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2007 Journal Article A refined agonist pharmacophore for protease activated receptor 2Barry, Grant D., Suen, Jacky Y., Low, Heng Boon, Pfeiffer, Bernhard, Flanagan, Bernadine, Halili, Maria, Le, Giang T. and Fairlie, David P. (2007). A refined agonist pharmacophore for protease activated receptor 2. Bioorganic & Medicinal Chemistry Letters, 17 (20), 5552-5557. doi: 10.1016/j.bmcl.2007.08.026 |
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2007 Journal Article Profiling the enzymatic properties and inhibition of human complement factor BLe, G. T, Abbenante, G. and Fairlie, D. P (2007). Profiling the enzymatic properties and inhibition of human complement factor B. Journal of Biological Chemistry, 282 (48), 34809-34816. doi: 10.1074/jbc.M705646200 |
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2007 Journal Article Organic azide inhibitors of cysteine proteases (vol 128, pg 12396, 2006)Le, Giang Thanh, Abbenante, Giovanni, Madala, Praveen K., Hoang, Huy N. and Fairlie, David P. (2007). Organic azide inhibitors of cysteine proteases (vol 128, pg 12396, 2006). Journal of the American Chemical Society, 129 (30), 9532-9532. doi: 10.1021/ja076897i |
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2007 Journal Article Generation and characterization of proteolytically active and highly stable truncated and full-length recombinant West Nile virus NS3Chappell, K. J., Stoermer, M. J., Fairlie, D. P. and Young, P. R. (2007). Generation and characterization of proteolytically active and highly stable truncated and full-length recombinant West Nile virus NS3. Protein Expression and Purification, 53 (1), 87-96. doi: 10.1016/j.pep.2006.10.022 |
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2007 Journal Article Erratum: Latest developments in the treatment of inflammatory disease (Current Medicinal Chemistry (2005) vol. 12 (25) (2923-224))Fairlie, David (2007). Erratum: Latest developments in the treatment of inflammatory disease (Current Medicinal Chemistry (2005) vol. 12 (25) (2923-224)). Current Medicinal Chemistry, 14 (8) doi: 10.2174/092986707780362989 |
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2007 Journal Article A new paradigm for protein kinase inhibition: blocking phosphorylation without directly targeting ATP bindingBogoyevitch, M. A and Fairlie, D. P (2007). A new paradigm for protein kinase inhibition: blocking phosphorylation without directly targeting ATP binding. Drug Discovery Today, 12 (15-16), 622-633. doi: 10.1016/j.drudis.2007.06.008 |
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2007 Journal Article Unexpected photolytic decomposition of alkyl azides under mild conditionsAbbenante, G., Le, G. and Fairlie, D. P. (2007). Unexpected photolytic decomposition of alkyl azides under mild conditions. Chemical Communications, 2007 (43), 4501-4503. doi: 10.1039/b708134k |
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2007 Journal Article Substrate specificity of recombinant dengue 2 virus NS2B-NS3 protease: Influence of natural and unnatural basic amino acids on hydrolysis of synthetic fluorescent substratesGouvea, I. E, Izidoro, M. A, Judice, W. A. S, Cezari, M. H. S, Caliendo, G., Santagada, V., dos Santos, C. N. D, Queiroz, M. H, Juliano, M. A, Young, P. R, Fairlie, D. P and Juliano, L. (2007). Substrate specificity of recombinant dengue 2 virus NS2B-NS3 protease: Influence of natural and unnatural basic amino acids on hydrolysis of synthetic fluorescent substrates. Archives of Biochemistry and Biophysics, 457 (2), 187-196. doi: 10.1016/j.abb.2006.11.005 |
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2007 Journal Article Function, structure and therapeutic potential of complement C5a receptorsMonk, PN, Scola, A. M., Madala, P. and Fairlie, D. P. (2007). Function, structure and therapeutic potential of complement C5a receptors. British Journal of Pharmacology, 152 (4), 429-448. doi: 10.1038/sj.bjp.0707332 |
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2007 Journal Article The role of the N-terminal domain of the complement fragment receptor C5L2 in ligand bindingScola, A. M., Higginbottom, A., Partridge, L, J., Reid, R. C., Woodruff, T., Taylor, S. M., Fairlie, D. P. and Monk, P. N. (2007). The role of the N-terminal domain of the complement fragment receptor C5L2 in ligand binding. Journal of Biological Chemistry, 282 (6), 3664-3671. doi: 10.1074/jbc.M609178200 |
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2007 Journal Article Nonpeptidic ligands for peptide-activated G protein-coupled receptorsBlakeney, J. S, Reid, R. C, Le, G. T and Fairlie, D. P (2007). Nonpeptidic ligands for peptide-activated G protein-coupled receptors. Chemical Reviews, 107 (7), 2960-3041. doi: 10.1021/cr050984g |
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2007 Journal Article Intravenous immunoglobulin (IVIG) protects the brain against experimental stroke by preventing complement-mediated neuronal cell deathArumugam, T. V, Tang, S. C, Lathia, J. D, Cheng, A, Mughal, M. R, Chigurupati, S, Magnus, T, Chan, S. L, Jo, D. G, Ouyang, X, Fairlie, D. P, Granger, D. N, Vortmeyer, A, Basta, M and Mattson, M. P (2007). Intravenous immunoglobulin (IVIG) protects the brain against experimental stroke by preventing complement-mediated neuronal cell death. Proceedings of The National Academy of Sciences of The United States of America, 104 (35), 14104-14109. doi: 10.1073/pnas.0700506104 |
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2006 Journal Article Inhibitors of cyclo-oxygenase-2 and secretory phospholipase A2 preserve bone architecture following ovariectomy in adult ratsGregory, Laura S., Kelly, Wendy L., Reid, Robert C., Fairlie, David P. and Forwood, Mark R. (2006). Inhibitors of cyclo-oxygenase-2 and secretory phospholipase A2 preserve bone architecture following ovariectomy in adult rats. Bone, 39 (1), 134-142. doi: 10.1016/j.bone.2005.12.017 |
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2006 Journal Article Antifibrotic activity of an inhibitor of group IIA secretory phospholipase A(2) in young spontaneously hypertensive ratsLevick, Scott, Loch, David, Rolfe, Barbara, Reid, Robert C., Fairlie, David P., Taylor, Stephan M. and Brown, Lindsay (2006). Antifibrotic activity of an inhibitor of group IIA secretory phospholipase A(2) in young spontaneously hypertensive rats. Journal of Immunology, 176 (11), 7000-7007. doi: 10.4049/jimmunol.176.11.7000 |
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2006 Journal Article Potencies of human immunodeficiency virus protease inhibitors in vitro against Plasmodium falciparum and in vivo against murine malariaAndrews, Katherine T., Fairlie, David P., Madala, Praveen K., Ray, John, Wyatt, David M., Hilton, Petrina M., Melville, Lewis A., Beattie, Lynette, Gardiner, Donald L., Reid, Robert C., Stoermer, Martin J., Skinner-Adams, Tina, Berry, Colin and McCarthy, James S. (2006). Potencies of human immunodeficiency virus protease inhibitors in vitro against Plasmodium falciparum and in vivo against murine malaria. Antimicrobial Agents And Chemotherapy, 50 (2), 639-648. doi: 10.1128/AAC.50.2.639-648.2006 |
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2006 Journal Article Self-condensation of a thiazole-peptide bearing a 21-membered loop into a library of giant macrocycles with multiple orthogonal loopsSingh, Y, Hoang, HN, Flanagan, B and Fairlie, DP (2006). Self-condensation of a thiazole-peptide bearing a 21-membered loop into a library of giant macrocycles with multiple orthogonal loops. Organic Letters, 8 (6), 1053-1056. doi: 10.1021/ol052842e |
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2006 Journal Article Design, Synthesis, Potency and Cytoselectivity of Anticancer Agents Derived by Parallel Synthesis from alpha-Aminosuberic AcidKahnberg, P. C., Lucke, A., Glenn, M. P., Boyle, G. M., Tyndall, J. D., Parsons, P. G. and Fairlie, D. P. (2006). Design, Synthesis, Potency and Cytoselectivity of Anticancer Agents Derived by Parallel Synthesis from alpha-Aminosuberic Acid. Journal of Medicinal Chemistry, 49 (26), 7611-7622. doi: 10.1021/jm050214x |
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2006 Journal Article New insights into growth hormone actionWaters, M. J., Hoang, H. N., Fairlie, D. P., Pelekanos, R. A. and Brown, R. J. (2006). New insights into growth hormone action. Journal of Molecular Endocrinology, 36 (1), 1-7. doi: 10.1677/jmr.1.01933 |
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2006 Journal Article Agonists and antagonists of protease activated receptors (PARs)Barry, GD, Le, GT and Fairlie, DP (2006). Agonists and antagonists of protease activated receptors (PARs). Current Medicinal Chemistry, 13 (3), 243-265. doi: 10.2174/092986706775476070 |
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2006 Journal Article New Cysteine Derivatives with Antiproliferative Activity on Melanoma CellsLucke, A., Boyle, G. M., Parsons, P. G. and Fairlie, D. (2006). New Cysteine Derivatives with Antiproliferative Activity on Melanoma Cells. Medicinal Chemistry, 2 (2), 123-132. doi: 10.2174/157340606776056124 |
