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2025 Journal Article Inflammation and metabolic dysfunction underly anhedonia-like behavior in antidepressant resistant male ratsVarela, Roger B, Macpherson, Heather, Walker, Adam J, Houghton, Tristan, Yates, Clarissa, Yates, Nathanael J, Daygon, Dara and Tye, Susannah J (2025). Inflammation and metabolic dysfunction underly anhedonia-like behavior in antidepressant resistant male rats. Brain, Behavior, and Immunity, 127, 170-182. doi: 10.1016/j.bbi.2025.03.001 |
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2024 Journal Article Exploring the impact of childhood maltreatment on epigenetic and brain-derived neurotrophic factor changes in bipolar disorder and healthy controlPossamai-Della, Taise, Peper-Nascimento, Jefté, Varela, Roger B., Daminelli, Thiani, Fries, Gabriel R., Ceretta, Luciane B., Juruena, Mario F., Quevedo, João and Valvassori, Samira S. (2024). Exploring the impact of childhood maltreatment on epigenetic and brain-derived neurotrophic factor changes in bipolar disorder and healthy control. European Archives of Psychiatry and Clinical Neuroscience. doi: 10.1007/s00406-024-01917-6 |
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2024 Journal Article Anti‐manic effect of deep brain stimulation of the ventral tegmental area in an animal model of mania induced by methamphetamineVarela, Roger B., Boschen, Suelen L., Yates, Nathanael, Houghton, Tristan, Blaha, Charles D., Lee, Kendall H., Bennet, Kevin E., Kouzani, Abbas Z., Berk, Michael, Quevedo, João, Valvassori, Samira S. and Tye, Susannah J. (2024). Anti‐manic effect of deep brain stimulation of the ventral tegmental area in an animal model of mania induced by methamphetamine. Bipolar Disorders, 26 (4), 376-387. doi: 10.1111/bdi.13423 |
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2024 Conference Publication Exploring the relationship between childhood trauma and epigenetic alterations in bipolar disorderDella, T. de Souza Possamai, Peper-Nascimento, J., Varela, R.B., Daminelli, T., Fries, G.R., Ceretta, L.B., Quevedo, J. and Valvassori, S.S. (2024). Exploring the relationship between childhood trauma and epigenetic alterations in bipolar disorder. 37th ECNP Congress 2024, Milan, Italy, 21-24 September 2024. Amsterdam, Netherlands: Elsevier. doi: 10.1016/j.nsa.2024.104182 |
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2023 Journal Article Increasing dopamine synthesis in nigrostriatal circuits increases phasic dopamine release and alters dorsal striatal connectivity: implications for schizophreniaSrivastav, Sunil, Cui, Xiaoying, Varela, Roger Bitencourt, Kesby, James P. and Eyles, Darryl (2023). Increasing dopamine synthesis in nigrostriatal circuits increases phasic dopamine release and alters dorsal striatal connectivity: implications for schizophrenia. Schizophrenia, 9 (1) 69, 69. doi: 10.1038/s41537-023-00397-2 |
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2023 Journal Article Haloperidol alters neurotrophic factors and epigenetic parameters in an animal model of schizophrenia induced by ketamineValvassori, Samira S., da Rosa, Richard T., Dal-Pont, Gustavo C., Varela, Roger B., Mastella, Gustavo A., Daminelli, Thiani, Fries, Gabriel R., Quevedo, Joao and Zugno, Alexandra I. (2023). Haloperidol alters neurotrophic factors and epigenetic parameters in an animal model of schizophrenia induced by ketamine. International Journal of Developmental Neuroscience, 83 (8), 691-702. doi: 10.1002/jdn.10296 |
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2023 Journal Article Antidepressant effect of sodium butyrate is accompanied by brain epigenetic modulation in rats subjected to early or late life stressValvassori, Samira Silva, Varela, Roger Bitencourt, Resende, Wilson Rodrigues, Della, Taise Possamai, Borba, Laura Araújo, Behenck, João Paulo, Réus, Gislaine Zilli and Quevedo, João (2023). Antidepressant effect of sodium butyrate is accompanied by brain epigenetic modulation in rats subjected to early or late life stress. Current Neurovascular Research, 20 (5), 586-598. doi: 10.2174/0115672026277345240115101852 |
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2022 Journal Article Enriched environment causes epigenetic changes in hippocampus and improves long-term cognitive function in sepsisCorneo, Emily, Michels, Monique, Abatti, Mariane, Vieira, Andriele, Goncalves, Renata Casagrande, Gabriel, Filipe Fernandes, Borges, Heloisa, Goulart, Amanda, Matos, Natan da Silva, Dominguini, Diogo, Varela, Roger, Valvassori, Samira and Dal-Pizzol, Felipe (2022). Enriched environment causes epigenetic changes in hippocampus and improves long-term cognitive function in sepsis. Scientific Reports, 12 (1) 21092. doi: 10.1038/s41598-022-14660-6 |
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2022 Journal Article Contributions of epigenetic inheritance to the predisposition of major psychiatric disorders: Theoretical framework, evidence, and implicationsVarela, Roger B., Cararo, José Henrique, Tye, Susannah J., Carvalho, Andre F., Valvassori, Samira S., Fries, Gabriel R. and Quevedo, João (2022). Contributions of epigenetic inheritance to the predisposition of major psychiatric disorders: Theoretical framework, evidence, and implications. Neuroscience and Biobehavioral Reviews, 135 104579, 104579. doi: 10.1016/j.neubiorev.2022.104579 |
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2022 Book Chapter Behavioral models of bipolar disorderVarela, Roger B., Dal-Pont, Gustavo C., Quevedo, João and Valvassori, Samira S. (2022). Behavioral models of bipolar disorder. Biomarkers in Bipolar Disorders. (pp. 63-80) London, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-821398-8.00015-1 |
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2021 Journal Article Effects of maternal folic acid supplementation on nuclear methyltransferase activity of adult rats subjected to an animal model of schizophreniaCanever, Lara, Varela, Roger, Mastella, Gustavo A., Damazio, Louyse S., Valvassori, Samira S., Quevedo, Joao L. and Zugno, Alexandra (2021). Effects of maternal folic acid supplementation on nuclear methyltransferase activity of adult rats subjected to an animal model of schizophrenia. International Journal of Developmental Neuroscience, 81 (5), 461-467. doi: 10.1002/jdn.10109 |
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2021 Journal Article Ouabain induces memory impairment and alter the BDNF signaling pathway in an animal model of bipolar disorder: Cognitive and neurochemical alterations in BD modelValvassori, Samira S., Dal-Pont, Gustavo C., Varela, Roger B., Resende, Wilson R., Gava, Fernanda F., Mina, Franciele G., Budni, Josiane and Quevedo, João (2021). Ouabain induces memory impairment and alter the BDNF signaling pathway in an animal model of bipolar disorder: Cognitive and neurochemical alterations in BD model. Journal of Affective Disorders, 282, 1195-1202. doi: 10.1016/j.jad.2020.12.190 |
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2020 Journal Article Role of epigenetic regulatory enzymes in animal models of mania induced by amphetamine and paradoxical sleep deprivationVarela, Roger B., Resende, Wilson R., Dal-Pont, Gustavo C., Gava, Fernanda F., Nadas, Gabriella B., Tye, Susannah J., Andersen, Monica L., Quevedo, João and Valvassori, Samira S (2020). Role of epigenetic regulatory enzymes in animal models of mania induced by amphetamine and paradoxical sleep deprivation. European Journal of Neuroscience, 53 (2) ejn.14922, 649-662. doi: 10.1111/ejn.14922 |
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2020 Journal Article Increased inflammatory biomarkers and changes in biological rhythms in bipolar disorder: a case-control studyBavaresco, Daniela, da Rosa, Maria Ines, Rodrigues Uggioni, Maria Laura, Ferraz, Sarah D., Pacheco, Tamires R., Zuehl Dal Toe, Helena C., da Silveira, Andressa P., Quadros, Luiz F. A., de Souza, Thiani Daminelli, Varela, Roger B., Vieira, Andriele A. S., Dal Pizzol, Felipe, Valvassori, Samira S. and Quevedo, Joao (2020). Increased inflammatory biomarkers and changes in biological rhythms in bipolar disorder: a case-control study. Journal of Affective Disorders, 271, 115-122. doi: 10.1016/j.jad.2020.03.073 |
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2020 Journal Article HDAC inhibitors reverse mania-like behavior and modulate epigenetic regulatory enzymes in an animal model of mania induced by OuabainVarela, Roger B., Resende, Wilson R., Dal-Pont, Gustavo C., Gava, Fernanda F., Tye, Susannah J., Quevedo, João and Valvassori, Samira S. (2020). HDAC inhibitors reverse mania-like behavior and modulate epigenetic regulatory enzymes in an animal model of mania induced by Ouabain. Pharmacology Biochemistry and Behavior, 193 172917, 172917. doi: 10.1016/j.pbb.2020.172917 |
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2019 Journal Article Efficacy of folic acid as an adjunct to lithium therapy on manic-like behaviors, oxidative stress and inflammatory parameters in an animal model of maniaMenegas, Samira, Dal-Pont, Gustavo C., Cararo, José H., Varela, Roger B., Aguiar-Geraldo, Jorge M., Possamai-Della, Taise, Andersen, Monica L., Quevedo, João and Valvassori, Samira S. (2019). Efficacy of folic acid as an adjunct to lithium therapy on manic-like behaviors, oxidative stress and inflammatory parameters in an animal model of mania. Metabolic Brain Disease, 35 (2), 413-425. doi: 10.1007/s11011-019-00503-3 |
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2019 Journal Article Coadministration of lithium and celecoxib reverses manic-like behavior and decreases oxidative stress in a dopaminergic model of mania induced in ratsValvassori, Samira S., Tonin, Paula T., Dal-Pont, Gustavo C., Varela, Roger B., Cararo, José Henrique, Garcia, Abel Freitas, Gava, Fernanda F., Menegas, Samira, Soares, Jair C. and Quevedo, João (2019). Coadministration of lithium and celecoxib reverses manic-like behavior and decreases oxidative stress in a dopaminergic model of mania induced in rats. Translational Psychiatry, 9 (1) 297, 1-11. doi: 10.1038/s41398-019-0637-9 |
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2019 Journal Article Coadministration of lithium and celecoxib attenuates the behavioral alterations and inflammatory processes induced by amphetamine in an animal model of maniaValvassori, Samira S., Dal-Pont, Gustavo C., Tonin, Paula T., Varela, Roger B., Ferreira, Camila L., Gava, Fernanda F., Andersen, Monica L., Soares, Jair C. and Quevedo, Joao (2019). Coadministration of lithium and celecoxib attenuates the behavioral alterations and inflammatory processes induced by amphetamine in an animal model of mania. Pharmacology, Biochemistry and Behavior, 183, 56-63. doi: 10.1016/j.pbb.2019.05.009 |
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2019 Journal Article Validation of the animal model of bipolar disorder induced by Ouabain: face, construct and predictive perspectivesValvassori, Samira S., Dal-Pont, Gustavo C., Resende, Wilson R., Varela, Roger B., Lopes-Borges, Jessica, Cararo, Jose Henrique and Quevedo, Joao (2019). Validation of the animal model of bipolar disorder induced by Ouabain: face, construct and predictive perspectives. Translational Psychiatry, 9 (1) 158. doi: 10.1038/s41398-019-0494-6 |
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2019 Journal Article Tamoxifen has an anti-manic effect but not protect the brain against oxidative stress in an animal model of mania induced by ouabainDal-Pont, Gustavo C., Resende, Wilson R., Bianchini, Guilherme, Gava, Fernanda F., Peterle, Bruna R., Trajano, Kerolen S., Varela, Roger B., Quevedo, Joao and Valvassori, Samira S. (2019). Tamoxifen has an anti-manic effect but not protect the brain against oxidative stress in an animal model of mania induced by ouabain. Journal of Psychiatric Research, 113, 181-189. doi: 10.1016/j.jpsychires.2019.03.020 |
