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2006 Journal Article Potencies of human immunodeficiency virus protease inhibitors in vitro against Plasmodium falciparum and in vivo against murine malariaAndrews, Katherine T., Fairlie, David P., Madala, Praveen K., Ray, John, Wyatt, David M., Hilton, Petrina M., Melville, Lewis A., Beattie, Lynette, Gardiner, Donald L., Reid, Robert C., Stoermer, Martin J., Skinner-Adams, Tina, Berry, Colin and McCarthy, James S. (2006). Potencies of human immunodeficiency virus protease inhibitors in vitro against Plasmodium falciparum and in vivo against murine malaria. Antimicrobial Agents And Chemotherapy, 50 (2), 639-648. doi: 10.1128/AAC.50.2.639-648.2006 |
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2006 Journal Article New insights into growth hormone actionWaters, M. J., Hoang, H. N., Fairlie, D. P., Pelekanos, R. A. and Brown, R. J. (2006). New insights into growth hormone action. Journal of Molecular Endocrinology, 36 (1), 1-7. doi: 10.1677/jmr.1.01933 |
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2006 Journal Article Protease-activated receptor-2 peptides activate neurokinin-1 receptors in the mouse isolated tracheaAbey, HT, Fairlie, DP, Moffatt, JD, Balzary, RW and Cocks, TM (2006). Protease-activated receptor-2 peptides activate neurokinin-1 receptors in the mouse isolated trachea. Journal of Pharmacology And Experimental Therapeutics, 317 (2), 598-605. doi: 10.1124/jpet.105.097121 |
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2006 Journal Article Agonists and antagonists of protease activated receptors (PARs)Barry, GD, Le, GT and Fairlie, DP (2006). Agonists and antagonists of protease activated receptors (PARs). Current Medicinal Chemistry, 13 (3), 243-265. doi: 10.2174/092986706775476070 |
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2006 Journal Article New Cysteine Derivatives with Antiproliferative Activity on Melanoma CellsLucke, A., Boyle, G. M., Parsons, P. G. and Fairlie, D. (2006). New Cysteine Derivatives with Antiproliferative Activity on Melanoma Cells. Medicinal Chemistry, 2 (2), 123-132. doi: 10.2174/157340606776056124 |
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2006 Journal Article Organic Azide Inhibitors of Cysteine ProteasesLe, G. T., Abbenante, G., Madala, P. K., Hoang, H. N. and Fairlie, D. P. (2006). Organic Azide Inhibitors of Cysteine Proteases. Journal of the American Chemical Society, 128 (38), 12396-12397. doi: 10.1021/ja0637649 |
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2006 Journal Article Modular alpha-helical mimetics with antiviral activity against respiratory syncitial virusShepherd, Nicholas E., Hoang, Huy N., Desai, Vishal S., Letouze, Eric, Young, Paul R. and Fairlie, David P. (2006). Modular alpha-helical mimetics with antiviral activity against respiratory syncitial virus. Journal of The American Chemical Society, 128 (40), 13284-13289. doi: 10.1021/ja064058a |
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2006 Journal Article Insights to substrate binding and processing by West Nile Virus NS3 protease through combined modeling, protease mutagenesis, and kinetic studiesChappell, K. J., Stoermer, M. J., Fairlie, D. P. and Young, P. R. (2006). Insights to substrate binding and processing by West Nile Virus NS3 protease through combined modeling, protease mutagenesis, and kinetic studies. Journal of Biological Chemistry, 281 (50), 38448-38458. doi: 10.1074/jbc.M607641200 |
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2006 Journal Article Current Status of Short Synthetic Peptides as VaccinesHans, D., Young, P. R. and Fairlie, D. (2006). Current Status of Short Synthetic Peptides as Vaccines. Medicinal Chemistry, 2 (6), 627-646. doi: 10.2174/1573406410602060627 |
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2006 Journal Article Self-condensation of a thiazole-peptide bearing a 21-membered loop into a library of giant macrocycles with multiple orthogonal loopsSingh, Y, Hoang, HN, Flanagan, B and Fairlie, DP (2006). Self-condensation of a thiazole-peptide bearing a 21-membered loop into a library of giant macrocycles with multiple orthogonal loops. Organic Letters, 8 (6), 1053-1056. doi: 10.1021/ol052842e |
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2006 Journal Article Design, Synthesis, Potency and Cytoselectivity of Anticancer Agents Derived by Parallel Synthesis from alpha-Aminosuberic AcidKahnberg, P. C., Lucke, A., Glenn, M. P., Boyle, G. M., Tyndall, J. D., Parsons, P. G. and Fairlie, D. P. (2006). Design, Synthesis, Potency and Cytoselectivity of Anticancer Agents Derived by Parallel Synthesis from alpha-Aminosuberic Acid. Journal of Medicinal Chemistry, 49 (26), 7611-7622. doi: 10.1021/jm050214x |
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2005 Journal Article Nonpeptide ligands that target peptide-activated GPCRs in inflammationBlakeney, JS and Fairlie, DP (2005). Nonpeptide ligands that target peptide-activated GPCRs in inflammation. Current Medicinal Chemistry, 12 (25), 3027-3042. doi: 10.2174/092986705774462888 |
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2005 Journal Article Therapeutic targets in inflammatory diseaseHume, David A. and Fairlie, David P. (2005). Therapeutic targets in inflammatory disease. Current Medicinal Chemistry, 12 (25), 2925-2929. doi: 10.2174/092986705774462923 |
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2005 Journal Article Comparative agonist/antagonist responses in mutant human C5a receptors define the ligand binding siteHigginbottom, Adrian, Cain, Stuart A., Woodruff, Trent M., Proctor, Lavinia M., Madala, Praveen K., Tyndall, Joel D. A., Taylor, Stephen M., Fairlie, David P. and Monk, Peter N. (2005). Comparative agonist/antagonist responses in mutant human C5a receptors define the ligand binding site. Journal of Biological Chemistry, 280 (18), 17831-17840. doi: 10.1074/jbc.M410797200 |
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2005 Journal Article A potent and selective inhibitor of group IIa secretory phospholipase A2 protects rats from TNBS-induced colitisWoodruff, Trent M., Arumugam, Thiruma V., Shiels, Ian A., Newman, Michelle L., Ross, Paul A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2005). A potent and selective inhibitor of group IIa secretory phospholipase A2 protects rats from TNBS-induced colitis. International Immunopharmacology, 5 (5), 883-892. doi: 10.1016/j.intimp.2005.01.003 |
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2005 Journal Article Single turn peptide alpha helices with exceptional stability in waterShepherd, N. E., Hoang, H. N., Abbenante, G. and Fairlie, D. P. (2005). Single turn peptide alpha helices with exceptional stability in water. Journal of The American Chemical Society, 127 (9), 2974-2983. doi: 10.1021/ja0456003 |
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2005 Journal Article Site-directed mutagenesis and kinetic studies of the West Nile virus NS3 protease identify key enzyme-substrate interactionsChappell, Keith J., Nall, Tessa A., Stoermer, Martin J., Fang, Ning-Xia, Tyndall, Joel D. A., Fairlie, David P. and Young, Paul R. (2005). Site-directed mutagenesis and kinetic studies of the West Nile virus NS3 protease identify key enzyme-substrate interactions. Journal of Biological Chemistry, 280 (4), 2896-2903. doi: 10.1074/jbc.M409931200 |
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2005 Journal Article Structural mimicry of two cytochrome b(562) interhelical loops using macrocycles constrained by oxazoles and thiazolesSingh, Y, Stoermer, MJ, Lucke, AJ, Guthrie, T and Fairlie, DP (2005). Structural mimicry of two cytochrome b(562) interhelical loops using macrocycles constrained by oxazoles and thiazoles. Journal of The American Chemical Society, 127 (18), 6563-6572. doi: 10.1021/ja0455300 |
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2005 Journal Article Tumour necrosis factor alpha converting enzymeFairlie, D (2005). Tumour necrosis factor alpha converting enzyme. Current Medicinal Chemistry, 12 (25), 2923-2924. doi: 10.2174/092986705774462897 |
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2005 Journal Article Proteases universally recognize beta strands in their active sitesTyndall, JDA, Nall, T and Fairlie, DP (2005). Proteases universally recognize beta strands in their active sites. Chemical Reviews, 105 (3), 973-999. doi: 10.1021/cr040669e |
