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2022

Journal Article

Depletion of exhausted alloreactive T cells enables targeting of stem-like memory T cells to generate tumor-specific immunity

Minnie, Simone A., Waltner, Olivia G., Ensbey, Kathleen S., Nemychenkov, Nicole S., Schmidt, Christine R., Bhise, Shruti S., Legg, Samuel R. W., Campoy, Gabriela, Samson, Luke D., Kuns, Rachel D., Zhou, Ting, Huck, John D., Vuckovic, Slavica, Zamora, Danniel, Yeh, Albert, Spencer, Andrew, Koyama, Motoko, Markey, Kate A., Lane, Steven W., Boeckh, Michael, Ring, Aaron M., Furlan, Scott N. and Hill, Geoffrey R. (2022). Depletion of exhausted alloreactive T cells enables targeting of stem-like memory T cells to generate tumor-specific immunity. Science Immunology, 7 (76) eabo3420, 1-18. doi: 10.1126/sciimmunol.abo3420

Depletion of exhausted alloreactive T cells enables targeting of stem-like memory T cells to generate tumor-specific immunity

2022

Journal Article

Parents' experiences and perceptions of the acceptability of a whole-hospital, pro-active electronic pediatric early warning system (the DETECT study): a qualitative interview study

Saron, Holly, Carter, Bernie, Siner, Sarah, Preston, Jennifer, Peak, Matthew, Mehta, Fulya, Lane, Steven, Lambert, Caroline, Jones, Dawn, Hughes, Hannah, Harris, Jane, Evans, Leah, Dee, Sarah, Eyton-Chong, Chin-Kien, Carrol, Enitan D. and Sefton, Gerri (2022). Parents' experiences and perceptions of the acceptability of a whole-hospital, pro-active electronic pediatric early warning system (the DETECT study): a qualitative interview study. Frontiers in Pediatrics, 10 954738. doi: 10.3389/fped.2022.954738

Parents' experiences and perceptions of the acceptability of a whole-hospital, pro-active electronic pediatric early warning system (the DETECT study): a qualitative interview study

2022

Journal Article

Paving the way to improve therapy for Myeloproliferative Neoplasms

Bywater, Megan and Lane, Steven W. (2022). Paving the way to improve therapy for Myeloproliferative Neoplasms. Nature Communications, 13 (1) 5025. doi: 10.1038/s41467-022-32694-2

Paving the way to improve therapy for Myeloproliferative Neoplasms

2022

Journal Article

Epigenetic activation of Plasmacytoid DCs drives IFNAR-dependent therapeutic differentiation of AML

Salmon, Jessica M., Todorovski, Izabela, Stanley, Kym L., Bruedigam, Claudia, Kearney, Conor J., Martelotto, Luciano G., Rossello, Fernando, Semple, Timothy, Arnau, Gisela Mir, Zethoven, Magnus, Bots, Michael, Bjelosevic, Stefan, Cluse, Leonie A., Fraser, Peter J., Litalien, Veronique, Vidacs, Eva, McArthur, Kate, Matthews, Antony Y., Gressier, Elise, De Weerd, Nicole A., Lichte, Jens, Kelly, Madison J., Hogg, Simon J., Hertzog, Paul J., Kats, Lev M., Vervoort, Stephin J., De Carvalho, Daniel D., Scheu, Stefanie, Bedoui, Sammy ... Johnstone, Ricky W. (2022). Epigenetic activation of Plasmacytoid DCs drives IFNAR-dependent therapeutic differentiation of AML. Cancer Discovery, 12 (6), 1560-1579. doi: 10.1158/2159-8290.CD-20-1145

Epigenetic activation of Plasmacytoid DCs drives IFNAR-dependent therapeutic differentiation of AML

2022

Journal Article

Panel-based gene testing in myelodysplastic/myeloproliferative neoplasm overlap syndromes: Australasian Leukaemia and Lymphoma Group (ALLG) consensus statement

Enjeti, Anoop K., Agarwal, Rishu, Blombery, Piers, Chee, Lynette, Chua, Chong Chyn, Grigg, Andrew, Hamad, Nada, Iland, Harry, Lane, Steven, Perkins, Andrew, Singhal, Deepak, Tate, Courtney, Tiong, Ing Soo and Ross, David M. (2022). Panel-based gene testing in myelodysplastic/myeloproliferative neoplasm overlap syndromes: Australasian Leukaemia and Lymphoma Group (ALLG) consensus statement. Pathology, 54 (4), 389-398. doi: 10.1016/j.pathol.2022.03.002

Panel-based gene testing in myelodysplastic/myeloproliferative neoplasm overlap syndromes: Australasian Leukaemia and Lymphoma Group (ALLG) consensus statement

2022

Journal Article

Vitamin D, vitamin D-binding protein, free vitamin D and COVID-19 mortality in hospitalized patients

Subramanian, Sreedhar, Rhodes, Jonathan M., Taylor, Joseph M., Milan, Anna M., Lane, Steven, Hewison, Martin, Chun, Rene F., Jorgensen, Andrea, Richardson, Paul, Nitchingham, Darshan, Aslan, Joseph, Shah, Maya, Chandrasekar, Coonoor R., Wood, Amanda, Beadsworth, Mike and Pirmohamed, Munir (2022). Vitamin D, vitamin D-binding protein, free vitamin D and COVID-19 mortality in hospitalized patients. American Journal of Clinical Nutrition, 115 (5), 1367-1377. doi: 10.1093/ajcn/nqac027

Vitamin D, vitamin D-binding protein, free vitamin D and COVID-19 mortality in hospitalized patients

2022

Journal Article

Better the cure you know: why patients with AML ≥60 years of age should be offered early allogeneic stem cell transplantation

Tey, Siok-Keen and Lane, Steven W (2022). Better the cure you know: why patients with AML ≥60 years of age should be offered early allogeneic stem cell transplantation. Blood Advances, 6 (5), 1619-1622. doi: 10.1182/bloodadvances.2021004829

Better the cure you know: why patients with AML ≥60 years of age should be offered early allogeneic stem cell transplantation

2022

Journal Article

PLCG1 is required for AML1-ETO leukemia stem cell self-renewal

Schnoeder, Tina M., Schwarzer, Adrian, Jayavelu, Ashok Kumar, Hsu, Chen-Jen, Kirkpatrick, Joanna, Döhner, Konstanze, Perner, Florian, Eifert, Theresa, Huber, Nicolas, Arreba-Tutusaus, Patricia, Dolnik, Anna, Assi, Salam A, Nafria, Monica, Jiang, Lu, Dai, Yu-Ting, Chen, Zhu, Chen, Sai-Juan, Kellaway, Sophie G., Ptasinska, Anetta, Ng, Elizabeth S., Stanley, Edouard G., Elefanty, Andrew G., Buschbeck, Marcus, Bierhoff, Holger, Brodt, Steffen, Matziolis, Georg, Fischer, Klaus-Dieter, Hochhaus, Andreas, Chen, Chun-Wei ... Heidel, Florian (2022). PLCG1 is required for AML1-ETO leukemia stem cell self-renewal. Blood, 139 (7), 1080-1097. doi: 10.1182/blood.2021012778

PLCG1 is required for AML1-ETO leukemia stem cell self-renewal

2022

Journal Article

Reduction of NETosis by targeting CXCR1/2 reduces thrombosis, lung injury, and mortality in experimental human and murine sepsis

Alsabani, Mohmad, Abrams, Simon T., Cheng, Zhenxing, Morton, Ben, Lane, Steven, Alosaimi, Samar, Yu, Weiping, Wang, Guozheng and Toh, Cheng-Hock (2022). Reduction of NETosis by targeting CXCR1/2 reduces thrombosis, lung injury, and mortality in experimental human and murine sepsis. British Journal of Anaesthesia, 128 (2), 283-293. doi: 10.1016/j.bja.2021.10.039

Reduction of NETosis by targeting CXCR1/2 reduces thrombosis, lung injury, and mortality in experimental human and murine sepsis

2021

Journal Article

Optimizing DNA hypomethylating therapy in acute myeloid leukemia and myelodysplastic syndromes

Straube, Jasmin, Lane, Steven W. and Vu, Therese (2021). Optimizing DNA hypomethylating therapy in acute myeloid leukemia and myelodysplastic syndromes. BioEssays, 43 (10) 2100125, 1-14. doi: 10.1002/bies.202100125

Optimizing DNA hypomethylating therapy in acute myeloid leukemia and myelodysplastic syndromes

2021

Journal Article

Prevalence of depression and anxiety in patients with chronic obstructive pulmonary disease and their association with psychosocial outcomes: a cross-sectional study from Pakistan

Husain, Muhammad Omair, Chaudhry, Imran B., Blakemore, Amy, Shakoor, Suleman, Husain, Muhammad Ali, Lane, Steven, Kiran, Tayyeba, Jafri, Farhat, Memon, Rakhshi, Panagioti, Maria and Husain, Nusrat (2021). Prevalence of depression and anxiety in patients with chronic obstructive pulmonary disease and their association with psychosocial outcomes: a cross-sectional study from Pakistan. Sage Open Medicine, 9. doi: 10.1177/20503121211032813

Prevalence of depression and anxiety in patients with chronic obstructive pulmonary disease and their association with psychosocial outcomes: a cross-sectional study from Pakistan

2021

Journal Article

Do women with HIV/AIDS on anti-retroviral therapy have a lower incidence of symptoms associated with menstrual dysfunction?

Tempest, Nicola, Edirisinghe, Damitha N., Lane, Steven and Hapangama, Dharani K. (2021). Do women with HIV/AIDS on anti-retroviral therapy have a lower incidence of symptoms associated with menstrual dysfunction?. European Journal of Obstetrics and Gynecology and Reproductive Biology, 265, 137-142. doi: 10.1016/j.ejogrb.2021.08.027

Do women with HIV/AIDS on anti-retroviral therapy have a lower incidence of symptoms associated with menstrual dysfunction?

2021

Journal Article

cardiac pathology and outcomes vary between Kawasaki disease and PIMS-TS (vol 229, 108780, 2021)

Felsenstein, S., Duong, P., Lane, S., Jones, C., Paine, C. E. and Hedrich, C. M. (2021). cardiac pathology and outcomes vary between Kawasaki disease and PIMS-TS (vol 229, 108780, 2021). Clinical Immunology, 231 108855, 108855. doi: 10.1016/j.clim.2021.108855

cardiac pathology and outcomes vary between Kawasaki disease and PIMS-TS (vol 229, 108780, 2021)

2021

Journal Article

Expression of CD49f defines subsets of human regulatory T cells with divergent transcriptional landscape and function that correlate with ulcerative colitis disease activity

Weerakoon, Harshi, Straube, Jasmin, Lineburg, Katie, Cooper, Leanne, Lane, Steven, Smith, Corey, Alabbas, Saleh, Begun, Jakob, Miles, John J., Hill, Michelle M. and Lepletier, Ailin (2021). Expression of CD49f defines subsets of human regulatory T cells with divergent transcriptional landscape and function that correlate with ulcerative colitis disease activity. Clinical and Translational Immunology, 10 (9) e1334, e1334. doi: 10.1002/cti2.1334

Expression of CD49f defines subsets of human regulatory T cells with divergent transcriptional landscape and function that correlate with ulcerative colitis disease activity

2021

Journal Article

Are public health measures and individualised care compatible in the face of a pandemic? A national observational study of bereaved relatives' experiences during the COVID-19 pandemic

Mayland, Catriona R., Hughes, Rosemary, Lane, Steven, McGlinchey, Tamsin, Donnellan, Warren, Bennett, Kate, Hanna, Jeffrey, Rapa, Elizabeth, Dalton, Louise and Mason, Stephen R. (2021). Are public health measures and individualised care compatible in the face of a pandemic? A national observational study of bereaved relatives' experiences during the COVID-19 pandemic. Palliative Medicine, 35 (8), 1480-1491. doi: 10.1177/02692163211019885

Are public health measures and individualised care compatible in the face of a pandemic? A national observational study of bereaved relatives' experiences during the COVID-19 pandemic

2021

Journal Article

Circulating histones play a central role in COVID-19-associated coagulopathy and mortality

Shaw, Rebecca J., Abrams, Simon T., Austin, James, Taylor, Joseph M., Lane, Steven, Dutt, Tina, Downey, Colin, Du, Min, Turtle, Lance, Baillie, J. Kenneth, Openshaw, Peter J. M., Wang, Guozheng, Semple, Malcolm G. and Toh, Cheng-Hock (2021). Circulating histones play a central role in COVID-19-associated coagulopathy and mortality. Haematologica, 106 (9), 2493-2498. doi: 10.3324/haematol.2021.278492

Circulating histones play a central role in COVID-19-associated coagulopathy and mortality

2021

Journal Article

Ataxia and mobility in children following surgical resection of posterior fossa tumour: A longitudinal cohort study

Hartley, H., Lane, S., Pizer, B., Bunn, L., Carter, B., Cassidy, E., Mallucci, C. and Kumar, R. (2021). Ataxia and mobility in children following surgical resection of posterior fossa tumour: A longitudinal cohort study. Childs Nervous System, 37 (9), 2831-2838. doi: 10.1007/s00381-021-05246-0

Ataxia and mobility in children following surgical resection of posterior fossa tumour: A longitudinal cohort study

2021

Journal Article

Cardiac pathology and outcomes vary between Kawasaki disease and PIMS-TS

Felsenstein, Susanna, Phuoc Duong, , Lane, Steven, Jones, Caroline, Pain, Clare E. and Hedrich, Christian M. (2021). Cardiac pathology and outcomes vary between Kawasaki disease and PIMS-TS. Clinical Immunology, 229 108780. doi: 10.1016/j.clim.2021.108780

Cardiac pathology and outcomes vary between Kawasaki disease and PIMS-TS

2021

Journal Article

Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias

Thijssen, Rachel, Diepstraten, Sarah T., Moujalled, Donia, Chew, Edward, Flensburg, Christoffer, Shi, Melissa X., Dengler, Michael A., Litalien, Veronique, MacRaild, Sarah, Chen, Maoshan, Anstee, Natasha S., Reljić, Boris, Gabriel, Sarah S., Djajawi, Tirta M., Riffkin, Chris D., Aubrey, Brandon J., Chang, Catherine, Tai, Lin, Xu, Zhen, Morley, Thomas, Pomilio, Giovanna, Bruedigam, Claudia, Kallies, Axel, Stroud, David A., Bajel, Ashish, Kluck, Ruth M., Lane, Steven W., Schoumacher, Marie, Banquet, Sébastien ... Wei, Andrew H. (2021). Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias. Blood, 137 (20), 2721-2735. doi: 10.1182/blood.2020010167

Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias

2021

Journal Article

IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease

Henden, Andrea S., Koyama, Motoko, Robb, Renee J., Forero, Adriana, Kuns, Rachel D., Chang, Karshing, Ensbey, Kathleen S., Varelias, Antiopi, Kazakoff, Stephen H., Waddell, Nicole, Clouston, Andrew D., Giri, Rabina, Begun, Jakob, Blazar, Bruce R., Degli-Esposti, Mariapia A., Kotenko, Sergei V., Lane, Steven W., Bowerman, Kate L., Savan, Ram, Hugenholtz, Philip, Gartlan, Kate H. and Hill, Geoffrey R. (2021). IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease. Blood, 138 (8), 722-737. doi: 10.1182/blood.2020006375

IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease