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2000 Journal Article Small peptides do not inhibit human non-pancreatic secretory phospholipase-A 2 (Type IIA)Clark, C. I., Reid, R. C., McGeary, R. P., Schafer, K. and Fairlie, D. P. (2000). Small peptides do not inhibit human non-pancreatic secretory phospholipase-A 2 (Type IIA). Bioichemistry BIophysical Research Communications, 274 (3), 831-834. doi: 10.1006/bbrc.2000.3221 |
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2000 Journal Article A new small molecule C5a receptor antagonist inhibits the reverse-passive arthus reaction and endotoxic shock in ratsStrachan, A. J., Woodruff, T.M., Haaima, G., Fairlie, D. P. and Taylor, S. M. (2000). A new small molecule C5a receptor antagonist inhibits the reverse-passive arthus reaction and endotoxic shock in rats. Journal of Immunology, 164 (4), 6560-6565. |
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2000 Journal Article Inhibition of C5a-induced neutrophil chemotaxis and macrophage cytokine production In Vitro by a new C5a receptor antagonistHaynes, DR, Harkin, DG, Bignold, LP, Hutchens, MJ, Taylor, SM and Fairlie, DP (2000). Inhibition of C5a-induced neutrophil chemotaxis and macrophage cytokine production In Vitro by a new C5a receptor antagonist. Biochemical Pharmacology, 60 (5), 729-733. doi: 10.1016/S0006-2952(00)00361-0 |
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2000 Journal Article The first solution structure of a single a-helical turn. A pentapeptide a -Helix stabilized by a metal clipKelso, M. J., Hoang, H. N., Appleton, T. G. and Fairlie, D. (2000). The first solution structure of a single a-helical turn. A pentapeptide a -Helix stabilized by a metal clip. Journal of Americal Chemical Society, 122 (42), 10488-10489. doi: 10.1021/ja002416i |
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2000 Journal Article Conformations of cyclic octapeptides and the influence of heterocyclic ring constraints upon calcium bindingCusack, R. M., Grondahl, L., Abbenante, G., Fairlie, D. P., Gahan, L. R., Hanson, G. R. and Hambley, T. W. (2000). Conformations of cyclic octapeptides and the influence of heterocyclic ring constraints upon calcium binding. Journal of The Chemical Society-perkin Transactions 2 (2), 323-331. doi: 10.1039/a906090a |
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2000 Journal Article Conformational selection of inhibitors and substrates by proteolytic enzymes: Implications for drug design and polypeptide processingFairlie, D. P., Tyndall, J. D. A., Reid, R. C., Wong, A. K., Abbenante, G., Scanlon, M. J., March, D. R., Bergman, D. A., Chai, C. L. L. and Burkett, B. A. (2000). Conformational selection of inhibitors and substrates by proteolytic enzymes: Implications for drug design and polypeptide processing. Journal of Medicinal Chemistry, 43 (7), 1271-1281. doi: 10.1021/jm990315t |
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2000 Journal Article Is oxidative damage by b- amyloid and prion peptides mediated by hydrogen atom transfer from glycine a-carbon to methionine sulfur within b- sheets?Rauk, A., Armstrong, D. A. and Fairlie, D. P. (2000). Is oxidative damage by b- amyloid and prion peptides mediated by hydrogen atom transfer from glycine a-carbon to methionine sulfur within b- sheets?. Journal of American Chemical Society, 122 (40), 9761-9767. doi: 10.1021/ja994436u |
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2000 Journal Article Synthesis, stability, antiviral activity, and protease-bound structures of substrate-mimicking constrained macrocyclic inhibitors of HIV-1 proteaseTyndall, J. D. A., Reid, R. C., Tyssen, D. P., Jardine, D. K., Todd, B., Passmore, M., March, D. R., Pattenden, L., Bergman, D. A., Alewood, D., Hu, S., Alewood, P.F., Birch, C. J., Martin, J. L. and Fairlie, D. (2000). Synthesis, stability, antiviral activity, and protease-bound structures of substrate-mimicking constrained macrocyclic inhibitors of HIV-1 protease. Journal of Medicinal Chemistry, 43 (19), 3495-3504. doi: 10.1021/jm000013n |
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2000 Journal Article Characterization of copper interactions with alzheimer amyloid bpeptides: Identification of an attomolar-affinity copper binding site on Amyloid 1-42Atwood, C. S., Scarpa, R. C., Huang, X., Moir, R. D., Jones, W. D., Fairlie, D. P., Tanzi, R. E. and Bush, A. I. (2000). Characterization of copper interactions with alzheimer amyloid bpeptides: Identification of an attomolar-affinity copper binding site on Amyloid 1-42. Journal of Neurochemistry, 75 (3), 1219-1233. doi: 10.1046/j.1471-4159.2000.0751219.x |
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1999 Journal Article Cu(II) potentiation of Alzheimer A beta neurotoxicity - Correlation with cell-free hydrogen peroxide production and metal reductionHuang, XD, Cuajungco, MP, Atwood, CS, Hartshorn, MA, Tyndall, JDA, Hanson, GR, Stokes, KC, Leopold, M, Multhaup, G, Goldstein, LE, Scarpa, RC, Saunders, AJ, Lim, J, Moir, RD, Glabe, C, Bowden, EF, Masters, CL, Fairlie, DP, Tanzi, RE and Bush, AI (1999). Cu(II) potentiation of Alzheimer A beta neurotoxicity - Correlation with cell-free hydrogen peroxide production and metal reduction. Journal of Biological Chemistry, 274 (52), 37111-37116. doi: 10.1074/jbc.274.52.37111 |
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1999 Journal Article Homology model of the dengue 2 virus NS3 protease: putative interactions with both substrate and NS2B cofactor.Brinkworth, R. I., Fairlie, D., Leung, D. and Young, P. R. (1999). Homology model of the dengue 2 virus NS3 protease: putative interactions with both substrate and NS2B cofactor.. Journal of General Virology, 80 (5), 1167-1177. doi: 10.1099/0022-1317-80-5-1167 |
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1999 Journal Article Effects of a new C5a receptor antagonist on C5a- and endotoxin-induced neutropenia in the ratShort, Anna, Wong, Allan K., Finch, Angela M., Haaima, Gerald, Shiels, Ian A., Fairlie, David P. and Taylor, Stephen M. (1999). Effects of a new C5a receptor antagonist on C5a- and endotoxin-induced neutropenia in the rat. British Journal of Pharmacology, 126 (2), 551-554. doi: 10.1038/sj.bjp.0702338 |
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1999 Journal Article Aqueous Dissolution of Alzheimer's Disease Ab Amyloid Deposits by Biometal DepletionCherny, R. A., Legg, J. T., McLean, C. A., Fairlie, D., Huang, X., Atwood, C.S., Beyreuther, K., Tanzi, R. E., Masters, C. L. and Bush, A. (1999). Aqueous Dissolution of Alzheimer's Disease Ab Amyloid Deposits by Biometal Depletion. Journal of Biological Chemistry, 274 (33), 23223-23228. doi: 10.1074/jbc.274.33.23223 |
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1999 Journal Article Interaction of zinc(II) with the cyclic octapeptides, cyclo[Ile(Oxn)-D-Val(Thz)](2) and ascidiacyclamide, a cyclic peptide from Lissoclinum patellaGrondahl, L., Sokolenko, N., Abbenante, G., Fairlie, D. P., Hanson, G. R. and Gahan, L. R. (1999). Interaction of zinc(II) with the cyclic octapeptides, cyclo[Ile(Oxn)-D-Val(Thz)](2) and ascidiacyclamide, a cyclic peptide from Lissoclinum patella. Journal of The Chemical Society-dalton Transactions (8), 1227-1234. doi: 10.1039/a808836e |
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1999 Journal Article Facile and steroselective condensation of acetone with ammonia ligands on cobalt ( III):structure of a N-bonded cyanate complex containing the 2-methyl-2-amino-4-imino-pentane ligandFairlie, D., Turner, M., Byriel, K., McKeon, J. A. and Jackson, G. W. (1999). Facile and steroselective condensation of acetone with ammonia ligands on cobalt ( III):structure of a N-bonded cyanate complex containing the 2-methyl-2-amino-4-imino-pentane ligand. Inorganica Chimica Acta, 290 (2), 133-138. doi: 10.1016/S0020-1693(99)00110-3 |
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1999 Journal Article Cu (II ) Potentiation of Alzheimer Ab NeurotoxicityHuang, X., Cuajungco, M. P., Atwood, C. S., Hartshorn, M. A., Tyndall, J. D., Hanson, G. R., Stokes, K. C., Leopold, M., Multhaup, G., Goldstein, L. E., Scarpa, R. C., Saunders, A. J., Lim, J., Moir, R. D., Glabe, C., Bowden, E. F., Masters, C. L., Fairlie, D., Tanzi, R. E. and Bush, A. I. (1999). Cu (II ) Potentiation of Alzheimer Ab Neurotoxicity. Jornal of Biological Chemistry, 274 (52), 37111-37116. |
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1999 Journal Article Anti-tumour activity in vitro and in vivo of selective differentiating agents containing hydroxamate.Qiu, L., Kelso, M., Hansen, C., West, M. L., Fairlie, D. and Parsons, P. (1999). Anti-tumour activity in vitro and in vivo of selective differentiating agents containing hydroxamate.. British Journal of Cancer, 80 (8), 1252-1258. doi: 10.1038/sj.bjc.6690493 |
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1999 Journal Article The possible origin of free radicals from amyloid peptides in Alzheimer's diseaseBush, A. I., Huang, X. and Fairlie, D. (1999). The possible origin of free radicals from amyloid peptides in Alzheimer's disease. Neurobiology of Aging, 20 (3), 335-337. doi: 10.1016/S0197-4580(99)00058-5 |
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1999 Journal Article Con formational homogeneity in molecular recognition by proteolytic enzymesTyndall, J. and Fairlie, D. (1999). Con formational homogeneity in molecular recognition by proteolytic enzymes. Journal of Molecular Recognition, 12 (6), 363-370. doi: 10.1002/(SICI)1099-1352(199911/12)12:63.3.CO;2-D |
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1999 Journal Article Low-molecular-weight peptidic and cyclic antagonists of the receptor for the complement factor C5aFinch, A., Wong, A. K., Paczkowski, N. J., Wadi, S. K., Craik, D. J., Fairlie, D. and Taylor, S. M. (1999). Low-molecular-weight peptidic and cyclic antagonists of the receptor for the complement factor C5a. Journal of Medicinal Chemistry, 42 (6), 1965-1974. doi: 10.1021/jm9806594 |
