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2000

Journal Article

Conformations of cyclic octapeptides and the influence of heterocyclic ring constraints upon calcium binding

Cusack, R. M., Grondahl, L., Abbenante, G., Fairlie, D. P., Gahan, L. R., Hanson, G. R. and Hambley, T. W. (2000). Conformations of cyclic octapeptides and the influence of heterocyclic ring constraints upon calcium binding. Journal of The Chemical Society-perkin Transactions 2 (2), 323-331. doi: 10.1039/a906090a

Conformations of cyclic octapeptides and the influence of heterocyclic ring constraints upon calcium binding

2000

Journal Article

Conformational selection of inhibitors and substrates by proteolytic enzymes: Implications for drug design and polypeptide processing

Fairlie, D. P., Tyndall, J. D. A., Reid, R. C., Wong, A. K., Abbenante, G., Scanlon, M. J., March, D. R., Bergman, D. A., Chai, C. L. L. and Burkett, B. A. (2000). Conformational selection of inhibitors and substrates by proteolytic enzymes: Implications for drug design and polypeptide processing. Journal of Medicinal Chemistry, 43 (7), 1271-1281. doi: 10.1021/jm990315t

Conformational selection of inhibitors and substrates by proteolytic enzymes: Implications for drug design and polypeptide processing

2000

Conference Publication

Coordination with Pd(en)2+ imposes an a-helical structure on a pentapeptide

Appleton, T. G., Hoang, H. N. and Fairlie, D. (2000). Coordination with Pd(en)2+ imposes an a-helical structure on a pentapeptide. Pacifichem 2000, Honolulu, Hawaii, 14-19 December, 2000. American Chemical Society.

Coordination with Pd(en)2+ imposes an a-helical structure on a pentapeptide

2000

Journal Article

Regulators of the anaphylatoxin C5a

Taylor, SM and Fairlie, DP (2000). Regulators of the anaphylatoxin C5a. Expert Opinion in Therapeutic Patents, 10 (4), 449-458. doi: 10.1517/13543776.10.4.449

Regulators of the anaphylatoxin C5a

2000

Journal Article

Characterization of copper interactions with alzheimer amyloid bpeptides: Identification of an attomolar-affinity copper binding site on Amyloid 1-42

Atwood, C. S., Scarpa, R. C., Huang, X., Moir, R. D., Jones, W. D., Fairlie, D. P., Tanzi, R. E. and Bush, A. I. (2000). Characterization of copper interactions with alzheimer amyloid bpeptides: Identification of an attomolar-affinity copper binding site on Amyloid 1-42. Journal of Neurochemistry, 75 (3), 1219-1233. doi: 10.1046/j.1471-4159.2000.0751219.x

Characterization of copper interactions with alzheimer amyloid bpeptides: Identification of an attomolar-affinity copper binding site on Amyloid 1-42

2000

Journal Article

The first solution structure of a single a-helical turn. A pentapeptide a -Helix stabilized by a metal clip

Kelso, M. J., Hoang, H. N., Appleton, T. G. and Fairlie, D. (2000). The first solution structure of a single a-helical turn. A pentapeptide a -Helix stabilized by a metal clip. Journal of Americal Chemical Society, 122 (42), 10488-10489. doi: 10.1021/ja002416i

The first solution structure of a single a-helical turn. A pentapeptide a -Helix stabilized by a metal clip

1999

Journal Article

Cu(II) potentiation of Alzheimer A beta neurotoxicity - Correlation with cell-free hydrogen peroxide production and metal reduction

Huang, XD, Cuajungco, MP, Atwood, CS, Hartshorn, MA, Tyndall, JDA, Hanson, GR, Stokes, KC, Leopold, M, Multhaup, G, Goldstein, LE, Scarpa, RC, Saunders, AJ, Lim, J, Moir, RD, Glabe, C, Bowden, EF, Masters, CL, Fairlie, DP, Tanzi, RE and Bush, AI (1999). Cu(II) potentiation of Alzheimer A beta neurotoxicity - Correlation with cell-free hydrogen peroxide production and metal reduction. Journal of Biological Chemistry, 274 (52), 37111-37116. doi: 10.1074/jbc.274.52.37111

Cu(II) potentiation of Alzheimer A beta neurotoxicity - Correlation with cell-free hydrogen peroxide production and metal reduction

1999

Journal Article

Homology model of the dengue 2 virus NS3 protease: putative interactions with both substrate and NS2B cofactor.

Brinkworth, R. I., Fairlie, D., Leung, D. and Young, P. R. (1999). Homology model of the dengue 2 virus NS3 protease: putative interactions with both substrate and NS2B cofactor.. Journal of General Virology, 80 (5), 1167-1177. doi: 10.1099/0022-1317-80-5-1167

Homology model of the dengue 2 virus NS3 protease: putative interactions with both substrate and NS2B cofactor.

1999

Journal Article

Effects of a new C5a receptor antagonist on C5a- and endotoxin-induced neutropenia in the rat

Short, Anna, Wong, Allan K., Finch, Angela M., Haaima, Gerald, Shiels, Ian A., Fairlie, David P. and Taylor, Stephen M. (1999). Effects of a new C5a receptor antagonist on C5a- and endotoxin-induced neutropenia in the rat. British Journal of Pharmacology, 126 (2), 551-554. doi: 10.1038/sj.bjp.0702338

Effects of a new C5a receptor antagonist on C5a- and endotoxin-induced neutropenia in the rat

1999

Journal Article

Anti-tumour activity in vitro and in vivo of selective differentiating agents containing hydroxamate.

Qiu, L., Kelso, M., Hansen, C., West, M. L., Fairlie, D. and Parsons, P. (1999). Anti-tumour activity in vitro and in vivo of selective differentiating agents containing hydroxamate.. British Journal of Cancer, 80 (8), 1252-1258. doi: 10.1038/sj.bjc.6690493

Anti-tumour activity in vitro and in vivo of selective differentiating agents containing hydroxamate.

1999

Journal Article

Low-molecular-weight peptidic and cyclic antagonists of the receptor for the complement factor C5a

Finch, A., Wong, A. K., Paczkowski, N. J., Wadi, S. K., Craik, D. J., Fairlie, D. and Taylor, S. M. (1999). Low-molecular-weight peptidic and cyclic antagonists of the receptor for the complement factor C5a. Journal of Medicinal Chemistry, 42 (6), 1965-1974. doi: 10.1021/jm9806594

Low-molecular-weight peptidic and cyclic antagonists of the receptor for the complement factor C5a

1999

Journal Article

Development of C5a receptor antagonists

Wong, A., Taylor, S. M. and Fairlie, D. (1999). Development of C5a receptor antagonists. Investigational Drugs, 2 (7), 686-693.

Development of C5a receptor antagonists

1999

Journal Article

Aqueous Dissolution of Alzheimer's Disease Ab Amyloid Deposits by Biometal Depletion

Cherny, R. A., Legg, J. T., McLean, C. A., Fairlie, D., Huang, X., Atwood, C.S., Beyreuther, K., Tanzi, R. E., Masters, C. L. and Bush, A. (1999). Aqueous Dissolution of Alzheimer's Disease Ab Amyloid Deposits by Biometal Depletion. Journal of Biological Chemistry, 274 (33), 23223-23228. doi: 10.1074/jbc.274.33.23223

Aqueous Dissolution of Alzheimer's Disease Ab Amyloid Deposits by Biometal Depletion

1999

Journal Article

Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease

Martin, J. L., Begun, J., Schindeler, A., Wickramasinghe, W. A., Alewood, D., Alewood, P. F., Bergman, D. A., Brinkworth, R. I., Abbenante, G., March, D. R., Reid, R. C., Fairlie, D. P. and Armstrong, Richard A. (1999). Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease. Biochemistry, 38 (25), 7978-7988. doi: 10.1021/bi990174x

Molecular recognition of macrocyclic peptidomimetic inhibitors by HIV-1 protease

1999

Journal Article

Cyclooligomerization of Thiazole-Containing Tetrapeptides. Symmetrical Macrocycles with up to 76 Amino Acids

Sokolenko, N., Abbenante, G., Scanlon, M. J., Jones, A., Gahan, L. R., Hanson, G. R. and Fairlie, D. P. (1999). Cyclooligomerization of Thiazole-Containing Tetrapeptides. Symmetrical Macrocycles with up to 76 Amino Acids. Journal of the American Chemical Society, 121 (11), 2603-2604. doi: 10.1021/ja983354n

Cyclooligomerization of Thiazole-Containing Tetrapeptides. Symmetrical Macrocycles with up to 76 Amino Acids

1999

Conference Publication

Homology model of the dengue 2 virus NS3 protease: Interactions with NS2B co-factor

White, H., Young, P. R., Brinkworth, R. I., Fairlie, D. and Leung, D. D. (1999). Homology model of the dengue 2 virus NS3 protease: Interactions with NS2B co-factor. XIth International Congress of Virology, Sydney, 9-13 August 1999. Sydney: International Union of Microbiological Societies.

Homology model of the dengue 2 virus NS3 protease: Interactions with NS2B co-factor

1999

Journal Article

Facile and steroselective condensation of acetone with ammonia ligands on cobalt ( III):structure of a N-bonded cyanate complex containing the 2-methyl-2-amino-4-imino-pentane ligand

Fairlie, D., Turner, M., Byriel, K., McKeon, J. A. and Jackson, G. W. (1999). Facile and steroselective condensation of acetone with ammonia ligands on cobalt ( III):structure of a N-bonded cyanate complex containing the 2-methyl-2-amino-4-imino-pentane ligand. Inorganica Chimica Acta, 290 (2), 133-138. doi: 10.1016/S0020-1693(99)00110-3

Facile and steroselective condensation of acetone with ammonia ligands on cobalt ( III):structure of a N-bonded cyanate complex containing the 2-methyl-2-amino-4-imino-pentane ligand

1999

Journal Article

Pharmacological characterization of antagonists of the C5a receptor

Paczkowski, NJ, Finch, AM, Whitmore, JB, Short, AJ, Wong, AK, Monk, PN, Cain, SA, Fairlie, DP and Taylor, SM (1999). Pharmacological characterization of antagonists of the C5a receptor. British Journal of Pharmacology, 128 (10), 1461-1466. doi: 10.1038/sj.bjp.0702938

Pharmacological characterization of antagonists of the C5a receptor

1999

Other Outputs

Cyclic agonists and antagonists of c5a receptors and g protein-coupled receptors

Fairlie, David, Taylor, Stephen Maxwell, Finch, Angela Monique and Wong, Allan (1999). Cyclic agonists and antagonists of c5a receptors and g protein-coupled receptors. WO/1999/000406.

Cyclic agonists and antagonists of c5a receptors and g protein-coupled receptors

1999

Journal Article

Interaction of zinc(II) with the cyclic octapeptides, cyclo[Ile(Oxn)-D-Val(Thz)](2) and ascidiacyclamide, a cyclic peptide from Lissoclinum patella

Grondahl, L., Sokolenko, N., Abbenante, G., Fairlie, D. P., Hanson, G. R. and Gahan, L. R. (1999). Interaction of zinc(II) with the cyclic octapeptides, cyclo[Ile(Oxn)-D-Val(Thz)](2) and ascidiacyclamide, a cyclic peptide from Lissoclinum patella. Journal of The Chemical Society-dalton Transactions (8), 1227-1234. doi: 10.1039/a808836e

Interaction of zinc(II) with the cyclic octapeptides, cyclo[Ile(Oxn)-D-Val(Thz)](2) and ascidiacyclamide, a cyclic peptide from Lissoclinum patella