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2018 Journal Article Process intensification and integration studies for the generation of a key aminoimidazole intermediate in the synthesis of lanabecestatZnidar, Desiree, Cantillo, David, Inglesby, Phillip, Boyd, Alistair and Kappe, C. Oliver (2018). Process intensification and integration studies for the generation of a key aminoimidazole intermediate in the synthesis of lanabecestat. Organic Process Research and Development, 22 (5), 633-640. doi: 10.1021/acs.oprd.8b00089 |
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2018 Journal Article Continuous multistep synthesis of 2-(azidomethyl)oxazolesRossa, Thais A., Suveges, Nicolas S., Sa, Marcus M., Cantillo, David and Kappe, C. Oliver (2018). Continuous multistep synthesis of 2-(azidomethyl)oxazoles. Beilstein Journal of Organic Chemistry, 14, 506-514. doi: 10.3762/bjoc.14.36 |
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2017 Other Outputs Processes and oxazolidine-containing intermediates for the preparation of morphine analogs and derivativesKappe, C. O., Gutmann, B., Weigl, U., Egli, P., Cox, P. D. and Cantillo, D. (2017). Processes and oxazolidine-containing intermediates for the preparation of morphine analogs and derivatives. WO2017185004. |
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2017 Conference Publication Continuous flow synthesis of 1,4-benzoxazinones via a fully integrated nitration/hydrogenation/cyclization sequenceCantillo, David, Wolf, Bernd, Goetz, Roland and Kappe, C. (2017). Continuous flow synthesis of 1,4-benzoxazinones via a fully integrated nitration/hydrogenation/cyclization sequence. 254th National Meeting and Exposition of the American-Chemical-Society (ACS) on Chemistry's Impact on the Global Economy, Washington, DC United States, 20-24 August 2017. Washington, DC United States: American Chemical Society. |
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2017 Other Outputs Process for manufacturing 1,4-benzoxazinonesWolf, Bernd, Goetz, Roland, Kappe, C. Oliver and Cantillo, David (2017). Process for manufacturing 1,4-benzoxazinones. EP3184515A1. |
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2017 Journal Article An integrated continuous-flow synthesis of a key oxazolidine intermediate to noroxymorphone from naturally occurring opioidsMata, Alejandro, Cantillo, David and Kappe, C. Oliver (2017). An integrated continuous-flow synthesis of a key oxazolidine intermediate to noroxymorphone from naturally occurring opioids. European Journal of Organic Chemistry, 2017 (44), 6505-6510. doi: 10.1002/ejoc.201700811 |
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2017 Journal Article Hydrogen sulfide chemistry in continuous flow: Efficient synthesis of 2-oxopropanethioamideCantillo, David, Inglesby, Phillip A., Boyd, Alistair and Kappe, C. Oliver (2017). Hydrogen sulfide chemistry in continuous flow: Efficient synthesis of 2-oxopropanethioamide. Journal of Flow Chemistry, 7 (2), 29-32. doi: 10.1556/1846.2017.00006 |
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2017 Journal Article Halogenation of organic compounds using continuous flow and microreactor technologyCantillo, David and Kappe, C. Oliver (2017). Halogenation of organic compounds using continuous flow and microreactor technology. Reaction Chemistry and Engineering, 2 (1), 7-19. doi: 10.1039/c6re00186f |
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2017 Journal Article Design and development of Pd-catalyzed aerobic N-demethylation strategies for the synthesis of noroxymorphone in continuous flow modeGutmann, Bernhard, Cantillo, David, Weigl, Ulrich, Cox, D. Phillip and Kappe, C. Oliver (2017). Design and development of Pd-catalyzed aerobic N-demethylation strategies for the synthesis of noroxymorphone in continuous flow mode. European Journal of Organic Chemistry, 2017 (4), 914-927. doi: 10.1002/ejoc.201601453 |
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2017 Journal Article Continuous flow synthesis of a key 1,4-benzoxazinone intermediate via a nitration/hydrogenation/cyclization sequenceCantillo, David, Wolf, Bernd, Goetz, Roland and Kappe, C. Oliver (2017). Continuous flow synthesis of a key 1,4-benzoxazinone intermediate via a nitration/hydrogenation/cyclization sequence. Organic Process Research and Development, 21 (1), 125-132. doi: 10.1021/acs.oprd.6b00409 |
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2016 Journal Article Visible-light photoredox catalysis using a macromolecular ruthenium complex: reactivity and recovery by size-exclusion nanofiltration in continuous flowGuerra, Javier, Cantillo, David and Kappe, C. Oliver (2016). Visible-light photoredox catalysis using a macromolecular ruthenium complex: reactivity and recovery by size-exclusion nanofiltration in continuous flow. Catalysis Science and Technology, 6 (13), 4695-4699. doi: 10.1039/c6cy00070c |
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2016 Journal Article Diazo strategy for the synthesis of pyridazines: pivotal impact of the configuration of the diazo precursor on the processNikolaev, Valerij A., Cantillo, David, Kappe, C. Oliver, Medvedev, Jury J., Prakash, G. K. Surya and Supurgibekov, Murat B. (2016). Diazo strategy for the synthesis of pyridazines: pivotal impact of the configuration of the diazo precursor on the process. Chemistry: A European Journal, 22 (1), 174-184. doi: 10.1002/chem.201503448 |
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2016 Journal Article A laboratory-scale continuous flow chlorine generator for organic synthesisStrauss, Franz J., Cantillo, David, Guerra, Javier and Kappe, C. Oliver (2016). A laboratory-scale continuous flow chlorine generator for organic synthesis. Reaction Chemistry and Engineering, 1 (5), 472-476. doi: 10.1039/c6re00135a |
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2016 Journal Article Safe generation and use of bromine azide under continuous flow conditions - selective 1,2-bromoazidation of olefinsCantillo, David, Gutmann, Bernhard and Kappe, C. Oliver (2016). Safe generation and use of bromine azide under continuous flow conditions - selective 1,2-bromoazidation of olefins. Organic and Biomolecular Chemistry, 14 (3), 853-857. doi: 10.1039/c5ob02425k |
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2015 Journal Article A pioneering early microreactor concept for ultrafast nitration reactions — Placing the seminal Brennecke and Kobe 1956 contribution into perspectiveDavid Cantillo (2015). A pioneering early microreactor concept for ultrafast nitration reactions — Placing the seminal Brennecke and Kobe 1956 contribution into perspective. Journal of Flow Chemistry, 5 (4), 195-196. doi: 10.1556/1846.2015.00021 |
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2015 Journal Article Light-induced C-H arylation of (hetero)arenes by in situ generated diazo anhydridesCantillo, David, Mateos, Carlos, Rincon, Juan A., de Frutos, Oscar and Oliver Kappe, C. (2015). Light-induced C-H arylation of (hetero)arenes by in situ generated diazo anhydrides. Chemistry: A European Journal, 21 (37), 12894-12898. doi: 10.1002/chem.201502357 |
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2015 Journal Article Homogeneous vs immobilized palladium catalysts for continuous flow cross-coupling chemistryCantillo, David and Kappe, C. Oliver (2015). Homogeneous vs immobilized palladium catalysts for continuous flow cross-coupling chemistry. Chimica Oggi, 33 (4), 6-10. |
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2015 Journal Article Continuous-flow technology - A tool for the safe manufacturing of active pharmaceutical ingredientsGutmann, Bernhard, Cantillo, David and Kappe, C. Oliver (2015). Continuous-flow technology - A tool for the safe manufacturing of active pharmaceutical ingredients. Angewandte Chemie (International Edition), 54 (23), 6688-6728. doi: 10.1002/anie.201409318 |
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2015 Journal Article Covalent adduct formation between the plasmalogen-derived modification product 2-chlorohexadecanal and phloretinUllen, Andreas, Nusshold, Christoph, Glasnov, Toma, Saf, Robert, Cantillo, David, Eibinger, Gerald, Reicher, Helga, Fauler, Guenter, Bernhart, Eva, Hallstrom, Seth, Kogelnik, Nora, Zangger, Klaus, Kappe, C. Oliver, Malle, Ernst and Sattler, Wolfgang (2015). Covalent adduct formation between the plasmalogen-derived modification product 2-chlorohexadecanal and phloretin. Biochemical Pharmacology, 93 (4), 470-481. doi: 10.1016/j.bcp.2014.12.017 |
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2015 Journal Article Benchmarking immobilized Di- and triarylphosphine palladium catalysts for continuous-flow cross-coupling reactions: efficiency, durability, and metal leaching studiesGreco, Roberto, Goessler, Walter, Cantillo, David and Kappe, C. Oliver (2015). Benchmarking immobilized Di- and triarylphosphine palladium catalysts for continuous-flow cross-coupling reactions: efficiency, durability, and metal leaching studies. ACS Catalysis, 5 (2), 1303-1312. doi: 10.1021/cs5020089 |
