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2007 Journal Article A new paradigm for protein kinase inhibition: blocking phosphorylation without directly targeting ATP bindingBogoyevitch, M. A and Fairlie, D. P (2007). A new paradigm for protein kinase inhibition: blocking phosphorylation without directly targeting ATP binding. Drug Discovery Today, 12 (15-16), 622-633. doi: 10.1016/j.drudis.2007.06.008 |
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2007 Journal Article Substrate specificity of recombinant dengue 2 virus NS2B-NS3 protease: Influence of natural and unnatural basic amino acids on hydrolysis of synthetic fluorescent substratesGouvea, I. E, Izidoro, M. A, Judice, W. A. S, Cezari, M. H. S, Caliendo, G., Santagada, V., dos Santos, C. N. D, Queiroz, M. H, Juliano, M. A, Young, P. R, Fairlie, D. P and Juliano, L. (2007). Substrate specificity of recombinant dengue 2 virus NS2B-NS3 protease: Influence of natural and unnatural basic amino acids on hydrolysis of synthetic fluorescent substrates. Archives of Biochemistry and Biophysics, 457 (2), 187-196. doi: 10.1016/j.abb.2006.11.005 |
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2007 Journal Article Unexpected photolytic decomposition of alkyl azides under mild conditionsAbbenante, G., Le, G. and Fairlie, D. P. (2007). Unexpected photolytic decomposition of alkyl azides under mild conditions. Chemical Communications, 2007 (43), 4501-4503. doi: 10.1039/b708134k |
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2007 Journal Article Function, structure and therapeutic potential of complement C5a receptorsMonk, PN, Scola, A. M., Madala, P. and Fairlie, D. P. (2007). Function, structure and therapeutic potential of complement C5a receptors. British Journal of Pharmacology, 152 (4), 429-448. doi: 10.1038/sj.bjp.0707332 |
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2006 Journal Article Inhibitors of cyclo-oxygenase-2 and secretory phospholipase A2 preserve bone architecture following ovariectomy in adult ratsGregory, Laura S., Kelly, Wendy L., Reid, Robert C., Fairlie, David P. and Forwood, Mark R. (2006). Inhibitors of cyclo-oxygenase-2 and secretory phospholipase A2 preserve bone architecture following ovariectomy in adult rats. Bone, 39 (1), 134-142. doi: 10.1016/j.bone.2005.12.017 |
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2006 Journal Article Antifibrotic activity of an inhibitor of group IIA secretory phospholipase A(2) in young spontaneously hypertensive ratsLevick, Scott, Loch, David, Rolfe, Barbara, Reid, Robert C., Fairlie, David P., Taylor, Stephan M. and Brown, Lindsay (2006). Antifibrotic activity of an inhibitor of group IIA secretory phospholipase A(2) in young spontaneously hypertensive rats. Journal of Immunology, 176 (11), 7000-7007. doi: 10.4049/jimmunol.176.11.7000 |
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2006 Journal Article Potencies of human immunodeficiency virus protease inhibitors in vitro against Plasmodium falciparum and in vivo against murine malariaAndrews, Katherine T., Fairlie, David P., Madala, Praveen K., Ray, John, Wyatt, David M., Hilton, Petrina M., Melville, Lewis A., Beattie, Lynette, Gardiner, Donald L., Reid, Robert C., Stoermer, Martin J., Skinner-Adams, Tina, Berry, Colin and McCarthy, James S. (2006). Potencies of human immunodeficiency virus protease inhibitors in vitro against Plasmodium falciparum and in vivo against murine malaria. Antimicrobial Agents And Chemotherapy, 50 (2), 639-648. doi: 10.1128/AAC.50.2.639-648.2006 |
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2006 Journal Article Protease-activated receptor-2 peptides activate neurokinin-1 receptors in the mouse isolated tracheaAbey, HT, Fairlie, DP, Moffatt, JD, Balzary, RW and Cocks, TM (2006). Protease-activated receptor-2 peptides activate neurokinin-1 receptors in the mouse isolated trachea. Journal of Pharmacology And Experimental Therapeutics, 317 (2), 598-605. doi: 10.1124/jpet.105.097121 |
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2006 Journal Article Agonists and antagonists of protease activated receptors (PARs)Barry, GD, Le, GT and Fairlie, DP (2006). Agonists and antagonists of protease activated receptors (PARs). Current Medicinal Chemistry, 13 (3), 243-265. doi: 10.2174/092986706775476070 |
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2006 Journal Article New Cysteine Derivatives with Antiproliferative Activity on Melanoma CellsLucke, A., Boyle, G. M., Parsons, P. G. and Fairlie, D. (2006). New Cysteine Derivatives with Antiproliferative Activity on Melanoma Cells. Medicinal Chemistry, 2 (2), 123-132. doi: 10.2174/157340606776056124 |
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2006 Journal Article Organic Azide Inhibitors of Cysteine ProteasesLe, G. T., Abbenante, G., Madala, P. K., Hoang, H. N. and Fairlie, D. P. (2006). Organic Azide Inhibitors of Cysteine Proteases. Journal of the American Chemical Society, 128 (38), 12396-12397. doi: 10.1021/ja0637649 |
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2006 Journal Article Modular alpha-helical mimetics with antiviral activity against respiratory syncitial virusShepherd, Nicholas E., Hoang, Huy N., Desai, Vishal S., Letouze, Eric, Young, Paul R. and Fairlie, David P. (2006). Modular alpha-helical mimetics with antiviral activity against respiratory syncitial virus. Journal of The American Chemical Society, 128 (40), 13284-13289. doi: 10.1021/ja064058a |
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2006 Journal Article Insights to substrate binding and processing by West Nile Virus NS3 protease through combined modeling, protease mutagenesis, and kinetic studiesChappell, K. J., Stoermer, M. J., Fairlie, D. P. and Young, P. R. (2006). Insights to substrate binding and processing by West Nile Virus NS3 protease through combined modeling, protease mutagenesis, and kinetic studies. Journal of Biological Chemistry, 281 (50), 38448-38458. doi: 10.1074/jbc.M607641200 |
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2006 Journal Article Current Status of Short Synthetic Peptides as VaccinesHans, D., Young, P. R. and Fairlie, D. (2006). Current Status of Short Synthetic Peptides as Vaccines. Medicinal Chemistry, 2 (6), 627-646. doi: 10.2174/1573406410602060627 |
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2006 Journal Article Self-condensation of a thiazole-peptide bearing a 21-membered loop into a library of giant macrocycles with multiple orthogonal loopsSingh, Y, Hoang, HN, Flanagan, B and Fairlie, DP (2006). Self-condensation of a thiazole-peptide bearing a 21-membered loop into a library of giant macrocycles with multiple orthogonal loops. Organic Letters, 8 (6), 1053-1056. doi: 10.1021/ol052842e |
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2006 Journal Article Design, Synthesis, Potency and Cytoselectivity of Anticancer Agents Derived by Parallel Synthesis from alpha-Aminosuberic AcidKahnberg, P. C., Lucke, A., Glenn, M. P., Boyle, G. M., Tyndall, J. D., Parsons, P. G. and Fairlie, D. P. (2006). Design, Synthesis, Potency and Cytoselectivity of Anticancer Agents Derived by Parallel Synthesis from alpha-Aminosuberic Acid. Journal of Medicinal Chemistry, 49 (26), 7611-7622. doi: 10.1021/jm050214x |
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2006 Journal Article New insights into growth hormone actionWaters, M. J., Hoang, H. N., Fairlie, D. P., Pelekanos, R. A. and Brown, R. J. (2006). New insights into growth hormone action. Journal of Molecular Endocrinology, 36 (1), 1-7. doi: 10.1677/jmr.1.01933 |
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2005 Journal Article Therapeutic targets in inflammatory diseaseHume, David A. and Fairlie, David P. (2005). Therapeutic targets in inflammatory disease. Current Medicinal Chemistry, 12 (25), 2925-2929. doi: 10.2174/092986705774462923 |
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2005 Journal Article Nonpeptide ligands that target peptide-activated GPCRs in inflammationBlakeney, JS and Fairlie, DP (2005). Nonpeptide ligands that target peptide-activated GPCRs in inflammation. Current Medicinal Chemistry, 12 (25), 3027-3042. doi: 10.2174/092986705774462888 |
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2005 Journal Article Comparative agonist/antagonist responses in mutant human C5a receptors define the ligand binding siteHigginbottom, Adrian, Cain, Stuart A., Woodruff, Trent M., Proctor, Lavinia M., Madala, Praveen K., Tyndall, Joel D. A., Taylor, Stephen M., Fairlie, David P. and Monk, Peter N. (2005). Comparative agonist/antagonist responses in mutant human C5a receptors define the ligand binding site. Journal of Biological Chemistry, 280 (18), 17831-17840. doi: 10.1074/jbc.M410797200 |
