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2013 Journal Article The evolution of cytochrome P450 enzymes as biocatalysts in drug discovery and developmentGillam, Elizabeth M. J. and Hayes, Martin A. (2013). The evolution of cytochrome P450 enzymes as biocatalysts in drug discovery and development. Current Topics in Medicinal Chemistry, 13 (18), 2254-2280. doi: 10.2174/15680266113136660158 |
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2013 Journal Article Differential expression of human cytochrome P450 enzymes from the CYP3A subfamily in the brains of alcoholic subjects and drug-free controlsDepaz, Iris M. Booth, Toselli, Francesca, Wilce, Peter A. and Gillam, Elizabeth M. J. (2013). Differential expression of human cytochrome P450 enzymes from the CYP3A subfamily in the brains of alcoholic subjects and drug-free controls. Drug Metabolism and Disposition, 41 (6), 1187-1194. doi: 10.1124/dmd.113.051359 |
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2013 Journal Article Soluble and membrane-bound Drosophila melanogaster CYP6G1 expressed in Escherichia coli: purification, activity, and binding properties toward multiple pesticidesCheesman, Matthew J., Traylor, Matthew. J., Hilton, Margaret E., Richards, Katelyn E., Taylor, Matthew C., Daborn, Philip J., Russell, Robyn J., Gillam, Elizabeth M. J. and Oakeshott, John G. (2013). Soluble and membrane-bound Drosophila melanogaster CYP6G1 expressed in Escherichia coli: purification, activity, and binding properties toward multiple pesticides. Insect Biochemistry and Molecular Biology, 43 (5), 455-465. doi: 10.1016/j.ibmb.2013.02.003 |
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2012 Journal Article Directed evolution reveals requisite sequence elements in the functional expression of P450 2F1 in Escherichia coliBehrendorff, James B. Y. H., Moore, Chad D., Kim, Keon-Hee, Kim, Dae-Hwan, Smith, Christopher A., Johnston, Wayne A., Yun, Chui-Ho, Yost, Garold S. and Gillam, Elizabeth M. J. (2012). Directed evolution reveals requisite sequence elements in the functional expression of P450 2F1 in Escherichia coli. Chemical Research in Toxicology, 25 (9), 1964-1974. doi: 10.1021/tx300281g |
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2012 Journal Article Is the undergraduate research experience (URE) always best?: The power of choice in a bifurcated practical stream for a large introductory biochemistry classRowland, Susan L., Lawrie, Gwen A., Behrendorff, James B. Y. H. and Gillam, Elizabeth M. J. (2012). Is the undergraduate research experience (URE) always best?: The power of choice in a bifurcated practical stream for a large introductory biochemistry class. Biochemistry and Molecular Biology Education, 40 (1), 46-62. doi: 10.1002/bmb.20576 |
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2011 Journal Article Cytochrome P450 is present in both ferrous and ferric forms in the resting state within intact Escherichia coli and hepatocytesJohnston, Wayne A., Hunter, Dominic J. B., Noble, Christopher J., Hanson, Graeme R., Stok, Jeanette E., Hayes, Martin A., De Voss, James J. and Gillam, Elizabeth M.J. (2011). Cytochrome P450 is present in both ferrous and ferric forms in the resting state within intact Escherichia coli and hepatocytes. Journal of Biological Chemistry, 286 (47), 40750-40759. doi: 10.1074/jbc.M111.300871 |
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2011 Journal Article Facile production of minor metabolites for drug development using a CYP3A shuffled libraryHunter, D.J.B., Behrendorff, J.B.Y.H., Johnston, W.A., Hayes, P.Y., Huang, W., Bonn, B., Hayes, M.A., De Voss, J.J. and Gillam, E.M.J (2011). Facile production of minor metabolites for drug development using a CYP3A shuffled library. Metabolic Engineering, 13 (6), 682-693. doi: 10.1016/j.ymben.2011.09.001 |
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2011 Journal Article The concept lens diagram: A new mechanism for presenting biochemistry content in terms of "big ideas"Rowland, Susan L., Smith, Christopher A., Gillam, Elizabeth M. A. and Wright, Tony (2011). The concept lens diagram: A new mechanism for presenting biochemistry content in terms of "big ideas". Biochemistry and Molecular Biology Education, 39 (4), 267-279. doi: 10.1002/bmb.20517 |
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2010 Journal Article Metabolism of the major Echinacea alkylamide N-isobutyldodeca-2E,4E,8Z,10Z-tetraenamide by human recombinant cytochrome P450 enzymes and human liver microsomesToselli, F, Matthias, A, Bone, KM, Gillam, EMJ and Lehmann, RP (2010). Metabolism of the major Echinacea alkylamide N-isobutyldodeca-2E,4E,8Z,10Z-tetraenamide by human recombinant cytochrome P450 enzymes and human liver microsomes. Phytotherapy Research, 24 (8), 1195-1201. doi: 10.1002/ptr.3111 |
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2009 Journal Article In silico characterization of protein chimeras: Relating sequence and function within the same foldBuske, Fabian A., Their, Ricarda, Gillam, Elizabeth M. J. and Boden, Mikael (2009). In silico characterization of protein chimeras: Relating sequence and function within the same fold. Proteins: Structure, Function, and Bioinformatics, 77 (1), 111-120. doi: 10.1002/prot.22422 |
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2009 Journal Article Membrane integration of recombinant human P450 formsShukla, A., Huang, W., Depaz, I. M. and Gillam, E. M. J. (2009). Membrane integration of recombinant human P450 forms. Xenobiotica, 39 (7), 495-507. doi: 10.1080/00498250902934884 |
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2009 Journal Article Echinacea metabolism and drug interactions: The case for standardization of a complementary medicineToselli, F., Matthias, A. and Gillam, E. M. J. (2009). Echinacea metabolism and drug interactions: The case for standardization of a complementary medicine. Life Sciences, 85 (3-4), 97-106. doi: 10.1016/j.lfs.2009.04.023 |
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2008 Journal Article Re-engineering of CYP2C9 to probe acid-base substrate selectivityTai, Guoying, Dickmann, Leslie J., Matovic, Nicholas, DeVoss, James J., Gillam, Elizabeth M. J. and Rettie, Allan E. (2008). Re-engineering of CYP2C9 to probe acid-base substrate selectivity. Drug Metabolism and Disposition, 36 (10), 1992-1997. doi: 10.1124/dmd.108.022186 |
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2008 Journal Article Quantitative whole-cell cytochrome P450 measurement suitable for high-throughput applicationJohnston, Wayne A., Huang, Weiliang, De Voss, James J., Hayes, Martin A. and Gillam, Elizabeth M.J. (2008). Quantitative whole-cell cytochrome P450 measurement suitable for high-throughput application. Journal of Biomolecular Screening, 13 (2), 135-141. doi: 10.1177/1087057107312780 |
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2008 Journal Article Engineering cytochrome P450 enzymesGillam, E. M. J. (2008). Engineering cytochrome P450 enzymes. Chemical Research in Toxicology, 21 (1), 220-231. doi: 10.1021/tx7002849 |
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2008 Journal Article A novel CYP2A6 allele, CYP2A6*23, impairs enzyme function in vitro and in vivo and decreases smoking in a population of Black-African descentHo, M. K., Mwenifumbo, J. C., Zhao, B., Gillam, E. M. J. and Tyndale, R. F. (2008). A novel CYP2A6 allele, CYP2A6*23, impairs enzyme function in vitro and in vivo and decreases smoking in a population of Black-African descent. Pharmacogenetics and Genomics, 18 (1), 67-75. doi: 10.1097/FPC.0b013e3282f3606e |
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2007 Journal Article Chemical defense and exploitation, biotransformation of xenobiotics by cytochrome P450 enzymesGillam, Elizabeth M. J. and Hunter, Dominic J. B. (2007). Chemical defense and exploitation, biotransformation of xenobiotics by cytochrome P450 enzymes. Metal Ions in Life Sciences, 3, 477-560. |
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2007 Journal Article A shuffled CYP1A library shows both structural integrity and functional diversityJohnston, Wayne A., Huang, Weiliang, De Voss, James J., Hayes, Martin A. and Gillam, Elizabeth M.J. (2007). A shuffled CYP1A library shows both structural integrity and functional diversity. Drug Metabolism And Disposition, 35 (12), 2177-2185. doi: 10.1124/dmd.107.017939 |
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2007 Journal Article A shuffled CYP2C library with a high degree of structural integrity and functional versatilityHuang, Weiliang, Johnston, Wayne A., Hayes, Martin A., De Voss, James J. and Gillam, Elizabeth M.J. (2007). A shuffled CYP2C library with a high degree of structural integrity and functional versatility. Archives of Biochemistry And Biophysics, 467 (2), 193-205. doi: 10.1016/j.abb.2007.08.023 |
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2007 Journal Article Extending the diversity of cytochrome P450 enzymes by DNA family shufflingRosic, Nedeljka N., Huang, Weiliang, Johnston, Wayne A., DeVoss, James J. and Gillam, Elizabeth M.J. (2007). Extending the diversity of cytochrome P450 enzymes by DNA family shuffling. Gene, 395 (1-2), 40-48. doi: 10.1016/j.gene.2007.01.031 |
