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2026 Journal Article Deep brain stimulation of the nucleus accumbens modulates effort-based decision-making and phasic dopamine release in male Wistar ratsMcCullough, Sebastian, Varela, Roger B., Houghton, Tristan, Cruickshank, Heather and Tye, Susannah J. (2026). Deep brain stimulation of the nucleus accumbens modulates effort-based decision-making and phasic dopamine release in male Wistar rats. Journal of Neurochemistry, 170 (6) e70485. doi: 10.1111/jnc.70485 |
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2026 Journal Article Melatonin in bipolar disorderMacpherson, Heather K., Varela, Roger B., Truong, Trang T. T., Walder, Ken, Berk, Michael and Tye, Susannah J. (2026). Melatonin in bipolar disorder. Journal of Affective Disorders, 398 120871, 1-24. doi: 10.1016/j.jad.2025.120871 |
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2026 Journal Article ATP bioenergetics and fatigue in young adults with and without major depressionCullen, Kathryn R., Tye, Susannah J., Klimes-Dougan, Bonnie, Wiesner, Hannes M., Varela, Roger B., Morath, Brooke, Zhang, Lin, Chen, Wei and Zhu, Xiao-Hong (2026). ATP bioenergetics and fatigue in young adults with and without major depression. Translational Psychiatry, 16 (1) 158. doi: 10.1038/s41398-026-03904-y |
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2025 Other Outputs Unpredictable circadian rhythm disruption in Wistar rats: biological and behavioural changes reflecting bipolar disorder pathophysiologyMacPherson, Heather, Varela, Roger B., McCullough, Sebastian C., Houghton, Tristan, Chawla, Isha, Wang, Ning, Daygon, Venea Dara, Cui, Xiaoying and Tye, Susannah J. (2025). Unpredictable circadian rhythm disruption in Wistar rats: biological and behavioural changes reflecting bipolar disorder pathophysiology. doi: 10.1101/2025.09.06.674601 |
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2025 Other Outputs Melatonin mitigates oxidative stress and metabolic dysfunction induced by interleukin-6 and dopamine in SH-SY5Y cellsMacPherson, Heather, Varela, Roger B., Daygon, Venea Dara, Kesby, James P., Cui, Xiaoying and Tye, Susannah J. (2025). Melatonin mitigates oxidative stress and metabolic dysfunction induced by interleukin-6 and dopamine in SH-SY5Y cells. doi: 10.1101/2025.09.03.673920 |
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2025 Conference Publication Unpredictable Circadian Disturbance Induces Bipolar-Like Behavioural and Immunometabolic Dysregulation in RatsMacpherson, Heather, Varela, Roger, McCullough, Sebastian, Houghton, Tristan, Chawla, Isha, Wang, Ning, Daygon, Venea, Cui, Xiaoying and Tye, Susannah (2025). Unpredictable Circadian Disturbance Induces Bipolar-Like Behavioural and Immunometabolic Dysregulation in Rats. 27th Annual Conference of the International Society for Bipolar Disorders, Chiba, Japan, 17-19 September 2025. Hoboken, NJ, United States: Wiley-Blackwell. |
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2025 Conference Publication Melatonin Mitigates IL-6-Induced Hyperdopaminergia, Oxidative Stress, and Metabolic Dysfunction: Implications for Dopaminergic Dysregulation in Bipolar DisorderMacpherson, Heather, Varela, Roger, Daygon, Venea, Kesby, James, Cui, Xiaoying and Tye, Susannah (2025). Melatonin Mitigates IL-6-Induced Hyperdopaminergia, Oxidative Stress, and Metabolic Dysfunction: Implications for Dopaminergic Dysregulation in Bipolar Disorder. The 27th Annual Conference of the International Society for Bipolar Disorders, Chiba, Japan, 17 – 19 September 2025. Hoboken, NJ, United States: Wiley-Blackwell Publishing. |
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2025 Conference Publication Bioenergetic Dysregulation in Peripheral Immune Cells: Links to Anhedonia and Fatigue in Depressed Young AdultsVarela, Roger, Cullen, Kathryn, Morath, Brooke and Tye, Susannah (2025). Bioenergetic Dysregulation in Peripheral Immune Cells: Links to Anhedonia and Fatigue in Depressed Young Adults. The 27th Annual Conference of the International Society for Bipolar Disorders, Chiba, Japan, 17 – 19 September 2025. Hoboken, NJ, United States: Wiley-Blackwell Publishing. |
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2025 Conference Publication Immunometabolic dysfunction and dopaminergic impairment in an animal model of treatment-resistant anhedonia: implications for bipolar disorderVarela, Roger, Macpherson, Heather, Houghton, Tristan, Yates, Clarissa, Yates, Nathanael, Daygon, Dara and Tye, Susannah (2025). Immunometabolic dysfunction and dopaminergic impairment in an animal model of treatment-resistant anhedonia: implications for bipolar disorder. The 27th Annual Conference of the International Society for Bipolar Disorders, Chiba, Japan, 17 – 19 September 2025. Hoboken, NJ, United States: Wiley-Blackwell Publishing. |
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2025 Journal Article Inflammation and metabolic dysfunction underly anhedonia-like behavior in antidepressant resistant male ratsVarela, Roger B., Macpherson, Heather, Walker, Adam J., Houghton, Tristan, Yates, Clarissa, Yates, Nathanael J., Daygon, Dara and Tye, Susannah J. (2025). Inflammation and metabolic dysfunction underly anhedonia-like behavior in antidepressant resistant male rats. Brain, Behavior, and Immunity, 127, 170-182. doi: 10.1016/j.bbi.2025.03.001 |
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2025 Journal Article Exploring the impact of childhood maltreatment on epigenetic and brain-derived neurotrophic factor changes in bipolar disorder and healthy controlPossamai-Della, Taise, Peper-Nascimento, Jefté, Varela, Roger B., Daminelli, Thiani, Fries, Gabriel R., Ceretta, Luciane B., Juruena, Mario F., Quevedo, João and Valvassori, Samira S. (2025). Exploring the impact of childhood maltreatment on epigenetic and brain-derived neurotrophic factor changes in bipolar disorder and healthy control. European Archives of Psychiatry and Clinical Neuroscience, 275 (7), 1969-1981. doi: 10.1007/s00406-024-01917-6 |
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2024 Conference Publication Inflammation in combination with metabolic deficits underly Anhedonia-like behavior in treatment resistant male ratsVarela, Roger, Macpherson, Heather, Houghton, Tristan, Yates, Clarissa, Yates, Nathanael, Daygon, Dara and Tye, Susannah (2024). Inflammation in combination with metabolic deficits underly Anhedonia-like behavior in treatment resistant male rats. ACNP 63rd Annual Meeting: Poster Abstracts P609-P914, Phoenix, AZ United States, 8-11 December 2024. London, United Kingdom: Nature Publishing Group. |
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2024 Journal Article Anti‐manic effect of deep brain stimulation of the ventral tegmental area in an animal model of mania induced by methamphetamineVarela, Roger B., Boschen, Suelen L., Yates, Nathanael, Houghton, Tristan, Blaha, Charles D., Lee, Kendall H., Bennet, Kevin E., Kouzani, Abbas Z., Berk, Michael, Quevedo, João, Valvassori, Samira S. and Tye, Susannah J. (2024). Anti‐manic effect of deep brain stimulation of the ventral tegmental area in an animal model of mania induced by methamphetamine. Bipolar Disorders, 26 (4), 376-387. doi: 10.1111/bdi.13423 |
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2024 Conference Publication Exploring the relationship between childhood trauma and epigenetic alterations in bipolar disorderDella, T. de Souza Possamai, Peper-Nascimento, J., Varela, R.B., Daminelli, T., Fries, G.R., Ceretta, L.B., Quevedo, J. and Valvassori, S.S. (2024). Exploring the relationship between childhood trauma and epigenetic alterations in bipolar disorder. 37th ECNP Congress 2024, Milan, Italy, 21-24 September 2024. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.nsa.2024.104182 |
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2023 Journal Article Increasing dopamine synthesis in nigrostriatal circuits increases phasic dopamine release and alters dorsal striatal connectivity: implications for schizophreniaSrivastav, Sunil, Cui, Xiaoying, Varela, Roger Bitencourt, Kesby, James P. and Eyles, Darryl (2023). Increasing dopamine synthesis in nigrostriatal circuits increases phasic dopamine release and alters dorsal striatal connectivity: implications for schizophrenia. Schizophrenia, 9 (1) 69, 69. doi: 10.1038/s41537-023-00397-2 |
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2023 Journal Article Haloperidol alters neurotrophic factors and epigenetic parameters in an animal model of schizophrenia induced by ketamineValvassori, Samira S., da Rosa, Richard T., Dal-Pont, Gustavo C., Varela, Roger B., Mastella, Gustavo A., Daminelli, Thiani, Fries, Gabriel R., Quevedo, Joao and Zugno, Alexandra I. (2023). Haloperidol alters neurotrophic factors and epigenetic parameters in an animal model of schizophrenia induced by ketamine. International Journal of Developmental Neuroscience, 83 (8), 691-702. doi: 10.1002/jdn.10296 |
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2023 Journal Article Antidepressant effect of sodium butyrate is accompanied by brain epigenetic modulation in rats subjected to early or late life stressValvassori, Samira Silva, Varela, Roger Bitencourt, Resende, Wilson Rodrigues, Della, Taise Possamai, Borba, Laura Araújo, Behenck, João Paulo, Réus, Gislaine Zilli and Quevedo, João (2023). Antidepressant effect of sodium butyrate is accompanied by brain epigenetic modulation in rats subjected to early or late life stress. Current Neurovascular Research, 20 (5), 586-598. doi: 10.2174/0115672026277345240115101852 |
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2022 Journal Article Enriched environment causes epigenetic changes in hippocampus and improves long-term cognitive function in sepsisCorneo, Emily, Michels, Monique, Abatti, Mariane, Vieira, Andriele, Goncalves, Renata Casagrande, Gabriel, Filipe Fernandes, Borges, Heloisa, Goulart, Amanda, Matos, Natan da Silva, Dominguini, Diogo, Varela, Roger, Valvassori, Samira and Dal-Pizzol, Felipe (2022). Enriched environment causes epigenetic changes in hippocampus and improves long-term cognitive function in sepsis. Scientific Reports, 12 (1) 21092. doi: 10.1038/s41598-022-14660-6 |
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2022 Journal Article Contributions of epigenetic inheritance to the predisposition of major psychiatric disorders: Theoretical framework, evidence, and implicationsVarela, Roger B., Cararo, José Henrique, Tye, Susannah J., Carvalho, Andre F., Valvassori, Samira S., Fries, Gabriel R. and Quevedo, João (2022). Contributions of epigenetic inheritance to the predisposition of major psychiatric disorders: Theoretical framework, evidence, and implications. Neuroscience and Biobehavioral Reviews, 135 104579, 104579. doi: 10.1016/j.neubiorev.2022.104579 |
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2022 Book Chapter Behavioral models of bipolar disorderVarela, Roger B., Dal-Pont, Gustavo C., Quevedo, João and Valvassori, Samira S. (2022). Behavioral models of bipolar disorder. Biomarkers in Bipolar Disorders. (pp. 63-80) London, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-821398-8.00015-1 |
