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2022 Journal Article A designed cyclic analogue of gomesin has potent activity against Staphylococcus aureus biofilmsDias, Susana A., Pinto, Sandra N., Silva-Herdade, Ana S., Cheneval, Olivier, Craik, David J., Coutinho, Ana, Castanho, Miguel A. R. B., Henriques, Sónia T. and Veiga, Ana Salomé (2022). A designed cyclic analogue of gomesin has potent activity against Staphylococcus aureus biofilms. Journal of Antimicrobial Chemotherapy, 77 (12), 3256-3264. doi: 10.1093/jac/dkac309 |
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2022 Journal Article µ-Conotoxins targeting the human voltage-gated sodium channel subtype NaV1.7McMahon, Kirsten L., Tran, Hue N. T., Deuis, Jennifer R., Craik, David J., Vetter, Irina and Schroeder, Christina I. (2022). µ-Conotoxins targeting the human voltage-gated sodium channel subtype NaV1.7. Toxins, 14 (9) 600, 1-16. doi: 10.3390/toxins14090600 |
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2022 Journal Article Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica feroxXie, Jing, Robinson, Samuel D., Gilding, Edward K., Jami, Sina, Deuis, Jennifer R., Rehm, Fabian B.H., Yap, Kuok, Ragnarsson, Lotten, Chan, Lai Yue, Hamilton, Brett R., Harvey, Peta J., Craik, David J., Vetter, Irina and Durek, Thomas (2022). Neurotoxic and cytotoxic peptides underlie the painful stings of the tree nettle Urtica ferox. Journal of Biological Chemistry, 298 (8) 102218, 1-12. doi: 10.1016/j.jbc.2022.102218 |
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2022 Journal Article Mutagenesis of cyclotide Cter 27 exemplifies a robust folding strategy for bracelet cyclotidesDang, Tien T., Harvey, Peta J., Chan, Lai Yue, Huang, Yen-Hua, Kaas, Quentin and Craik, David J. (2022). Mutagenesis of cyclotide Cter 27 exemplifies a robust folding strategy for bracelet cyclotides. Peptide Science, 114 (6) e24284. doi: 10.1002/pep2.24284 |
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2022 Journal Article Antinociceptive peptides from venomous arthropodsMuller, Jessica A. I., Chan, Lai Y., Toffoli-Kadri, Monica C., Mortari, Marcia R., Craik, David J. and Koehbach, Johannes (2022). Antinociceptive peptides from venomous arthropods. Toxin Reviews, 42 (1), 1-20. doi: 10.1080/15569543.2022.2065510 |
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2022 Journal Article Cystine knot peptides with tuneable activity and mechanismLi, Choi Yi, Rehm, Fabian B. H., Yap, Kuok, Zdenek, Christina N., Harding, Maxim D., Fry, Bryan G., Durek, Thomas, Craik, David J. and Veer, Simon J. (2022). Cystine knot peptides with tuneable activity and mechanism. Angewandte Chemie, 61 (19) e202200951, e202200951. doi: 10.1002/ange.202200951 |
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2022 Journal Article Phage display-based discovery of cyclic peptides against the broad spectrum bacterial anti-virulence target CsrAJakob, Valentin, Zoller, Ben G. E., Rinkes, Julia, Wu, Yingwen, Kiefer, Alexander F., Hust, Michael, Polten, Saskia, White, Andrew M., Harvey, Peta J., Durek, Thomas, Craik, David J., Siebert, Andreas, Kazmaier, Uli and Empting, Martin (2022). Phage display-based discovery of cyclic peptides against the broad spectrum bacterial anti-virulence target CsrA. European Journal of Medicinal Chemistry, 231 114148, 114148. doi: 10.1016/j.ejmech.2022.114148 |
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2022 Journal Article An N-capping asparagine–lysine–proline (NKP) motif contributes to a hybrid flexible/stable multifunctional peptide scaffoldCardoso, Marlon H., Chan, Lai Y., Cândido, Elizabete S., Buccini, Danieli F., Rezende, Samilla B., Torres, Marcelo D. T., Oshiro, Karen G. N., Silva, Ítala C., Gonçalves, Sónia, Lu, Timothy K., Santos, Nuno C., de la Fuente-Nunez, Cesar, Craik, David J. and Franco, Octávio L. (2022). An N-capping asparagine–lysine–proline (NKP) motif contributes to a hybrid flexible/stable multifunctional peptide scaffold. Chemical Science, 13 (32), 9410-9424. doi: 10.1039/d1sc06998e |
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2022 Journal Article ɑO-Conotoxin GeXIVA isomers modulate N-type calcium (CaV2.2) channels and inwardly-rectifying potassium (GIRK) channels via GABAB receptor activationYousuf, Arsalan, Wu, Xiaosa, Bony, Anuja R., Sadeghi, Mahsa, Huang, Yen-Hua, Craik, David J. and Adams, David J. (2022). ɑO-Conotoxin GeXIVA isomers modulate N-type calcium (CaV2.2) channels and inwardly-rectifying potassium (GIRK) channels via GABAB receptor activation. Journal of Neurochemistry, 160 (2), 154-171. doi: 10.1111/jnc.15535 |
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2021 Journal Article Evaluation of efficient non-reducing enzymatic and chemical ligation strategies for complex disulfide-rich peptidesTran, Hue N. T., Tran, Poanna, Deuis, Jennifer R., McMahon, Kirsten L., Yap, Kuok, Craik, David J., Vetter, Irina and Schroeder, Christina I. (2021). Evaluation of efficient non-reducing enzymatic and chemical ligation strategies for complex disulfide-rich peptides. Bioconjugate Chemistry, 32 (11) acs.bioconjchem.1c00452, 2407-2419. doi: 10.1021/acs.bioconjchem.1c00452 |
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2021 Journal Article Enabling efficient folding and high-resolution crystallographic analysis of bracelet cyclotidesHuang, Yen-Hua, Du, Qingdan, Jiang, Zhihao, King, Gordon J., Collins, Brett M., Wang, Conan K. and Craik, David J. (2021). Enabling efficient folding and high-resolution crystallographic analysis of bracelet cyclotides. Molecules, 26 (18) 5554, 5554. doi: 10.3390/molecules26185554 |
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2021 Journal Article Interactions of globular and ribbon [γ4E]GID with α4β2 neuronal nicotinic acetylcholine receptorWu, Xiaosa, Craik, David J. and Kaas, Quentin (2021). Interactions of globular and ribbon [γ4E]GID with α4β2 neuronal nicotinic acetylcholine receptor. Marine Drugs, 19 (9) 482, 482. doi: 10.3390/md19090482 |
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2021 Journal Article How can we improve peptide drug discovery? Learning from the pastCraik, David J. and Kan, Meng-Wei (2021). How can we improve peptide drug discovery? Learning from the past. Expert Opinion on Drug Discovery, 16 (12), 1-4. doi: 10.1080/17460441.2021.1961740 |
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2021 Journal Article Effects of backbone cyclization on the pharmacokinetics and drug efficiency of the orally active analgesic conotoxin cVc1.1Poth, Aaron G., Chiu, Francis C.K., Stalmans, Sofie, Hamilton, Brett R., Huang, Yen-Hua, Shackleford, David M., Patil, Rahul, Le, Thao T., Kan, Meng-Wei, Durek, Thomas, Wynendaele, Evelien, De Spiegeleer, Bart, Powell, Andrew K., Venter, Deon J., Clark, Richard J., Charman, Susan A. and Craik, David J. (2021). Effects of backbone cyclization on the pharmacokinetics and drug efficiency of the orally active analgesic conotoxin cVc1.1. Medicine in Drug Discovery, 10 100087, 1-10. doi: 10.1016/j.medidd.2021.100087 |
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2021 Journal Article Converting peptides into drugs targeting intracellular protein–protein interactionsPhilippe, Grégoire J.B., Craik, David J. and Henriques, Sónia T. (2021). Converting peptides into drugs targeting intracellular protein–protein interactions. Drug Discovery Today, 26 (6), 1521-1531. doi: 10.1016/j.drudis.2021.01.022 |
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2021 Journal Article Engineered conotoxin differentially blocks and discriminates rat and human α7 nicotinic acetylcholine receptorsWang, Shuai, Zhu, Xiaopeng, Zhangsun, Manqi, Wu, Yong, Yu, Jinpeng, Harvey, Peta J., Kaas, Quentin, Zhangsun, Dongting, Craik, David J. and Luo, Sulan (2021). Engineered conotoxin differentially blocks and discriminates rat and human α7 nicotinic acetylcholine receptors. Journal of Medicinal Chemistry, 64 (9), 5620-5631. doi: 10.1021/acs.jmedchem.0c02079 |
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2021 Journal Article Antimicrobial and anticancer properties of synthetic peptides derived from the wasp Parachartergus fraternusMuller, Jessica A. I., Lawrence, Nicole, Chan, Lai Yue, Harvey, Peta J., Elliott, Alysha G., Blaskovich, Mark A. T., Gonçalves, Jacqueline C., Galante, Priscilla, Mortari, Marcia R., Toffoli-Kadri, Mônica C., Koehbach, Johannes and Craik, David (2021). Antimicrobial and anticancer properties of synthetic peptides derived from the wasp Parachartergus fraternus. Chembiochem , 22 (8) cbic.202000716, 1415-1423. doi: 10.1002/cbic.202000716 |
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2021 Journal Article Computational and functional mapping of human and rat α6β4 nicotinic acetylcholine receptors reveals species-specific ligand-binding motifsHone, Arik J., Kaas, Quentin, Kearns, Ireland, Hararah, Fuaad, Gajewiak, Joanna, Christensen, Sean, Craik, David J. and McIntosh, J. Michael (2021). Computational and functional mapping of human and rat α6β4 nicotinic acetylcholine receptors reveals species-specific ligand-binding motifs. Journal of Medicinal Chemistry, 64 (3), 1685-1700. doi: 10.1021/acs.jmedchem.0c01973 |
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2021 Journal Article In planta discovery and chemical synthesis of bracelet cystine knot peptides from Rinorea bengalensisDang, Tien T., Chan, Lai Y., Tombling, Benjamin J., Harvey, Peta J., Gilding, Edward K. and Craik, David J. (2021). In planta discovery and chemical synthesis of bracelet cystine knot peptides from Rinorea bengalensis. Journal of Natural Products, 84 (2), 395-407. doi: 10.1021/acs.jnatprod.0c01065 |
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2021 Journal Article Cyclotides from Brazilian Palicourea sessilis and their effects on human lymphocytesPinto, Meri Emili F., Chan, Lai Yue, Koehbach, Johannes, Devi, Seema, Gründemann, Carsten, Gruber, Christian W., Gomes, Mario, Bolzani, Vanderlan S., Cilli, Eduardo Maffud and Craik, David J. (2021). Cyclotides from Brazilian Palicourea sessilis and their effects on human lymphocytes. Journal of Natural Products, 84 (1) acs.jnatprod.0c01069, 81-90. doi: 10.1021/acs.jnatprod.0c01069 |
