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2012 Journal Article Antagonism of protease-activated receptor 2 protects against experimental colitis.Lohman, Rink-Jan, Cotterell, Adam J., Suen, Jacky, Liu, Ligong, Do, Anh T., Vesey, David A. and Fairlie, David P. (2012). Antagonism of protease-activated receptor 2 protects against experimental colitis.. Journal of Pharmacology and Experimental Therapeutics, 340 (2), 256-265. doi: 10.1124/jpet.111.187062 |
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2012 Journal Article Lysine acetylation in obesity, diabetes and metabolic diseaseIyer, Abishek, Fairlie, David P. and Brown, Lindsay (2012). Lysine acetylation in obesity, diabetes and metabolic disease. Immunology and Cell Biology, 90 (1), 39-46. doi: 10.1038/icb.2011.99 |
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2012 Journal Article HDACs and their inhibitors in immunology: teaching anticancer drugs new tricksFairlie, David P. and Sweet, Matthew J. (2012). HDACs and their inhibitors in immunology: teaching anticancer drugs new tricks. Immunology and Cell Biology, 90 (1), 3-5. doi: 10.1038/icb.2011.105 |
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2012 Journal Article HDAC inhibitors: Modulating leukocyte differentiation, survival, proliferation and inflammationSweet, Matthew J., Shakespear, Melanie R., Kamal, Nabilah A. and Fairlie, David P. (2012). HDAC inhibitors: Modulating leukocyte differentiation, survival, proliferation and inflammation. Immunology and Cell Biology, 90 (1), 14-22. doi: 10.1038/icb.2011.88 |
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2012 Journal Article Structures of peptide agonists for human protease activated receptor 2Stoermer, Martin J., Flanagan, Bernadine, Beyer, Renée L., Madala, Praveen K. and Fairlie, David P. (2012). Structures of peptide agonists for human protease activated receptor 2. Bioorganic and Medicinal Chemistry Letters, 22 (2), 916-919. doi: 10.1016/j.bmcl.2011.12.029 |
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2011 Journal Article Synthesis of the Thiazole-Thiazoline Fragment of Largazole AnaloguesDiness, Frederik, Nielsen, Daniel S. and Fairlie, David P. (2011). Synthesis of the Thiazole-Thiazoline Fragment of Largazole Analogues. Journal of Organic Chemistry, 76 (23), 9845-9851. doi: 10.1021/jo201675r |
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2011 Journal Article Histone deacetylase inhibitors and periodontal bone lossCantley, M. D., Bartold, P. M., Marino, V., Fairlie, D. P., Le, G. T., Lucke, A. J. and Haynes, D. R. (2011). Histone deacetylase inhibitors and periodontal bone loss. Journal of Periodontal Research, 46 (6), 697-703. doi: 10.1111/j.1600-0765.2011.01392.x |
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2011 Journal Article Inhibitors of histone deacetylases in class I and class II suppress human osteoclasts in vitroCantley, M. D., Fairlie, D. P., Bartold, P. M., Rainsford, K. D., Le, G. T., Lucke, A. J., Holding, C. A. and Haynes, D. R. (2011). Inhibitors of histone deacetylases in class I and class II suppress human osteoclasts in vitro. Journal of Cellular Physiology, 226 (12), 3233-3241. doi: 10.1002/jcp.22684 |
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2011 Journal Article Protein a-turns recreated in structurally stable small moleculesHoang, Huy N., Driver, Russell W., Beyer, Renée L., Malde, Alpeshkumar K., Le, Giang T., Abbenante, Giovanni, Mark, Alan E. and Fairlie, David P. (2011). Protein a-turns recreated in structurally stable small molecules. Angewandte Chemie International Edition, 123 (47), 11303-11307. doi: 10.1002/ange.201105119 |
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2011 Journal Article Inhibition of inflammation and fibrosis by a complement C5a receptor antagonist in DOCA-salt hypertensive ratsIyer, Abishek, Woodruff, Trent M., Wu, Mike C. L., Stylianou, Con, Reid, Robert C., Fairlie, David P., Taylor, Stephen M. and Brown, Lindsay (2011). Inhibition of inflammation and fibrosis by a complement C5a receptor antagonist in DOCA-salt hypertensive rats. Journal of Cardiovascular Pharmacology, 58 (5), 479-486. doi: 10.1097/FJC.0b013e31822a7a09 |
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2011 Journal Article Histone deacetylases as regulators of inflammation and immunityShakespear, Melanie R., Halili, Maria A., Irvine, Katharine M., Fairlie, David P. and Sweet, Matthew J. (2011). Histone deacetylases as regulators of inflammation and immunity. Trends in Immunology, 32 (7), 335-343. doi: 10.1016/j.it.2011.04.001 |
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2011 Journal Article Structure, function and pathophysiology of protease activated receptorsAdams, Mark N., Ramachandran, Rithwik, Yau, Mei-Kwan, Suen, Jacky Y., Fairlie, David P., Hollenberg, Morley D. and Hooper, John D. (2011). Structure, function and pathophysiology of protease activated receptors. Pharmacology and Therapeutics, 120 (3), 248-282. doi: 10.1016/j.pharmthera.2011.01.003 |
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2011 Journal Article Ex Vivo activity of histone deacetylase inhibitors against multidrug-resistant clinical isolates of Plasmodium falciparum and P. vivaxMarfurt, Jutta, Chalfein, Ferryanto, Prayoga, Pak, Wabiser, Frans, Kenangalem, Enny, Piera, Kim A., Fairlie, David P., Tjitra, Emiliana, Anstey, Nicholas M., Andrews, Kathy T. and Price, Rick N. (2011). Ex Vivo activity of histone deacetylase inhibitors against multidrug-resistant clinical isolates of Plasmodium falciparum and P. vivax. Antimicrobial agents and chemotherapy, 55 (3), 961-966. doi: 10.1128/AAC.01220-10 |
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2011 Journal Article Amyloid formation from an α-helical peptide bundle is seeded by 310-helix aggregatesSingh, Yogendra, Sharpe, Philip C., Hoang, Huy N., Lucke, Andrew J., McDowall, Alasdair W., Bottomley, Stephen P. and Fairlie, David P. (2011). Amyloid formation from an α-helical peptide bundle is seeded by 310-helix aggregates. Chemistry: A European Journal, 17 (1), 151-160. doi: 10.1002/chem.201002500 |
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2010 Journal Article Inhibitors selective for HDAC6 in enzymes and cellsGupta, Praveer K., Reid, Robert C., Liu, Ligong, Lucke, Andrew J., Broomfield, Steve A., Andrews, Melanie R., Sweet, Matthew J. and Fairlie, David P. (2010). Inhibitors selective for HDAC6 in enzymes and cells. Bioorganic & Medicinal Chemistry Letters, 20 (23), 7067-7070. doi: 10.1016/j.bmcl.2010.09.100 |
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2010 Journal Article Antimalarial histone deacetylase inhibitors containing cinnamate or NSAID componentsWheatley, Nicole C., Andrews, Katherine T., Tran, Truc L., Lucke, Andrew J., Reid, Robert C. and Fairlie, David P. (2010). Antimalarial histone deacetylase inhibitors containing cinnamate or NSAID components. Bioorganic & Medicinal Chemistry Letters, 20 (23), 7080-7084. doi: 10.1016/j.bmcl.2010.09.096 |
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2010 Journal Article Novel helix-constrained nociceptin derivatives are potent agonists and antagonists of ERK phosphorylation and thermal analgesia in miceHarrison, Rosemary S., Ruiz-Gomez, Gloria, Hill, Timothy A., Chow, Shiao Y., Shepherd, Nicholas E., Lohman, Rink-Jan, Abbenante, Giovanni, Hoang, Huy N. and Fairlie, David P. (2010). Novel helix-constrained nociceptin derivatives are potent agonists and antagonists of ERK phosphorylation and thermal analgesia in mice. Journal of Medicinal Chemistry, 53 (23), 8400-8408. doi: 10.1021/jm101139f |
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2010 Journal Article Selective Hexapeptide Agonists and Antagonists for Human Complement C3a Receptor (Journal of Medicinal Chemistry (2010) 53 (4938)Scully, Conor C. G., Blakeney, Jade S., Singh, Ranee, Hoang, Huy N., Abbenante, Giovanni, Reid, Robert C. and Fairlie, David P. (2010). Selective Hexapeptide Agonists and Antagonists for Human Complement C3a Receptor (Journal of Medicinal Chemistry (2010) 53 (4938). Journal of Medicinal Chemistry, 53 (22), 8208-8208. doi: 10.1021/jm1013314 |
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2010 Journal Article Profiling gene expression induced by protease-activated receptor 2 (PAR2) activation in human kidney cellsSuen, JY, Gardiner, B, Grimmond, S and Fairlie, DP (2010). Profiling gene expression induced by protease-activated receptor 2 (PAR2) activation in human kidney cells. PLoS One, 5 (11) e13809, e13809-1-e13809-14. doi: 10.1371/journal.pone.0013809 |
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2010 Journal Article Novel agonists and antagonists for human protease activated receptor 2Barry, Grant D., Suen, Jacky Y., Le, Giang T., Cotterell, Adam, Reid, Robert C. and Fairlie, David P. (2010). Novel agonists and antagonists for human protease activated receptor 2. Journal of Medicinal Chemistry, 53 (20), 7428-7440. doi: 10.1021/jm100984y |
