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2026 Journal Article Risk stratification for endometrial cancer: independent and joint effects of polygenic risk score and body mass index in 129,829 UK Biobank participantsWang, Xuemin, Dossus, Laure, Gunter, Marc J., Crosbie, Emma J., Ong, Jue-Sheng, Glubb, Dylan M. and O’Mara, Tracy A. (2026). Risk stratification for endometrial cancer: independent and joint effects of polygenic risk score and body mass index in 129,829 UK Biobank participants. BMC Medicine, 24 (1) 26, 1. doi: 10.1186/s12916-025-04570-5 |
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2026 Journal Article Prioritizing context-specific genetic risk mechanisms in 11 solid cancersWu, Xueyao, Kim, Artem, Breeze, Charles E., O'Mara, Tracy A., Ramachandran, Dhanya, Dork, Thilo, Koutros, Stella, Rothman, Nathaniel, Prokunina-Olsson, Ludmila, Mancuso, Nicholas, Lindstrom, Sara and Kraft, Peter (2026). Prioritizing context-specific genetic risk mechanisms in 11 solid cancers. Jnci-Journal of the National Cancer Institute djag073. doi: 10.1093/jnci/djag073 |
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2026 Conference Publication Cell type-specific mapping of endometrial cancer risk genes using single-nucleus multi-omicsBajwa, Preety, Chapman, Carly, Glubb, Dylan and O'Mara, Tracy (2026). Cell type-specific mapping of endometrial cancer risk genes using single-nucleus multi-omics. AACR Annual Meeting, San Diego Ca, Apr 17-22, 2026. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. doi: 10.1158/1538-7445.AM2026-5921 |
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2025 Conference Publication The common and rare facets of germline polygenicity converge through intercellular crosstalk in the tumor microenvironment of nasopharyngeal carcinomaGlubb, Dylan, Naumann, Bianca, Rowland, Hollie, Chapman, Carly, Gertz, Jason and O'Mara, Tracy (2025). The common and rare facets of germline polygenicity converge through intercellular crosstalk in the tumor microenvironment of nasopharyngeal carcinoma. 58th Conference of the European-Society-of-Human-Genetics (ESHG), Milan Italy, May 24-27, 2025. LONDON: SPRINGERNATURE. |
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2025 Journal Article GWAS meta-analysis identifies five susceptibility loci for endometrial cancerRamachandran, Dhanya, Wang, Xuemin, Laisk, Triin, Zheng, Ying, Ingold, Nathan, Canson, Daffodil M., Kho, Pik Fang, Naumann, Bianca J., Chapman, Carly J., Bousset, Kristine, Krause, Anna V., Schürmann, Peter, Wieland, Britta, Hanel, Patricia, Hülse, Fabienne, Häfner, Norman, Runnebaum, Ingo, Dubrowinskaja, Natalia, Turmanov, Nurzhan, Yugay, Tatyana, Yessimsiitova, Zura Berkutovna, Amant, Frédéric, Annibali, Daniela, Beckmann, Matthias W., Bodelon, Clara, Buchanan, Daniel D., Chen, Chu, Clarke, Megan A., Cook, Linda S. ... O'Mara, Tracy A. (2025). GWAS meta-analysis identifies five susceptibility loci for endometrial cancer. eBioMedicine, 118 105830, 1-17. doi: 10.1016/j.ebiom.2025.105830 |
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2025 Journal Article Independent effects of hypothyroidism and obesity on endometrial cancer risk revealed by Mendelian randomisationGlubb, Dylan M., Wang, Xuemin and O’Mara, Tracy A. (2025). Independent effects of hypothyroidism and obesity on endometrial cancer risk revealed by Mendelian randomisation. Biomedicines, 13 (7) 1729, 1-13. doi: 10.3390/biomedicines13071729 |
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2025 Journal Article Multi-tissue expression and splicing data prioritise anatomical subsite- and sex-specific colorectal cancer susceptibility genesHazelwood, Emma, Canson, Daffodil M., Deslandes, Benedita, Wang, Xuemin, Kho, Pik Fang, Legge, Danny, Constantinescu, Andrei-Emil, Lee, Matthew A., Bishop, D. Timothy, Chan, Andrew T., Gruber, Stephen B., Hampe, Jochen, Le Marchand, Loic, Woods, Michael O., Pai, Rish K., Schmit, Stephanie L., Figueiredo, Jane C., Zheng, Wei, Huyghe, Jeroen R., Murphy, Neil, Gunter, Marc J., Richardson, Tom G., Whitehall, Vicki L. J., Vincent, Emma E., Glubb, Dylan M. and O’Mara, Tracy A. (2025). Multi-tissue expression and splicing data prioritise anatomical subsite- and sex-specific colorectal cancer susceptibility genes. Nature Communications, 16 (1) 5043, 1-13. doi: 10.1038/s41467-025-60275-6 |
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2025 Journal Article Endometrial tumorigenesis involves epigenetic plasticity demarcating non-coding somatic mutations and 3D-genome alterationsGregoricchio, Sebastian, Kojic, Aleksandar, Hoogstraat, Marlous, Schuurman, Karianne, Stelloo, Suzan, Severson, Tesa M., O’Mara, Tracy A., Droog, Marjolein, Singh, Abhishek A., Glubb, Dylan M., Wessels, Lodewyk F. A., Vermeulen, Michiel, van Leeuwen, Flora E. and Zwart, Wilbert (2025). Endometrial tumorigenesis involves epigenetic plasticity demarcating non-coding somatic mutations and 3D-genome alterations. Genome Biology, 26 (1) 124. doi: 10.1186/s13059-025-03596-5 |
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2025 Journal Article The multi-kinase inhibitor GZD824 (olverembatinib) shows pre-clinical efficacy in endometrial cancerLiu, Dongli, Glubb, Dylan, O'Mara, Tracy and Ford, Caroline E. (2025). The multi-kinase inhibitor GZD824 (olverembatinib) shows pre-clinical efficacy in endometrial cancer. Cancer Medicine, 14 (1) e70531, 1-12. doi: 10.1002/cam4.70531 |
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2024 Journal Article Correction to: AI is a viable alternative to high throughput screening: a 318-target study (Scientific Reports, (2024), 14, 1, (7526), 10.1038/s41598-024-54655-z)Giles, Ellie, Heifets, Abraham, Artía, Zoraima, Inde, Zintis, Liu, Zhongle, Zhang, Zhiguo, Wang, Zhenghe, Su, Zhengchen, Chung, Zara, Frangos, Zachary J., Li, Yunlong, Yen, Yun, Sidorova, Yulia A., Tse-Dinh, Yuk-Ching, He, Yuan, Tang, Young, Li, Yong, Pérez-Pertejo, Yolanda, Gupta, Yogesh K., Zhu, Yini, Sun, Ying, Li, Yihe, Chen, Yicheng, Aldhamen, Yasser Ali, Hu, Yanmei, Zhang, Yan Jessie, Zhang, Xu, Yuan, Xinrui, Wang, Xingyou ... Wallach, Izhar (2024). Correction to: AI is a viable alternative to high throughput screening: a 318-target study (Scientific Reports, (2024), 14, 1, (7526), 10.1038/s41598-024-54655-z). Scientific Reports, 14 (1) 21579. doi: 10.1038/s41598-024-70321-w |
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2024 Journal Article AI is a viable alternative to high throughput screening: a 318-target studyWallach, Izhar, Bernard, Denzil, Nguyen, Kong, Ho, Gregory, Morrison, Adrian, Stecula, Adrian, Rosnik, Andreana, O’Sullivan, Ann Marie, Davtyan, Aram, Samudio, Ben, Thomas, Bill, Worley, Brad, Butler, Brittany, Laggner, Christian, Thayer, Desiree, Moharreri, Ehsan, Friedland, Greg, Truong, Ha, van den Bedem, Henry, Ng, Ho Leung, Stafford, Kate, Sarangapani, Krishna, Giesler, Kyle, Ngo, Lien, Mysinger, Michael, Ahmed, Mostafa, Anthis, Nicholas J., Henriksen, Niel, Gniewek, Pawel ... The Atomwise AIMS Program (2024). AI is a viable alternative to high throughput screening: a 318-target study. Scientific Reports, 14 (1) 7526, 1-16. doi: 10.1038/s41598-024-54655-z |
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2024 Conference Publication Highlighting the combined effects of BMI and polygenic risk score on endometrial cancer riskO'Mara, Tracy A., Wang, Xuemin, Dossus, Laure, Gunter, Marc J., Crosbie, Emma J. and Glubb, Dylan M. (2024). Highlighting the combined effects of BMI and polygenic risk score on endometrial cancer risk. AACR Special Conference on Endometrial Cancer: Transforming Care through Science, Boston, MA United States, 16-18 November 2023. Philadelphia, PA United States: American Association for Cancer Research. doi: 10.1158/1557-3265.endo24-pr001 |
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2023 Journal Article The clinical utility and costs of whole-genome sequencing to detect cancer susceptibility variants—a multi-site prospective cohort studyDavidson, Aimee L., Dressel, Uwe, Norris, Sarah, Canson, Daffodil M., Glubb, Dylan M., Fortuno, Cristina, Hollway, Georgina E., Parsons, Michael T., Vidgen, Miranda E., Holmes, Oliver, Koufariotis, Lambros T., Lakis, Vanessa, Leonard, Conrad, Wood, Scott, Xu, Qinying, McCart Reed, Amy E., Pickett, Hilda A., Al-Shinnag, Mohammad K., Austin, Rachel L., Burke, Jo, Cops, Elisa J., Nichols, Cassandra B., Goodwin, Annabel, Harris, Marion T., Higgins, Megan J., Ip, Emilia L., Kiraly-Borri, Catherine, Lau, Chiyan, Mansour, Julia L. ... Ward, Robyn L. (2023). The clinical utility and costs of whole-genome sequencing to detect cancer susceptibility variants—a multi-site prospective cohort study. Genome Medicine, 15 (1) 74, 1-16. doi: 10.1186/s13073-023-01223-1 |
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2023 Journal Article Multi-trait GWAS identifies a novel endometrial cancer risk locus that associates with testosterone levelsWang, Xuemin, Kho, Pik Fang, Ramachandran, Dhanya, Bafligil, Cemsel, Amant, Frederic, Goode, Ellen L., Scott, Rodney J., Tomlinson, Ian, Evans, D. Gareth, Crosbie, Emma J., Dörk, Thilo, Spurdle, Amanda B., Glubb, Dylan M. and O'Mara, Tracy A. (2023). Multi-trait GWAS identifies a novel endometrial cancer risk locus that associates with testosterone levels. iScience, 26 (5) 106590, 1-19. doi: 10.1016/j.isci.2023.106590 |
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2023 Journal Article Splicing annotation of endometrial cancer GWAS risk loci reveals potentially causal variants and supports a role for NF1 and SKAP1 as susceptibility genesCanson, Daffodil M., O’Mara, Tracy A., Spurdle, Amanda B. and Glubb, Dylan M. (2023). Splicing annotation of endometrial cancer GWAS risk loci reveals potentially causal variants and supports a role for NF1 and SKAP1 as susceptibility genes. Human Genetics and Genomics Advances, 4 (2) 100185, 1-7. doi: 10.1016/j.xhgg.2023.100185 |
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2023 Journal Article SpliceAI-10k calculator for the prediction of pseudoexonization, intron retention, and exon deletionCanson, Daffodil M., Davidson, Aimee L., de la Hoya, Miguel, Parsons, Michael T., Glubb, Dylan M., Kondrashova, Olga and Spurdle, Amanda B. (2023). SpliceAI-10k calculator for the prediction of pseudoexonization, intron retention, and exon deletion. Bioinformatics, 39 (4) btad179, 1-3. doi: 10.1093/bioinformatics/btad179 |
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2023 Journal Article Dietary factors and endometrial cancer risk: A Mendelian randomization studyWang, Xuemin, Glubb, Dylan M. and O’Mara, Tracy A. (2023). Dietary factors and endometrial cancer risk: A Mendelian randomization study. Nutrients, 15 (3) 603, 1-11. doi: 10.3390/nu15030603 |
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2023 Journal Article Erratum: The splicing effect of variants at branchpoint elements in cancer genes (Genetics in Medicine (2022) 24(2) (398–409), (S109836002105348X), (10.1016/j.gim.2021.09.020))Canson, Daffodil M., Dumenil, Troy, Parsons, Michael T., O'Mara, Tracy A., Davidson, Aimee L., Okano, Satomi, Signal, Bethany, Mercer, Tim R., Glubb, Dylan M. and Spurdle, Amanda B. (2023). Erratum: The splicing effect of variants at branchpoint elements in cancer genes (Genetics in Medicine (2022) 24(2) (398–409), (S109836002105348X), (10.1016/j.gim.2021.09.020)). Genetics in Medicine, 25 (1), 166-166. doi: 10.1016/j.gim.2022.11.015 |
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2022 Journal Article Variant effect on splicing regulatory elements, branchpoint usage, and pseudoexonization: strategies to enhance bioinformatic prediction using hereditary cancer genes as exemplarsCanson, Daffodil, Glubb, Dylan and Spurdle, Amanda B. (2022). Variant effect on splicing regulatory elements, branchpoint usage, and pseudoexonization: strategies to enhance bioinformatic prediction using hereditary cancer genes as exemplars. Human Mutation, 43 (12), 2328-2328. doi: 10.1002/humu.24500 |
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2022 Journal Article 10 Years of GWAS discovery in endometrial cancer: aetiology, function and translationWang, Xuemin, Glubb, Dylan M. and O'Mara, Tracy A. (2022). 10 Years of GWAS discovery in endometrial cancer: aetiology, function and translation. eBioMedicine, 77 103895, 1-13. doi: 10.1016/j.ebiom.2022.103895 |
