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2012 Journal Article Clinical trial in healthy malaria-naïve adults to evaluate the safety, tolerability, immunogenicity and efficacy of MuStDO5, a five-gene, sporozoite/hepatic stage Plasmodium falciparum DNA vaccine combined with escalating dose human GM-CSF DNARichie, Thomas L, Charoenvit, Yupin, Wang, Ruobing, Epstein, Judith E, Hedstrom, Richard C, Kumar, Sanjai, Luke, Thomas C, Freilich, Daniel A, Aguiar, Joao C, Sacci, John B, Sedegah, Martha, Nosek, Ronald A, De La Vega, Patricia, Berzins, Mara P, Majam, Victoria F, Abot, Esteban N, Ganeshan, Harini, Richie, Nancy O, Banania, Jo Glenna, Baraceros, Maria Fe B, Geter, Tanya G, Mere, Robin, Bebris, Lolita, Limbach, Keith, Hickey, Bradley W, Lanar, David E, Ng, Jennifer, Shi, Meng, Hobart, Peter M ... Hoffman, Stephen L (2012). Clinical trial in healthy malaria-naïve adults to evaluate the safety, tolerability, immunogenicity and efficacy of MuStDO5, a five-gene, sporozoite/hepatic stage Plasmodium falciparum DNA vaccine combined with escalating dose human GM-CSF DNA. Human Vaccines and Immunotherapeutics, 8 (11), 1564-1584. doi: 10.4161/hv.22129 |
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2012 Journal Article Addressing the bottleneck at clinical testing of candidate malaria vaccinesDoolan, Denise L. and Apte, Simon H. (2012). Addressing the bottleneck at clinical testing of candidate malaria vaccines. Pathogens and Global Health, 106 (6). doi: 10.1179/2047772412Z.00000000081 |
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2012 Conference Publication Dissecting T cell or antibody immunodominance in a complex host-pathogen systemProietti, Carla, Krause, Lutz, Roddick, Joanne, Trieu, Angela and Doolan, Denise L. (2012). Dissecting T cell or antibody immunodominance in a complex host-pathogen system. Challenges in Malaria Research, Basel, Switzerland, 10-12 October 2012. London, United Kingdom: BioMed Central. doi: 10.1186/1475-2875-11-s1-o23 |
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2012 Journal Article Vaccination with lipid core peptides fails to induce epitope-specific T cell responses but confers non-specific protective immunity in a malaria model.Apte, Simon H., Groves, Penny L., Skwarczynski, Mariusz, Fujita, Yoshio, Chang, Chenghung, Toth, Istvan and Doolan, Denise L. (2012). Vaccination with lipid core peptides fails to induce epitope-specific T cell responses but confers non-specific protective immunity in a malaria model.. PLoS One, 7 (8 Article. No.e40928) e40928, e40928. doi: 10.1371/journal.pone.0040928 |
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2012 Book Chapter Schistosomiasis Vaccines - New Approaches to Antigen Discovery and Promising New CandidatesLoukas, Alex, Gaze, Soraya, Pearson, Mark, Doolan, Denise, Felgner, Philip, Diemert, David, Mcmanus, Donald P., Driguez, Patrick and Bethony, Jeffrey (2012). Schistosomiasis Vaccines - New Approaches to Antigen Discovery and Promising New Candidates. Parasitic Helminths: Targets, Screens, Drugs and Vaccines. (pp. 421-433) Wiley-VCH. doi: 10.1002/9783527652969.ch25 |
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2012 Journal Article Correction: Modification of Ad5 hexon hypervariable regions circumvents pre-existing Ad5 neutralizing antibodies and induces protective immune responsesBruder, Joseph T., Semenova, Elena, Chen, Ping, Limbach, Keith, Patterson, Noelle B., Stefaniak, Maureen E., Konovalova, Svetlana, Thomas, Charlie, Hamilton, Melissa, King, C. Richter, Richie, Thomas L. and Doolan, Denise L. (2012). Correction: Modification of Ad5 hexon hypervariable regions circumvents pre-existing Ad5 neutralizing antibodies and induces protective immune responses. PLoS One, 7 (5). doi: 10.1371/annotation/c110beed-3cac-48db-9039-ba4498d5db50 |
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2012 Journal Article Modification of Ad5 hexon hypervariable regions circumvents pre-existing Ad5 neutralizing antibodies and induces protective immune responsesBruder, Joseph T., Semenova, Elena, Chen, Ping, Limbach, Keith, Patterson, Noelle B., Stefaniak, Maureen E., Konovalova, Svetlana, Thomas, Charlie, Hamilton, Melissa, King, C. Richter, Richie, Thomas L. and Doolan, Denise L. (2012). Modification of Ad5 hexon hypervariable regions circumvents pre-existing Ad5 neutralizing antibodies and induces protective immune responses. PLoS One, 7 (4) e33920, 1-13. doi: 10.1371/journal.pone.0033920 |
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2012 Journal Article The role of age and exposure to Plasmodium falciparum in the rate of acquisition of naturally acquired immunity: a randomized controlled trialGuinovart, Caterina, Dobaño, Carlota, Bassat, Quique, Nhabomba, Augusto, Quintó, Llorenç, Manaca, Maria Nélia, Aguilar, Ruth, Rodríguez, Mauricio H, Barbosa, Arnoldo, Aponte, John J, Mayor, Alfredo G, Renom, Montse, Moraleda, Cinta, Roberts, David J, Schwarzer, Evelin, Le Souëf, Peter N, Schofield, Louis, Chitnis, Chetan E, Doolan, Denise L and Alonso, Pedro L (2012). The role of age and exposure to Plasmodium falciparum in the rate of acquisition of naturally acquired immunity: a randomized controlled trial. PLoS One, 7 (3) e32362, 1-11. doi: 10.1371/journal.pone.0032362 |
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2012 Journal Article Intermittent preventive treatment with sulfadoxine-pyrimethamine does not modify plasma cytokines and chemokines or intracellular cytokine responses to Plasmodium falciparum in Mozambican childrenQuelhas, Diana, Puyol, Laura, Quintó, Llorenç, Nhampossa, Tacilta, Serra-Casas, Elisa, Macete, Eusébio, Aide, Pedro, Sanz, Sergi, Aponte, John J, Doolan, Denise L, Alonso, Pedro L, Menéndez, Clara and Dobaño, Carlota (2012). Intermittent preventive treatment with sulfadoxine-pyrimethamine does not modify plasma cytokines and chemokines or intracellular cytokine responses to Plasmodium falciparum in Mozambican children. BMC Immunology, 13 (1) 5, 1-18. doi: 10.1186/1471-2172-13-5 |
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2011 Journal Article EditorialDoolan, Denise L. and Spithill, Terry (2011). Editorial. International Journal for Parasitology: Drugs and Drug Resistance, 1 (1), 1-1. doi: 10.1016/j.ijpddr.2011.09.001 |
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2011 Journal Article Evaluation of approaches to identify the targets of cellular immunity on a proteome-wide scaleCardoso, Fernanda C., Roddick, Joanne S., Groves, Penny and Doolan, Denise L. (2011). Evaluation of approaches to identify the targets of cellular immunity on a proteome-wide scale. Plos One, 6 (11) e27666, e27666.1-e27666.14. doi: 10.1371/journal.pone.0027666 |
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2011 Journal Article The stability and complexity of antibody responses to the major surface antigen of plasmodium falciparum are associated with age in a malaria endemic areaBarry, Alyssa E., Trieu, Angela, Fowkes, Freya J. I., Pablo, Jozelyn, Kalantari-Dehaghi, Matthew, Jasinskas, Algis, Tan, Xiaolin, Kayala, Matthew A., Tavul, Livingstone, Siba, Peter M., Day, Karen P., Baldi, Pierre, Felgner, Philip L. and Doolan, Denise L. (2011). The stability and complexity of antibody responses to the major surface antigen of plasmodium falciparum are associated with age in a malaria endemic area. Molecular and Cellular Proteomics, 10 (11) M111.008326, 1-12. doi: 10.1074/mcp.M111.008326 |
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2011 Journal Article Adenovirus 5-vectored P. falciparum vaccine expressing CSP and AMA1. Part A: safety and immunogenicity in seronegative adultsSedegah, Martha, Tamminga, Cindy, McGrath, Shannon, House, Brent, Ganeshan, Harini, Lejano, Jennylynn, Abot, Esteban, Banania, Glenna J, Sayo, Renato, Farooq, Fouzia, Belmonte, Maria, Manohar, Nalini, Richie, Nancy O, Wood, Chloe, Long, Carole A, Regis, David, Williams, Francis T, Shi, Meng, Chuang, Ilin, Spring, Michele, Epstein, Judith E, Mendoza-Silveiras, Jose, Limbach, Keith, Patterson, Noelle B, Bruder, Joseph T, Doolan, Denise L, King, C Richter, Soisson, Lorraine, Diggs, Carter ... Richie, Thomas L (2011). Adenovirus 5-vectored P. falciparum vaccine expressing CSP and AMA1. Part A: safety and immunogenicity in seronegative adults. PLoS One, 6 (10) e24586, 1-22. doi: 10.1371/journal.pone.0024586 |
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2011 Journal Article Adenovirus-5-vectored P. falciparum vaccine expressing CSP and AMA1. Part B: safety, immunogenicity and protective efficacy of the CSP componentTamminga, Cindy, Sedegah, Martha, Regis, David, Chuang, Ilin, Epstein, Judith E, Spring, Michele, Mendoza-Silveiras, Jose, McGrath, Shannon, Maiolatesi, Santina, Reyes, Sharina, Steinbeiss, Victoria, Fedders, Charlotte, Smith, Kathryn, House, Brent, Ganeshan, Harini, Lejano, Jennylynn, Abot, Esteban, Banania, Glenna J, Sayo, Renato, Farooq, Fouzia, Belmonte, Maria, Murphy, Jittawadee, Komisar, Jack, Williams, Jackie, Shi, Meng, Brambilla, Donald, Manohar, Nalini, Richie, Nancy O, Wood, Chloe ... Richie, Thomas L (2011). Adenovirus-5-vectored P. falciparum vaccine expressing CSP and AMA1. Part B: safety, immunogenicity and protective efficacy of the CSP component. PLoS One, 6 (10) e25868, 1-20. doi: 10.1371/journal.pone.0025868 |
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2011 Journal Article High-throughput multi-parameter flow-cytometric analysis from micro-quantities of plasmodium-infected bloodApte, Simon H., Groves, Penny L., Roddick, Joanne S., P da Hora, Vanusa and Doolan, Denise L. (2011). High-throughput multi-parameter flow-cytometric analysis from micro-quantities of plasmodium-infected blood. International Journal for Parasitology, 41 (12), 1285-94. doi: 10.1016/j.ijpara.2011.07.010 |
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2011 Conference Publication Intermittent preventive treatment with sulfadoxine-pyrimethamine does not modify levels of antibodies against variant surface antigens, growth inhibitory antibodies, or cytokine responses to <i>Plasmodium falciparum</i> in Mozambican childrenQuelhas, D., Puyol, L., Jimenez, A., Quinto, L., Serra-Casas, E., Mayor, A., Nhampossa, T., Macete, E., Aide, P., Aponte, J., Alonso, P. L., Doolan, D., Beeson, J. G., Menendez, C. and Dobano, C. (2011). Intermittent preventive treatment with sulfadoxine-pyrimethamine does not modify levels of antibodies against variant surface antigens, growth inhibitory antibodies, or cytokine responses to Plasmodium falciparum in Mozambican children. MALDEN: WILEY-BLACKWELL. |
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2011 Conference Publication Immune responses to <i>Plasmodium falciparum</i> in a cohort of Mozambican pregnant women and their children in relation to age, exposure and clinical outcomesDobano, C., Mayor, A. G., Nhabomba, A., Manaca, N., Guinovart, C., Berthoud, T., Quinto, L., Aguilar, R., Barbosa, A., Jimenez, A., Bassat, Q., Aponte, J. J., Chitnis, C., Doolan, D. L. and Alonso, P. L. (2011). Immune responses to Plasmodium falciparum in a cohort of Mozambican pregnant women and their children in relation to age, exposure and clinical outcomes. MALDEN: WILEY-BLACKWELL. |
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2011 Journal Article Sterile protective immunity to malaria is associated with a panel of novel P. falciparum antigensTrieu, Angela, Kayala, Matthew A., Burk, Chad, Molina, Douglas M., Freilich, Daniel A., Richie, Thomas L., Baldi, Pierre, Felgner, Philip L. and Doolan, Denise L. (2011). Sterile protective immunity to malaria is associated with a panel of novel P. falciparum antigens. Molecular and Cellular Proteomics, 10 (9) M111.007948, 1-15. doi: 10.1074/mcp.M111.007948 |
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2011 Journal Article Vaccinomics for the major blood feeding helminths of humansLoukas, Alex, Gaze, Soraya, Mulvenna, Jason P., Gasser, Robin B, Brindley, Paul J., Doolan, Denise L., Bethony, Jeffrey M., Jones, Malcolm K., Gobert, Geoffrey N., Driguez, Patrick, McManus, Donald P. and Hotez, Peter J. (2011). Vaccinomics for the major blood feeding helminths of humans. OMICS: A Journal of Integrative Biology, 15 (9), 567-577. doi: 10.1089/omi.2010.0150 |
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2011 Journal Article Toward a surrogate marker of malaria exposure: Modeling longitudinal antibody measurements under outbreak conditionsCampo, Joseph J., Whitman, Timothy J., Freilich, Daniel, Burgess, Timothy H., Martin, Gregory J. and Doolan, Denise L. (2011). Toward a surrogate marker of malaria exposure: Modeling longitudinal antibody measurements under outbreak conditions. PLoS One, 6 (7) e21826, 1-6. doi: 10.1371/journal.pone.0021826 |
