared attenuated total reflection spectroscopy of articular cartilage: potential and challenges for diagnosing osteoarthritis

Krebs, P., Nägele, M., Fomina, P., Virtanen, V., Nippolainen, E., Shaikh, R., Afara, I. O., Töyräs, J., Usenov, I., Sakharova, T., Artyushenko, V., Tafintseva, V., Solheim, J.H., Zimmermann, B., Kohler, A., König, O., Saarakkala, S. and Mizaikoff, B. (2024). Laser-irradiating infrared attenuated total reflection spectroscopy of articular cartilage: potential and challenges for diagnosing osteoarthritis. Osteoarthritis and Cartilage Open, 6 (2) 100466, 100466. doi: 10.1016/j.ocarto.2024.100466

Laser-irradiating infrared attenuated total reflection spectroscopy of articular cartilage: potential and challenges for diagnosing osteoarthritis

2024

Journal Article

Sleep stage continuity is associated with objective daytime sleepiness in patients with suspected obstructive sleep apnea

Chen, Xin, Leppänen, Timo, Kainulainen, Samu, Howarth, Timothy P., Oksenberg, Arie, Töyräs, Juha, Terrill, Philip I. and Korkalainen, Henri (2024). Sleep stage continuity is associated with objective daytime sleepiness in patients with suspected obstructive sleep apnea. Journal of Clinical Sleep Medicine, 20 (10), 1595-1606. doi: 10.5664/jcsm.11198

Sleep stage continuity is associated with objective daytime sleepiness in patients with suspected obstructive sleep apnea

2024

Journal Article

Site-specific elastic and viscoelastic biomechanical properties of healthy and osteoarthritic human knee joint articular cartilage

Linus, Awuniji, Tanska, Petri, Nippolainen, Ervin, Tiitu, Virpi, Töyras, Juha, Korhonen, Rami K., Afara, Isaac O. and Mononen, Mika E. (2024). Site-specific elastic and viscoelastic biomechanical properties of healthy and osteoarthritic human knee joint articular cartilage. Journal of Biomechanics, 169 112135, 112135. doi: 10.1016/j.jbiomech.2024.112135

Site-specific elastic and viscoelastic biomechanical properties of healthy and osteoarthritic human knee joint articular cartilage

2024

Journal Article

Reaction time in psychomotor vigilance task is related to hypoxic load in males with sleep apnea

Pahari, Purbanka, Korkalainen, Henri, Karhu, Tuomas, Arnardottir, Erna Sif, Töyräs, Juha, Leppänen, Timo and Nikkonen, Sami (2024). Reaction time in psychomotor vigilance task is related to hypoxic load in males with sleep apnea. Journal of Sleep Research, 33 (2) e13988, e13988. doi: 10.1111/jsr.13988

Reaction time in psychomotor vigilance task is related to hypoxic load in males with sleep apnea

2024

Journal Article

Increased flow limitation during sleep is associated with increased psychomotor vigilance task lapses in individuals with suspected obstructive sleep apnea

Staykov, Eric, Mann, Dwayne L., Duce, Brett, Kainulainen, Samu, Leppänen, Timo, Töyräs, Juha, Azarbarzin, Ali, Georgeson, Thomas, Sands, Scott A. and Terrill, Philip I. (2024). Increased flow limitation during sleep is associated with increased psychomotor vigilance task lapses in individuals with suspected obstructive sleep apnea. CHEST, 165 (4), 990-1003. doi: 10.1016/j.chest.2023.11.031

Increased flow limitation during sleep is associated with increased psychomotor vigilance task lapses in individuals with suspected obstructive sleep apnea

2024

Journal Article

Prolonged lung-to-finger circulation time indicates an increased risk of intermittent hypoxemia in sleep apnea patients

Pahari, Purbanka, Korkalainen, Henri, Arnardóttir, Erna Sif, Islind, Anna Sigridur, August, Elias, Oksenberg, Arie, Töyräs, Juha, Leppänen, Timo and Nikkonen, Sami (2024). Prolonged lung-to-finger circulation time indicates an increased risk of intermittent hypoxemia in sleep apnea patients. ERJ Open Research, 10 (4) 01051-2023, 1-12. doi: 10.1183/23120541.01051-2023

Prolonged lung-to-finger circulation time indicates an increased risk of intermittent hypoxemia in sleep apnea patients

2024

Journal Article

Beat-to-beat cardiac repolarization lability increases during hypoxemia and arousals in obstructive sleep apnea patients

Ebrahimian, Serajeddin, Sillanmäki, Saara, Hietakoste, Salla, Kulkas, Antti, Töyräs, Juha, Bailon, Raquel, Hernando, David, Lombardi, Carolina, Grote, Ludger, Bonsignore, Maria R, Saaresranta, Tarja, Pépin, Jean-Louis, Leppänen, Timo and Kainulainen, Samu (2024). Beat-to-beat cardiac repolarization lability increases during hypoxemia and arousals in obstructive sleep apnea patients. American Journal of Physiology-Heart and Circulatory Physiology, 326 (5), H1094-H1104. doi: 10.1152/ajpheart.00760.2023

Beat-to-beat cardiac repolarization lability increases during hypoxemia and arousals in obstructive sleep apnea patients

2024

Journal Article

Cationic tantalum oxide nanoparticle contrast agent for micro computed tomography reveals articular cartilage proteoglycan distribution and collagen architecture alterations

Jäntti, Jiri, Joenathan, Anisha, Fugazzola, Maria, Tuppurainen, Juuso, Honkanen, Juuso T. J., Töyräs, Juha, van Weeren, René, Snyder, Brian D., Grinstaff, Mark W., Matikka, Hanna and Mäkelä, Janne T.A. (2024). Cationic tantalum oxide nanoparticle contrast agent for micro computed tomography reveals articular cartilage proteoglycan distribution and collagen architecture alterations. Osteoarthritis and Cartilage, 32 (3), 299-309. doi: 10.1016/j.joca.2023.11.020

Cationic tantalum oxide nanoparticle contrast agent for micro computed tomography reveals articular cartilage proteoglycan distribution and collagen architecture alterations

2024

Journal Article

Variation in the photoplethysmogram response to arousal from sleep depending on the cause of arousal and the presence of desaturation

Luukinen, Mieli, Pitkänen, Henna, Leppänen, Timo, Töyräs, Juha, Islind, Anna Sigridur, Kainulainen, Samu and Korkalainen, Henri (2024). Variation in the photoplethysmogram response to arousal from sleep depending on the cause of arousal and the presence of desaturation. IEEE Journal of Translational Engineering in Health and Medicine, 12, 328-339. doi: 10.1109/jtehm.2024.3349916

Variation in the photoplethysmogram response to arousal from sleep depending on the cause of arousal and the presence of desaturation

2024

Journal Article

Triple contrast computed tomography reveals site‐specific biomechanical differences in the human knee joint—A proof of concept study

Orava, Heta, Paakkari, Petri, Jäntti, Jiri, Honkanen, Miitu K. M., Honkanen, Juuso T. J., Virén, Tuomas, Joenathan, Anisha, Tanska, Petri, Korhonen, Rami K., Grinstaff, Mark W., Töyräs, Juha and Mäkelä, Janne T. A. (2024). Triple contrast computed tomography reveals site‐specific biomechanical differences in the human knee joint—A proof of concept study. Journal of Orthopaedic Research, 42 (2), 415-424. doi: 10.1002/jor.25683

Triple contrast computed tomography reveals site‐specific biomechanical differences in the human knee joint—A proof of concept study

2024

Conference Publication

Comparing novel electrophysiological biomarkers and circulating cardiac biomarkers in predicting cardiovascular mortality and all-cause mortality in the Akershus Sleep Apnea (ASAP) epidemiological cohort

Hrubos-Strøm, H., Øverby, T.C., Sigurdardottir, F., Feng, X., Nikkonen, S., Korkalainen, H., Leppanen, T., Töyräs, J. and Arnardottir, E.S. (2024). Comparing novel electrophysiological biomarkers and circulating cardiac biomarkers in predicting cardiovascular mortality and all-cause mortality in the Akershus Sleep Apnea (ASAP) epidemiological cohort. 17th World Sleep Congress, Rio de Janeiro, Brazil, 20-25 October 2023. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.sleep.2023.11.910

Comparing novel electrophysiological biomarkers and circulating cardiac biomarkers in predicting cardiovascular mortality and all-cause mortality in the Akershus Sleep Apnea (ASAP) epidemiological cohort

2024

Journal Article

Acute cardiorespiratory coupling impairment in worsening sleep apnea-related intermittent hypoxemia

Hietakoste, Salla, Armañac-Julián, Pablo, Karhu, Tuomas, Bailón, Raquel, Sillanmäki, Saara, Töyräs, Juha, Leppänen, Timo, Myllymaa, Sami and Kainulainen, Samu (2024). Acute cardiorespiratory coupling impairment in worsening sleep apnea-related intermittent hypoxemia. IEEE Transactions on Biomedical Engineering, 71 (1), 326-333. doi: 10.1109/tbme.2023.3300079

Acute cardiorespiratory coupling impairment in worsening sleep apnea-related intermittent hypoxemia

2023

Journal Article

Respiratory event index underestimates severity of sleep apnea compared to apnea-hypopnea index

Pitkänen, Minna, Nath, Rajdeep Kumar, Korkalainen, Henri, Nikkonen, Sami, Mahamid, Alaa, Oksenberg, Arie, Duce, Brett, Töyräs, Juha, Kainulainen, Samu and Leppänen, Timo (2023). Respiratory event index underestimates severity of sleep apnea compared to apnea-hypopnea index. Sleep Advances, 5 (1) zpad054, 1-9. doi: 10.1093/sleepadvances/zpad054

Respiratory event index underestimates severity of sleep apnea compared to apnea-hypopnea index