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2017 Journal Article Continuous flow synthesis of a key 1,4-benzoxazinone intermediate via a nitration/hydrogenation/cyclization sequenceCantillo, David, Wolf, Bernd, Goetz, Roland and Kappe, C. Oliver (2017). Continuous flow synthesis of a key 1,4-benzoxazinone intermediate via a nitration/hydrogenation/cyclization sequence. Organic Process Research and Development, 21 (1), 125-132. doi: 10.1021/acs.oprd.6b00409 |
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2016 Journal Article Visible-light photoredox catalysis using a macromolecular ruthenium complex: reactivity and recovery by size-exclusion nanofiltration in continuous flowGuerra, Javier, Cantillo, David and Kappe, C. Oliver (2016). Visible-light photoredox catalysis using a macromolecular ruthenium complex: reactivity and recovery by size-exclusion nanofiltration in continuous flow. Catalysis Science and Technology, 6 (13), 4695-4699. doi: 10.1039/c6cy00070c |
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2016 Journal Article Diazo strategy for the synthesis of pyridazines: pivotal impact of the configuration of the diazo precursor on the processNikolaev, Valerij A., Cantillo, David, Kappe, C. Oliver, Medvedev, Jury J., Prakash, G. K. Surya and Supurgibekov, Murat B. (2016). Diazo strategy for the synthesis of pyridazines: pivotal impact of the configuration of the diazo precursor on the process. Chemistry: A European Journal, 22 (1), 174-184. doi: 10.1002/chem.201503448 |
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2016 Journal Article A laboratory-scale continuous flow chlorine generator for organic synthesisStrauss, Franz J., Cantillo, David, Guerra, Javier and Kappe, C. Oliver (2016). A laboratory-scale continuous flow chlorine generator for organic synthesis. Reaction Chemistry and Engineering, 1 (5), 472-476. doi: 10.1039/c6re00135a |
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2016 Journal Article Safe generation and use of bromine azide under continuous flow conditions - selective 1,2-bromoazidation of olefinsCantillo, David, Gutmann, Bernhard and Kappe, C. Oliver (2016). Safe generation and use of bromine azide under continuous flow conditions - selective 1,2-bromoazidation of olefins. Organic and Biomolecular Chemistry, 14 (3), 853-857. doi: 10.1039/c5ob02425k |
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2015 Journal Article A pioneering early microreactor concept for ultrafast nitration reactions — Placing the seminal Brennecke and Kobe 1956 contribution into perspectiveDavid Cantillo (2015). A pioneering early microreactor concept for ultrafast nitration reactions — Placing the seminal Brennecke and Kobe 1956 contribution into perspective. Journal of Flow Chemistry, 5 (4), 195-196. doi: 10.1556/1846.2015.00021 |
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2015 Journal Article Light-induced C-H arylation of (hetero)arenes by in situ generated diazo anhydridesCantillo, David, Mateos, Carlos, Rincon, Juan A., de Frutos, Oscar and Oliver Kappe, C. (2015). Light-induced C-H arylation of (hetero)arenes by in situ generated diazo anhydrides. Chemistry: A European Journal, 21 (37), 12894-12898. doi: 10.1002/chem.201502357 |
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2015 Journal Article Homogeneous vs immobilized palladium catalysts for continuous flow cross-coupling chemistryCantillo, David and Kappe, C. Oliver (2015). Homogeneous vs immobilized palladium catalysts for continuous flow cross-coupling chemistry. Chimica Oggi, 33 (4), 6-10. |
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2015 Journal Article Continuous-flow technology - A tool for the safe manufacturing of active pharmaceutical ingredientsGutmann, Bernhard, Cantillo, David and Kappe, C. Oliver (2015). Continuous-flow technology - A tool for the safe manufacturing of active pharmaceutical ingredients. Angewandte Chemie (International Edition), 54 (23), 6688-6728. doi: 10.1002/anie.201409318 |
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2015 Journal Article Covalent adduct formation between the plasmalogen-derived modification product 2-chlorohexadecanal and phloretinUllen, Andreas, Nusshold, Christoph, Glasnov, Toma, Saf, Robert, Cantillo, David, Eibinger, Gerald, Reicher, Helga, Fauler, Guenter, Bernhart, Eva, Hallstrom, Seth, Kogelnik, Nora, Zangger, Klaus, Kappe, C. Oliver, Malle, Ernst and Sattler, Wolfgang (2015). Covalent adduct formation between the plasmalogen-derived modification product 2-chlorohexadecanal and phloretin. Biochemical Pharmacology, 93 (4), 470-481. doi: 10.1016/j.bcp.2014.12.017 |
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2015 Journal Article Benchmarking immobilized Di- and triarylphosphine palladium catalysts for continuous-flow cross-coupling reactions: efficiency, durability, and metal leaching studiesGreco, Roberto, Goessler, Walter, Cantillo, David and Kappe, C. Oliver (2015). Benchmarking immobilized Di- and triarylphosphine palladium catalysts for continuous-flow cross-coupling reactions: efficiency, durability, and metal leaching studies. ACS Catalysis, 5 (2), 1303-1312. doi: 10.1021/cs5020089 |
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2014 Journal Article Immobilized transition metals as catalysts for cross-couplings in continuous flow-a critical assessment of the reaction mechanism and metal leachingCantillo, David and Kappe, C. Oliver (2014). Immobilized transition metals as catalysts for cross-couplings in continuous flow-a critical assessment of the reaction mechanism and metal leaching. ChemCatChem, 6 (12), 3286-3305. doi: 10.1002/cctc.201402483 |
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2014 Journal Article Sequential nitration/hydrogenation protocol for the synthesis of triaminophloroglucinol: safe generation and use of an explosive intermediate under continuous-flow conditionsCantillo, David, Damm, Markus, Dallinger, Doris, Bauser, Marcus, Berger, Markus and Kappe, C. Oliver (2014). Sequential nitration/hydrogenation protocol for the synthesis of triaminophloroglucinol: safe generation and use of an explosive intermediate under continuous-flow conditions. Organic Process Research and Development, 18 (11), 1360-1366. doi: 10.1021/op5001435 |
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2014 Journal Article A continuous-flow protocol for light-induced benzylic fluorinationsCantillo, David, de Frutos, Oscar, Rincon, Juan A., Mateos, Carlos and Kappe, C. Oliver (2014). A continuous-flow protocol for light-induced benzylic fluorinations. The Journal of Organic Chemistry, 79 (17), 8486-8490. doi: 10.1021/jo5016757 |
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2014 Conference Publication α-Trifluoromethylation of ketones by metal-free visible light photoredox catalysis: Batch and continuous flow strategiesKappe, C. Oliver and Cantillo, David (2014). α-Trifluoromethylation of ketones by metal-free visible light photoredox catalysis: Batch and continuous flow strategies. 248th National Meeting of the American-Chemical-Society (ACS), San Francisco, CA United States, 10-14 August 2014. Washington, DC United States: American Chemical Society. |
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2014 Journal Article Stepwise formation of 1,3-diazolium-4-thiolates by munchnone cycloadditions: promising candidates for nonlinear opticsCantillo, David, Avalos, Martin, Babiano, Reyes, Cintas, Pedro, Jimenez, Jose L., Light, Mark E., Palacios, Juan C. and Porro, Rocio (2014). Stepwise formation of 1,3-diazolium-4-thiolates by munchnone cycloadditions: promising candidates for nonlinear optics. The Journal of Organic Chemistry, 79 (9), 4201-4205. doi: 10.1021/jo500349g |
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2014 Journal Article Continuous flow α-trifluoromethylation of ketones by metal-free visible light photoredox catalysisCantillo, David, de Frutos, Oscar, Rincon, Juan A., Mateos, Carlos and Kappe, C. Oliver (2014). Continuous flow α-trifluoromethylation of ketones by metal-free visible light photoredox catalysis. Organic Letters, 16 (3), 896-899. doi: 10.1021/ol403650y |
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2014 Journal Article Effect of configuration of 2-vinyldiazocarbonyl compounds on their reactivity: experimental and computational studySupurgibekov, Murat B., Cantillo, David, Kappe, C. Oliver, Prakash, G. K. Surya and Nikolaev, Valerij A. (2014). Effect of configuration of 2-vinyldiazocarbonyl compounds on their reactivity: experimental and computational study. Organic and Biomolecular Chemistry, 12 (4), 682-689. doi: 10.1039/c3ob42102c |
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2014 Journal Article A scalable procedure for light-induced benzylic brominations in continuous flowCantillo, David, de Frutos, Oscar, Rincon, Juan A., Mateos, Carlos and Kappe, C. Oliver (2014). A scalable procedure for light-induced benzylic brominations in continuous flow. The Journal of Organic Chemistry, 79 (1), 223-229. doi: 10.1021/jo402409k |
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2013 Journal Article Direct preparation of nitriles from carboxylic acids in continuous flowCantillo, David and Kappe, C. Oliver (2013). Direct preparation of nitriles from carboxylic acids in continuous flow. The Journal of Organic Chemistry, 78 (20), 10567-10571. doi: 10.1021/jo401945r |
