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2023

Journal Article

Indian Hedgehog release from TNF-activated renal epithelia drives local and remote organ fibrosis

O'Sullivan, Eoin D., Mylonas, Katie J., Xin, Cuiyan, Baird, David P., Carvalho, Cyril, Docherty, Marie-Helena, Campbell, Ross, Matchett, Kylie P., Waddell, Scott H., Walker, Alexander D., Gallagher, Kevin M., Jia, Siyang, Leung, Steve, Laird, Alexander, Wilflingseder, Julia, Willi, Michaela, Reck, Maximilian, Finnie, Sarah, Pisco, Angela, Gordon-Keylock, Sabrina, Medvinsky, Alexander, Boulter, Luke, Henderson, Neil C., Kirschner, Kristina, Chandra, Tamir, Conway, Bryan R., Hughes, Jeremy, Denby, Laura, Bonventre, Joseph V. and Ferenbach, David A. (2023). Indian Hedgehog release from TNF-activated renal epithelia drives local and remote organ fibrosis. Science Translational Medicine, 15 (698) abn0736, eabn0736. doi: 10.1126/scitranslmed.abn0736

Indian Hedgehog release from TNF-activated renal epithelia drives local and remote organ fibrosis

2022

Journal Article

Single-cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis

O'Sullivan, Eoin D., Mylonas, Katie J., Bell, Rachel, Carvalho, Cyril, Baird, David P., Cairns, Carolynn, Gallagher, Kevin M., Campbell, Ross, Docherty, Marie, Laird, Alexander, Henderson, Neil C., Chandra, Tamir, Kirschner, Kristina, Conway, Bryan, Dihazi, Gry H., Zeisberg, Michael, Hughes, Jeremy, Denby, Laura, Dihazi, Hassan and Ferenbach, David A. (2022). Single-cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis. JCI Insight, 7 (22) e154124. doi: 10.1172/jci.insight.154124

Single-cell analysis of senescent epithelia reveals targetable mechanisms promoting fibrosis

2022

Journal Article

Cognitive bias is a crucial factor in nurses' decision making

O'sullivan, Eoin D. (2022). Cognitive bias is a crucial factor in nurses' decision making. Evidence-Based Nursing, 26 (1), 37-37. doi: 10.1136/ebnurs-2022-103585

Cognitive bias is a crucial factor in nurses' decision making

2022

Journal Article

Covid-19: the government's gaslighting has left vulnerable patients feeling forgotten

O'Sullivan, Eoin D. (2022). Covid-19: the government's gaslighting has left vulnerable patients feeling forgotten. The BMJ (378) o2033. doi: 10.1136/bmj.o2033

Covid-19: the government's gaslighting has left vulnerable patients feeling forgotten

2022

Journal Article

Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Abani, Obbina, Abbas, Ali, Abbas, Fatima, Abbas, Mustafa, Abbasi, Sadia, Abbass, Hakam, Abbott, Alfie, Abdallah, Nabeel, Abdelaziz, Ashraf, Abdelfattah, Mohamed, Abdelqader, Bushra, Abdul, Basir, Abdul Rasheed, Althaf, Abdulakeem, Ajibode, Abdul-Kadir, Rezan, Abdullah, Abdullah, Abdulmumeen, Abdulfatahi, Abdul-Raheem, Rasheed, Abdulshukkoor, Niyaz, Abdusamad, Kula, Abed El Khaleq, Yazeed, Abedalla, Mai, Ul-Amna, Abeer, Abernethy, Katrina, Aboaba, Adebanke, Abo-Leyah, Hani, Abou-Haggar, Ahmed, Abouibrahim, Mahmoud, Abraham, Miriam ... RECOVERY Collaborative Group (2022). Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet, 399 (10325), 665-676. doi: 10.1016/S0140-6736(22)00163-5

Casirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

2022

Journal Article

Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Abani, Obbina, Abbas, Ali, Abbas, Fatima, Abbas, Mustafa, Abbasi, Sadia, Abbass, Hakam, Abbott, Alfie, Abdallah, Nabeel, Abdelaziz, Ashraf, Abdelfattah, Mohamed, Abdelqader, Bushra, Abdul, Basir, Abdul Rasheed, Althaf, Abdulakeem, Ajibode, Abdul-Kadir, Rezan, Abdullah, Abdullah, Abdulmumeen, Abdulfatahi, Abdul-Raheem, Rasheed, Abdulshukkoor, Niyaz, Abdusamad, Kula, Abed El Khaleq, Yazeed, Abedalla, Mai, Abeer Ul Amna, Abeer Ul Amna, Abernethy, Katrina, Aboaba, Adebanke, Abo-Leyah, Hani, Abou-Haggar, Ahmed, Abouibrahim, Mahmoud, Abraham, Miriam ... RECOVERY Collaborative Group (2022). Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet, 399 (10320), 143-151. doi: 10.1016/S0140-6736(21)01825-0

Aspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

2021

Journal Article

Aging modulates the effects of ischemic injury upon mesenchymal cells within the renal interstitium and microvasculature

Shaw, Isaac W., O'Sullivan, Eoin D., Pisco, Angela O., Borthwick, Gary, Gallagher, Kevin M., Péault, Bruno, Hughes, Jeremy and Ferenbach, David A. (2021). Aging modulates the effects of ischemic injury upon mesenchymal cells within the renal interstitium and microvasculature. Stem Cells Translational Medicine, 10 (8), 1232-1248. doi: 10.1002/sctm.20-0392

Aging modulates the effects of ischemic injury upon mesenchymal cells within the renal interstitium and microvasculature

2021

Journal Article

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

Abani, Obbina, Abbas, Ali, Abbas, Fatima, Abbas, Mustafa, Abbasi, Sadia, Abbass, Hakam, Abbott, Alfie, Abdallah, Nabeel, Abdelaziz, Ashraf, Abdelfattah, Mohamed, Abdelqader, Bushra, Abdo, David, Abdul, Basir, Abdul Rasheed, Althaf, Abdulakeem, Ajibode, Abdul-Kadir, Rezan, Abdulle, Amina, Abdulmumeen, Abdulfatahi, Abdul-Raheem, Rasheed, Abdulshukkoor, Niyaz, Abdusamad, Kula, Abed El Khaleq, Yazeed, Abedalla, Mai, Abeer Ul Amna, Abeer Ul Amna, Abernethy, Katrina, Aboaba, Adebanke, Abo-Leyah, Hani, Abou-Haggar, Ahmed, Abouibrahim, Mahmoud ... RECOVERY Collaborative Group (2021). Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial. The Lancet, 397 (10289), 2049-2059. doi: 10.1016/S0140-6736(21)00897-7

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

2021

Journal Article

Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair

Mylonas, Katie J., O’Sullivan, Eoin D., Humphries, Duncan, Baird, David P., Docherty, Marie-Helena, Neely, Sarah A., Krimpenfort, Paul J., Melk, Anette, Schmitt, Roland, Ferreira-Gonzalez, Sofia, Forbes, Stuart J., Hughes, Jeremy and Ferenbach, David A. (2021). Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair. Science Translational Medicine, 13 (594) eabb0203. doi: 10.1126/scitranslmed.abb0203

Cellular senescence inhibits renal regeneration after injury in mice, with senolytic treatment promoting repair

2021

Journal Article

Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Abani, Obbina, Abbas, Ali, Abbas, Fatima, Abbas, Mustafa, Abbasi, Sadia, Abbass, Hakam, Abbott, Alfie, Abdallah, Nabeel, Abdelaziz, Ashraf, Abdelfattah, Mohamed, Abdelqader, Bushra, Abdul, Basir, Abdul Rasheed, Althaf, Abdulakeem, Ajibode, Abdul-Kadir, Rezan, Abdulmumeen, Abdulfatahi, Abdul-Raheem, Rasheed, Abdulshukkoor, Niyaz, Abdusamad, Kula, Abed El Khaleq, Yazeed, Abedalla, Mai, Abeer Ul Amna, Abeer, Abernethy, Katrina, Aboaba, Adebanke, Abo-Leyah, Hani, Abou-Haggar, Ahmed, Abouibrahim, Mahmoud, Abraham, Miriam, Abraham, Tizzy ... RECOVERY Collaborative Group (2021). Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet, 397 (10285), 1637-1645. doi: 10.1016/S0140-6736(21)00676-0

Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

2021

Journal Article

The future role of machine learning in clinical transplantation

Connor, Katie L., O’Sullivan, Eoin D., Marson, Lorna P., Wigmore, Stephen J. and Harrison, Ewen M. (2021). The future role of machine learning in clinical transplantation. Transplantation, 105 (4), 723-735. doi: 10.1097/TP.0000000000003424

The future role of machine learning in clinical transplantation

2021

Journal Article

Prolonged SARS-CoV-2 viral shedding in patients with chronic kidney disease

O'Sullivan, Eoin D., Lees, Jennifer S., Howie, Katie L., Pugh, Dan, Gillis, Keith A., Traynor, Jamie P., Macintyre, Iain and Mark, Patrick B. (2021). Prolonged SARS-CoV-2 viral shedding in patients with chronic kidney disease. Nephrology, 26 (4), 328-332. doi: 10.1111/nep.13844

Prolonged SARS-CoV-2 viral shedding in patients with chronic kidney disease

2021

Journal Article

Interventions for atypical haemolytic uraemic syndrome

Pugh, Dan, O'Sullivan, Eoin D., Duthie, Fiona A. I., Masson, Philip and Kavanagh, David (2021). Interventions for atypical haemolytic uraemic syndrome. Cochrane Database of Systematic Reviews, 2021 (3) CD012862. doi: 10.1002/14651858.CD012862.pub2

Interventions for atypical haemolytic uraemic syndrome

2021

Journal Article

Dexamethasone in Hospitalized Patients with Covid-19

RECOVERY Collaborative Group, Horby, Peter, Lim, Wei Shen, Emberson, Jonathan R., Mafham, Marion, Bell, Jennifer L., Linsell, Louise, Staplin, Natalie, Brightling, Christopher, Ustianowski, Andrew, Elmahi, Einas, Prudon, Benjamin, Green, Christopher, Felton, Timothy, Chadwick, David, Rege, Kanchan, Fegan, Christopher, Chappell, Lucy C., Faust, Saul N., Jaki, Thomas, Jeffery, Katie, Montgomery, Alan, Rowan, Kathryn, Juszczak, Edmund, Baillie, J Kenneth, Haynes, Richard, Landray, Martin J. and O'Sullivan, Eoin (2021). Dexamethasone in Hospitalized Patients with Covid-19. The New England Journal of Medicine, 384 (8), 693-704. doi: 10.1056/NEJMoa2021436

Dexamethasone in Hospitalized Patients with Covid-19

2021

Journal Article

Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Abaleke, Eugenia, Abbas, Mustafa, Abbasi, Sadia, Abbott, Alfie, Abdelaziz, Ashraf, Abdelbadiee, Sherif, Abdelfattah, Mohamed, Abdul, Basir, Abdul Rasheed, Althaf, Abdul-Kadir, Rezan, Abdulmumeen, Abdulfatahi, Abdulshukkoor, Niyaz, Abdusamad, Kula, Abed El Khaleq, Yazeed, Abedalla, Mai, Abeer Ul Amna, Abeer UA, Aboaba, Adebanke, Abo-Leyah, Hani, Abou-Haggar, Ahmed, Abouibrahim, Mahmoud, Abraham, Miriam, Abraham, Tizzy, Abraheem, Abraheem, Abrams, Judith, Abu, Hyacinth-John, Abu-Arafeh, Ahmad, Abubacker, Syed M, Abung, Akata, Aceampong, Yaa ... RECOVERY Collaborative Group (2021). Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial. The Lancet, 397 (10274), 605-612. doi: 10.1016/S0140-6736(21)00149-5

Azithromycin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

2020

Journal Article

Kidney single-cell atlas reveals myeloid heterogeneity in progression and regression of kidney disease

Conway, Bryan R., O’Sullivan, Eoin D., Cairns, Carolynn, O’Sullivan, James, Simpson, Daniel J., Salzano, Angela, Connor, Katie, Ding, Peng, Humphries, Duncan, Stewart, Kevin, Teenan, Oliver, Pius, Riinu, Henderson, Neil C., Bénézech, Cécile, Ramachandran, Prakash, Ferenbach, David, Hughes, Jeremy, Chandra, Tamir and Denby, Laura (2020). Kidney single-cell atlas reveals myeloid heterogeneity in progression and regression of kidney disease. Journal of the American Society of Nephrology, 31 (12), 2833-2854. doi: 10.1681/ASN.2020060806

Kidney single-cell atlas reveals myeloid heterogeneity in progression and regression of kidney disease

2020

Journal Article

Effect of hydroxychloroquine in hospitalized patients with Covid-19

RECOVERY Collaborative Group, Horby, Peter, Mafham, Marion, Linsell, Louise, Bell, Jennifer L, Staplin, Natalie, Emberson, Jonathan R, Wiselka, Martin, Ustianowski, Andrew, Elmahi, Einas, Prudon, Benjamin, Whitehouse, Tony, Felton, Timothy, Williams, John, Faccenda, Jakki, Underwood, Jonathan, Baillie, J Kenneth, Chappell, Lucy C, Faust, Saul N, Jaki, Thomas, Jeffery, Katie, Lim, Wei Shen, Montgomery, Alan, Rowan, Kathryn, Tarning, Joel, Watson, James A, White, Nicholas J, Juszczak, Edmund, Haynes, Richard ... O'Sullivan, Eoin (RECOVERY Collaborative Group member) (2020). Effect of hydroxychloroquine in hospitalized patients with Covid-19. The New England Journal of Medicine, 383 (21), 2030-2040. doi: 10.1056/NEJMoa2022926

Effect of hydroxychloroquine in hospitalized patients with Covid-19

2020

Journal Article

Individual patient risk assessment and cost–benefit analysis of patiromer in AMBER

O'Sullivan, Eoin D. and MacIntyre, Iain M. (2020). Individual patient risk assessment and cost–benefit analysis of patiromer in AMBER. The Lancet, 396 (10247), 311-311. doi: 10.1016/S0140-6736(20)30545-6

Individual patient risk assessment and cost–benefit analysis of patiromer in AMBER

2020

Journal Article

PPE guidance for covid-19: be honest about resource shortages

O'Sullivan, Eoin D. (2020). PPE guidance for covid-19: be honest about resource shortages. The BMJ, 369 m1507. doi: 10.1136/bmj.m1507

PPE guidance for covid-19: be honest about resource shortages

2019

Journal Article

Motivators and barriers to engagement with evidence-based practice among medical and dental trainees from the UK and Republic of Ireland: a national survey

Hong, Bosun, O'Sullivan, Eoin Daniel, Henein, Christin and Jones, Christopher Mark (2019). Motivators and barriers to engagement with evidence-based practice among medical and dental trainees from the UK and Republic of Ireland: a national survey. BMJ Open, 9 (10) 031809, e031809. doi: 10.1136/bmjopen-2019-031809

Motivators and barriers to engagement with evidence-based practice among medical and dental trainees from the UK and Republic of Ireland: a national survey