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2001 Journal Article Determining liver stage parasite burden by real time quantitative PCR as a method for evaluating pre-erythrocytic malaria vaccine efficacyWitney, Adam A., Doolan, Denise L., Anthony, Robert M., Weiss, Walter R., Hoffman, Stephen L. and Carucci, Daniel J. (2001). Determining liver stage parasite burden by real time quantitative PCR as a method for evaluating pre-erythrocytic malaria vaccine efficacy. Molecular and Biochemical Parasitology, 118 (2), 233-245. doi: 10.1016/S0166-6851(01)00372-3 |
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2001 Journal Article Foreword--MBP thematic issue on genomicsDoolan, D. L., Coppel, R. L. and Waters, A. P. (2001). Foreword--MBP thematic issue on genomics. Molecular and Biochemical Parasitology, 118 (2), 127-8. doi: 10.1016/s0166-6851(01)00389-9 |
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2001 Journal Article Expression of the chemokine MIG is a sensitive and predictive marker for antigen-specific, genetically restricted IFN-γ production and IFN-γ-secreting cellsBrice, G. T., Graber, N. L., Hoffman, S. L. and Doolan, D. L. (2001). Expression of the chemokine MIG is a sensitive and predictive marker for antigen-specific, genetically restricted IFN-γ production and IFN-γ-secreting cells. Journal of Immunological Methods, 257 (1-2), 55-69. doi: 10.1016/s0022-1759(01)00446-x |
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2001 Journal Article Induction of CD4+ T cell-dependent CD8+ type 1 responses in humans by a malaria DNA vaccineWang, Ruobing, Epstein, Judith, Baraceros, Fe Maria, Gorak, Edward J., Charoenvit, Yupin, Carucci, Daniel J., Hedstrom, Richard C., Rahardjo, Nancy, Gay, Tanya, Hobart, Peter, Stout, Rick, Jones, Trevor R., Richie, Thomas L., Parker, Suezanne E., Doolan, Denise L., Norman, Jon and Hoffman, Stephen L. (2001). Induction of CD4+ T cell-dependent CD8+ type 1 responses in humans by a malaria DNA vaccine. Proceedings of the National Academy of Sciences of the United States of America, 98 (19), 10817-10822. doi: 10.1073/pnas.181123498 |
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2001 Journal Article DNA-based vaccines against malaria: Status and promise of the Multi-Stage Malaria DNA Vaccine OperationDoolan, Denise L and Hoffman, Stephen L (2001). DNA-based vaccines against malaria: Status and promise of the Multi-Stage Malaria DNA Vaccine Operation. International Journal for Parasitology, 31 (8), 753-762. doi: 10.1016/S0020-7519(01)00184-9 |
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2001 Journal Article Interleukin-12- and gamma interferon-dependent protection against malaria conferred by CpG oligodeoxynucleotide in miceGramzinski, R. A., Doolan, D. L., Sedegah, M., Davis, H. L., Krieg, A. M. and Hoffman, S. L. (2001). Interleukin-12- and gamma interferon-dependent protection against malaria conferred by CpG oligodeoxynucleotide in mice. Infection and Immunity, 69 (3), 1643-1649. doi: 10.1128/IAI.69.3.1643-1649.2001 |
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2000 Journal Article Malaria vaccines-targeting infected hepatocytesHoffman, Stephen L. and Doolan, Denise L. (2000). Malaria vaccines-targeting infected hepatocytes. Nature Medicine, 6 (11), 1218-1219. doi: 10.1038/81315 |
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2000 Journal Article HLA degenerate T-cell epitopes from Plasmodium falciparum liver stage-specific antigen 1 (LSA-1) are highly conserved in isolates from geographically distinct areasRavichandran, M., Doolan, D. L., Cox-Singh, J., Hoffman, S. L. and Singh, B. (2000). HLA degenerate T-cell epitopes from Plasmodium falciparum liver stage-specific antigen 1 (LSA-1) are highly conserved in isolates from geographically distinct areas. Parasite Immunology, 22 (9), 469-473. doi: 10.1046/j.1365-3024.2000.00324.x |
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2000 Journal Article The complexity of protective immunity against liver-stage malariaDoolan, Denise L. and Hoffman, Stephen L. (2000). The complexity of protective immunity against liver-stage malaria. Journal of Immunology, 165 (3), 1453-1462. doi: 10.4049/jimmunol.165.3.1453 |
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2000 Journal Article HLA-DR-promiscuous T cell epitopes frown Plasmodium falciparum pre- erythrocytic-stage antigens restricted by multiple HLA class II allelesDoolan, Denise L., Southwood, Scott, Chesnut, Robert, Appella, Ettore, Gomez, Eduardo, Richards, Allen, Higashimoto, Yuichiro I., Maewal, Ajesh, Sidney, John, Gramzinski, Robert A., Mason, Carl, Koech, Davy, Hoffman, Stephen L. and Sette, Alessandro (2000). HLA-DR-promiscuous T cell epitopes frown Plasmodium falciparum pre- erythrocytic-stage antigens restricted by multiple HLA class II alleles. Journal of Immunology, 165 (2), 1123-1137. doi: 10.4049/jimmunol.165.2.1123 |
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2000 Journal Article Safety, tolerability and humoral immune responses after intramuscular administration of a malaria DNA vaccine to healthy adult volunteersLe, T. P., Coonan, K. M., Hedstrom, R. C., Charoenvit, Y., Sedegah, M., Epstein, J. E., Kumar, S., Wang, R., Doolan, D. L., Maguire, J. D., Parker, S. E., Hobart, P., Norman, J. and Hoffman, S. L. (2000). Safety, tolerability and humoral immune responses after intramuscular administration of a malaria DNA vaccine to healthy adult volunteers. Vaccine, 18 (18), 1893-1901. doi: 10.1016/s0264-410x(99)00407-7 |
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2000 Journal Article Can malaria DNA vaccines on their own be as immunogenic and protective as prime-boost approaches to immunization?Hoffman, S. L. and Doolan, D. L. (2000). Can malaria DNA vaccines on their own be as immunogenic and protective as prime-boost approaches to immunization?. Developments in biologicals, 104, 121-132. |
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1999 Journal Article IL-12 and NK cells are required for antigen-specific adaptive immunity against malaria initiated by CD8+ T cells in the Plasmodium yoelii modelDoolan, Denise L. and Hoffman, Stephen L. (1999). IL-12 and NK cells are required for antigen-specific adaptive immunity against malaria initiated by CD8+ T cells in the Plasmodium yoelii model. Journal of Immunology, 163 (2), 884-892. |
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1999 Journal Article Immune effector mechanisms in malariaGood, Michael F. and Doolan, Denise L. (1999). Immune effector mechanisms in malaria. Current Opinion in Immunology, 11 (4), 412-419. doi: 10.1016/S0952-7915(99)80069-7 |
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1999 Journal Article CD4+ T-cell- and gamma interferon-dependent protection against murine malaria by immunization with linear synthetic peptides from a Plasmodium yoelii 17-kilodalton hepatocyte erythrocyte proteinCharoenvit, Yupin, Majam, Victoria Fallarme, Corradin, Giampietro, Sacci Jr., John B., Wang, Ruobing, Doolan, Denise L., Jones, Trevor R., Abot, Esteban, Patarroyo, Manuel E., Guzman, Fanny and Hoffman, Stephen L. (1999). CD4+ T-cell- and gamma interferon-dependent protection against murine malaria by immunization with linear synthetic peptides from a Plasmodium yoelii 17-kilodalton hepatocyte erythrocyte protein. Infection and Immunity, 67 (11), 5604-5614. doi: 10.1128/iai.67.11.5604-5614.1999 |
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1998 Journal Article Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccineWang, R, Doolan, D L, Le, T P, Hedstrom, R C, Coonan, K M, Charoenvit, Y, Jones, T R, Hobart, P, Margalith, M, Ng, J, Weiss, W R, Sedegah, M, de Taisne, C, Norman, J A and Hoffman, S L (1998). Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine. Science (New York, N.Y.), 282 (5388), 476-80. doi: 10.1126/science.282.5388.476 |
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1998 Journal Article Simultaneous induction of multiple antigen-specific cytotoxic T lymphocytes in nonhuman primates by immunization with a mixture of four Plasmodium falciparum DNA plasmidsWang, Ruobing, Doolan, Denise L., Charoenvit, Yupin, Hedstrom, Richard C., Gardner, Malcolm J., Hobart, Peter, Tine, John, Sedegah, Martha, Fallarme, Victoria, Sacci Jr., John B., Kaur, Manjit, Klinman, Dennis M., Hoffman, Stephen L. and Weiss, Walter R. (1998). Simultaneous induction of multiple antigen-specific cytotoxic T lymphocytes in nonhuman primates by immunization with a mixture of four Plasmodium falciparum DNA plasmids. Infection and Immunity, 66 (9), 4193-4202. doi: 10.1128/.66.9.4193-4202.1998 |
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1998 Journal Article In vitro expression and in vivo immunogenicity of Plasmodium falciparum pre-erythrocytic stage DNA vaccinesHedstrom, R. C., Doolan, D. L., Wang, R., Kumar, A., Sacci Jr., J. B., Gardner, M. J., Aguiar, J. C., Charoenvit, Y., Sedegah, M., Tine, J. A., Margalith, M., Hobart, P. and Hoffman, S. L. (1998). In vitro expression and in vivo immunogenicity of Plasmodium falciparum pre-erythrocytic stage DNA vaccines. International journal of molecular medicine, 2 (1), 29-38. doi: 10.3892/ijmm.2.1.29 |
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1997 Journal Article DNA vaccination as an approach to malaria control: Current status and strategiesDoolan, D. L., Hedstrom, R. C., Gardner, M. J., Sedegah, M., Wang, H., Gramzinski, R. A., Maroatith, M., Hobart, P. and Hoffman, S. L. (1997). DNA vaccination as an approach to malaria control: Current status and strategies. Current Topics in Microbiology and Immunology, 226, 37-56. |
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1997 Journal Article The development of a multivalent DNA vaccine for malariaHedstrom, Richard C., Doolan, Denise L., Wang, Ruobing, Gardner, Malcolm J., Kumar, Anita, Sedegah, Martha, Gramzinski, Robert A., Sacci Jr., John B., Charoenvit, Yupin, Weiss, Walter R., Margalith, Michal, Norman, Jon A., Hobart, Peter and Hoffman, Stephen L. (1997). The development of a multivalent DNA vaccine for malaria. Springer Seminars in Immunopathology, 19 (2), 147-159. doi: 10.1007/BF00870265 |
