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2010

Journal Article

Nitric oxide induced sinusoidal relaxation after a propranolol priming dose in the perfused rat liver reduces propranolol availability on subsequent dosing

Liu, Xin, Zou, Yuhong, Khlentzos, Alexander M., Yang, Yan, Nikolovski, Julijana, Weiss, Michael and Roberts, Michael S. (2010). Nitric oxide induced sinusoidal relaxation after a propranolol priming dose in the perfused rat liver reduces propranolol availability on subsequent dosing. Clinical and Experimental Pharmacology and Physiology, 37 (10), 1028-1033. doi: 10.1111/j.1440-1681.2010.05434.x

Nitric oxide induced sinusoidal relaxation after a propranolol priming dose in the perfused rat liver reduces propranolol availability on subsequent dosing

2010

Journal Article

Therapeutic drug monitoring of beta-lactams in critically ill patients: Proof of concept

Roberts, Jason A., Ulldemolins, Marta, Roberts, Michael S., McWhinney, Brett, Ungerer, Jacobus, Paterson, David L. and Lipman, Jeffrey (2010). Therapeutic drug monitoring of beta-lactams in critically ill patients: Proof of concept. International Journal of Antimicrobial Agents, 36 (4), 332-339. doi: 10.1016/j.ijantimicag.2010.06.008

Therapeutic drug monitoring of beta-lactams in critically ill patients: Proof of concept

2010

Journal Article

Are commercially available nanoparticles safe when applied to the skin?

Robertson, Thomas A., Sanchez, Washington Y. and Roberts, Michael S. (2010). Are commercially available nanoparticles safe when applied to the skin?. Journal of Biomedical Nanotechnology, 6 (5), 452-468. doi: 10.1166/jbn.2010.1145

Are commercially available nanoparticles safe when applied to the skin?

2010

Journal Article

An improved nonlinear model describing the hepatic pharmacokinetics of digoxin: Evidence for two functionally different uptake systems and saturable binding

Weiss, Michael, Li, Peng and Roberts, Michael S. (2010). An improved nonlinear model describing the hepatic pharmacokinetics of digoxin: Evidence for two functionally different uptake systems and saturable binding. Pharmaceutical Research, 27 (9), 1999-2007. doi: 10.1007/s11095-010-0204-9

An improved nonlinear model describing the hepatic pharmacokinetics of digoxin: Evidence for two functionally different uptake systems and saturable binding

2010

Journal Article

Nanopatch-targeted skin vaccination against West Nile virus and chikungunya virus in mice

Prow, Tarl W., Chen, Xianfeng, Prow, Natalie A., Fernando, Germain J. P., Tan, Cindy S. E., Raphael, Anthony P., Chang, David, Ruutu, Merja P., Jenkins, Derek W. K., Pyke, Alyssa, Crichton, Michael L., Raphaelli, Kristin, Goh, Lucas Y. H., Frazer, Ian H., Roberts, Michael S., Gardner, Joy, Khromykh, Alexander A., Suhrbier, Andreas, Hall, Roy A. and Kendall, Mark A. F. (2010). Nanopatch-targeted skin vaccination against West Nile virus and chikungunya virus in mice. Small, 6 (16), 1776-1784. doi: 10.1002/smll.201000331

Nanopatch-targeted skin vaccination against West Nile virus and chikungunya virus in mice

2010

Journal Article

Analysis of the metabolic deterioration of ex vivo skin from ischemic necrosis through the imaging of intracellular NAD(P)H by multiphoton tomography and fluorescence lifetime imaging microscopy

Sanchez, Washington Y., Prow, Tarl W., Sanchez, Washington H., Grice, Jeffrey E. and Roberts, Michael S. (2010). Analysis of the metabolic deterioration of ex vivo skin from ischemic necrosis through the imaging of intracellular NAD(P)H by multiphoton tomography and fluorescence lifetime imaging microscopy. Journal of Biomedical Optics, 15 (4) 046008, 046008-1-046008-11. doi: 10.1117/1.3466580

Analysis of the metabolic deterioration of ex vivo skin from ischemic necrosis through the imaging of intracellular NAD(P)H by multiphoton tomography and fluorescence lifetime imaging microscopy

2010

Journal Article

Tracing multiscale mechanisms of drug disposition in normal and diseased livers

Park, Sunwoo, Kim, Sean H. J., Ropella, Glen E. P., Roberts, Michael S. and Hunt, C. Anthony (2010). Tracing multiscale mechanisms of drug disposition in normal and diseased livers. Journal of Pharmacology and Experimental Therapeutics, 334 (1), 124-136. doi: 10.1124/jpet.110.168526

Tracing multiscale mechanisms of drug disposition in normal and diseased livers

2010

Journal Article

The application of molecular structural predictors of intestinal absorption to screening of compounds for transdermal penetration

Grice, Jeffrey E., Cross, Sheree E., Brownlie, Craig and Roberts, Michael S. (2010). The application of molecular structural predictors of intestinal absorption to screening of compounds for transdermal penetration. Journal of Pharmacy and Pharmacology, 62 (6), 750-755. doi: 10.1211/jpp.62.06.0011

The application of molecular structural predictors of intestinal absorption to screening of compounds for transdermal penetration

2010

Journal Article

Cardiac troponin may be released by ischemia alone, without necrosis

Hickman, Peter E., Potter, Julia M., Aroney, Con, Koerbin, Gus, Southcott, Emma, Wu, Alan H. B. and Roberts, Michael S. (2010). Cardiac troponin may be released by ischemia alone, without necrosis. Clinica Chimica Acta, 411 (5-6), 318-323. doi: 10.1016/j.cca.2009.12.009

Cardiac troponin may be released by ischemia alone, without necrosis

2010

Journal Article

Acute human self-poisoning with bispyribac-containing herbicide Nominee (R): a prospective observational study

Gawarammana, Indika Bandara, Roberts, Darren M., Mohamed, Fahim, Roberts, Michael S., Medley, Gregory, Jayamanne, Shaluka and Dawson, Andrew (2010). Acute human self-poisoning with bispyribac-containing herbicide Nominee (R): a prospective observational study. Clinical Toxicology, 48 (3), 198-202. doi: 10.3109/15563651003660000

Acute human self-poisoning with bispyribac-containing herbicide Nominee (R): a prospective observational study

2010

Journal Article

Mechanisms of transforming growth factor beta(1)/Smad signalling mediated by mitogen-activated protein kinase pathways in keloid fibroblasts

He, S., Liu, X., Yang, Y., Huang, W., Xu, S., Yang, S., Zhang, X. and Roberts, M. S. (2010). Mechanisms of transforming growth factor beta(1)/Smad signalling mediated by mitogen-activated protein kinase pathways in keloid fibroblasts. British Journal of Dermatology, 162 (3), 538-546. doi: 10.1111/j.1365-2133.2009.09511.x

Mechanisms of transforming growth factor beta(1)/Smad signalling mediated by mitogen-activated protein kinase pathways in keloid fibroblasts

2010

Journal Article

First-dose and steady-state population pharmacokinetics and pharmacodynamics of piperacillin by continuous or intermittent dosing in critically ill patients with sepsis

Roberts, Jason A., Kirkpatrick, Carl M. J., Roberts, Michael S., Dalley, Andrew J. and Lipman, Jeffrey (2010). First-dose and steady-state population pharmacokinetics and pharmacodynamics of piperacillin by continuous or intermittent dosing in critically ill patients with sepsis. International Journal of Antimicrobial Agents, 35 (2), 156-163. doi: 10.1016/j.ijantimicag.2009.10.008

First-dose and steady-state population pharmacokinetics and pharmacodynamics of piperacillin by continuous or intermittent dosing in critically ill patients with sepsis

2010

Journal Article

Relative uptake of minoxidil into appendages and stratum corneum and permeation through human skin in vitro

Grice, Jeffrey E., Ciotti, Susan, Weiner, Norman, Lockwood, Peter, Cross, Sheree E. and Roberts, Michael S. (2010). Relative uptake of minoxidil into appendages and stratum corneum and permeation through human skin in vitro. Journal of Pharmaceutical Sciences, 99 (2), 712-718. doi: 10.1002/jps.21856

Relative uptake of minoxidil into appendages and stratum corneum and permeation through human skin in vitro

2010

Journal Article

Compound Astragalus and Salvia miltiorrhiza extract inhibits cell invasion by modulating transforming growth factor-beta/Smad in HepG2

Liu, Xin, Yang, Yan, Zhang, Xiaoxiang, Xu, Shengxin, He, Shufang, Huang, Weijuan and Roberts, Michael S. (2010). Compound Astragalus and Salvia miltiorrhiza extract inhibits cell invasion by modulating transforming growth factor-beta/Smad in HepG2. Journal of Gastroenterology and Hepatology, 25 (2), 420-426. doi: 10.1111/j.1440-1746.2009.05981.x

Compound Astragalus and Salvia miltiorrhiza extract inhibits cell invasion by modulating transforming growth factor-beta/Smad in HepG2

2010

Book Chapter

Cutaneous metabolism and active transport in transdermal drug delivery

Dancik, Yuri, Thompson, Camilla, Krishnan, Gayathri and Roberts, Michael S. (2010). Cutaneous metabolism and active transport in transdermal drug delivery. Toxicology of the skin. (pp. 69-82) edited by Nancy A. Monteiro-Riviere, A. Wallace Hayes, John A. Thomas and Donald E. Gardner. New York , NY, U.S.A.: Informa Healthcare USA.

Cutaneous metabolism and active transport in transdermal drug delivery

2010

Conference Publication

Clearance of antibiotics by high and low intensity continuous renal replacement therapy in critically ill patients

Roberts, D. M., Roberts, M. S., Liu, X., Roberts, J. A., Lipman, J. and Bellomo, R. (2010). Clearance of antibiotics by high and low intensity continuous renal replacement therapy in critically ill patients. ESICM 2010: 23rd Annual Meeting of the European Society of Intensive Care Medicine, Barcelona, Spain, 9-13 October, 2010. Heidelberg, Germany: Springer. doi: 10.1007/s00134-010-1999-x

Clearance of antibiotics by high and low intensity continuous renal replacement therapy in critically ill patients

2010

Journal Article

Skin abrasion: Transdermal delivery, cosmetic and immunological applications

Grice, J. E. and Roberts, M. S. (2010). Skin abrasion: Transdermal delivery, cosmetic and immunological applications. Transdermal, 2 (1), 11-16.

Skin abrasion: Transdermal delivery, cosmetic and immunological applications

2010

Journal Article

Potent immunity to low doses of influenza vaccine by probabilistic guided micro-targeted skin delivery in a mouse model

Fernando, Germain J. P., Chen, Xianfeng, Prow, Tarl W., Crichton, Michael L., Fairmaid, Emily J., Roberts, Michael S., Frazer, Ian H., Brown, Lorena E. and Kendall, Mark A. F. (2010). Potent immunity to low doses of influenza vaccine by probabilistic guided micro-targeted skin delivery in a mouse model. PLoS One, 5 (4) e10266, e10266.1-e10266.11. doi: 10.1371/journal.pone.0010266

Potent immunity to low doses of influenza vaccine by probabilistic guided micro-targeted skin delivery in a mouse model

2010

Conference Publication

Flexible nanosomes (SECosomes) enable efficient siRNA delivery in cultured primary skin cells and in viable epidermis of ex-vivo human skin

Geusens, B., Van Gele, M., Braat, S., De Smedt, S. C., Stuart, M. C. A., Prow, T., Sanchez, W., Roberts, M. S., Sanders, N. N. and Lambert, J. (2010). Flexible nanosomes (SECosomes) enable efficient siRNA delivery in cultured primary skin cells and in viable epidermis of ex-vivo human skin. 12th International Conference Perspectives in Percutaneous Penetration, La Grande Motte, France, 7‐10 April, 2010. Oxford, United Kingdom: John Wiley & Sons.

Flexible nanosomes (SECosomes) enable efficient siRNA delivery in cultured primary skin cells and in viable epidermis of ex-vivo human skin

2010

Conference Publication

ZnO and TiO(2) particles: a study on nanosafety and photoprotection

Popov, Alexey, Zhao, Xin, Zvyagin, Andrei, Lademann, Jürgen, Roberts, Michael, Sanchez, Washington, Priezzhev, Alexander and Myllylä, Risto (2010). ZnO and TiO(2) particles: a study on nanosafety and photoprotection. SPIE Photonics Europe 2010. Biophotonics: Photonic Solutions for Better Health Care, Brussels, Belgium, 12-16 April, 2010. Bellingham, WA, United States: S P I E - International Society for Optical Engineering. doi: 10.1117/12.854561

ZnO and TiO(2) particles: a study on nanosafety and photoprotection