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2000 Journal Article What makes P450s work? Searches for answers with known and new P450s*Guengerich, F. P., Parikh, A., Yun, C., Kim, D., Nakamura, K., Notley, L. and Gillam, E. M. J. (2000). What makes P450s work? Searches for answers with known and new P450s*. Drug Metabolism Reviews, 32 (3-4), 267-281. doi: 10.1081/DMR-100102334 |
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2000 Journal Article Association of CYP1B1 genetic polymorphism with incidence to breast and lung cancerWatanabe, J., Shimada, T., Gillam, E. M. J., Ikuta, T., Suemasu, K., Higashi, Y., Gotoh, O. and Kawajiri, K. (2000). Association of CYP1B1 genetic polymorphism with incidence to breast and lung cancer. Pharmacogenetics, 10 (1), 25-33. doi: 10.1097/00008571-200002000-00004 |
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1999 Journal Article Enhancement of cytochrome P-450 3A4 catalytic activities by cytochrome b(5) in bacterial membranesYamazaki, H, Nakajima, M, Nakamura, M, Asahi, S, Shimada, N, Gillam, EMJ, Guengerich, FP, Shimada, T and Yokoi, T (1999). Enhancement of cytochrome P-450 3A4 catalytic activities by cytochrome b(5) in bacterial membranes. Drug Metabolism and Disposition, 27 (9), 999-1004. doi: 10.1016/s0090-9556(24)15017-9 |
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1999 Journal Article Catalytic properties of polymorphic human cytochrome P450 1B1 variantsShimada, Tsutomu, Watanabe, Junko, Kawajiri, Kaname, Sutter, Thomas R., Guengerich, F. Peter, Gillam, Elizabeth M. J. and Inoue, Kiyoshi (1999). Catalytic properties of polymorphic human cytochrome P450 1B1 variants. Carcinogenesis, 20 (8), 1607-1613. doi: 10.1093/carcin/20.8.1607 |
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1999 Journal Article Formation of indigo by recombinant mammalian cytochrome P450Gillam, E. M. J., Aguinaldo, A. M. A., Notley, L. M., Kim, D., Mundkowski, R. G., Volkov, A. A., Arnold, F. H., Soucek, P., DeVoss, J. J. and Guengerich, F. P. (1999). Formation of indigo by recombinant mammalian cytochrome P450. Biochemical and Biophysical Research Communications, 265 (2), 469-472. doi: 10.1006/bbrc.1999.1702 |
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1999 Journal Article Metabolism of Benzo(a)pyrene to trans-7,8Dihydroxy-7,8-dihydrobenzo(a)pyrene by Recombinant Human Cytochrome P450 1B1 and Purified Liver Epoxide HydrolaseShimada, Tsutomu, Gillam, Elizabeth M. J., Oda, Yoshimitsu, Tsumura, Fujiko, Sutter, Thomas R., Guengerich, F. Peter and Inoue, Kiyoshi (1999). Metabolism of Benzo(a)pyrene to trans-7,8Dihydroxy-7,8-dihydrobenzo(a)pyrene by Recombinant Human Cytochrome P450 1B1 and Purified Liver Epoxide Hydrolase. Chemical Research in Toxicology, 12 (7), 623-629. doi: 10.1021/tx990028s |
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1998 Journal Article Analysis of cytochrome P450 2D6: Substrate interactions by site-directed mutagenesisHanna, I. H. and Gillam, E. M J (1998). Analysis of cytochrome P450 2D6: Substrate interactions by site-directed mutagenesis. FASEB Journal, 12 (8) |
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1998 Journal Article Twenty years of biochemistry of human P450s - Purification, expression, mechanism, and relevance to drugsGuengerich, FP, Hosea, NA, Parikh, A, Bell-Parikh, LC, Johnson, WW, Gillam, EMJ and Shimada, T (1998). Twenty years of biochemistry of human P450s - Purification, expression, mechanism, and relevance to drugs. Drug Metabolism and Disposition, 26 (12), 1175-1178. |
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1998 Journal Article Human cytochrome P450 enzymes expressed in bacteria: Reagents to probe molecular interactions in toxicologyGillam, EMJ (1998). Human cytochrome P450 enzymes expressed in bacteria: Reagents to probe molecular interactions in toxicology. Clinical and Experimental Pharmacology and Physiology, 25 (11), 877-886. doi: 10.1111/j.1440-1681.1998.tb02338.x |
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1998 Journal Article Recombinant human cytochrome P450 1B1 expression in Escherichia coliShimada, T, Wunsch, RM, Hanna, IH, Sutter, TR, Guengerich, FP and Gillam, EMJ (1998). Recombinant human cytochrome P450 1B1 expression in Escherichia coli. Archives of Biochemistry and Biophysics, 357 (1), 111-120. doi: 10.1006/abbi.1998.0808 |
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1998 Journal Article Bacterial expression of two human aryl sulfotransferasesBidwell, L. M., Gillam, E. M. J., Gaedigk, A., Zhu, X., Grant, D. and McManus, M. E. (1998). Bacterial expression of two human aryl sulfotransferases. Chemico-biological Interactions, 109 (1-3), 137-141. doi: 10.1016/S0009-2797(97)00128-2 |
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1997 Journal Article Expression of cytochrome P450 3A7 in Escherichia coli: Effects of 5' modification and catalytic characterization of recombinant enzyme expressed in bicistronic format with NADPH-cytochrome P450 reductaseGillam, EMJ, Wunsch, RM, Ueng, YF, Shimada, T, Reilly, PEB, Kamataki, T and Guengerich, FP (1997). Expression of cytochrome P450 3A7 in Escherichia coli: Effects of 5' modification and catalytic characterization of recombinant enzyme expressed in bicistronic format with NADPH-cytochrome P450 reductase. Archives of Biochemistry and Biophysics, 346 (1), 81-90. doi: 10.1006/abbi.1997.0286 |
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1997 Journal Article Bioactivation of Phenytoin by Human Cytochrome P450: Characterization of the Mechanism and Targets of Covalent Adduct FormationMunns, Andrew J., De Voss, James J., Hooper, Wayne D., Dickinson, Ronald G. and Gillam, Elizabeth M. J. (1997). Bioactivation of Phenytoin by Human Cytochrome P450: Characterization of the Mechanism and Targets of Covalent Adduct Formation. Chemical Research In Toxicology, 10 (9), 1049-1058. doi: 10.1021/tx9700836 |
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1997 Journal Article Drug metabolism by Escherichia coli expressing human cytochromes P450Parikh, A, Gillam, EMJ and Guengerich, FP (1997). Drug metabolism by Escherichia coli expressing human cytochromes P450. Nature Biotechnology, 15 (8), 784-788. doi: 10.1038/nbt0897-784 |
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1997 Journal Article Reconstitution of recombinant cytochrome P450 2C10(2C9) and comparison with cytochrome P450 3A4 and other forms: Effects of cytochrome P450-P450 and cytochrome P450-b5 interactionsYamazaki, H, Gillam, EMJ, Dong, MS, Johnson, WW, Guengerich, FP and Shimada, T (1997). Reconstitution of recombinant cytochrome P450 2C10(2C9) and comparison with cytochrome P450 3A4 and other forms: Effects of cytochrome P450-P450 and cytochrome P450-b5 interactions. Archives of Biochemistry and Biophysics, 342 (2), 329-337. doi: 10.1006/abbi.1997.0125 |
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1997 Journal Article Oxidation of xenobiotics by recombinant human cytochrome P450 1B1Shimada, T., Gillam, E. M. J., Sutter, T. R., Strickland, P. T., Guengerich, F. P. and Yamazaki, H. (1997). Oxidation of xenobiotics by recombinant human cytochrome P450 1B1. Drug Metabolism and Disposition, 25 (5), 617-622. |
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1996 Journal Article Requirements for cytochrome b5 in the oxidation of 7-ethoxycoumarin, chlorzoxazone, aniline, and N-nitrosodimethylamine by recombinant cytochrome P450 2E1 and by human liver microsomesYamazaki, H, Nakano, M, Gillam, EMJ, Bell, LC, Guengerich, FP and Shimada, T (1996). Requirements for cytochrome b5 in the oxidation of 7-ethoxycoumarin, chlorzoxazone, aniline, and N-nitrosodimethylamine by recombinant cytochrome P450 2E1 and by human liver microsomes. Biochemical Pharmacology, 52 (2), 301-309. doi: 10.1016/0006-2952(96)00208-0 |
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1996 Journal Article New applications of bacterial systems to problems in toxicologyGuengerich, FP, Gillam, EMJ and Shimada, T (1996). New applications of bacterial systems to problems in toxicology. Critical Reviews in Toxicology, 26 (5), 551-583. doi: 10.3109/10408449609037477 |
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1995 Journal Article Expression of Cytochrome P450 2D6 in Escherichia coli, Purification, and Spectral and Catalytic CharacterizationGillam, Emj, Guo, ZY, Martin, MV, Jenkins, CM and Guengerich, FP (1995). Expression of Cytochrome P450 2D6 in Escherichia coli, Purification, and Spectral and Catalytic Characterization. Archives of Biochemistry and Biophysics, 319 (2), 540-550. doi: 10.1006/abbi.1995.1329 |
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1995 Journal Article Expression of Cytochrome-P450-3A5 in Escherichia-Coli - Effects of 5' Modification, Purification, Spectral Characterization, Reconstitution Conditions, and Catalytic Activities (Vol 317, Pg 374, 1995)Gillam, Emj, Guo, ZY, Ueng, YF, Yamazaki, H, Cock, I, Reilly, Peb, Hooper, WD and Guengerich, FP (1995). Expression of Cytochrome-P450-3A5 in Escherichia-Coli - Effects of 5' Modification, Purification, Spectral Characterization, Reconstitution Conditions, and Catalytic Activities (Vol 317, Pg 374, 1995). Archives of Biochemistry and Biophysics, 318 (2), 498-498. doi: 10.1006/abbi.1995.1259 |
