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2005 Journal Article Proteases universally recognize beta strands in their active sitesTyndall, JDA, Nall, T and Fairlie, DP (2005). Proteases universally recognize beta strands in their active sites. Chemical Reviews, 105 (3), 973-999. doi: 10.1021/cr040669e |
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2005 Journal Article Protease inhibitors in the clinicAbbenante, Giovanni and Fairlie , David P. (2005). Protease inhibitors in the clinic. Medicinal Chemistry, 1 (1), 71-104. doi: 10.2174/1573406053402569 |
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2005 Journal Article Over 100 peptide-activated GPCRS recognize turn motifs in ligandsFairlie, D. P., Tyndall, J. D. A., Abbenante, G. and Pfeiffer, B. (2005). Over 100 peptide-activated GPCRS recognize turn motifs in ligands. Abstracts of Papers of The American Chemical Society, 229, U106-U106. |
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2004 Journal Article Formation of mononuclear and chloro-bridged binuclear copper(II) complexes of patellamide D, a naturally occurring cyclic peptide: influence of anion and solventvan den Brenk, Anna L., Tyndall, Joel D. A., Cusack, Rodney M., Jones, Alun, Fairlie, David P., Gahan, Lawrence R. and Hanson, Graeme R. (2004). Formation of mononuclear and chloro-bridged binuclear copper(II) complexes of patellamide D, a naturally occurring cyclic peptide: influence of anion and solvent. Journal of Inorganic Biochemistry, 98 (11), 1857-1866. doi: 10.1016/j.jinorgbio.2004.08.005 |
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2004 Journal Article Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in ratsArumugam, Thiruma V., Woodruff, Trent M., Stocks, Shelli Z., Proctor, Lavinia M., Pollitt, Sandra, Shiels, Ian A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2004). Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in rats. Journal of Hepatology, 40 (6), 934-941. doi: 10.1016/S0168-8278(04)00066-2 |
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2004 Journal Article Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in ratsArumugam, Thiruma V., Woodruff, Trent M., Stocks, Shelli Z., Proctor, Lavinia M., Pollitt, Sandra, Shiels, Ian A., Reid, Robert C., Fairlie, David P., Taylor, Stephen M. and M. Colombo (2004). Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in rats. Journal of Hepatology, 40 (6), 934-941. doi: 10.1016/j.jhep.2004.02.017 |
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2004 Journal Article Alpha-turn mimetics: short peptide alpha-Helices composed of cyclic metallopentapeptide modulesKelso, Michael J., Beyer, Renée L., Hoang, Huy N., Lakdawala, Ami S., Snyder, James P., Oliver, Warren V., Robertson, Tom A., Appleton, Trevor G. and Fairlie, David P. (2004). Alpha-turn mimetics: short peptide alpha-Helices composed of cyclic metallopentapeptide modules. Journal of The American Chemical Society, 126 (15), 4828-4842. doi: 10.1021/ja037980i |
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2004 Journal Article Comparative anti-inflammatory activities of antagonists to C3a and C5a receptors in a rat model of intestinal ischaemia/reperfusion injuryProctor, Lavinia M., Arumugam, Thiruma V., Shiels, Ian, Reid, Robert C., Fairlie, David P. and Taylor, Stephen M . (2004). Comparative anti-inflammatory activities of antagonists to C3a and C5a receptors in a rat model of intestinal ischaemia/reperfusion injury. British Journal of Pharmacology, 142 (4), 756-764. doi: 10.1038/sj.bjp.0705819 |
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2004 Journal Article Countering cooperative effects in protease inhibitors using constrained b-strand-mimicking templates in focused combinatorial librariesReid, Robert C., Pattenden, Lenard K., Tyndall, Joel D. A., Martin, Jennifer L., Walsh, Terry and Fairlie, David P. (2004). Countering cooperative effects in protease inhibitors using constrained b-strand-mimicking templates in focused combinatorial libraries. Journal of Medicinal Chemistry, 47 (7), 1641-1651. doi: 10.1021/jm030337m |
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2004 Journal Article Potent cyclic antagonists of the complement C5a receptor on human polymorphonulcear leukocytes. Relationships between structures and activityMarch, Darren R., Proctor, Lavinia M., Stoermer, Martin J., Sbaglia, Robert, Abbenante, Giovanni, Reid, Robert C., Woodruff, Trent M., Wadi, Khemar, Paczkowski, Natalii, Tyndall, Joel D. A., Taylor, Stephen M. and Fairlie, David P. (2004). Potent cyclic antagonists of the complement C5a receptor on human polymorphonulcear leukocytes. Relationships between structures and activity. Molecular Pharmacology, 65 (4), 868-879. doi: 10.1124/mol.65.4.868 |
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2004 Journal Article Antiproliferative and phenotype-transforming antitumor agents derived from cysteineGlenn, MP, Kahnberg, P, Boyle, GM, Hansford, KA, Hans, D, Martyn, AC, Parsons, PG and Fairlie, DP (2004). Antiproliferative and phenotype-transforming antitumor agents derived from cysteine. Journal of Medicinal Chemistry, 47 (12), 2984-2994. doi: 10.1021/jm030222i |
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2004 Journal Article Metal Clips Induce Folding of a Short Unstructured Peptide into an a-Helix via Turn Conformations in Water. Kinetic versus Thermodynamic ProductsBeyer, Renee L., Hoang, Huy N., Appleton, Trevor G. and Fairlie, David P. (2004). Metal Clips Induce Folding of a Short Unstructured Peptide into an a-Helix via Turn Conformations in Water. Kinetic versus Thermodynamic Products. Journal of The American Chemical Society, 126 (46), 15096-15105. doi: 10.1021/ja0453782 |
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2004 Journal Article Consecutive cyclic pentapeptide modules form short alpha-helices that are very stable to water and denaturantsShepherd, N. E., Abbenante, G. and Fairlie, D. P. (2004). Consecutive cyclic pentapeptide modules form short alpha-helices that are very stable to water and denaturants. Angewandte Chemie-international Edition, 43 (20), 2687-2690. doi: 10.1002/anie.200352659 |
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2004 Journal Article Beta-strand mimeticsLoughlin, WA, Tyndall, JDA, Glenn, MP and Fairlie, DP (2004). Beta-strand mimetics. Chemical Reviews, 104 (12), 6085-6117. doi: 10.1021/cr040648k |
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2004 Journal Article Protective effects of a potent C5a receptor antagonist on experimental acute limb ishemia-reperfusion in ratsWoodruff, Trent M., Arumugam, Thiruma V., Shiels, Ian A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2004). Protective effects of a potent C5a receptor antagonist on experimental acute limb ishemia-reperfusion in rats. Journal of Surgical Research, 116 (1), 81-90. doi: 10.1016/j.jss.2003.04.001 |
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2004 Journal Article Enzymatic characterization and homology model of a catalytically active recombinant West Nile virus NS3 proteaseNall, T. A., Chappell, K. J., Stoermer, M. J., Fang, N. X., Tyndall, J. D. A., Young, P. R. and Fairlie, D. P. (2004). Enzymatic characterization and homology model of a catalytically active recombinant West Nile virus NS3 protease. Journal of Biological Chemistry, 279 (47), 48535-48542. doi: 10.1074/jbc.M406810200 |
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2003 Journal Article A potent human C5a receptor antagonist protects against disease pathology in a rat model of inflammatory bowel diseaseWoodruff, Trent M., Arumugam, Thiruma V., Shiels, Ian A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2003). A potent human C5a receptor antagonist protects against disease pathology in a rat model of inflammatory bowel disease. Journal of Immunology, 171 (10), 5514-5520. doi: 10.4049/jimmunol.171.10.5514 |
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2003 Journal Article Studies of the interaction of Potassium(I), Calcium(II), Magnesium(II), and Copper(II) with Cyclosporin ACusack, Rodney M., Grondahl, Lisbeth, Fairlie, David P., Hanson, Graeme R. and Gahan, Lawrence R. (2003). Studies of the interaction of Potassium(I), Calcium(II), Magnesium(II), and Copper(II) with Cyclosporin A. Journal of Inorganic Biochemistry, 97 (2), 191-198. doi: 10.1016/S0162-0134(03)00288-5 |
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2003 Journal Article Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2, COX-1 and COX-2 selective inhibitors, and an LTC4 receptor antagonistArumugam, Thiruma V., Arnold, Naomi, Proctor, Lavinia M., Newman, Michelle, Reid, Robert C., Hansford, Karl A., Fairlie, David P., Shiels, Ian A. and Taylor, Stephen M. (2003). Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2, COX-1 and COX-2 selective inhibitors, and an LTC4 receptor antagonist. British Journal of Pharmacology, 140 (1), 71-80. doi: 10.1038/sj.bjp.0705402 |
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2003 Journal Article A convergent solution-phase synthesis of the macrocycle Ac-Phe-[Orn-Pro-D-Cha-Trp-Arg], a potent new antiinflammatory drugReid, Robert C., Abbenante, Giovanni, Taylor, Stephen M. and Fairlie, David P. (2003). A convergent solution-phase synthesis of the macrocycle Ac-Phe-[Orn-Pro-D-Cha-Trp-Arg], a potent new antiinflammatory drug. Journal of Organic Chemistry, 68 (11), 4464-4471. doi: 10.1021/jo034228r |
