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2019 Journal Article Discovery and characterization of cyclic and acyclic trypsin inhibitors from Momordica dioicaDu, Junqiao, Chan, Lai Yue, Poth, Aaron G. and Craik, David J. (2019). Discovery and characterization of cyclic and acyclic trypsin inhibitors from Momordica dioica. Journal of Natural Products, 82 (2) acs.jnatprod.8b00716, 293-300. doi: 10.1021/acs.jnatprod.8b00716 |
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2019 Journal Article Peptide-membrane interactions affect the inhibitory potency and selectivity of spider toxins ProTx-II and GpTx-1Lawrence, Nicole, Wu, Bin, Ligutti, Joseph, Cheneval, Olivier, Agwa, Akello Joanna, Benfield, Aurélie H., Biswas, Kaustav, Craik, David J., Miranda, Les P., Henriques, Sónia Troeira and Schroeder, Christina I. (2019). Peptide-membrane interactions affect the inhibitory potency and selectivity of spider toxins ProTx-II and GpTx-1. ACS Chemical Biology, 14 (1), 118-130. doi: 10.1021/acschembio.8b00989 |
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2019 Journal Article Characterising the subsite specificity of urokinase-type plasminogen activator and tissue-type plasminogen activator using a sequence-defined peptide aldehyde libraryLi, Choi Yi, de Veer, Simon J., Law, Ruby H. P., Whisstock, James C., Craik, David J. and Swedberg, Joakim E. (2019). Characterising the subsite specificity of urokinase-type plasminogen activator and tissue-type plasminogen activator using a sequence-defined peptide aldehyde library. ChemBioChem, 19 (1), 46-50. doi: 10.1002/cbic.201800395 |
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2019 Journal Article Evaluation of the in vitro antitumor activity of nanostructured cyclotides in polymers of Eudragit (R) L 100-55 and RS 30 DSilva, Osmar N., Pinto, Michelle F. S., Viana, Juliane F. C., Freitas, Camila G., Fensterseifer, Isabel C. M., Craik, David J. and Franco, Octavio L. (2019). Evaluation of the in vitro antitumor activity of nanostructured cyclotides in polymers of Eudragit (R) L 100-55 and RS 30 D. Letters in Drug Design and Discovery, 16 (4), 437-445. doi: 10.2174/1570180815666180801115526 |
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2018 Journal Article Mechanism of bacterial membrane permeabilization of crotalicidin (Ctn) and its fragment Ctn[15-34], antimicrobial peptides from rattlesnake venomPérez-Peinado, Clara, Almeida Dias, Susana, Domingues, Marco M., Benfield, Aurélie H., Freire, João Miguel, Radis-Baptista, Gandhi, Gaspar, Diana, Castanho, Miguel A. R. B., Craik, David J., Henriques, Sonia Troeira, Veiga, Ana S. and Andreu, David (2018). Mechanism of bacterial membrane permeabilization of crotalicidin (Ctn) and its fragment Ctn[15-34], antimicrobial peptides from rattlesnake venom. The Journal of Biological Chemistry, 293 (5), 1536-1549. doi: 10.1074/jbc.RA117.000125 |
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2018 Journal Article Potent, selective, and cell-penetrating inhibitors of Kallikrein-related peptidase 4 based on the cyclic peptide MCoTI-IISwedberg, Joakim E., Ghani, Hafiza Abdul, Harris, Jonathan M., de Veer, Simon J. and Craik, David J. (2018). Potent, selective, and cell-penetrating inhibitors of Kallikrein-related peptidase 4 based on the cyclic peptide MCoTI-II. ACS Medicinal Chemistry Letters, 9 (12) acsmedchemlett.8b00422, 1258-1262. doi: 10.1021/acsmedchemlett.8b00422 |
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2018 Journal Article Synthesis, racemic x-ray crystallographic, and permeability studies of bioactive orbitides from Jatropha speciesRamalho, Suelem D., Wang, Conan K., King, Gordon J., Byriel, Karl A., Huang, Yen-Hua, Bolzani, Vanderlan S. and Craik, David J. (2018). Synthesis, racemic x-ray crystallographic, and permeability studies of bioactive orbitides from Jatropha species. Journal of Natural Products, 81 (11) acs.jnatprod.8b00447, 2436-2445. doi: 10.1021/acs.jnatprod.8b00447 |
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2018 Journal Article Discovery and characterization of cyclotides from Rinorea speciesNiyomploy, Ploypat, Chan, Lai Yue, Harvey, Peta J., Poth, Aaron G., Colgrave, Michelle L. and Craik, David J. (2018). Discovery and characterization of cyclotides from Rinorea species. Journal of Natural Products, 81 (11) acs.jnatprod.8b00572, 2512-2520. doi: 10.1021/acs.jnatprod.8b00572 |
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2018 Journal Article Single amino acid substitution in α-conotoxin TxID reveals a specific α3β4 nicotinic acetylcholine receptor antagonistYu, Jinpeng, Zhu, Xiaopeng, Harvey, Peta J., Kaas, Quentin, Zhangsun, Dongting, Craik, David J. and Luo, Sulan (2018). Single amino acid substitution in α-conotoxin TxID reveals a specific α3β4 nicotinic acetylcholine receptor antagonist. Journal of Medicinal Chemistry, 61 (20), 9256-9265. doi: 10.1021/acs.jmedchem.8b00967 |
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2018 Journal Article A computationally designed peptide derived from Escherichia coli as a potential drug template for antibacterial and antibiofilm therapiesCardoso, Marlon, Cândido, Elizabete, Chan, Lai, Torres, Marcelo Der Torossian, Oshiro, Karen, Rezende, Samilla, Porto, William F., Lu, Timothy K., de la Fuente-Nunez, Cesar, Craik, David J. and Franco, Octávio L. (2018). A computationally designed peptide derived from Escherichia coli as a potential drug template for antibacterial and antibiofilm therapies. ACS Infectious Diseases, 4 (12) acsinfecdis.8b00219, 1727-1736. doi: 10.1021/acsinfecdis.8b00219 |
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2018 Journal Article NMR structure of µ-conotoxin GIIIC: Leucine 18 induces local repacking of the N-terminus resulting in reduced Nav channel potencyHarvey, Peta J., Kurniawan, Nyoman D., Finol-Urdaneta, Rocio K., McArthur, Jeffrey R., Van Lysebetten, Dorien, Dash, Thomas S., Hill, Justine M., Adams, David J., Durek, Thomas and Craik, David J. (2018). NMR structure of µ-conotoxin GIIIC: Leucine 18 induces local repacking of the N-terminus resulting in reduced Nav channel potency. Molecules, 23 (10) molecules23102715, 2715. doi: 10.3390/molecules23102715 |
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2018 Journal Article Targeted delivery of cyclotides via conjugation to a nanobodyKwon, Soohyun, Duarte, Joao N., Li, Zeyang, Ling, Jingjing J., Cheneval, Olivier, Durek, Thomas, Schroeder, Christina I., Craik, David J. and Ploegh, Hidde L. (2018). Targeted delivery of cyclotides via conjugation to a nanobody. ACS Chemical Biology, 13 (10), 2973-2980. doi: 10.1021/acschembio.8b00653 |
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2018 Journal Article Efficient enzymatic ligation of inhibitor cystine knot spider venom peptides: using sortase a to form double-knottins that probe voltage-gated sodium channel NaV1.7Agwa, Akello J., Blomster, Linda V., Craik, David J., King, Glenn F. and Schroeder, Christina I. (2018). Efficient enzymatic ligation of inhibitor cystine knot spider venom peptides: using sortase a to form double-knottins that probe voltage-gated sodium channel NaV1.7. Bioconjugate Chemistry, 29 (10) acs.bioconjchem.8b00505, 3309-3319. doi: 10.1021/acs.bioconjchem.8b00505 |
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2018 Journal Article Molecular determinants of α-conotoxin potency for inhibition of human and rat α6β4 nicotinic acetylcholine receptorsHone, Arik J., Talley, Todd T, Bobango, Janet, Huidobro Melo, Cesar, Hararah, Fuaad, Gajewiak, Joanna B., Christensen, Sean B, Harvey, Peta J., Craik, David J. and McIntosh, J. Michael (2018). Molecular determinants of α-conotoxin potency for inhibition of human and rat α6β4 nicotinic acetylcholine receptors. Journal of Biological Chemistry, 293 (46), 17838-17852. doi: 10.1074/jbc.ra118.005649 |
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2018 Journal Article Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIBWu, Xiaosa, Tae, Han-Shen, Huang, Yen-Hua, Adams, David J., Craik, David J. and Kaas, Quentin (2018). Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIB. Biochemical Pharmacology, 155, 288-297. doi: 10.1016/j.bcp.2018.07.007 |
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2018 Journal Article Engineering potent mesotrypsin inhibitors based on the plant-derived cyclic peptide, sunflower trypsin inhibitor-1de Veer, Simon J., Li, Choi Yi, Swedberg, Joakim E., Schroeder, Christina I. and Craik, David J. (2018). Engineering potent mesotrypsin inhibitors based on the plant-derived cyclic peptide, sunflower trypsin inhibitor-1. European Journal of Medicinal Chemistry, 155, 695-704. doi: 10.1016/j.ejmech.2018.06.029 |
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2018 Journal Article Defense peptides engineered from human platelet factor 4 kill Plasmodium by selective membrane disruptionLawrence, Nicole, Dennis, Adelaide S. M., Lehane, Adele M., Ehmann, Anna, Harvey, Peta J., Benfield, Aurélie H., Cheneval, Olivier, Henriques, Sónia Troeira, Craik, David J. and McMorran, Brendan J. (2018). Defense peptides engineered from human platelet factor 4 kill Plasmodium by selective membrane disruption. Cell Chemical Biology, 25 (9), 1140-+. doi: 10.1016/j.chembiol.2018.06.009 |
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2018 Journal Article Molecular basis for the production of cyclic peptides by plant asparaginyl endopeptidasesJackson, M. A., Gilding, E. K., Shafee, T., Harris, K. S., Kaas, Q., Poon, S., Yap, K., Jia, H., Guarino, R., Chan, L. Y., Durek, T., Anderson, M. A. and Craik, D. J. (2018). Molecular basis for the production of cyclic peptides by plant asparaginyl endopeptidases. Nature Communications, 9 (1) 2411, 2411. doi: 10.1038/s41467-018-04669-9 |
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2018 Journal Article Calcium-mediated allostery of the EGF foldWang, Conan K., Ghani, Hafiza Abdul, Bundock, Anna, Weidmann, Joachim, Harvey, Peta J., Edwards, Ingrid A., Schroeder, Christina I., Swedberg, Joakim E. and Craik, David J. (2018). Calcium-mediated allostery of the EGF fold. ACS Chemical Biology, 13 (6), 1659-1667. doi: 10.1021/acschembio.8b00291 |
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2018 Journal Article Structure-activity studies reveal the molecular basis for GABAB-receptor mediated inhibition of high voltage-activated calcium channels by α-conotoxin Vc1.1Sadeghi, Mahsa, Carstens, Bodil B., Callaghan, Brid P., Daniel, James T., Tae, Han Shen, O'Donnell, Tracey, Castro, Joel, Brierley, Stuart M., Adams, David J., Craik, David J. and Clark, Richard J. (2018). Structure-activity studies reveal the molecular basis for GABAB-receptor mediated inhibition of high voltage-activated calcium channels by α-conotoxin Vc1.1. ACS Chemical Biology, 13 (6), 1577-1587. doi: 10.1021/acschembio.8b00190 |
