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2005 Journal Article Single turn peptide alpha helices with exceptional stability in waterShepherd, N. E., Hoang, H. N., Abbenante, G. and Fairlie, D. P. (2005). Single turn peptide alpha helices with exceptional stability in water. Journal of The American Chemical Society, 127 (9), 2974-2983. doi: 10.1021/ja0456003 |
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2005 Journal Article Site-directed mutagenesis and kinetic studies of the West Nile virus NS3 protease identify key enzyme-substrate interactionsChappell, Keith J., Nall, Tessa A., Stoermer, Martin J., Fang, Ning-Xia, Tyndall, Joel D. A., Fairlie, David P. and Young, Paul R. (2005). Site-directed mutagenesis and kinetic studies of the West Nile virus NS3 protease identify key enzyme-substrate interactions. Journal of Biological Chemistry, 280 (4), 2896-2903. doi: 10.1074/jbc.M409931200 |
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2005 Journal Article Proteases universally recognize beta strands in their active sitesTyndall, JDA, Nall, T and Fairlie, DP (2005). Proteases universally recognize beta strands in their active sites. Chemical Reviews, 105 (3), 973-999. doi: 10.1021/cr040669e |
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2005 Journal Article Over 100 peptide-activated GPCRS recognize turn motifs in ligandsFairlie, D. P., Tyndall, J. D. A., Abbenante, G. and Pfeiffer, B. (2005). Over 100 peptide-activated GPCRS recognize turn motifs in ligands. Abstracts of Papers of The American Chemical Society, 229, U106-U106. |
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2005 Journal Article Protease inhibitors in the clinicAbbenante, Giovanni and Fairlie , David P. (2005). Protease inhibitors in the clinic. Medicinal Chemistry, 1 (1), 71-104. doi: 10.2174/1573406053402569 |
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2005 Journal Article Over one hundred peptide-activated G protein-coupled receptors recognize ligands with turn structureTyndall, J. D. A., Pfeiffer, B., Abbenante, G. and Fairlie, D. P. (2005). Over one hundred peptide-activated G protein-coupled receptors recognize ligands with turn structure. Chemical Reviews, 105 (3), 793-826. doi: 10.1021/cr040689g |
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2005 Journal Article Structural mimicry of two cytochrome b(562) interhelical loops using macrocycles constrained by oxazoles and thiazolesSingh, Y, Stoermer, MJ, Lucke, AJ, Guthrie, T and Fairlie, DP (2005). Structural mimicry of two cytochrome b(562) interhelical loops using macrocycles constrained by oxazoles and thiazoles. Journal of The American Chemical Society, 127 (18), 6563-6572. doi: 10.1021/ja0455300 |
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2005 Journal Article Tumour necrosis factor alpha converting enzymeFairlie, D (2005). Tumour necrosis factor alpha converting enzyme. Current Medicinal Chemistry, 12 (25), 2923-2924. doi: 10.2174/092986705774462897 |
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2004 Journal Article Formation of mononuclear and chloro-bridged binuclear copper(II) complexes of patellamide D, a naturally occurring cyclic peptide: influence of anion and solventvan den Brenk, Anna L., Tyndall, Joel D. A., Cusack, Rodney M., Jones, Alun, Fairlie, David P., Gahan, Lawrence R. and Hanson, Graeme R. (2004). Formation of mononuclear and chloro-bridged binuclear copper(II) complexes of patellamide D, a naturally occurring cyclic peptide: influence of anion and solvent. Journal of Inorganic Biochemistry, 98 (11), 1857-1866. doi: 10.1016/j.jinorgbio.2004.08.005 |
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2004 Journal Article Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in ratsArumugam, Thiruma V., Woodruff, Trent M., Stocks, Shelli Z., Proctor, Lavinia M., Pollitt, Sandra, Shiels, Ian A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2004). Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in rats. Journal of Hepatology, 40 (6), 934-941. doi: 10.1016/S0168-8278(04)00066-2 |
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2004 Journal Article Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in ratsArumugam, Thiruma V., Woodruff, Trent M., Stocks, Shelli Z., Proctor, Lavinia M., Pollitt, Sandra, Shiels, Ian A., Reid, Robert C., Fairlie, David P., Taylor, Stephen M. and M. Colombo (2004). Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in rats. Journal of Hepatology, 40 (6), 934-941. doi: 10.1016/j.jhep.2004.02.017 |
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2004 Journal Article Alpha-turn mimetics: short peptide alpha-Helices composed of cyclic metallopentapeptide modulesKelso, Michael J., Beyer, Renée L., Hoang, Huy N., Lakdawala, Ami S., Snyder, James P., Oliver, Warren V., Robertson, Tom A., Appleton, Trevor G. and Fairlie, David P. (2004). Alpha-turn mimetics: short peptide alpha-Helices composed of cyclic metallopentapeptide modules. Journal of The American Chemical Society, 126 (15), 4828-4842. doi: 10.1021/ja037980i |
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2004 Journal Article Comparative anti-inflammatory activities of antagonists to C3a and C5a receptors in a rat model of intestinal ischaemia/reperfusion injuryProctor, Lavinia M., Arumugam, Thiruma V., Shiels, Ian, Reid, Robert C., Fairlie, David P. and Taylor, Stephen M . (2004). Comparative anti-inflammatory activities of antagonists to C3a and C5a receptors in a rat model of intestinal ischaemia/reperfusion injury. British Journal of Pharmacology, 142 (4), 756-764. doi: 10.1038/sj.bjp.0705819 |
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2004 Journal Article Consecutive cyclic pentapeptide modules form short alpha-helices that are very stable to water and denaturantsShepherd, N. E., Abbenante, G. and Fairlie, D. P. (2004). Consecutive cyclic pentapeptide modules form short alpha-helices that are very stable to water and denaturants. Angewandte Chemie-international Edition, 43 (20), 2687-2690. doi: 10.1002/anie.200352659 |
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2004 Journal Article Beta-strand mimeticsLoughlin, WA, Tyndall, JDA, Glenn, MP and Fairlie, DP (2004). Beta-strand mimetics. Chemical Reviews, 104 (12), 6085-6117. doi: 10.1021/cr040648k |
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2004 Journal Article Enzymatic characterization and homology model of a catalytically active recombinant West Nile virus NS3 proteaseNall, T. A., Chappell, K. J., Stoermer, M. J., Fang, N. X., Tyndall, J. D. A., Young, P. R. and Fairlie, D. P. (2004). Enzymatic characterization and homology model of a catalytically active recombinant West Nile virus NS3 protease. Journal of Biological Chemistry, 279 (47), 48535-48542. doi: 10.1074/jbc.M406810200 |
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2004 Journal Article Countering cooperative effects in protease inhibitors using constrained b-strand-mimicking templates in focused combinatorial librariesReid, Robert C., Pattenden, Lenard K., Tyndall, Joel D. A., Martin, Jennifer L., Walsh, Terry and Fairlie, David P. (2004). Countering cooperative effects in protease inhibitors using constrained b-strand-mimicking templates in focused combinatorial libraries. Journal of Medicinal Chemistry, 47 (7), 1641-1651. doi: 10.1021/jm030337m |
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2004 Journal Article Potent cyclic antagonists of the complement C5a receptor on human polymorphonulcear leukocytes. Relationships between structures and activityMarch, Darren R., Proctor, Lavinia M., Stoermer, Martin J., Sbaglia, Robert, Abbenante, Giovanni, Reid, Robert C., Woodruff, Trent M., Wadi, Khemar, Paczkowski, Natalii, Tyndall, Joel D. A., Taylor, Stephen M. and Fairlie, David P. (2004). Potent cyclic antagonists of the complement C5a receptor on human polymorphonulcear leukocytes. Relationships between structures and activity. Molecular Pharmacology, 65 (4), 868-879. doi: 10.1124/mol.65.4.868 |
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2004 Journal Article Protective effects of a potent C5a receptor antagonist on experimental acute limb ishemia-reperfusion in ratsWoodruff, Trent M., Arumugam, Thiruma V., Shiels, Ian A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2004). Protective effects of a potent C5a receptor antagonist on experimental acute limb ishemia-reperfusion in rats. Journal of Surgical Research, 116 (1), 81-90. doi: 10.1016/j.jss.2003.04.001 |
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2004 Journal Article Antiproliferative and phenotype-transforming antitumor agents derived from cysteineGlenn, MP, Kahnberg, P, Boyle, GM, Hansford, KA, Hans, D, Martyn, AC, Parsons, PG and Fairlie, DP (2004). Antiproliferative and phenotype-transforming antitumor agents derived from cysteine. Journal of Medicinal Chemistry, 47 (12), 2984-2994. doi: 10.1021/jm030222i |
