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2003 Journal Article A convergent solution-phase synthesis of the macrocycle Ac-Phe-[Orn-Pro-D-Cha-Trp-Arg], a potent new antiinflammatory drugReid, Robert C., Abbenante, Giovanni, Taylor, Stephen M. and Fairlie, David P. (2003). A convergent solution-phase synthesis of the macrocycle Ac-Phe-[Orn-Pro-D-Cha-Trp-Arg], a potent new antiinflammatory drug. Journal of Organic Chemistry, 68 (11), 4464-4471. doi: 10.1021/jo034228r |
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2003 Other Outputs New cyclic peptide or peptidomimetic compounds, are G-protein coupled receptor antagonists useful for treating inflammatory disorders such as rheumatoid arthritis, reperfusion injury or dermal inflammationTaylor, Steve, Shiels, Ian Alexander and Fairlie, David (2003). New cyclic peptide or peptidomimetic compounds, are G-protein coupled receptor antagonists useful for treating inflammatory disorders such as rheumatoid arthritis, reperfusion injury or dermal inflammation. WO/2003/033528. |
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2003 Conference Publication Template-assembled peptide loops, helices, sheets and nanofibresFairlie, DP, Singh, Y, Sharpe, P and Stoermer, M (2003). Template-assembled peptide loops, helices, sheets and nanofibres. 225th National Meeting of the American-Chemical-Society, New Orleans Louisiana, Mar 23-27, 2003. WASHINGTON: AMER CHEMICAL SOC. |
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2003 Journal Article A cyclic metallopeptide induces alpha helicity in short peptide fragments of thermolysinKelso, Michael J., Hoang, Huy N., Oliver, Warren, Sokolenko, Nikolai, March, Darren R., Appleton, Trevor G. and Fairlie, David P. (2003). A cyclic metallopeptide induces alpha helicity in short peptide fragments of thermolysin. Angewandte Chemie International Edition, 42 (4), 421-424. doi: 10.1002/anie.200390128 |
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2003 Journal Article Conformationally homogeneous cyclic tetrapeptides: Useful new three-dimensional scaffoldsGlenn, MP, Kelso, MJ, Tyndall, JDA and Fairlie, DP (2003). Conformationally homogeneous cyclic tetrapeptides: Useful new three-dimensional scaffolds. Journal of The American Chemical Society, 125 (3), 640-641. doi: 10.1021/ja029205t |
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2003 Conference Publication Template-assembled peptide loops, helices, sheets, and nanofibersFairlie, David P ., Singh, Yogendra, Sharpe, Philip and Stoermer, Martin (2003). Template-assembled peptide loops, helices, sheets, and nanofibers. 225th ACS National Meeting, New Orleans, LA, United States, 23-27 March 2003. |
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2003 Journal Article Tumor cell-specific cytotoxicity by targeting cell cycle checkpointsWarrener, R, Beamish, H, Burgess, A, Waterhouse, NJ, Giles, N, Fairlie, DP and Gabrielli, B (2003). Tumor cell-specific cytotoxicity by targeting cell cycle checkpoints. Faseb Journal, 17 (9), 1550-1570. doi: 10.1096/fj.02-1003fje |
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2003 Journal Article Designing supramolecular structures from models of cyclic peptide scaffolds with heterocyclic constraintsLucke, AJ, Tyndall, JDA, Singh, Y and Fairlie, DP (2003). Designing supramolecular structures from models of cyclic peptide scaffolds with heterocyclic constraints. Journal of Molecular Graphics & Modelling, 21 (5), 341-355. doi: 10.1016/S1093-3263(02)00181-X |
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2003 Conference Publication Short peptide alpha helices induced by multiple metal clipsHoang, Huy N., Bryant, Gavin K., Kelso, Micheal J., Beyer, Renee L., Appleton, Trevor G. and Fairlie, David P. (2003). Short peptide alpha helices induced by multiple metal clips. 11th International Conference on Biological Inorganic Chemistry, Cairns, Australia, 19-23 July, 2003. New York, USA: Elsevier. doi: 10.1016/S0162-0134(03)80638-4 |
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2003 Conference Publication Studies of the interaction of potassium(I), calcium(II), magnesium(II) and copper(II) with cyclosporin AGahan, Lawrence R., Cusack, Rodney M., Grondahl, Lisbeth H., Fairlie, David P. and Hanson, Graeme R. (2003). Studies of the interaction of potassium(I), calcium(II), magnesium(II) and copper(II) with cyclosporin A. 11th International Conference on Biological Inorganic Chemistry, New York, USA, 19-23July, 2003. New York, USA: Elseiver. doi: 10.1016/S0162-0134(03)80624-4 |
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2003 Journal Article Hookworm aspartic protease, Na-APR-2, cleaves human hemoglobin and serum proteins in a host-specific fashionWilliamson, A. L., Brindley, P. J., Abbenante, G., Datu, B. J. D., Prociv, P., Berry, C., Girdwood, K., Pritchard, D. I., Fairlie, D. P., Hotez, P. J., Zhan, B. and Loukas, A. (2003). Hookworm aspartic protease, Na-APR-2, cleaves human hemoglobin and serum proteins in a host-specific fashion. Journal of Infectious Diseases, 187 (3), 484-494. doi: 10.1086/367708 |
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2003 Journal Article D-Tyrosine as a chiral precusor to potent inhibitors of human nonpancreatic secretory phospholipase A(2) (IIa) with antiinflammatory activityHansford, Karl A., Reid, Robert C., Clark, Chris I., Tyndall, Joel D. A., Whitehouse, Michael W., Guthrie, Tom, McGeary, Ross P., Schafer, Karl, Martin, Jennifer L. and Fairlie, David P. (2003). D-Tyrosine as a chiral precusor to potent inhibitors of human nonpancreatic secretory phospholipase A(2) (IIa) with antiinflammatory activity. Chembiochem, 4 (2-3), 181-185. doi: 10.1002/cbic.200390029 |
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2003 Journal Article A small molecule C5a receptor antagonist protects kidneys from ischemia/reperfusion injury in ratsArumugam, T. V., Shiels, I. A., Strachan, A. J., Abbenante, G., Fairlie, D. P. and Taylor, S. M. (2003). A small molecule C5a receptor antagonist protects kidneys from ischemia/reperfusion injury in rats. Kidney International, 63 (1), 134-142. doi: 10.1046/j.1523-1755.2003.00737.x |
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2003 Book Chapter Current approaches to peptidomimeticsKelso, M. J. and Fairlie, D. (2003). Current approaches to peptidomimetics. Molecular Pathomechanisms and New Trends in Drug Research. (pp. 579-598) edited by I. Toth and G. Keri. London and New York: Taylor and Francis. |
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2003 Conference Publication Short peptide alpha helices induced by multiple metal clipsHoang, Huy N., Bryant, Gavin K., Kelso, Micheal J., Beyer, Renee L., Appleton, Trevor G. and Fairlie, David P. (2003). Short peptide alpha helices induced by multiple metal clips. 11th International Conference on Biological Inorganic Chemistry, Cairns, Australia, 19-23 July 2003. New York, USA: Elsevier. doi: 10.1016/S0162-0134(03)80638-4 |
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2003 Journal Article Cycloadditions of isobenzofuran to a constrained template bearing neighboring dienophilesStoermer, M. J., Butler, D. N., Warrener, R. N., Weerasuria, K. D. V. and Fairlie, D. P. (2003). Cycloadditions of isobenzofuran to a constrained template bearing neighboring dienophiles. Chemistry-a European Journal, 9 (9), 2068-2071. doi: 10.1002/chem.200204619 |
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2003 Conference Publication Helix inducing metal clips in short peptidesBeyer, R. L., Kelso, M. J., Hoang, H. N., Appleton, T. G. and Fairlie, D. (2003). Helix inducing metal clips in short peptides. Proceedings of the First International Symposium on Biomolecuy, Awaji, Japan, 2-5 December, 2003. Tokyo, Japan: Maruzen Co. Ltd.. |
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2002 Journal Article Antiarthritic activity of an orally active C5a receptor antagonist against antigen-induced monarticular arthritis in the ratWoodruff, Trent M., Strachan, Anna J., Dryburgh, Nathan, Shiels, Ian A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2002). Antiarthritic activity of an orally active C5a receptor antagonist against antigen-induced monarticular arthritis in the rat. Arthritis and Rheumatism, 46 (9), 2476-2485. doi: 10.1002/art.10449 |
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2002 Journal Article Cleavage of hemoglobin by hookworm cathespin D aspartic proteases and its potential contribution to host specificityWilliamson, Angela L., Brindley, Paul J., Abbenante, Giovanni, Prociv, Paul, Berry, Colin, Girdwood, Karen, Pritchard, David I., Fairlie, David P., Hotez, Peter J., Dalton, John P. and Loukas, Alex C. (2002). Cleavage of hemoglobin by hookworm cathespin D aspartic proteases and its potential contribution to host specificity. The FASEB Journal, 16 (10), 1458-1460. doi: 10.1096/fj.02-0181fje |
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2002 Journal Article Protective effect of a new C5a receptor antagonist against Ischemia-reperfusion injury in the rat small intestineArumugam, Thiruma V., Shiels, Ian A., Woodruff, Trent M., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2002). Protective effect of a new C5a receptor antagonist against Ischemia-reperfusion injury in the rat small intestine. Journal of Surgical Research, 103 (2), 260-267. doi: 10.1006/jsre.2002.6369 |
