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2013 Journal Article Pharmacologic stabilization of HIF-1α increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiationForristal, Catherine E., Winkler, Ingrid G., Nowlan, Bianca, Barbier, Valerie, Walkinshaw, Gail and Levesque, Jean-Pierre (2013). Pharmacologic stabilization of HIF-1α increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiation. Blood, 121 (5), 759-769. doi: 10.1182/blood-2012-02-408419 |
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2013 Conference Publication Mobilising Doses of G-Csf Stop Medullary Erythropoiesis by Depleting Cd169+MacrophagesJacobsen, Rebecca, Pettit, Allison, Barbier, Valerie, Nowlan, Bianca, Raggatt, Liza, Winkler, Ingrid and Levesque, Jean-Pierre (2013). Mobilising Doses of G-Csf Stop Medullary Erythropoiesis by Depleting Cd169+Macrophages. 42nd Annual Scientific Meeting of ISEH - Society for Hematology and Stem Cells, Vienna, Austria, 22-25 August 2013. Philadelphia, PA United States: Elsevier Inc. doi: 10.1016/j.exphem.2013.05.230 |
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2013 Conference Publication Mobilizing Doses Of G-CSF Stop Medullary Erythropoiesis By Depleting F4/8o+VCAM1+ER-HR3+CD169+Erythroid-Island MacrophagesJacobsen, Rebecca, Pettit, Allison R., Raggatt, Liza J., Nowlan, Bianca, Barbier, Valerie, Forristal, Catherine E., Winkler, Ingrid G. and Levesque, Jean-Pierre (2013). Mobilizing Doses Of G-CSF Stop Medullary Erythropoiesis By Depleting F4/8o+VCAM1+ER-HR3+CD169+Erythroid-Island Macrophages. 55th Annual Meeting of the American-Society-of-Hematology, New Orleans, LA, United States, 7-10 December 2013. WASHINGTON: AMER SOC HEMATOLOGY. |
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2013 Journal Article E-selectin, a key regulator of the division of hematopoietic stem cells and their resistance to chemotherapyLevesque, Jean-Pierre and Winkler, Ingrid G. (2013). E-selectin, a key regulator of the division of hematopoietic stem cells and their resistance to chemotherapy. Medecine/Sciences, 29 (3), 249-251. doi: 10.1051/medsci/2013293007 |
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2012 Conference Publication FG-4497, a Pharmacological Stabilizer of HIF-1 alpha Protein, Synergistically Enhances Hematopoietic Stem Cells (HSC) Mobilization in Response to G-CSF and PlerixaforForristal, Catherine E., Nowlan, Bianca, Barbier, Valerie, Winkler, Ingrid G., Walkinshaw, Gail and Levesque, Jean-Pierre (2012). FG-4497, a Pharmacological Stabilizer of HIF-1 alpha Protein, Synergistically Enhances Hematopoietic Stem Cells (HSC) Mobilization in Response to G-CSF and Plerixafor. 54th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Atlanta, GA, United States, 8-11 December 2012. Washington, DC, United States: American Society of Hematology. doi: 10.1182/blood.V120.21.216.216 |
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2012 Journal Article Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistanceWinkler, Ingrid G., Barbier, Valerie, Nowlan, Bianca, Jacobsen, Rebecca N., Forristal, Catherine E., Patton, John T., Magnani, John L. and Levesque, Jean-Pierre (2012). Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance. Nature Medicine, 18 (11), 1651-1657. doi: 10.1038/nm.2969 |
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2012 Journal Article Hematopoietic stem cell mobilizing agents G-CSF, cyclophosphamide or AMD3100 have distinct mechanisms of action on bone marrow HSC niches and bone formationWinkler, I. G., Pettit, A. R., Raggatt, L. J., Jacobsen, R. N., Forristal, C. E., Barbier, V., Nowlan, B., Cisterne, A., Bendall, L. J., Sims, N. A. and Levesque, J-P. (2012). Hematopoietic stem cell mobilizing agents G-CSF, cyclophosphamide or AMD3100 have distinct mechanisms of action on bone marrow HSC niches and bone formation. Leukemia, 26 (7), 1594-1601. doi: 10.1038/leu.2012.17 |
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2012 Book Chapter Flow cytometry measurement of bone marrow perfusion in the mouse and sorting of progenitors and stems cells according to position relative to blood flow in vivoBarbier, Valérie, Winkler, Ingrid G., Wadley, Robert and Lévesque, Jean-Pierre (2012). Flow cytometry measurement of bone marrow perfusion in the mouse and sorting of progenitors and stems cells according to position relative to blood flow in vivo. Leucocytes: methods and protocols. (pp. 45-63) edited by Ashman, RB. New York, United States: Humana Press. doi: 10.1007/978-1-61779-527-5_4 |
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2012 Conference Publication Hypoxia and E-selectin are opposite regulators of hematopoietic stem cell quiescence in the nicheLevesque, Jean-Pierre, Forristal, Catherine and Winkler, Ingrid (2012). Hypoxia and E-selectin are opposite regulators of hematopoietic stem cell quiescence in the niche. 41st Annual Scientific Meeting of the ISEH Society for Hematology and Stem Cells, Amsterdam Netherlands, 23-26 August 2012. Philadelphia, PA United States: Elsevier. |
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2012 Book Chapter Flow cytometry analysis of cell cycling and proliferation in mouse hematopoietic stem and progenitor cellsBarbier, Valérie, Nowlan, Bianca, Lévesque, Jean-Pierre and Winkler, Ingrid G. (2012). Flow cytometry analysis of cell cycling and proliferation in mouse hematopoietic stem and progenitor cells. Leucocytes: methods and protocols. (pp. 31-43) edited by Ashman, RB. New York, United States: Humana Press. doi: 10.1007/978-1-61779-527-5_3 |
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2012 Book Chapter Mobilization of hematopoietic stem cells by depleting bone marrow macrophagesBarbier, Valerie, Winkler, Ingrid G. and Levesque, Jean-Paul (2012). Mobilization of hematopoietic stem cells by depleting bone marrow macrophages. In Stem cell mobilization: methods and protocols (pp. 117-137) New York, United States: Humana Press. doi:10.1007/978-1-61779-943-3_11 |
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2012 Conference Publication Interaction of c-Myb with p300 is required for the induction of acute myeloid leukemia by human AML oncogenes, and represents a potential therapeutic targetPattabiraman, Diwakar R., Shakhbazov, Konstantin, Barbier, Valerie, McGirr, Crystal, Krishnan, Keerthana, Mukhopadhyay, Pamela, Hawthorne, Paula, Trezise, Ann, Grimmond, Sean, Papathanasiou, Peter, Perkins, Andrew C., Levesque, Jean-Pierre, Alexander, Warren S., Winkler, Ingrid G. and Gonda, Thomas J. (2012). Interaction of c-Myb with p300 is required for the induction of acute myeloid leukemia by human AML oncogenes, and represents a potential therapeutic target. 54th Annual Meeting and Exposition of the American Society of Hematology (ASH), Atlanta, GA, United States, 8-11 Deceember, 2012. Washington, DC, United States: American Society of Hematology. doi: 10.1182/blood.V120.21.2402.2402 |
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2011 Conference Publication Oxygen-Independent Stabilization of the Oxygen-Labile Transcription Factor HIF-1 alpha with Dimethyloxalyl Glycine or FG-4497 Increases Hematopoietic Stem Cell Quiescence In Vivo and Mobilization in Response to G-CSFForristal, Catherine, Nowlan, Bianca, Barbier, Valerie, McCarthy, Domenica, Walkinshaw, Gail, Winkler, Ingrid G. and Levesque, Jean-Pierre (2011). Oxygen-Independent Stabilization of the Oxygen-Labile Transcription Factor HIF-1 alpha with Dimethyloxalyl Glycine or FG-4497 Increases Hematopoietic Stem Cell Quiescence In Vivo and Mobilization in Response to G-CSF. 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, San Diego, CA, United States, 10-13 December 2011. Washington, DC, United States: American Society of Hematology. |
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2011 Conference Publication Impairment of Hematopoietic Stem Cell (HSC) Niche by G-CSF Is Associated with Rapid Mobilization of Serially Reconstituting HSC and Reduced Competitive Repopulation of Mobilized Bone MarrowLevesque, Jean-Pierre, Barbier, Valerie, Nowlan, Bianca, McCarhty, Domenica and Winkler, Ingrid G. (2011). Impairment of Hematopoietic Stem Cell (HSC) Niche by G-CSF Is Associated with Rapid Mobilization of Serially Reconstituting HSC and Reduced Competitive Repopulation of Mobilized Bone Marrow. 53rd Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/Symposium on the Basic Science of Hemostasis and Thrombosis, San Diego, CA, United States, 10-13 December 2011. Washington, DC, United States: American Society of Hematology. |
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2011 Journal Article Mobilisation strategies for normal and malignant cellsTo, L. Bik, Levesque, Jean-Pierre, Herbert, Kirsten E., Winkler, Ingrid G., Bendall, Linda J., Hiwase, Devendra K., Antonenas, Vicki, Rice, Alison M., Gottlieb, David, Mills, Anthony K., Rasko, John E. J., Larsen, Stephen, Beligaswatte, Ashanka, Nilsson, Susan K., Cooney, Julian P., Cambareri, Antony C. and Lewis, Ian D. (2011). Mobilisation strategies for normal and malignant cells. Pathology, 43 (6), 547-565. doi: 10.1097/PAT.0b013e32834a9eb8 |
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2011 Conference Publication Mobilizing agents G-CSF, cyclophosphamide or AMD3100 (Plerixafor) Have distinct effects on osteoblasts, hematopoietic stem cell niches, and B-LymphopoiesisLevesque, Jean-Pierre, Bendall, Linda J., Pettit, Allison R., Raggatt, Liza, Jacobsen, Rebecca, Barbier, Valarie, Nowlan, Bianca, Shen, Yi Shen, Sims, Natalie A. and Winkler, Ingrid G. (2011). Mobilizing agents G-CSF, cyclophosphamide or AMD3100 (Plerixafor) Have distinct effects on osteoblasts, hematopoietic stem cell niches, and B-Lymphopoiesis. 53rd Annual Meeting and Exposition of the American Society of Hematology (ASH), San Diego CA, United States, 10-13 December 2011. Washington, DC, United States: American Society of Hematology. |
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2011 Journal Article Hierarchy of immature hematopoietic cells related to blood flow and nicheLevesque, Jean-Pierre and Winkler, Ingrid G. (2011). Hierarchy of immature hematopoietic cells related to blood flow and niche. Current Opinion in Hematology, 18 (4), 220-225. doi: 10.1097/MOH.0b013e3283475fe7 |
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2010 Journal Article Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCsWinkler, Ingrid G., Sims, Natalie A., Pettit, Allison R., Barbier, Valérie, Nowlan, Bianca, Helwani, Falak, Poulton, Ingrid J., van Rooijen, Nico van, Alexander, Kylie A., Raggatt, Liza J. and Levesque, Jean-Pierre (2010). Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs. Blood, 116 (23), 4815-4828. doi: 10.1182/blood-2009-11-253534 |
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2010 Journal Article Tissue inhibitor of metalloproteinase-3 (TIMP-3) regulates hematopoiesis and bone formation in vivoShen, Yi, Winkler, Ingrid G., Barbier, Valerie, Sims, Natalie A., Hendy, Jean and Lévesque, Jean-Pierre (2010). Tissue inhibitor of metalloproteinase-3 (TIMP-3) regulates hematopoiesis and bone formation in vivo. PLoS One, 5 (9) e13086, e13086-1-e13086-13. doi: 10.1371/journal.pone.0013086 |
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2010 Conference Publication A molecular profile of the hematopoietic stem cell niche at the endosteumHelwani, F., Winkler, I., Price, G. and Levesque, J. P. (2010). A molecular profile of the hematopoietic stem cell niche at the endosteum. 39th Annual Scientific Meeting of the ISEH - Society for Hematology and Stem Cells, Melbourne, VIC, Australia, 15-18 September 2010. Philadelphia, PA, United States: Elsevier. |
