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2025 Journal Article Cyclization of the Analgesic α‐Conotoxin Vc1.1 With a Non‐Natural Linker: Effects on Structure, Stability, and BioactivityZhang, Yuhui, Tae, Han Shen, Adams, David J., Durek, Thomas and Craik, David J. (2025). Cyclization of the Analgesic α‐Conotoxin Vc1.1 With a Non‐Natural Linker: Effects on Structure, Stability, and Bioactivity. Journal of Peptide Science, 31 (6) e70017, e70017. doi: 10.1002/psc.70017 |
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2025 Journal Article An orthogonal protection strategy for the synthesis of conotoxins containing three disulfide bondsZhang, Hengyu, Chan, Lai Yue, Zhang, Huanhuan, Jiang, Tao, Craik, David J., Cai, Wenqing and Yu, Rilei (2025). An orthogonal protection strategy for the synthesis of conotoxins containing three disulfide bonds. Marine Drugs, 23 (4) 168, 1-11. doi: 10.3390/md23040168 |
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2025 Journal Article Anticoagulation during Extracorporeal Membrane Oxygenation (ECMO): A Selective Inhibitor of Activated Factor XII Compared to Heparin in an Ex Vivo ModelGandini, Lucia, de Veer, Simon J., Chan, Chris H. H., Passmore, Margaret R., Liu, Keibun, Lundon, Brooke, Rachakonda, Reema, White, Nicole, Rhodes, Madeleine, Shanahan, Emma, Yap, Kuok, See Hoe, Louise E., Semenzin, Clayton, Li Bassi, Gianluigi, Fraser, John F., Craik, David J. and Suen, Jacky Y. (2025). Anticoagulation during Extracorporeal Membrane Oxygenation (ECMO): A Selective Inhibitor of Activated Factor XII Compared to Heparin in an Ex Vivo Model. ACS Pharmacology & Translational Science, 8 (5), 1260-1269. doi: 10.1021/acsptsci.4c00352 |
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2025 Journal Article Selective inhibition of Rat α7 nicotinic acetylcholine receptors by LvID, a newly characterized α4/7-conotoxin from Conus lividusGuo, Man, Zhu, Xiaopeng, Ma, Tao, Xu, Chenxing, Zhangsun, Dongting, Yu, Jinpeng, Kaas, Quentin, Harvey, Peta J., McIntosh, J. Michael, Craik, David J. and Luo, Sulan (2025). Selective inhibition of Rat α7 nicotinic acetylcholine receptors by LvID, a newly characterized α4/7-conotoxin from Conus lividus. Journal of Medicinal Chemistry, 68 (8), 8163-8173. doi: 10.1021/acs.jmedchem.4c02810 |
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2025 Journal Article Cell-penetrating cyclic and disulfide-rich peptides are privileged molecular scaffolds for intracellular targetingTroeira Henriques, Sónia, Lawrence, Nicole, Kan, Meng-Wei, Malins, Lara R. and Craik, David J. (2025). Cell-penetrating cyclic and disulfide-rich peptides are privileged molecular scaffolds for intracellular targeting. Biochemistry, 64 (7), 1437-1449. doi: 10.1021/acs.biochem.4c00845 |
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2025 Journal Article Recombinant production of the cyclotide kalata B1 by conditional split inteinsCraik, David J., Yayci, Abdulkadir, Huang, Yen-Hua and Harvey, Peta J. (2025). Recombinant production of the cyclotide kalata B1 by conditional split inteins. ChemBioChem, 26 (4) e202400591, e202400591. doi: 10.1002/cbic.202400591 |
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2025 Journal Article The future of utilising semiochemical pest control methods to manage the destructive crown-of-thorns starfish outbreaks on coral reefsHarris, Richard J., Barnard, d'Artagnan L., Paxton, Gillian, Lockie, Stewart, Craik, David J., Cummins, Scott F., Wang, Conan K. and Motti, Cherie A. (2025). The future of utilising semiochemical pest control methods to manage the destructive crown-of-thorns starfish outbreaks on coral reefs. Biological Conservation, 302 110984, 110984-302. doi: 10.1016/j.biocon.2025.110984 |
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2025 Journal Article Exploring the utility of cell-penetrating peptides as vehicles for the delivery of distinct antimalarial drug cargoesGare, Caitlin L., Palombi, Isabella R., White, Andrew M., Chavchich, Marina, Edstein, Michael D., Lock, Aaron, Avery, Vicky M., Craik, David J., McMorran, Brendan J., Lawrence, Nicole and Malins, Lara Rebecca (2025). Exploring the utility of cell-penetrating peptides as vehicles for the delivery of distinct antimalarial drug cargoes. ChemMedChem, 20 (2) e202400637. doi: 10.1002/cmdc.202400637 |
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2025 Journal Article Synthesis and Investigation of Peptide-Drug Conjugates Comprising Camptothecin and a Human Protein-Derived Cell-Penetrating PeptidePalombi, Isabella R., White, Andrew M., Koda, Yasuko, Craik, David J., Lawrence, Nicole and Malins, Lara R. (2025). Synthesis and Investigation of Peptide-Drug Conjugates Comprising Camptothecin and a Human Protein-Derived Cell-Penetrating Peptide. Chemical Biology & Drug Design, 105 (1) e70051, 1-10. doi: 10.1111/cbdd.70051 |
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2025 Journal Article Analogs of cyclic peptide mortiamide‐d from marine fungi have improved membrane permeability and kill drug‐resistant melanoma cellsBergeron, Catherine, Bérubé, Christopher, Lamb, Henry, Koda, Yasuko, Craik, David J., Henriques, Sónia Troeira, Voyer, Normand and Lawrence, Nicole (2025). Analogs of cyclic peptide mortiamide‐d from marine fungi have improved membrane permeability and kill drug‐resistant melanoma cells. Peptide Science, 117 (1) e24380. doi: 10.1002/pep2.24380 |
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2025 Journal Article Recent progress on cyclotides: 2021-2024Kan, Meng-Wei, Roseli, Ras Baizureen, Chan, Lai Yue, Nguyen, Linh T. T. and Craik, David J. (2025). Recent progress on cyclotides: 2021-2024. ScienceAsia, 51S (1) 2025s009, 1-17. doi: 10.2306/scienceasia1513-1874.2025.s009 |
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2024 Journal Article Highly Efficient Transpeptidase-Catalyzed Isopeptide Ligationde Veer, Simon J., Craik, David J. and Rehm, Fabian B. H. (2024). Highly Efficient Transpeptidase-Catalyzed Isopeptide Ligation. Journal of the American Chemical Society, 147 (1), 557-565. doi: 10.1021/jacs.4c11964 |
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2024 Journal Article Peptide PaDBS1R6 has potent antibacterial activity on clinical bacterial isolates and integrates an immunomodulatory peptide fragment within its sequenceRezende, Samilla B., Chan, Lai Yue, Oshiro, Karen G.N., Buccini, Danieli F., Leal, Ana Paula Ferreira, Ribeiro, Camila F., Souza, Carolina M., Brandão, Amanda L.O., Gonçalves, Regina M., Cândido, Elizabete S., Macedo, Maria L.R., Craik, David J., Franco, Octávio L. and Cardoso, Marlon H. (2024). Peptide PaDBS1R6 has potent antibacterial activity on clinical bacterial isolates and integrates an immunomodulatory peptide fragment within its sequence. Biochimica et Biophysica Acta (BBA) - General Subjects, 1868 (11) 130693, 1-13. doi: 10.1016/j.bbagen.2024.130693 |
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2024 Journal Article Discovery of five classes of bacterial defensins: ancestral precursors of defensins from eukarya?Cardoso, Marlon H., de Lima, Lucas R., Pires, Allan S., Maximiano, Mariana R., Harvey, Peta J., Freitas, Camila G., Costa, Rosiane A., Fensterseifer, Isabel C. M., Rigueiras, Pietra O., Migliolo, Ludovico, Porto, William F., Craik, David J. and Franco, Octávio L. (2024). Discovery of five classes of bacterial defensins: ancestral precursors of defensins from eukarya?. ACS Omega, 9 (45), 45297-45308. doi: 10.1021/acsomega.4c06956 |
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2024 Journal Article Gene-guided identifications of a structure-chimeric cyclotide viphi I from Viola philippica: potential functions against cadmium and nematodesZhang, Xiaojie, Chen, Ruohong, Shu, Haoyue, Liang, Peihui, Qin, Ting, Wang, Kemei, Guo, Aimin, Craik, David J., Liao, Bin and Zhang, Jun (2024). Gene-guided identifications of a structure-chimeric cyclotide viphi I from Viola philippica: potential functions against cadmium and nematodes. Plant Science, 347 112185, 112185. doi: 10.1016/j.plantsci.2024.112185 |
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2024 Journal Article Conotoxins targeting voltage-gated sodium ion channelsPei, Shengrong, Wang, Nan, Mei, Zaoli, Zhangsun, Dongting, Craik, David J., McIntosh, J. Michael, Zhu, Xiaopeng and Luo, Sulan (2024). Conotoxins targeting voltage-gated sodium ion channels. Pharmacological Reviews, 76 (5), 828-845. doi: 10.1124/pharmrev.123.000923 |
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2024 Journal Article Cyclic tachyplesin I kills proliferative, non-proliferative and drug-resistant melanoma cells without inducing resistanceBenfield, Aurélie H., Vernen, Felicitas, Young, Reuben S. E., Nadal-Bufí, Ferran, Lamb, Henry, Hammerlindl, Heinz, Craik, David J., Schaider, Helmut, Lawrence, Nicole, Blanksby, Stephen J. and Henriques, Sónia Troeira (2024). Cyclic tachyplesin I kills proliferative, non-proliferative and drug-resistant melanoma cells without inducing resistance. Pharmacological Research, 207 107298, 107298. doi: 10.1016/j.phrs.2024.107298 |
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2024 Journal Article Display technologies for expanding the pharmaceutical applications of cyclotidesXie, Jing, Kan, Meng‐Wei, de Veer, Simon J., Wang, Conan and Craik, David J. (2024). Display technologies for expanding the pharmaceutical applications of cyclotides. Israel Journal of Chemistry, 64 (8-9) e202400010. doi: 10.1002/ijch.202400010 |
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2024 Journal Article Author Correction: Repurposing a plant peptide cyclase for targeted lysine acylationRehm, Fabian B. H., Tyler, Tristan J., Zhou, Yan, Huang, Yen-Hua, Wang, Conan K., Lawrence, Nicole, Craik, David J. and Durek, Thomas (2024). Author Correction: Repurposing a plant peptide cyclase for targeted lysine acylation. Nature Chemistry, 16 (9), 1565-1565. doi: 10.1038/s41557-024-01625-7 |
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2024 Journal Article Hijacking of N-fixing legume albumin-1 genes enables the cyclization and stabilization of defense peptidesGilding, Edward K., Jackson, Mark A., Nguyen, Linh T. T., Hamilton, Brett R., Farquharson, Katherine A., Ho, Wing L., Yap, Kuok, Hogg, Carolyn J., Belov, Katherine and Craik, David J. (2024). Hijacking of N-fixing legume albumin-1 genes enables the cyclization and stabilization of defense peptides. Nature Communications, 15 (1) 6565, 6565. doi: 10.1038/s41467-024-50742-x |
