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2005 Journal Article A potent and selective inhibitor of group IIa secretory phospholipase A2 protects rats from TNBS-induced colitisWoodruff, Trent M., Arumugam, Thiruma V., Shiels, Ian A., Newman, Michelle L., Ross, Paul A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2005). A potent and selective inhibitor of group IIa secretory phospholipase A2 protects rats from TNBS-induced colitis. International Immunopharmacology, 5 (5), 883-892. doi: 10.1016/j.intimp.2005.01.003 |
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2004 Journal Article Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in ratsArumugam, Thiruma V., Woodruff, Trent M., Stocks, Shelli Z., Proctor, Lavinia M., Pollitt, Sandra, Shiels, Ian A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2004). Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in rats. Journal of Hepatology, 40 (6), 934-941. doi: 10.1016/S0168-8278(04)00066-2 |
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2004 Journal Article Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in ratsArumugam, Thiruma V., Woodruff, Trent M., Stocks, Shelli Z., Proctor, Lavinia M., Pollitt, Sandra, Shiels, Ian A., Reid, Robert C., Fairlie, David P., Taylor, Stephen M. and M. Colombo (2004). Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in rats. Journal of Hepatology, 40 (6), 934-941. doi: 10.1016/j.jhep.2004.02.017 |
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2004 Journal Article Comparative anti-inflammatory activities of antagonists to C3a and C5a receptors in a rat model of intestinal ischaemia/reperfusion injuryProctor, Lavinia M., Arumugam, Thiruma V., Shiels, Ian, Reid, Robert C., Fairlie, David P. and Taylor, Stephen M . (2004). Comparative anti-inflammatory activities of antagonists to C3a and C5a receptors in a rat model of intestinal ischaemia/reperfusion injury. British Journal of Pharmacology, 142 (4), 756-764. doi: 10.1038/sj.bjp.0705819 |
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2004 Journal Article Potent cyclic antagonists of the complement C5a receptor on human polymorphonulcear leukocytes. Relationships between structures and activityMarch, Darren R., Proctor, Lavinia M., Stoermer, Martin J., Sbaglia, Robert, Abbenante, Giovanni, Reid, Robert C., Woodruff, Trent M., Wadi, Khemar, Paczkowski, Natalii, Tyndall, Joel D. A., Taylor, Stephen M. and Fairlie, David P. (2004). Potent cyclic antagonists of the complement C5a receptor on human polymorphonulcear leukocytes. Relationships between structures and activity. Molecular Pharmacology, 65 (4), 868-879. doi: 10.1124/mol.65.4.868 |
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2004 Journal Article Protective effects of a potent C5a receptor antagonist on experimental acute limb ishemia-reperfusion in ratsWoodruff, Trent M., Arumugam, Thiruma V., Shiels, Ian A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2004). Protective effects of a potent C5a receptor antagonist on experimental acute limb ishemia-reperfusion in rats. Journal of Surgical Research, 116 (1), 81-90. doi: 10.1016/j.jss.2003.04.001 |
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2004 Journal Article Countering cooperative effects in protease inhibitors using constrained b-strand-mimicking templates in focused combinatorial librariesReid, Robert C., Pattenden, Lenard K., Tyndall, Joel D. A., Martin, Jennifer L., Walsh, Terry and Fairlie, David P. (2004). Countering cooperative effects in protease inhibitors using constrained b-strand-mimicking templates in focused combinatorial libraries. Journal of Medicinal Chemistry, 47 (7), 1641-1651. doi: 10.1021/jm030337m |
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2003 Journal Article A potent human C5a receptor antagonist protects against disease pathology in a rat model of inflammatory bowel diseaseWoodruff, Trent M., Arumugam, Thiruma V., Shiels, Ian A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2003). A potent human C5a receptor antagonist protects against disease pathology in a rat model of inflammatory bowel disease. Journal of Immunology, 171 (10), 5514-5520. doi: 10.4049/jimmunol.171.10.5514 |
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2003 Journal Article Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2, COX-1 and COX-2 selective inhibitors, and an LTC4 receptor antagonistArumugam, Thiruma V., Arnold, Naomi, Proctor, Lavinia M., Newman, Michelle, Reid, Robert C., Hansford, Karl A., Fairlie, David P., Shiels, Ian A. and Taylor, Stephen M. (2003). Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2, COX-1 and COX-2 selective inhibitors, and an LTC4 receptor antagonist. British Journal of Pharmacology, 140 (1), 71-80. doi: 10.1038/sj.bjp.0705402 |
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2003 Journal Article A convergent solution-phase synthesis of the macrocycle Ac-Phe-[Orn-Pro-D-Cha-Trp-Arg], a potent new antiinflammatory drugReid, Robert C., Abbenante, Giovanni, Taylor, Stephen M. and Fairlie, David P. (2003). A convergent solution-phase synthesis of the macrocycle Ac-Phe-[Orn-Pro-D-Cha-Trp-Arg], a potent new antiinflammatory drug. Journal of Organic Chemistry, 68 (11), 4464-4471. doi: 10.1021/jo034228r |
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2003 Journal Article D-Tyrosine as a chiral precusor to potent inhibitors of human nonpancreatic secretory phospholipase A(2) (IIa) with antiinflammatory activityHansford, Karl A., Reid, Robert C., Clark, Chris I., Tyndall, Joel D. A., Whitehouse, Michael W., Guthrie, Tom, McGeary, Ross P., Schafer, Karl, Martin, Jennifer L. and Fairlie, David P. (2003). D-Tyrosine as a chiral precusor to potent inhibitors of human nonpancreatic secretory phospholipase A(2) (IIa) with antiinflammatory activity. Chembiochem, 4 (2-3), 181-185. doi: 10.1002/cbic.200390029 |
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2002 Journal Article Antiarthritic activity of an orally active C5a receptor antagonist against antigen-induced monarticular arthritis in the ratWoodruff, Trent M., Strachan, Anna J., Dryburgh, Nathan, Shiels, Ian A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2002). Antiarthritic activity of an orally active C5a receptor antagonist against antigen-induced monarticular arthritis in the rat. Arthritis and Rheumatism, 46 (9), 2476-2485. doi: 10.1002/art.10449 |
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2002 Journal Article Protective effect of a new C5a receptor antagonist against Ischemia-reperfusion injury in the rat small intestineArumugam, Thiruma V., Shiels, Ian A., Woodruff, Trent M., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2002). Protective effect of a new C5a receptor antagonist against Ischemia-reperfusion injury in the rat small intestine. Journal of Surgical Research, 103 (2), 260-267. doi: 10.1006/jsre.2002.6369 |
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2002 Journal Article beta-strand mimicking macrocyclic amino acids: Templates for protease inhibitors with antiviral activityGlenn, MP, Pattenden, LK, Reid, RC, Tyssen, DP, Tyndall, JDA, Birch, CJ and Fairlie, DP (2002). beta-strand mimicking macrocyclic amino acids: Templates for protease inhibitors with antiviral activity. Journal of Medicinal Chemistry, 45 (2), 371-381. doi: 10.1021/jm010414i |
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2002 Journal Article Conformationally constrained macrocycles that mimic tripeptide beta-strands in water and aprotic solventsReid, RC, Kelso, MJ, Scanlon, MJ and Fairlie, DP (2002). Conformationally constrained macrocycles that mimic tripeptide beta-strands in water and aprotic solvents. Journal of The American Chemical Society, 124 (20), 5673-5683. doi: 10.1021/ja0256461 |
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2002 Journal Article Inhibition of immune-complex mediated dermal inflammation in rats following either oral or topical administration of a small molecule C5a receptor antagonist (vol 134, pg 1778, 2001)Strachan, Anna J., Shiels, Ian A., Reid, Robert C., Fairlie, David P. and Taylor, Stephen M. (2002). Inhibition of immune-complex mediated dermal inflammation in rats following either oral or topical administration of a small molecule C5a receptor antagonist (vol 134, pg 1778, 2001). British Journal of Pharmacology, 135 (2), 579-580. doi: 10.1038/sj.bjp.0704531 |
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2001 Journal Article Inhibition of immune-complex mediated dermal inflammation in rats following either oral or topical administration of a small molecule C5a receptor antagonistStrachan, Anna J., Shiels, Ian A., Reid, Robert C., Fairlie, David P., Taylor, Stephen M. and R. A. North (2001). Inhibition of immune-complex mediated dermal inflammation in rats following either oral or topical administration of a small molecule C5a receptor antagonist. British Journal of Pharmacology, 134 (12), 1778-1786. doi: 10.1038/sj.bjp.0704417 |
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2000 Journal Article Synthesis, stability, antiviral activity, and protease-bound structures of substrate-mimicking constrained macrocyclic inhibitors of HIV-1 proteaseTyndall, J. D. A., Reid, R. C., Tyssen, D. P., Jardine, D. K., Todd, B., Passmore, M., March, D. R., Pattenden, L., Bergman, D. A., Alewood, D., Hu, S., Alewood, P.F., Birch, C. J., Martin, J. L. and Fairlie, D. (2000). Synthesis, stability, antiviral activity, and protease-bound structures of substrate-mimicking constrained macrocyclic inhibitors of HIV-1 protease. Journal of Medicinal Chemistry, 43 (19), 3495-3504. doi: 10.1021/jm000013n |
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2000 Journal Article Small peptides do not inhibit human non-pancreatic secretory phospholipase-A 2 (Type IIA)Clark, C. I., Reid, R. C., McGeary, R. P., Schafer, K. and Fairlie, D. P. (2000). Small peptides do not inhibit human non-pancreatic secretory phospholipase-A 2 (Type IIA). Bioichemistry BIophysical Research Communications, 274 (3), 831-834. doi: 10.1006/bbrc.2000.3221 |
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2000 Journal Article Conformational selection of inhibitors and substrates by proteolytic enzymes: Implications for drug design and polypeptide processingFairlie, D. P., Tyndall, J. D. A., Reid, R. C., Wong, A. K., Abbenante, G., Scanlon, M. J., March, D. R., Bergman, D. A., Chai, C. L. L. and Burkett, B. A. (2000). Conformational selection of inhibitors and substrates by proteolytic enzymes: Implications for drug design and polypeptide processing. Journal of Medicinal Chemistry, 43 (7), 1271-1281. doi: 10.1021/jm990315t |
