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2021

Journal Article

Symptom-level modelling unravels the shared genetic architecture of anxiety and depression

Thorp, Jackson G., Campos, Adrian I., Grotzinger, Andrew D., Gerring, Zachary F., An, Jiyuan, Ong, Jue-Sheng, Wang, Wei, Shringarpure, Suyash, Byrne, Enda M., MacGregor, Stuart, Martin, Nicholas G., Medland, Sarah E., Middeldorp, Christel M. and Derks, Eske M. (2021). Symptom-level modelling unravels the shared genetic architecture of anxiety and depression. Nature Human Behaviour, 5 (10), 1432-1442. doi: 10.1038/s41562-021-01094-9

Symptom-level modelling unravels the shared genetic architecture of anxiety and depression

2021

Journal Article

Comorbid chronic pain and depression: shared risk factors and differential antidepressant effectiveness

Roughan, William H., Campos, Adrián I., García-Marín, Luis M., Cuéllar-Partida, Gabriel, Lupton, Michelle K., Hickie, Ian B., Medland, Sarah E., Wray, Naomi R., Byrne, Enda M., Ngo, Trung Thanh, Martin, Nicholas G. and Rentería, Miguel E. (2021). Comorbid chronic pain and depression: shared risk factors and differential antidepressant effectiveness. Frontiers in Psychiatry, 12 643609, 1-13. doi: 10.3389/fpsyt.2021.643609

Comorbid chronic pain and depression: shared risk factors and differential antidepressant effectiveness

2021

Other Outputs

Shared genetic etiology between cortical brain morphology and tobacco, alcohol, and cannabis use

Rabinowitz, Jill A., Campos, Adrian I., Ong, Jue-Sheng, García-Marín, Luis M., Alcauter, Sarael, Mitchell, Brittany L., Grasby, Katrina S., Cuéllar-Partida, Gabriel, Gillespie, Nathan A., Huhn, Andrew S., Martin, Nicholas G., Thompson, Paul M., Medland, Sarah E., Maher, Brion S. and Rentería, Miguel E. (2021). Shared genetic etiology between cortical brain morphology and tobacco, alcohol, and cannabis use. doi: 10.1101/2021.03.28.21254282

Shared genetic etiology between cortical brain morphology and tobacco, alcohol, and cannabis use

2021

Journal Article

'Essential Tremor' Phenotype in FMR1 Premutation/Gray Zone Sibling Series: Exploring Possible Genetic Modifiers

Loesch, Danuta Z., Duffy, David L., Martin, Nicholas G., Tassone, Flora, Atkinson, Anna and Storey, Elsdon (2021). 'Essential Tremor' Phenotype in FMR1 Premutation/Gray Zone Sibling Series: Exploring Possible Genetic Modifiers. Twin Research and Human Genetics, 24 (2), 95-102. doi: 10.1017/thg.2021.10

'Essential Tremor' Phenotype in FMR1 Premutation/Gray Zone Sibling Series: Exploring Possible Genetic Modifiers

2021

Journal Article

Brain correlates of suicide attempt in 18,925 participants across 18 international cohorts

Campos, Adrian I., Thompson, Paul M., Veltman, Dick J., Pozzi, Elena, van Veltzen, Laura S., Jahanshad, Neda, Adams, Mark J., Baune, Bernhard T., Berger, Klaus, Brosch, Katharina, Bülow, Robin, Connolly, Colm G., Dannlowski, Udo, Davey, Christopher G., de Zubicaray, Greig I., Dima, Danai, Erwin-Grabner, Tracy, Evans, Jennifer W., Fu, Cynthia H.Y., Gotlib, Ian H., Goya-Maldonado, Roberto, Grabe, Hans J., Grotegerd, Dominik, Harris, Matthew A., Harrison, Ben J., Hatton, Sean N., Hermesdorf, Marco, Hickie, Ian B., Ho, Tiffany C. ... Rentería, Miguel E. (2021). Brain correlates of suicide attempt in 18,925 participants across 18 international cohorts. Biological Psychiatry, 90 (4), 243-252. doi: 10.1016/j.biopsych.2021.03.015

Brain correlates of suicide attempt in 18,925 participants across 18 international cohorts

2021

Journal Article

Genome-wide association study in almost 195,000 individuals identifies 50 previously unidentified genetic loci for eye color

Simcoe, Mark, Valdes, Ana, Liu, Fan, Furlotte, Nicholas A., Evans, David M., Hemani, Gibran, Ring, Susan M., Smith, George Davey, Duffy, David L., Zhu, Gu, Gordon, Scott D., Medland, Sarah E., Vuckovic, Dragana, Girotto, Giorgia, Sala, Cinzia, Catamo, Eulalia, Concas, Maria Pina, Brumat, Marco, Gasparini, Paolo, Toniolo, Daniela, Cocca, Massimiliano, Robino, Antonietta, Yazar, Seyhan, Hewitt, Alex, Wu, Wenting, Kraft, Peter, Hammond, Christopher J., Shi, Yuan, Chen, Yan ... the International Visible Trait Genetics Consortium (2021). Genome-wide association study in almost 195,000 individuals identifies 50 previously unidentified genetic loci for eye color. Science Advances, 7 (11) abd1239, eabd1239. doi: 10.1126/sciadv.abd1239

Genome-wide association study in almost 195,000 individuals identifies 50 previously unidentified genetic loci for eye color

2021

Journal Article

Genome-wide association study of phenotypes measuring progression from first cocaine or opioid use to dependence reveals novel risk genes

Sherva, Richard, Zhu, Congcong, Wetherill, Leah, Edenberg, Howard J., Johnson, Emma, Degenhardt, Louisa, Agrawal, Arpana, Martin, Nicholas G., Nelson, Elliot, Kranzler, Henry R., Gelernter, Joel and Farrer, Lindsay A. (2021). Genome-wide association study of phenotypes measuring progression from first cocaine or opioid use to dependence reveals novel risk genes. Exploration of Medicine, 2 (1), 60-73. doi: 10.37349/emed.2021.00032

Genome-wide association study of phenotypes measuring progression from first cocaine or opioid use to dependence reveals novel risk genes

2021

Journal Article

Can network analysis of self-reported psychopathology shed light on the core phenomenology of bipolar disorders in adolescents and young adults?

Scott, Jan, Crouse, Jacob J., Ho, Nicholas, Carpenter, Joanne, Martin, Nicholas, Medland, Sarah, Parker, Richard, Byrne, Enda, Couvy-Duchesne, Baptiste, Mitchell, Brittany, Merikangas, Kathleen, Gillespie, Nathan A. and Hickie, Ian (2021). Can network analysis of self-reported psychopathology shed light on the core phenomenology of bipolar disorders in adolescents and young adults?. Bipolar Disorders, 23 (6), 584-594. doi: 10.1111/bdi.13067

Can network analysis of self-reported psychopathology shed light on the core phenomenology of bipolar disorders in adolescents and young adults?

2021

Journal Article

Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries

Gharahkhani, Puya, NEIGHBORHOOD consortium, Jorgenson, Eric, Hysi, Pirro, Khawaja, Anthony P., Pendergrass, Sarah, Han, Xikun, Ong, Jue Sheng, Hewitt, Alex W., Segrè, Ayellet V., Rouhana, John M., Hamel, Andrew R., Igo, Robert P., Choquet, Helene, Qassim, Ayub, Josyula, Navya S., Cooke Bailey, Jessica N., Bonnemaijer, Pieter W. M., Iglesias, Adriana, Siggs, Owen M., Young, Terri L., Vitart, Veronique, Thiadens, Alberta A. H. J., Karjalainen, Juha, Uebe, Steffen, Melles, Ronald B., Nair, K. Saidas, Luben, Robert, Simcoe, Mark ... 23 and Me Research Team (2021). Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries. Nature Communications, 12 (1) 1258, 1-16. doi: 10.1038/s41467-020-20851-4

Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries

2021

Journal Article

Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3-90 years

Frangou, Sophia, Modabbernia, Amirhossein, Williams, Steven C. R., Papachristou, Efstathios, Doucet, Gaelle E., Agartz, Ingrid, Aghajani, Moji, Akudjedu, Theophilus N., Albajes-Eizagirre, Anton, Alnaes, Dag, Alpert, Kathryn I, Andersson, Micael, Andreasen, Nancy C, Andreassen, Ole A, Asherson, Philip, Banaschewski, Tobias, Bargallo, Nuria, Baumeister, Sarah, Baur-Streubel, Ramona, Bertolino, Alessandro, Bonvino, Aurora, Boomsma, Dorret I, Borgwardt, Stefan, Bourque, Josiane, Brandeis, Daniel, Breier, Alan, Brodaty, Henry, Brouwer, Rachel M, Buitelaar, Jan K ... Dima, Danai (2021). Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3-90 years. Human Brain Mapping, 43 (1) hbm.25364, 431-451. doi: 10.1002/hbm.25364

Cortical thickness across the lifespan: Data from 17,075 healthy individuals aged 3-90 years

2021

Journal Article

The augmented Classical Twin Design: incorporating genome‐wide identity by descent sharing into twin studies in order to model violations of the equal environments assumption

Hwang, Liang-Dar, Mitchell, Brittany L., Medland, Sarah E., Martin, Nicholas G., Neale, Michael C. and Evans, David M. (2021). The augmented Classical Twin Design: incorporating genome‐wide identity by descent sharing into twin studies in order to model violations of the equal environments assumption. Behavior Genetics, 51 (3), 223-236. doi: 10.1007/s10519-021-10044-0

The augmented Classical Twin Design: incorporating genome‐wide identity by descent sharing into twin studies in order to model violations of the equal environments assumption

2021

Journal Article

Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3-90 years

Dima, Danai, Modabbernia, Amirhossein, Papachristou, Efstathios, Doucet, Gaelle E., Agartz, Ingrid, Aghajani, Moji, Akudjedu, Theophilus N., Albajes-Eizagirre, Anton, Alnaes, Dag, Alpert, Kathryn I., Andersson, Micael, Andreasen, Nancy C., Andreassen, Ole A., Asherson, Philip, Banaschewski, Tobias, Bargallo, Nuria, Baumeister, Sarah, Baur-Streubel, Ramona, Bertolino, Alessandro, Bonvino, Aurora, Boomsma, Dorret I., Borgwardt, Stefan, Bourque, Josiane, Brandeis, Daniel, Breier, Alan, Brodaty, Henry, Brouwer, Rachel M., Buitelaar, Jan K., Busatto, Geraldo F. ... Karolinska Schizophrenia Project (KaSP) (2021). Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3-90 years. Human Brain Mapping, 43 (1) hbm.25320, 452-469. doi: 10.1002/hbm.25320

Subcortical volumes across the lifespan: Data from 18,605 healthy individuals aged 3-90 years

2021

Journal Article

16Up: Outline of a study investigating wellbeing and information and communication technology use in adolescent twins

Mitchell, Brittany L., Kirk, Katherine M., McAloney, Kerrie, Wright, Margaret J., Davenport, Tracey A., Hermens, Daniel F., Scott, James G., McGrath, John J., Gillespie, Nathan A., Carpenter, Joanne S., O’Callaghan, Victoria S., Medland, Sarah, Christensen, Helen, Martin, Nicholas G., Burns, Jane M. and Hickie, Ian B. (2021). 16Up: Outline of a study investigating wellbeing and information and communication technology use in adolescent twins. Twin Research and Human Genetics, 23 (6) PII S1832427420000833, 1-13. doi: 10.1017/thg.2020.83

16Up: Outline of a study investigating wellbeing and information and communication technology use in adolescent twins

2021

Journal Article

Comparison of Familial, Polygenic and Biochemical Predictors of Mortality

Whitfield, John B., Colodro-Conde, Lucía, Timmers, Paul R. H. J., Joshi, Peter K., Montgomery, Grant W. and Martin, Nicholas G. (2021). Comparison of Familial, Polygenic and Biochemical Predictors of Mortality. Twin Research and Human Genetics, 23 (6), 307-315. doi: 10.1017/thg.2020.89

Comparison of Familial, Polygenic and Biochemical Predictors of Mortality

2021

Journal Article

Are prescription misuse and illicit drug use etiologically distinct? A genetically-informed analysis of opioids and stimulants

Dash, Genevieve F., Martin, Nicholas G., Agrawal, Arpana, Lynskey, Michael T. and Slutske, Wendy S. (2021). Are prescription misuse and illicit drug use etiologically distinct? A genetically-informed analysis of opioids and stimulants. Psychological Medicine, 52 (14), 3176-3183. doi: 10.1017/S0033291720005267

Are prescription misuse and illicit drug use etiologically distinct? A genetically-informed analysis of opioids and stimulants

2021

Other Outputs

Genetic insights into the biological mechanisms governing human ovarian ageing

Ruth, Katherine S, Day, Felix R, Hussain, Jazib, Martínez-Marchal, Ana, Aiken, Catherine E, Azad, Ajuna, Thompson, Deborah J, Abe, Hironori, Tarry-Adkins, Jane L, Gonzalez, Javier Martin, Claringbould, Annique, Bakker, Olivier B, Sulem, Patrick, Turon, Sandra, Onland-Moret, N Charlotte, Hertz, Emil Peter Trane, Timshel, Pascal N, Shukla, Vallari, Borup, Rehannah, Olsen, Kristina W, Ferrer-Roda, Mònica, Huang, Yan, Stankovic, Stasa, Timmers, Paul RHJ, Ahearn, Thomas U, Alizadeh, Behrooz Z, Naderi, Elnaz, Andrulis, Irene L, Arnold, Alice M ... Perry, John RB (2021). Genetic insights into the biological mechanisms governing human ovarian ageing. doi: 10.1101/2021.01.11.20248322

Genetic insights into the biological mechanisms governing human ovarian ageing

2021

Journal Article

Inference of causal relationships between sleep-related traits and 1,527 phenotypes using genetic data

García-Marín, Luis M., Campos, Adrián I., Martin, Nicholas G., Cuéllar-Partida, Gabriel and Rentería, Miguel E. (2021). Inference of causal relationships between sleep-related traits and 1,527 phenotypes using genetic data. Sleep, 44 (1) zsaa154. doi: 10.1093/sleep/zsaa154

Inference of causal relationships between sleep-related traits and 1,527 phenotypes using genetic data

2021

Journal Article

Examining the Vanishing Twin Hypothesis of Neural Tube Defects: Application of an Epigenetic Predictor for Monozygotic Twinning

Van Dongen, Jenny, Gordon, Scott D., Odintsova, Veronika V., McRae, Allan F., Robinson, Wendy P., Hall, Judith G., Boomsma, Dorret I. and Martin, Nicholas G. (2021). Examining the Vanishing Twin Hypothesis of Neural Tube Defects: Application of an Epigenetic Predictor for Monozygotic Twinning. Twin Research and Human Genetics, 24 (3) PII S1832427421000256, 155-159. doi: 10.1017/thg.2021.25

Examining the Vanishing Twin Hypothesis of Neural Tube Defects: Application of an Epigenetic Predictor for Monozygotic Twinning

2021

Journal Article

Polygenic Risk Scores have high diagnostic capacity in ankylosing spondylitis

Li, Zhixiu, Wu, Xin, Leo, Paul J., De Guzman, Erika, Akkoc, Nurullah, Breban, Maxime, MacFarlane, Gary J., Mahmoudi, Mahdi, Marzo-Ortega, Helena, Anderson, Lisa K., Wheeler, Lawrie, Chou, Chung-Tei, Harrison, Andrew A., Stebbings, Simon, Jones, Gareth T., Bang, So-Young, Wang, Geng, Jamshidi, Ahmadreza, Farhadi, Elham, Song, Jing, Lin, Li, Li, Mengmeng, Wei, James Cheng-Chung, Martin, Nicholas G., Wright, Margaret J., Lee, MinJae, Wang, Yuqin, Zhan, Jian, Zhang, Jin-San ... Brown, Matthew A (2021). Polygenic Risk Scores have high diagnostic capacity in ankylosing spondylitis. Annals of the Rheumatic Diseases, 80 (9) annrheumdis-2020- 219446, annrheumdis-2020. doi: 10.1136/annrheumdis-2020-219446

Polygenic Risk Scores have high diagnostic capacity in ankylosing spondylitis

2020

Journal Article

Ten years of enhancing neuro-imaging genetics through meta-analysis: an overview from the ENIGMA Genetics Working Group

Medland, Sarah E., Grasby, Katrina L., Jahanshad, Neda, Painter, Jodie N., Colodro-Conde, Lucía, Bralten, Janita, Hibar, Derrek P., Lind, Penelope A., Pizzagalli, Fabrizio, Thomopoulos, Sophia I., Stein, Jason L., Franke, Barbara, Martin, Nicholas G. and Thompson, Paul M. (2020). Ten years of enhancing neuro-imaging genetics through meta-analysis: an overview from the ENIGMA Genetics Working Group. Human Brain Mapping, 43 (1), 292-299. doi: 10.1002/hbm.25311

Ten years of enhancing neuro-imaging genetics through meta-analysis: an overview from the ENIGMA Genetics Working Group